{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T03:10:01Z","timestamp":1749870601491,"version":"3.41.0"},"reference-count":30,"publisher":"Japanese Society of Toxicology","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2017]]},"DOI":"10.2131\/jts.42.1","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T22:13:13Z","timestamp":1483740793000},"page":"1-11","source":"Crossref","is-referenced-by-count":5,"title":["Altered susceptibility of an obese rat model to 13-week subchronic toxicity induced by 3-monochloropropane-1,2-diol"],"prefix":"10.2131","volume":"42","author":[{"given":"Takeshi","family":"Toyoda","sequence":"first","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Man","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-ichi","family":"Akagi","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"Mizuta","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyoshi","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Biological Safety Research Center, National Institute of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Imaida","sequence":"additional","affiliation":[{"name":"Onco-Pathology, Department of Pathology and Host-Defense, Kagawa University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Aigner, E., Feldman, A. and Datz, C. (2014): Obesity as an emerging risk factor for iron deficiency. Nutrients, <b>6<\/b>, 3587-3600.","DOI":"10.3390\/nu6093587"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Aleixandre de Arti\u00f1ano, A. and Miguel Castro, M. (2009): Experimental rat models to study the metabolic syndrome. Br. J. Nutr., <b>102<\/b>, 1246-1253.","DOI":"10.1017\/S0007114509990729"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Bakhiya, N., Abraham, K., G\u00fcrtler, R., Appel, K.E. and Lampen, A.(2011): Toxicological assessment of 3-chloropropane-1,2-diol and glycidol fatty acid esters in food. Mol. Nutr. Food Res., <b>55<\/b>, 509-521.","DOI":"10.1002\/mnfr.201000550"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Becker, C., Orozco, M., Solomons, N.W. and Schumann, K. (2015): Iron metabolism in obesity: how interaction between homoeostatic mechanisms can interfere with their original purpose. Part I: underlying homoeostatic mechanisms of energy storage and iron metabolisms and their interaction. J. Trace Elem. Med. Biol., <b>30<\/b>, 195-201.","DOI":"10.1016\/j.jtemb.2014.10.011"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Burin, G.J. and Saunders, D.R. (1999): Addressing human variability in risk assessment--the robustness of the intraspecies uncertainty factor. Regul. Toxicol. Pharmacol., <b>30<\/b>, 209-216.","DOI":"10.1006\/rtph.1999.1351"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Chaudhary, I.P., Tuntaterdtum, S., McNamara, P.J., Robertson, L.W. and Blouin, R.A. (1993): Effect of genetic obesity and phenobarbital treatment on the hepatic conjugation pathways. J. Pharmacol. Exp. Ther., <b>265<\/b>, 1333-1338.","DOI":"10.1016\/S0022-3565(25)38273-X"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Chen, J., Muntner, P., Hamm, L.L., Jones, D.W., Batuman, V., Fonseca, V., Whelton, P.K. and He, J. (2004): The metabolic syndrome and chronic kidney disease in U.S. adults. Ann. Intern. Med., <b>140<\/b>, 167-174.","DOI":"10.7326\/0003-4819-140-3-200402030-00007"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Cho, W.S., Han, B.S., Nam, K.T., Park, K., Choi, M., Kim, S.H., Jeong, J. and Jang, D.D. (2008): Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats. Food Chem. Toxicol., <b>46<\/b>, 3172-3177.","DOI":"10.1016\/j.fct.2008.07.003"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Coimbra, T.M., Janssen, U., Gr\u00f6ne, H.J., Ostendorf, T., Kunter, U., Schmidt, H., Brabant, G. and Floege, J. (2000): Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes. Kidney Int., <b>57<\/b>, 167-182.","DOI":"10.1046\/j.1523-1755.2000.00836.x"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Dorne, J.L. (2010): Metabolism, variability and risk assessment. Toxicology, <b>268<\/b>, 156-164.","DOI":"10.1016\/j.tox.2009.11.004"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Ejerblad, E., Fored, C.M., Lindblad, P., Fryzek, J., McLaughlin, J.K. and Nyr\u00e9n, O. (2006): Obesity and risk for chronic renal failure. J. Am. Soc. Nephrol., <b>17<\/b>, 1695-1702.","DOI":"10.1681\/ASN.2005060638"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Gallagher, E.J. and LeRoith, D. (2015): Obesity and diabetes: the increased risk of cancer and cancer-related mortality. Physiol. Rev., <b>95<\/b>, 727-748.","DOI":"10.1152\/physrev.00030.2014"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Gray, B., Steyn, F., Davies, P.S. and Vitetta, L. (2014): Liver function parameters, cholesterol, and phospholipid \u03b1-linoleic acid are associated with adipokine levels in overweight and obese adults. Nutr. Res., <b>34<\/b>, 375-382.","DOI":"10.1016\/j.nutres.2014.04.001"},{"key":"14","unstructured":"IARC (2012): 3-Monochloro-1,2-propanediol. IARC Monogr. Eval. Carcinog. Risks Hum., <b>101<\/b>, 349-374."