{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:29:20Z","timestamp":1767652160912},"reference-count":34,"publisher":"Japanese Society of Toxicology","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2017]]},"DOI":"10.2131\/jts.42.629","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T22:19:44Z","timestamp":1505254784000},"page":"629-640","source":"Crossref","is-referenced-by-count":19,"title":["Usefulness of urinary biomarkers for nephrotoxicity in cynomolgus monkeys treated with gentamicin, cisplatin, and puromycin aminonucleoside"],"prefix":"10.2131","volume":"42","author":[{"given":"Hiroshi","family":"Uchino","sequence":"first","affiliation":[{"name":"Shin Nippon Biomedical Laboratories, Ltd., Drug Safety Research Laboratories"},{"name":"SNBL USA, Ltd., USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Fujishima","sequence":"additional","affiliation":[{"name":"Shin Nippon Biomedical Laboratories, Ltd., Drug Safety Research Laboratories"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Fukuoka","sequence":"additional","affiliation":[{"name":"Shin Nippon Biomedical Laboratories, Ltd., Drug Safety Research Laboratories"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teppei","family":"Iwakiri","sequence":"additional","affiliation":[{"name":"Shin Nippon Biomedical Laboratories, Ltd., Drug Safety Research Laboratories"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kamikuri","sequence":"additional","affiliation":[{"name":"Shin Nippon Biomedical Laboratories, Ltd., Drug Safety Research Laboratories"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Maeda","sequence":"additional","affiliation":[{"name":"Shin Nippon Biomedical Laboratories, Ltd., Drug Safety Research Laboratories"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Nakama","sequence":"additional","affiliation":[{"name":"Shin Nippon Biomedical Laboratories, Ltd., Drug Safety Research Laboratories"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Alge, J.L. and Arthur, J.M. (2015): Biomarkers of AKI: a review of mechanistic relevance and potential therapeutic implications. Clin. J. Am. Soc. Nephrol., <b>10<\/b>, 147-155.","DOI":"10.2215\/CJN.12191213"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Bonventre, J.V., Vaidya, V.S., Schmouder, R., Feig, P. and Dieterle, F. (2010): Next-generation biomarkers for detecting kidney toxicity. Nat. Biotechnol., <b>28<\/b>, 436-440.","DOI":"10.1038\/nbt0510-436"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Clemo, F.A. (1998): Urinary enzyme evaluation of nephrotoxicity in the dog. Toxicol. Pathol., <b>26<\/b>, 29-32.","DOI":"10.1177\/019262339802600104"},{"key":"4","doi-asserted-by":"crossref","unstructured":"De Loor, J., Daminet, S., Smets, P., Maddens, B. and Meyer, E. (2013): Urinary biomarkers for acute kidney injury in dogs. J. Vet. Intern. Med., <b>27<\/b>, 998-1010.","DOI":"10.1111\/jvim.12155"},{"key":"5","unstructured":"European Medicines Agency (EMA), (2009): Final Conclusions on the Pilot Joint EMEA\/FDA VXDS Experience on Qualification of Nephrotoxicity Biomarkers. Doc. Ref. EMEA\/679719\/2008."},{"key":"6","unstructured":"European Medicines Agency (EMA), (2010): Qualification Opinion ILSI\/HESI Submission of Novel Renal Biomarkers for Toxicity. EMA\/CHMP\/SAWP\/283298\/2010."},{"key":"7","unstructured":"European Medicines Agency (EMA), (2014): Letter of Support for PSTC Translational Drug-induced Kidney Injury (DIKI) Biomarkers. EMA\/651243\/2014."},{"key":"8","doi-asserted-by":"crossref","unstructured":"Ferguson, M.A., Vaidya, V. and Bonventre, J.V. (2008): Biomarkers of nephrotoxic acute kidney injury. Toxicology, <b>245<\/b>, 182-193.","DOI":"10.1016\/j.tox.2007.12.024"},{"key":"9","unstructured":"Food and Drug Administration (FDA), (2008): Review of the Qualification of Seven Biomarkers of Drug-induced Nephrotoxicity in Rats."