{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:57:05Z","timestamp":1791331025580,"version":"4.3.1"},"reference-count":39,"publisher":"Japanese Society of Toxicology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2018]]},"DOI":"10.2131\/jts.43.229","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T22:46:55Z","timestamp":1521067615000},"page":"229-240","source":"Crossref","is-referenced-by-count":12,"title":["Improvement of human cell line activation test (h-CLAT) using short-time exposure methods for prevention of false-negative results"],"prefix":"10.2131","volume":"43","author":[{"given":"Kazuto","family":"Narita","sequence":"first","affiliation":[{"name":"Department of Chemical and Energy Engineering, Yokohama National University"},{"name":"Division of Risk Assessment, National Institute of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuuki","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Chemical and Energy Engineering, Yokohama National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuc Thi Hong","family":"Vo","sequence":"additional","affiliation":[{"name":"Department of Chemical and Energy Engineering, Yokohama National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Chemical and Energy Engineering, Yokohama National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Environment and Information Sciences, Yokohama National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiko","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Corporate Research Center, Daicel Corporation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Kojima","sequence":"additional","affiliation":[{"name":"Division of Risk Assessment, National Institute of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Itagaki","sequence":"additional","affiliation":[{"name":"Department of Chemical and Energy Engineering, Yokohama National University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Adler, S., Basketter, D., Creton, S., Pelkonen, O., van Benthem, J., et al. (2011): Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.Arch. Toxicol., <b>85<\/b>, 367-485.","DOI":"10.1007\/s00204-011-0693-2"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Aiba, S. (1998): Maturation of dendritic cells induced by cytokines and haptens.Tohoku J. Exp. Med., <b>184<\/b>, 159-172.","DOI":"10.1620\/tjem.184.159"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Aiba, S., Terunuma, A., Manome, H. and Tagami, H. (1997): Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co-stimulatory molecules.Eur. J. Immunol., <b>27<\/b>, 3031-3038.","DOI":"10.1002\/eji.1830271141"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Arrighi, J.-F., Rebsamen, M., Rousset, F., Kindler, V. and Hauser, C. (2001): A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-\u03b1, and contact sensitizers.J. Immunol., <b>166<\/b>, 3837-3845.","DOI":"10.4049\/jimmunol.166.6.3837"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Ashikaga, T., Sakaguchi, H., Sono, S., Kosaka, N., Ishikawa, M., Nukada, Y., Miyazawa, M., Ito, Y., Nishiyama, N. and Itagaki, H. (2010): A comparative evaluation of <i>in vitro<\/i> skin sensitisation tests: the human cell-line activation test (h-CLAT) versus the local lymph node assay (LLNA).Altern. Lab. Anim., <b>38<\/b>, 275-284.","DOI":"10.1177\/026119291003800403"},{"key":"6","first-page":"245","year":"1998","unstructured":"Banchereau, J. and Steinman, R.M. (1998): Dendritic cells and the control of immunity.Nature, <b>392<\/b>, 245-252.","journal-title":"Nature Cell Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"key":"7","first-page":"11","year":"2014","unstructured":"Basketter, D.A., Al\u00e9p\u00e9e, N., Ashikaga, T., Barroso, J., Gilmour, N., Goebel, C., Hibatallah, J., Hoffmann, S., Kern, P., Martinozzi-Teissier, S., Maxwell, G., Reisinger, K., Sakaguchi, H., Schepky, A., Tailhardat, M. and Templier, M. (2014): Categorization of chemicals according to their relative human skin sensitizing potency.Dermatitis, <b>25<\/b>, 11-21.","journal-title":"Dermatitis","ISSN":"https:\/\/id.crossref.org\/issn\/1710-3568","issn-type":"print"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Basketter, D., White, I.R., McFadden, J.P. and Kimber, I. (2015): Hexyl cinnamal: consideration of skin-sensitizing properties and suitability as a positive control.Cutan. Ocul. Toxicol., <b>34<\/b>, 227-231.","DOI":"10.3109\/15569527.2014.933973"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Cooper, J.A.2nd, Saracci, R. and Cole, P. (1979): Describing the validity of carcinogen screening tests.Br. J. Cancer, <b>39<\/b>, 87-89.","DOI":"10.1038\/bjc.1979.10"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Cumberbatch, M., Clelland, K., Dearman, R.J. and Kimber, I. (2005): Impact of cutaneous IL-10 on resident epidermal Langerhans\u2019 cells and the development of polarized immune responses.J. Immunol., <b>175<\/b>, 43-50.","DOI":"10.4049\/jimmunol.175.1.43"},{"key":"11","doi-asserted-by":"publisher","unstructured":"Cumberbatch, M., Dearman, R.J. and Kimber, I. (1997): Langerhans cells require signals from both tumour necrosis factor-\u03b1 and interleukin-1 \u03b2 for migration.Immunology, <b>92<\/b>, 388-395.","DOI":"10.1046\/j.1365-2567.1997.00360.