},{"key":"15","unstructured":"JECFA (2002): 3-Chloro-1,2-propanediol. WHO Food Addit. Ser., <b>48<\/b>, 401-432."},{"key":"16","doi-asserted-by":"crossref","unstructured":"Kim, M.S., Wang, S., Shen, Z., Kochansky, C.J., Strauss, J.R., Franklin, R.B. and Vincent, S.H. (2004): Differences in the pharmacokinetics of peroxisome proliferator-activated receptor agonists in genetically obese Zucker and sprague-dawley rats: implications of decreased glucuronidation in obese Zucker rats. Drug Metab. Dispos, <b>32<\/b>, 909-914.","DOI":"10.1016\/S0090-9556(24)02972-6"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Onami, S., Cho, Y.M., Toyoda, T., Akagi, J., Fujiwara, S., Ochiai, R., Tsujino, K., Nishikawa, A. and Ogawa, K. (2015): Orally administered glycidol and its fatty acid esters as well as 3-MCPD fatty acid esters are metabolized to 3-MCPD in the F344 rat. Regul. Toxicol. Pharmacol., <b>73<\/b>, 726-731.","DOI":"10.1016\/j.yrtph.2015.10.020"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Onami, S., Cho, Y.M., Toyoda, T., Horibata, K., Ishii, Y., Umemura, T., Honma, M., Nohmi, T., Nishikawa, A. and Ogawa, K. (2014a): Absence of <i>in vivo<\/i> genotoxicity of 3-monochloropropane-1,2-diol and associated fatty acid esters in a 4-week comprehensive toxicity study using F344 <i>gpt<\/i> delta rats. Mutagenesis, <b>29<\/b>, 295-302.","DOI":"10.1093\/mutage\/geu018"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Onami, S., Cho, Y.M., Toyoda, T., Mizuta, Y., Yoshida, M., Nishikawa, A. and Ogawa, K. (2014b): A 13-week repeated dose study of three 3-monochloropropane-1,2-diol fatty acid esters in F344 rats. Arch. Toxicol., <b>88<\/b>, 871-880.","DOI":"10.1007\/s00204-013-1190-6"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Pizarro, M., Balasubramaniyan, N., Solis, N., Solar, A., Duarte, I., Miquel, J.F., Suchy, F.J., Trauner, M., Accatino, L., Ananthanarayanan, M. and Arrese, M. (2004): Bile secretory function in the obese Zucker rat: evidence of cholestasis and altered canalicular transport function. Gut, <b>53<\/b>, 1837-1843.","DOI":"10.1136\/gut.2003.037689"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Renwick, A.G. and Lazarus, N.R. (1998): Human variability and noncancer risk assessment- An analysis of the default uncertainty factor. Regul. Toxicol. Pharmacol., <b>27<\/b>, 3-20.","DOI":"10.1006\/rtph.1997.1195"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Robjohns, S., Marshall, R., Fellows, M. and Kowalczyk, G. (2003): <i>In vivo<\/i> genotoxicity studies with 3-monochloropropan-1,2-diol. Mutagenesis, <b>18<\/b>, 401-404.","DOI":"10.1093\/mutage\/geg017"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Serkova, N.J., Jackman, M., Brown, J.L., Liu, T., Hirose, R., Roberts, J.P., Maher, J.J. and Niemann, C.U. (2006): Metabolic profiling of livers and blood from obese Zucker rats. J. Hepatol., <b>44<\/b>, 956-962.","DOI":"10.1016\/j.jhep.2005.07.009"},{"key":"24","unstructured":"Thamilselvan, S. and Khan, S.R. (1998): Oxalate and calcium oxalate crystals are injurious to renal epithelial cells: results of<i> in vivo<\/i> and <i>in vitro<\/i> studies. J. Nephrol., <b>11 Suppl 1<\/b>, 66-69."},{"key":"25","doi-asserted-by":"crossref","unstructured":"Toyoda, T., Cho, Y.M., Mizuta, Y., Akagi, J., Nishikawa, A. and Ogawa, K. (2014a): A 13-week subchronic toxicity study of sodium iron chlorophyllin in F344 rats. J. Toxicol. Sci., <b>39<\/b>, 109-119.","DOI":"10.2131\/jts.39.109"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Toyoda, T., Cho, Y.M., Mizuta, Y., Akagi, J. and Ogawa, K. (2014b): A 13-week subchronic toxicity study of ferric citrate in F344 rats. Food Chem. Toxicol., <b>74<\/b>, 68-75.","DOI":"10.1016\/j.fct.2014.09.005"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Young, R.A., Frink, R. and Longcope, C. (1982): Serum testosterone and gonadotropins in the genetically obese male Zucker rat. Endocrinology, <b>111<\/b>, 977-981.","DOI":"10.1210\/endo-111-3-977"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Younossi, Z.M., Koenig, A.B., Abdelatif, D., Fazel, Y., Henry, L. and Wymer, M. (2016): Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology, <b>64<\/b>, 73-84.","DOI":"10.1002\/hep.28431"},{"key":"29","doi-asserted-by":"crossref","unstructured":"Zhao, L., Zhang, X., Shen, Y., Fang, X., Wang, Y. and Wang, F. (2015): Obesity and iron deficiency: a quantitative meta-analysis.Obes. Rev., <b>16<\/b>, 1081-1093.","DOI":"10.1111\/obr.12323"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Zucker, L.M. and Zucker, T.F. (1961): Fatty, a new mutation in the rat. J. Hered, <b>52<\/b>, 275-278.","DOI":"10.1093\/oxfordjournals.jhered.a107093"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/42\/1\/42_1\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T02:41:37Z","timestamp":1749868897000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/42\/1\/42_1\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.42.1","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"type":"print","value":"0388-1350"},{"type":"electronic","value":"1880-3989"}],"subject":[],"published":{"date-parts":[[2017]]}}}