},{"key":"10","unstructured":"Food and Drug Administration (FDA), (2010): Biomarker Qualification Decision."},{"key":"11","unstructured":"Food and Drug Administration (FDA), (2014): Biomarker Letter of Support."},{"key":"12","doi-asserted-by":"crossref","unstructured":"Fuchs, T.C. and Hewitt, P. (2011): Biomarkers for drug-induced renal damage and nephrotoxicity - an overview for applied toxicology. AAPS J., <b>13<\/b>, 615-631.","DOI":"10.1208\/s12248-011-9301-x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Gautier, J.C., Gury, T., Guffroy, M., Masson, R., Khan-Malek, R., Hoffman, D., Pettit, S. and Harpur, E. (2014): Comparison between male and female Sprague-Dawley rats in the response of urinary biomarkers to injury induced by gentamicin. Toxicol. Pathol., <b>42<\/b>, 1105-1116.","DOI":"10.1177\/0192623314524489"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Gautier, J.C., Zhou, X., Yang, Y., Gury, T., Qu, Z., Palazzi, X., L\u00e9onard, J.F., Slaoui, M., Veeranagouda, Y., Guizon, I., Boitier, E., Filali-Ansary, A., van den Berg. B.H.J., Poetz, O., Joos, T., Zhang, T., Wang, J., Detilleux, P. and Li, B. (2016): Evaluation of novel biomarkers of nephrotoxicity in cynomolgus monkeys treated with gentamicin. Toxicol. Appl. Pharmacol., <b>303<\/b>, 1-10.","DOI":"10.1016\/j.taap.2016.04.012"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Girton, R.A., Sundin, D.P. and Rosenberg, M.E. (2002): Clusterin protects renal tubular epithelial cells from gentamicin-mediated cytotoxicity. Am. J. Physiol. Renal. Physiol.,<b> 282<\/b>, 703-709.","DOI":"10.1152\/ajprenal.00060.2001"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Guha, M., Heier, A., Price, S., Bielenstein, M., Caccese, R.G., Heathcote, D.I., Simpson, T.R., Stong, D.B. and Bodes, E. (2011): Assessment of biomarkers of drug-induced kidney injury in cynomolgus monkeys treated with a triple reuptake inhibitor. Toxicol. Sci., <b>120<\/b>, 269-283.","DOI":"10.1093\/toxsci\/kfr013"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Hall, R.L. and Everds, N.E. (2003): Factors affecting the interpretation of canine and nonhuman primate clinical pathology. Toxicol. Pathol., <b>31<\/b>, 6-10.","DOI":"10.1080\/01926230390174878"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Han, M., Li, Y., Liu, M., Li, Y. and Cong, B. (2012): Renal neutrophil gelatinase associated lipocalin expression in lipopolysaccharide-induced acute kidney injury in the rat. BMC Nephrol., <b>13<\/b>:25.","DOI":"10.1186\/1471-2369-13-25"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Hoffmann, D., Adler, M., Vaidya, V.S., Rached, E., Mulrane, L., Gallagher, W.M., Callanan, J.J., Gautier, J.C., Matheis, K., Staedtler, F., Dieterle, F., Brandenburg, A., Sposny, A., Hewitt, P., Ellinger-Ziegelbauer, H., Bonventre, J.V., Dekant, W. and Mally, A. (2010): Performance of novel kidney biomarkers in preclinical toxicity studies. Toxicol. Sci., <b>116<\/b>, 8-22.","DOI":"10.1093\/toxsci\/kfq029"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Kai, K., Yamaguchi, T., Yoshimatsu, Y., Kinoshita, J., Teranishi, M. and Takasaki, W. (2013): Neutrophil gelatinase-associated lipocalin, a sensitive urinary biomarker of acute kidney injury in dogs receiving gentamicin. J. Toxicol. Sci., <b>38<\/b>, 269-277.","DOI":"10.2131\/jts.38.269"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Kuwabara, T., Mori, K., Mukoyama, M., Kasahara, M., Yokoi, H., Saito, Y., Yoshioka, T., Ogawa, Y., Imamaki, H., Kusakabe, T., Ebihara, K., Omata, M., Satoh, N., Sugawara, A., Barasch, J. and Nakao, K. (2009): Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons. Kidney Int., <b>75<\/b>, 285-294.","DOI":"10.1038\/ki.2008.499"},{"key":"22","unstructured":"Pharmaceuticals and Medical Devices Agency (PMDA), (2010): Record for Pharmacogenomics\/Biomarker Consultation."