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"De Smedt, A.C., Van Den Heuvel, R.L., Zwi Berneman, N. and Schoeters, G.E. (2001): Modulation of phenotype, cytokine production and stimulatory function of CD34+-derived DC by NiCl(2) and SDS.Toxicol. In Vitro, <b>15<\/b>, 319-325.","DOI":"10.1016\/S0887-2333(01)00029-7"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Dearman, R.J., Warbrick, E.V., Humphreys, I.R. and Kimber, I. (2000): Characterization in mice of the immunological properties of five allergenic acid anhydrides.J. Appl. Toxicol., <b>20<\/b>, 221-230.","DOI":"10.1002\/(SICI)1099-1263(200005\/06)20:3<221::AID-JAT651>3.0.CO;2-#"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Delaine, T., Niklasson, I.B., Emter, R., Luthman, K., Karlberg, A.-T. and Natsch, A. (2011): Structure--activity relationship between the <i>in vivo<\/i> skin sensitizing potency of analogues of phenyl glycidyl ether and the induction of Nrf2-dependent luciferase activity in the KeratinoSens <i>in vitro<\/i> assay.Chem. Res. Toxicol., <b>24<\/b>, 1312-1318.","DOI":"10.1021\/tx200196s"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Enk, A.H., Angeloni, V.L., Udey, M.C. and Katz, S.I. (1993): An essential role for Langerhans cell-derived IL-1 beta in the initiation of primary immune responses in skin.J. Immunol., <b>150<\/b>, 3698-3704.","DOI":"10.4049\/jimmunol.150.9.3698"},{"key":"16","first-page":"157","year":"2005","unstructured":"Gerberick, G.F., Ryan, C.A., Kern, P.S., Schlatter, H., Dearman, R.J., Kimber, I., Patlewicz, G.Y. and Basketter, D.A. (2005): Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods.Dermatitis, <b>16<\/b>, 157-202.","journal-title":"Dermatitis","ISSN":"https:\/\/id.crossref.org\/issn\/1710-3568","issn-type":"print"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Gildea, L.A., Ryan, C.A., Foertsch, L.M., Kennedy, J.M., Dearman, R.J., Kimber, I. and Gerberick, G.F. (2006): Identification of gene expression changes induced by chemical allergens in dendritic cells: opportunities for skin sensitization testing.J. Invest. Dermatol., <b>126<\/b>, 1813-1822.","DOI":"10.1038\/sj.jid.5700319"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Goodwin, B.F. and Roberts, D.W. (1986): Structure-activity relationships in allergic contact dermatitis.Food Chem. Toxicol., <b>24<\/b>, 795-798.","DOI":"10.1016\/0278-6915(86)90188-2"},{"key":"19","unstructured":"International Agency for Research on Cancer (IARC). (1989): Some glycidyl ethers.IARC Monogr. Eval. Carcinog. Risks Hum., <b>47<\/b>, 237-261."},{"key":"20","doi-asserted-by":"crossref","unstructured":"Kanda, Y. (2013): Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics.Bone Marrow Transplant., <b>48<\/b>, 452-458.","DOI":"10.1038\/bmt.2012.244"},{"key":"21","unstructured":"Kligman, A.M. (1966): The identification of contact allergens by human assay. 3. The maximization test: a procedure for screening and rating contact sensitizers.J. Invest. Dermatol., <b>47<\/b>, 393-409."},{"key":"22","doi-asserted-by":"crossref","unstructured":"Moffitt, D.L. and Sansom, J.E. (2002): Allergic contact dermatitis from phthalic anhydride\/trimellitic anhydride\/glycols copolymer in nail varnish.Contact Dermat., <b>46<\/b>, 236.","DOI":"10.1034\/j.1600-0536.2002.460409.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Motolese, A., Truzzi, M., Giannini, A. and Seidenari, S. (1993): Contact dermatitis and contact sensitization among enamellers and decorators in the ceramics industry.Contact Dermat., <b>28<\/b>, 59-62.","DOI":"10.1111\/j.1600-0536.1993.tb03342.x"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Narita, K., Vo, P.T., Yamamoto, K., Kojima, H. and Itagaki, H. (2017): Preventing false-negatives in the <i>in vitro<\/i> skin sensitization testing of acid anhydrides using interleukin-8 release assays.Toxicol. In Vitro, <b>42<\/b>, 69-75.","DOI":"10.1016\/j.tiv.2017.04.008"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Natsch, A. and Emter, R. (2008): Skin sensitizers induce antioxidant response element dependent