{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:02:14Z","timestamp":1773302534634,"version":"3.50.1"},"reference-count":31,"publisher":"Japanese Society of Toxicology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2018]]},"DOI":"10.2131\/jts.43.493","type":"journal-article","created":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T22:20:56Z","timestamp":1533248456000},"page":"493-506","source":"Crossref","is-referenced-by-count":15,"title":["Conduction and contraction properties of human iPS cell-derived cardiomyocytes: analysis by motion field imaging compared with the guinea-pig isolated heart model"],"prefix":"10.2131","volume":"43","author":[{"given":"Takehito","family":"Isobe","sequence":"first","affiliation":[{"name":"Research Division, Chugai Pharmaceutical Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Honda","sequence":"additional","affiliation":[{"name":"Research Division, Chugai Pharmaceutical Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyasu","family":"Tabo","sequence":"additional","affiliation":[{"name":"Research Division, Chugai Pharmaceutical Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Ando, H., Yoshinaga, T., Yamamoto, W., Asakura, K., Uda, T., Taniguchi, T., Ojima, A., Shinkyo, R., Kikuchi, K., Osada, T., Hayashi, S., Kasai, C., Miyamoto, N., Tashibu, H., Yamazaki, D., Sugiyama, A., Kanda, Y., Sawada, K. and Sekino, Y. (2017): A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes. J. Pharmacol. Toxicol. Methods, <b>84<\/b>, 111-127.","DOI":"10.1016\/j.vascn.2016.12.003"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Cook, D., Brown, D., Alexander, R., March, R., Morgan, P., Satterthwaite, G. and Pangalos, M.N. (2014): Lessons learned from the fate of AstraZeneca\u2019s drug pipeline: a five-dimensional framework. Nat. Rev. Drug Discov., <b>13<\/b>, 419-431.","DOI":"10.1038\/nrd4309"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Denning, C., Borgdorff, V., Crutchley, J., Firth, K.S., George, V., Kalra, S., Kondrashov, A., Hoang, M.D., Mosqueira, D., Patel, A., Prodanov, L., Rajamohan, D., Skarnes, W.C., Smith, J.G. and Young, L.E. (2016): Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform. Biochim. Biophys. Acta, <b>1863<\/b> (7 Pt B), 1728-1748.","DOI":"10.1016\/j.bbamcr.2015.10.014"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Frohnwieser, B., Chen, L.Q., Schreibmayer, W. and Kallen, R.G. (1997): Modulation of the human cardiac sodium channel alpha-subunit by cAMP-dependent protein kinase and the responsible sequence domain. J. Physiol., <b>498<\/b>, 309-318.","DOI":"10.1113\/jphysiol.1997.sp021859"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Goineau, S., Castagn\u00e9, V., Guillaume, P. and Froget, G. (2012): The comparative sensitivity of three <i>in vitro<\/i> safety pharmacology models for the detection of lidocaine-induced cardiac effects. J. Pharmacol. Toxicol. Methods, <b>66<\/b>, 52-58.","DOI":"10.1016\/j.vascn.2012.06.001"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Guo, L., Abrams, R.M., Babiarz, J.E., Cohen, J.D., Kameoka, S., Sanders, M.J., Chiao, E. and Kolaja, K.L. (2011): Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol. Sci., <b>123<\/b>, 281-289.","DOI":"10.1093\/toxsci\/kfr158"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Guo, L., Dong, Z. and Guthrie, H. (2009): Validation of a guinea pig Langendorff heart model for assessing potential cardiovascular liability of drug candidates. J. Pharmacol. Toxicol. Methods, <b>60<\/b>, 130-151.","DOI":"10.1016\/j.vascn.2009.07.002"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Guth, B.D., Chiang, A.Y., Doyle, J., Engwall, M.J., Guillon, J.M., Hoffmann, P., Koerner, J., Mittelstadt, S., Ottinger, S., Pierson, J.B., Pugsley, M.K., Rossman, E.I., Walisser, J. and Sarazan, R.D. (2015): The evaluation of drug-induced changes in cardiac inotropy in dogs: results from a HESI-sponsored consortium. J. Pharmacol. Toxicol. Methods, <b>75<\/b>, 70-90.","DOI":"10.1016\/j.vascn.2015.02.002"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Harris, K., Aylott, M., Cui, Y., Louttit, J.B., McMahon, N.C. and Sridhar, A. (2013): Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays. Toxicol. Sci., <b>134<\/b>, 412-426.","DOI":"10.1093\/toxsci\/kft113"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Hayakawa, T., Kunihiro, T., Ando, T., Kobayashi, S., Matsui, E., Yada, H., Kanda, Y., Kurokawa, J. and