{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T16:56:52Z","timestamp":1758992212967},"reference-count":26,"publisher":"Japanese Society of Toxicology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2019]]},"DOI":"10.2131\/jts.44.113","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T23:00:48Z","timestamp":1549321248000},"page":"113-120","source":"Crossref","is-referenced-by-count":9,"title":["Bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridiolato)zinc(II) exhibits strong cytotoxicity and a high intracellular accumulation in cultured vascular endothelial cells"],"prefix":"10.2131","volume":"44","author":[{"given":"Tomoya","family":"Fujie","sequence":"first","affiliation":[{"name":"Department of Environmental Health, Faculty of Pharmaceutical Sciences, Toho University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Faculty of Pharmaceutical Sciences, Toho University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Faculty of Pharmaceutical Sciences, Toho University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Kaji","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Burch, R.E., Hahn, H.K. and Sullivan, J.F. (1975): Newer aspects of the roles of zinc, manganese, and copper in human nutrition. Clin. Chem., <b>21<\/b>, 501-520.","DOI":"10.1093\/clinchem\/21.4.501"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Fujie, T., Hara, T. and Kaji, T. (2016a): Toxicology of organic-inorganic hybrid molecules: bio-organometallics and its toxicology. J. Toxicol. Sci., <b>41<\/b> (Special), SP81-SP88.","DOI":"10.2131\/jts.41.SP81"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Fujie, T., Segawa, Y., Uehara, A., Nakamura, T., Kimura, T., Yoshida, E., Yamamoto, C., Uchiyama, M., Naka, H. and Kaji, T. (2016c): Zinc diethyldithiocarbamate as an inducer of metallothionein in cultured vascular endothelial cells. J. Toxicol. Sci., <b>41<\/b>, 217-224.","DOI":"10.2131\/jts.41.217"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Fujie, T., Segawa, Y., Yoshida, E., Kimura, T., Fujiwara, Y., Yamamoto, C., Satoh, M., Naka, H. and Kaji, T. (2016b): Induction of metallothionein isoforms by copper diethyldithiocarbamate in cultured vascular endothelial cells. J. Toxicol. Sci., <b>41<\/b>, 225-232.","DOI":"10.2131\/jts.41.225"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Fujimoto, S., Yasui, H. and Yoshikawa, Y. (2013): Development of a novel antidiabetic zinc complex with an organoselenium ligand at the lowest dosage in KK-A<sup>y<\/sup> mice. J. Inorg. Biochem., <b>121<\/b>, 10-15.","DOI":"10.1016\/j.jinorgbio.2012.12.008"},{"key":"6","unstructured":"de Groot, P.G., Gonsalves, M.D., Loesberg, C., van Buul-Wortelboer, M.F., van Aken, W.G. and van Mourik, J.A. (1984): Thrombin-induced release of von Willebrand factor from endothelial cells is mediated by phospholipid methylation. Prostacyclin synthesis is independent of phospholipid methylation. J. Biol. Chem., <b>259<\/b>, 13329-13333."},{"key":"7","doi-asserted-by":"crossref","unstructured":"Hara, T., Kojima, T., Matsuzaki, H., Nakamura, T., Yoshida, E., Fujiwara, Y., Yamamoto, C., Saito, S. and Kaji, T. (2017): Induction of syndecan-4 by organic-inorganic hybrid molecules with a 1,10-phenanthroline structure in cultured vascular endothelial cells. Int. J. Mol. Sci., <b>18<\/b>, 352.","DOI":"10.3390\/ijms18020352"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Hara, T., Matsuzaki, H., Nakamura, T., Yoshida, E., Ohkubo, T., Maruyama, H., Yamamoto, C., Saito, S. and Kaji, T. (2016): Cytotoxicity of zinc, copper and rhodium complexes with 1,10-phenanthroline or 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells. Fundam. Toxicol. Sci., <b>3<\/b>, 109-113.","DOI":"10.2131\/fts.3.109"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Hara, T., Nonaka, Y., Yasuike, S., Kaji, T. and Yamamoto, C. (2018): Structure-activity relationship of [1,5]azastibocines in cytotoxicity to vascular endothelial cells. J. Toxicol. Sci., <b>43<\/b>, 735-740.","DOI":"10.2131\/jts.43.735"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., Yamamoto, M. and Nabeshima, Y. (1997): An Nrf2\/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun., <b>236<\/b>, 313-322.","DOI":"10.1006\/bbrc.1997.6943"},{"key":"11","unstructured":"Kaji, T., Fujiwara, Y., Sakurai, S., Yamamoto, C., Kozuka, H. and Koizumi, F. (1995): Zinc promotes the repair of wounded monolayers of cultured vascular endothelial cells. Res. Commun. Mol. Pathol. Pharmacol., <b>89<\/b>, 189-198."