genes: application to the <i>in vitro<\/i> testing of the sensitization potential of chemicals.Toxicol. Sci., <b>102<\/b>, 110-119.","DOI":"10.1093\/toxsci\/kfm259"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Natsch, A. and Haupt, T. (2013): Utility of rat liver S9 fractions to study skin-sensitizing prohaptens in a modified KeratinoSens assay.Toxicol. Sci., <b>135<\/b>, 356-368.","DOI":"10.1093\/toxsci\/kft160"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Niklasson, I.B., Broo, K., Jonsson, C., Luthman, K. and Karlberg, A.T. (2009): Reduced sensitizing capacity of epoxy resin systems: a structure-activity relationship study.Chem. Res. Toxicol., <b>22<\/b>, 1787-1794.","DOI":"10.1021\/tx900193s"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Nukada, Y., Ashikaga, T., Sakaguchi, H., Sono, S., Mugita, N., Hirota, M., Miyazawa, M., Ito, Y., Sasa, H. and Nishiyama, N. (2011): Predictive performance for human skin sensitizing potential of the human cell line activation test (h-CLAT).Contact Dermat., <b>65<\/b>, 343-353.","DOI":"10.1111\/j.1600-0536.2011.01952.x"},{"key":"29","unstructured":"OECD. (2016): OECD guidelines for the testing of chemicals. Test No. 442E: <i>in vitro<\/i> skin sensitization: human cell line activation test (h-CLAT), adopted July 2016. Paris, France: Organisation for Economic Cooperation and Development."},{"key":"30","unstructured":"Opdyke, D.L. (1979): Monographs on fragrance raw materials.Food Cosmet. Toxicol., <b>17<\/b>, 259-266."},{"key":"31","unstructured":"Patlewicz, G., Dimitrov, S.D., Low, L.K., Kern, P.S., Dimitrova, G.D., Comber, M.I., Aptula, A.O., Phillips, R.D., Niemel\u00e4, J., Madsen, C., Wedebye, E.B., Roberts, D.W., Bailey, P.T. and Mekenyan, O.G. (2007): TIMES-SS--a promising tool for the assessment of skin sensitization hazard. A characterization with respect to the OECD validation principles for (Q)SARs and an external evaluation for predictivity.Regul. Toxicol. Pharmacol., <b>48<\/b>, 225-239."},{"key":"32","doi-asserted-by":"crossref","unstructured":"Patlewicz, G.Y., Wright, Z.M., Basketter, D.A., Pease, C.K., Lepoittevin, J.P. and Arnau, E.G. (2002): Structure-activity relationships for selected fragrance allergens.Contact Dermat., <b>47<\/b>, 219-226.","DOI":"10.1034\/j.1600-0536.2002.470406.x"},{"key":"33","unstructured":"RIFM. (2007): Data submission to NICEATM. Woodcliff Lake, NJ, USA. RIFM (Research Institute for Fragrance Materials, Inc.)"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Rothlein, R., Dustin, M.L., Marlin, S.D. and Springer, T.A. (1986): A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.J. Immunol., <b>137<\/b>, 1270-1274.","DOI":"10.4049\/jimmunol.137.4.1270"},{"key":"35","doi-asserted-by":"crossref","unstructured":"Ryan, C.A., Cruse, L.W., Skinner, R.A., Dearman, R.J., Kimber, I. and Gerberick, G.F. (2002): Examination of a vehicle for use with water soluble materials in the murine local lymph node assay.Food Chem. Toxicol., <b>40<\/b>, 1719-1725.","DOI":"10.1016\/S0278-6915(02)00116-3"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Symington, F.W., Brady, W. and Linsley, P.S. (1993): Expression and function of B7 on human epidermal Langerhans cells.J. Immunol., <b>150<\/b>, 1286-1295.","DOI":"10.4049\/jimmunol.150.4.1286"},{"key":"37","doi-asserted-by":"crossref","unstructured":"Takenouchi, O., Miyazawa, M., Saito, K., Ashikaga, T. and Sakaguchi, H. (2013): Predictive performance of the human Cell Line Activation Test (h-CLAT) for lipophilic chemicals with high octanol-water partition coefficients.J. Toxicol. Sci., <b>38<\/b>, 599-609.","DOI":"10.2131\/jts.38.599"},{"key":"38","doi-asserted-by":"crossref","unstructured":"Tsuchiya, S., Yamabe, M., Yamaguchi, Y., Kobayashi, Y., Konno, T. and Tada, K. (1980): Establishment and characterization of a human acute monocytic leukemia cell line (THP-1).Int. J. Cancer, <b>26<\/b>, 171-176.","DOI":"10.1002\/ijc.2910260208"},{"key":"39","first-page":"141","year":"1996","unstructured":"Weltzien, H.U., Moulon, C., Martin, S., Padovan, E., Hartmann, U. and Kohler, J. (1996): T cell immune responses to haptens. Structural models for allergic and autoimmune reactions.Toxicology, <b>107<\/b>, 141-151.","journal-title":"Toxicology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-483X","issn-type":"print"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/43\/3\/43_229\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T16:19:46Z","timestamp":1693585186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/43\/3\/43_229\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.43.229","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}