Furukawa, T. (2014): Image-based evaluation of contraction-relaxation kinetics of human-induced pluripotent stem cell-derived cardiomyocytes: correlation and complementarity with extracellular electrophysiology. J. Mol. Cell. Cardiol., <b>77<\/b>, 178-191.","DOI":"10.1016\/j.yjmcc.2014.09.010"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Hayakawa, T., Kunihiro, T., Dowaki, S., Uno, H., Matsui, E., Uchida, M., Kobayashi, S., Yasuda, A., Shimizu, T. and Okano, T. (2012): Noninvasive evaluation of contractile behavior of cardiomyocyte monolayers based on motion vector analysis. Tissue Eng. Part C Methods, <b>18<\/b>, 21-32.","DOI":"10.1089\/ten.tec.2011.0273"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Honda, M., Kiyokawa, J., Tabo, M. and Inoue, T. (2011): Electrophysiological characterization of cardiomyocytes derived from human induced pluripotent stem cells. J. Pharmacol. Sci., <b>117<\/b>, 149-159.","DOI":"10.1254\/jphs.11038FP"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Honda, M., Komatsu, R., Holzgrefe, H.H., Yamada, Y., Isobe, T., Kimura, K., Itoh, T., Tamaoki, N. and Tabo, M. (2010): Application of probabilistic analysis for precisely correcting the QT interval for heart rate in telemetered common marmosets. J. Pharmacol. Toxicol. Methods, <b>61<\/b>, 264-270.","DOI":"10.1016\/j.vascn.2010.01.005"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Izumi-Nakaseko, H., Nakamura, Y., Wada, T., Ando, K., Kanda, Y., Sekino, Y. and Sugiyama, A. (2017): Characterization of human iPS cell-derived cardiomyocyte sheets as a model to detect drug-induced conduction disturbance. J. Toxicol. Sci., <b>42<\/b>, 183-192.","DOI":"10.2131\/jts.42.183"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Kadota, S., Minami, I., Morone, N., Heuser, J.E., Agladze, K. and Nakatsuji, N. (2013): Development of a reentrant arrhythmia model in human pluripotent stem cell-derived cardiac cell sheets. Eur. Heart J., <b>34<\/b>, 1147-1156.","DOI":"10.1093\/eurheartj\/ehs418"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Kamp, T.J. and Hell, J.W. (2000): Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C. Circ. Res., <b>87<\/b>, 1095-1102.","DOI":"10.1161\/01.RES.87.12.1095"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Kitaguchi, T., Moriyama, Y., Taniguchi, T., Maeda, S., Ando, H., Uda, T., Otabe, K., Oguchi, M., Shimizu, S., Saito, H., Toratani, A., Asayama, M., Yamamoto, W., Matsumoto, E., Saji, D., Ohnaka, H. and Miyamoto, N. (2017): CSAHi study: detection of drug-induced ion channel\/receptor responses, QT prolongation, and arrhythmia using multi-electrode arrays in combination with human induced pluripotent stem cell-derived cardiomyocytes. J. Pharmacol. Toxicol. Methods, <b>85<\/b>, 73-81.","DOI":"10.1016\/j.vascn.2017.02.001"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Komatsu, R., Honda, M., Holzgrefe, H.H., Kubo, J., Yamada, Y., Isobe, T., Kimura, K., Itoh, T., Tamaoki, N. and Tabo, M. (2010): Sensitivity of common marmosets to detect drug-induced QT interval prolongation: moxifloxacin case study. J. Pharmacol. Toxicol. Methods, <b>61<\/b>, 271-276.","DOI":"10.1016\/j.vascn.2010.01.006"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Kopljar, I., De Bondt, A., Vinken, P., Teisman, A., Damiano, B., Goeminne, N., Van den Wyngaert, I., Gallacher, D.J. and Lu, H.R. (2017): Chronic drug-induced effects on contractile motion properties and cardiac biomarkers in human induced pluripotent stem cell-derived cardiomyocytes. Br. J. Pharmacol., <b>174<\/b>, 3766-3779.","DOI":"10.1111\/bph.13713"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Laverty, H., Benson, C., Cartwright, E., Cross, M., Garland, C., Hammond, T., Holloway, C., McMahon, N., Milligan, J., Park, B., Pirmohamed, M., Pollard, C., Radford, J., Roome, N., Sager, P., Singh, S., Suter, T., Suter, W., Trafford, A., Volders, P., Wallis, R., Weaver, R., York, M. and Valentin, J. (2011): How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines? Br. J. Pharmacol., <b>163<\/b>, 675-693.","DOI":"10.1111\/j.1476-5381.2011.01255.x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Li, M., Kanda, Y., Ashihara, T., Sasano, T., Nakai, Y., Kodama, M., Hayashi, E., Sekino, Y., Furukawa, T. and Kurokawa, J. (2017): Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs. J. Pharmacol. Sci., <b>134<\/b>, 75-85.","DOI":"10.1016\/j.jphs.2017.05.004"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Lu, H.R., Rohrbacher, J., Vlaminckx, E., Van Ammel, K., Yan, G.X. and Gallacher, D.J. (2010): Predicting drug-induced slowing of conduction and pro-arrhythmia: identifying the \u2018bad\u2019 sodium current blockers. Br. J. Pharmacol., <b>160<\/b>, 60-76.","DOI":"10.1111\/j.1476-5381.2010.00646.