},{"key":"12","doi-asserted-by":"crossref","unstructured":"Kaji, T., Fujiwara, Y., Yamamoto, C., Sakamoto, M. and Kozuka, H. (1994): Stimulation by zinc of cultured vascular endothelial cell proliferation: possible involvement of endogenous basic fibroblast growth factor. Life Sci., <b>55<\/b>, 1781-1787.","DOI":"10.1016\/0024-3205(94)90088-4"},{"key":"13","doi-asserted-by":"publisher","unstructured":"Kaji, T., Mishima, A., Koyanagi, E., Yamamoto, C., Sakamoto, M. and Kozuka, H. (1992): Possible mechanism for zinc protection against cadmium cytotoxicity in cultured vascular endothelial cells. Toxicology, <b>76<\/b>, 257-270.","DOI":"10.1016\/0300-483X(92)90194-J"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Katoh, A., Tsukahara, T., Saito, R., Ghosh, K.K., Yoshikawa, Y., Kojima, Y., Tamura, A. and Sakurai, H. (2002): An extremely high insulin-mimetic activity of bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridinolato)zinc(II) complex. Chem. Lett., <b>31<\/b>, 114-115.","DOI":"10.1246\/cl.2002.114"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Kissane, J.M. and Robins, E. (1958): The fluorometric measurement of deoxyribonucleic acid in animal tissues with special reference to the central nervous system. J. Biol. Chem., <b>233<\/b>, 184-188.","DOI":"10.1016\/S0021-9258(19)68051-8"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Kohri, K., Yoshida, E., Yasuike, S., Fujie, T., Yamamoto, C. and Kaji, T. (2015): The cytotoxicity of organobismuth compounds with certain molecular structures can be diminished by replacing the bismuth atom with an antimony atom in the molecules. J. Toxicol. Sci., <b>40<\/b>, 321-327.","DOI":"10.2131\/jts.40.321"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Levin, E.G. and Loskutoff, D.J. (1982): Regulation of plasminogen activator production by cultured endothelial cells. Ann. N. Y. Acad. Sci., <b>401<\/b>, 184-194.","DOI":"10.1111\/j.1749-6632.1982.tb25717.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Marcum, J.A., Atha, D.H., Fritze, L.M., Nawroth, P., Stern, D. and Rosenberg, R.D. (1986): Cloned bovine aortic endothelial cells synthesize anticoagulantly active heparan sulfate proteoglycan. J. Biol. Chem., <b>261<\/b>, 7507-7517.","DOI":"10.1016\/S0021-9258(17)38421-1"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Matsuoka, I., Nakahata, N. and Nakanishi, H. (1989): Inhibitory effect of 8-bromo cyclic GMP on an extracellular Ca2+-dependent arachidonic acid liberation in collagen-stimulated rabbit platelets. Biochem. Pharmacol., <b>38<\/b>, 1841-1847.","DOI":"10.1016\/0006-2952(89)90420-6"},{"key":"20","doi-asserted-by":"crossref","unstructured":"van Mourik, J.A., Lawrence, D.A. and Loskutoff, D.J. (1984): Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells. J. Biol. Chem., <b>259<\/b>, 14914-14921.","DOI":"10.1016\/S0021-9258(17)42691-3"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Murakami, M., Fujie, T., Matsumura, M., Yoshida, E., Yamamoto, C., Fujiwara, Y., Yasuike, S. and Kaji, T. (2015): Comparative cytotoxicity of triphenylstibane and fluorine-substituted triarylpnictogens in cultured vascular endothelial cells. Fundam. Toxicol. Sci., <b>2<\/b>, 61-66.","DOI":"10.2131\/fts.2.61"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Nakamura, T., Yoshida, E., Fujie, T., Ogata, F., Yamamoto, C., Kawasaki, N. and Kaji, T. (2017): Synergistic cytotoxicity caused by forming a complex of copper and 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells. J. Toxicol. Sci., <b>42<\/b>, 683-687.","DOI":"10.2131\/jts.42.683"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Radtke, F., Heuchel, R., Georgiev, O., Hergersberg, M., Gariglio, M., Dembic, Z. and Schaffner, W. (1993): Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter. EMBO J., <b>12<\/b>, 1355-1362.","DOI":"10.1002\/j.1460-2075.1993.tb05780.x"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Revtyak, G.E., Johnson, A.R. and Campbell, W.B. (1987): Prostaglandin synthesis in bovine coronary endothelial cells: comparison with other commonly studied endothelial cells. Thromb. Res., <b>48<\/b>, 671-683.","DOI":"10.1016\/0049-3848(87)90433-6"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Sato, Y. and Rifkin, D.B. (1988): Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis. J. Cell Biol., <b>107<\/b>, 1199-1205.","DOI":"10.1083\/jcb.107.3.1199"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Zhang, B., Egli, D., Georgiev, O. and Schaffner, W. (2001): The Drosophila homolog of mammalian zinc finger factor MTF-1 activates transcription in response to heavy metals. Mol. Cell. Biol., <b>21<\/b>, 4505-4514.","DOI":"10.1128\/MCB.21.14.4505-4514.2001"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/44\/2\/44_113\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T11:16:30Z","timestamp":1662894990000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/44\/2\/44_113\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.44.113","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}