},{"key":"23","doi-asserted-by":"crossref","unstructured":"Phillips, J.A., Holder, D.J., Ennulat, D., Gautier, J.C., Sauer, J.M., Yang, Y., McDuffie, E., Sonee, M., Gu, Y.Z., Troth, S.P., Lynch, K., Hamlin, D., Peters, D.G., Brees, D. and Walker, E.G. (2016): Rat urinary osteopontin and neutrophil gelatinase-associated lipocalin improve certainty of detecting drug-induced kidney injury. Toxicol. Sci., <b>151<\/b>, 214-223.","DOI":"10.1093\/toxsci\/kfw038"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Pinches, M.D., Betts, C.J., Bickerton, S.J., Beattie, L., Burdett, L.D., Thomas, H.T., Derbyshire, N.A. and Moores, M. (2012): Evaluation of novel urinary renal biomarkers with a cisplatin model of kidney injury: effects of collection period. Toxicol. Pathol., <b>40<\/b>, 534-540.","DOI":"10.1177\/0192623311432437"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Robertson, J.L. (1998): Chemically induced glomerular injury: a review of basic mechanisms and specific xenobiotics. Toxicol. Pathol., <b>26<\/b>, 64-72.","DOI":"10.1177\/019262339802600109"},{"key":"26","unstructured":"Scientific Committee on Health Environmental and Emerging Risks (SCHEER), (2017): The need for non-human primates in biomedical research, production and testing of products and devices (update 2017)"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Tonomura, Y., Tsuchiya, N., Torii, M. and Uehara, T. (2010): Evaluation of the usefulness of urinary biomarkers for nephrotoxicity in rats. Toxicology, <b>273<\/b>, 53-59.","DOI":"10.1016\/j.tox.2010.04.015"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Tonomura, Y., Uehara, T., Yamamoto, E., Torii, M. and Matsubara, M. (2011): Decrease in urinary creatinine in acute kidney injury influences diagnostic value of urinary biomarker-to-creatinine ratio in rats. Toxicology, <b>290<\/b>, 241-248.","DOI":"10.1016\/j.tox.2011.10.001"},{"key":"29","doi-asserted-by":"crossref","unstructured":"Vaidya, V.S., Ferguson, M.A. and Bonventre, J.V. (2008): Biomarkers of acute kidney injury. Annu. Rev. Pharmacol. Toxicol., <b>48<\/b>, 463-493.","DOI":"10.1146\/annurev.pharmtox.48.113006.094615"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Vlasakova, K., Erdos, Z., Troth, S.P., McNulty, K., Chapeau-Campredon, V., Mokrzycki, N., Muniappa, N., Gu, Y., Holder, D., Bailey, W.J., Sistare, F.D. and Glaab, W.E. (2014): Evaluation of the relative performance of 12 urinary biomarkers for renal safety across 22 rat sensitivity and specificity studies. Toxicol. Sci., <b>138<\/b>, 3-20.","DOI":"10.1093\/toxsci\/kft330"},{"key":"31","doi-asserted-by":"crossref","unstructured":"Waikar, S.S., Sabbisetti, V.S. and Bonventre, J.V. (2010): Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate. Kidney Int.,<b> 78<\/b>, 486-494.","DOI":"10.1038\/ki.2010.165"},{"key":"32","unstructured":"Working, P.K., Newman, M.S., Sullivan, T., Brunner, M., Podell, M., Sahenk, Z. and Turnerf, N. (1998): Comparative intravenous toxicity of cisplatin solution and cisplatin encapsulated in long-circulating, pegylated liposomes in cynomolgus monkeys. Toxicol. Sci., <b>46<\/b>, 155-165."},{"key":"33","doi-asserted-by":"crossref","unstructured":"Yao, X., Panichpisal, K., Kurtzman, N. and Nugent, K. (2007): Cisplatin nephrotoxicity. Am. J. Med. Sci., <b>334<\/b>, 115-124.","DOI":"10.1097\/MAJ.0b013e31812dfe1e"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Zhou, X., Ma, B., Lin, Z., Qu, Z., Huo, Y., Wang, J. and Li, B. (2014): Evaluation of the usefulness of novel biomarkers for drug-induced acute kidney injury in beagle dogs. Toxicol. Appl. Pharmacol., <b>280<\/b>, 30-35.","DOI":"10.1016\/j.taap.2014.07.002"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/42\/5\/42_629\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T11:34:40Z","timestamp":1570102480000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/42\/5\/42_629\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.42.629","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}