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Ma, J., Guo, L., Fiene, S.J., Anson, B.D., Thomson, J.A., Kamp, T.J., Kolaja, K.L., Swanson, B.J. and January, C.T. (2011): High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. Am. J. Physiol. Heart Circ. Physiol., <b>301<\/b>, H2006-H2017.","DOI":"10.1152\/ajpheart.00694.2011"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Nozaki, Y., Honda, Y., Watanabe, H., Saiki, S., Koyabu, K., Itoh, T., Nagasawa, C., Nakamori, C., Nakayama, C., Iwasaki, H., Suzuki, S., Washio, I., Takahashi, E., Miyamoto, K., Yamanishi, A., Endo, H., Shinozaki, J., Nogawa, H. and Kunimatsu, T. (2016): CSAHi study: validation of multi-electrode array systems (MEA60\/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability. Regul. Toxicol. Pharmacol., <b>77<\/b>, 75-86.","DOI":"10.1016\/j.yrtph.2016.02.007"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Pointon, A., Harmer, A.R., Dale, I.L., Abi-Gerges, N., Bowes, J., Pollard, C. and Garside, H. (2015): Assessment of cardiomyocyte contraction in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol. Sci., <b>144<\/b>, 227-237.","DOI":"10.1093\/toxsci\/kfu312"},{"key":"26","first-page":"2399","year":"2013","unstructured":"Rao, C., Prodromakis, T., Kolker, L., Chaudhry, U.A., Trantidou, T., Sridhar, A., Weekes, C., Camelliti, P., Harding, S.E., Darzi, A., Yacoub, M.H., Athanasiou, T. and Terracciano, C.M. (2013): The effect of microgrooved culture substrates on calcium cycling of cardiac myocytes derived from human induced pluripotent stem cells. Biomaterials, <b>34<\/b>, 2399-2411.","journal-title":"Biomaterials","ISSN":"https:\/\/id.crossref.org\/issn\/0142-9612","issn-type":"print"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Sakakibara, Y., Furukawa, T., Singer, D.H., Jia, H., Backer, C.L., Arentzen, C.E. and Wasserstrom, J.A. (1993): Sodium current in isolated human ventricular myocytes. Am. J. Physiol., <b>265<\/b>, H1301-H1309.","DOI":"10.1152\/ajpheart.1993.265.4.H1301"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Salameh, A., Krautblatter, S., Karl, S., Blanke, K., Gomez, D.R., Dhein, S., Pfeiffer, D. and Janousek, J. (2009): The signal transduction cascade regulating the expression of the gap junction protein connexin43 by beta-adrenoceptors. Br. J. Pharmacol., <b>158<\/b>, 198-208.","DOI":"10.1111\/j.1476-5381.2009.00344.x"},{"key":"29","doi-asserted-by":"crossref","unstructured":"Tabo, M., Komatsu, R., Isobe, T., Honda, M., Yamada, Y. and Kimura, K. (2010): Accurate detection of drug-induced delayed ventricular repolarization with a suitable correction formula in Langendorff guinea pig heart. J. Toxicol. Sci., <b>35<\/b>, 687-698.","DOI":"10.2131\/jts.35.687"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Takasuna, K., Asakura, K., Araki, S., Ando, H., Kazusa, K., Kitaguchi, T., Kunimatsu, T., Suzuki, S. and Miyamoto, N. (2017): Comprehensive <i>in vitro<\/i> cardiac safety assessment using human stem cell technology: overview of CSAHi HEART initiative. J. Pharmacol. Toxicol. Methods, <b>83<\/b>, 42-54.","DOI":"10.1016\/j.vascn.2016.09.004"},{"key":"31","doi-asserted-by":"crossref","unstructured":"Yamamoto, W., Asakura, K., Ando, H., Taniguchi, T., Ojima, A., Uda, T., Osada, T., Hayashi, S., Kasai, C., Miyamoto, N., Tashibu, H., Yoshinaga, T., Yamazaki, D., Sugiyama, A., Kanda, Y., Sawada, K. and Sekino, Y. (2016): Electrophysiological Characteristics of Human iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced Proarrhythmic Potential. PLoS One, <b>11<\/b>, e0167348.","DOI":"10.1371\/journal.pone.0167348"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/43\/8\/43_493\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,4]],"date-time":"2018-08-04T04:14:15Z","timestamp":1533356055000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/43\/8\/43_493\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.43.493","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}