{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:15:34Z","timestamp":1790248534195,"version":"4.1.0"},"reference-count":59,"publisher":"Japanese Society of Toxicology","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2019]]},"DOI":"10.2131\/jts.44.667","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T22:05:04Z","timestamp":1570140304000},"page":"667-679","source":"Crossref","is-referenced-by-count":3,"title":["Gene expression profiling of cultured mouse testis fragments treated with ethinylestradiol"],"prefix":"10.2131","volume":"44","author":[{"given":"Noriko","family":"Nakamura","sequence":"first","affiliation":[{"name":"Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Sloper","sequence":"additional","affiliation":[{"name":"Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro L.","family":"Del Valle","sequence":"additional","affiliation":[{"name":"Center for Drug Evaluation and Research, Food and Drug Administration, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Aarabi, M., Yu, Y., Xu, W., Tse, M.Y., Pang, S.C., Yi, Y.J., Sutovsky, P. and Oko, R. (2012): The testicular and epididymal expression profile of PLC\u03b6 in mouse and human does not support its role as a sperm-borne oocyte activating factor. PLoS One, <b>7<\/b>, e33496.","DOI":"10.1371\/journal.pone.0033496"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Adhikari, N., Sinha, N. and Saxena, D.K. (2000): Effect of lead on Sertoli-germ cell coculture of rat. Toxicol. Lett., <b>116<\/b>, 45-49.","DOI":"10.1016\/S0378-4274(00)00199-5"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Anastasiadou, M. and Michailidis, G. (2016): Transcriptional changes of cytokines in rooster testis and epididymis during sexual maturation stages and Salmonella infection. Anim. Reprod. Sci., <b>171<\/b>, 41-48.","DOI":"10.1016\/j.anireprosci.2016.05.012"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Chao, C., Joyce-Shaikh, B., Grein, J., Moshrefi, M., Raoufi, F., Laface, D.M., McClanahan, T.K., Bourne, P.A., Pierce, R.H., Gorman, D.M. and Pflanz, S. (2011): C17 prevents inflammatory arthritis and associated joint destruction in mice. PLoS One, <b>6<\/b>, e22256.","DOI":"10.1371\/journal.pone.0022256"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Di-Luoffo, M., Brousseau, C. and Tremblay, J.J. (2016): MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells. Andrology, <b>4<\/b>, 335-344.","DOI":"10.1111\/andr.12150"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Dix, D.J., Allen, J.W., Collins, B.W., Mori, C., Nakamura, N., Poorman-Allen, P., Goulding, E.H. and Eddy, E.M. (1996): Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. Proc. Natl. Acad. Sci. USA, <b>93<\/b>, 3264-3268.","DOI":"10.1073\/pnas.93.8.3264"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Eveno, C., Broqueres-You, D., Feron, J.G., Rampanou, A., Tijeras-Raballand, A., Ropert, S., Leconte, L., Levy, B.I. and Pocard, M. (2011): Netrin-4 delays colorectal cancer carcinomatosis by inhibiting tumor angiogenesis. Am. J. Pathol., <b>178<\/b>, 1861-1869.","DOI":"10.1016\/j.ajpath.2010.12.019"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Frazee, A.C., Pertea, G., Jaffe, A.E., Langmead, B., Salzberg, S.L. and Leek, J.T. (2015): Ballgown bridges the gap between transcriptome assembly and expression analysis. Nat. Biotechnol., <b>33<\/b>, 243-246.","DOI":"10.1038\/nbt.3172"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Ge, R.S., Hardy, D.O., Catterall, J.F. and Hardy, M.P. (1999): Opposing changes in 3alpha-hydroxysteroid dehydrogenase oxidative and reductive activities in rat leydig cells during pubertal development. Biol. Reprod., <b>60<\/b>, 855-860.","DOI":"10.1095\/biolreprod60.4.855"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Held, T., Paprotta, I., Khulan, J., Hemmerlein, B., Binder, L., Wolf, S., Schubert, S., Meinhardt, A., Engel, W. and Adham, I.M. (2006): Hspa4l-deficient mice display increased incidence of male infertility and hydronephrosis development. Mol. Cell. Biol., <b>26<\/b>, 8099-8108.","DOI":"10.1128\/MCB.01332-06"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Hessel, E.M., Cruikshank, W.W., Van Ark, I., De Bie, J.J., Van Esch, B., Hofman, G., Nijkamp, F.P., Center, D.M. and Van Oosterhout, A.J. (1998): Involvement of IL-16 in the induction of airway hyper-responsiveness and up-regulation of IgE in a murine model of allergic asthma. J. Immunol., <b>160<\/b>, 2998-3005.","DOI":"10.4049\/jimmunol.160.6.2998"},{"key":"12","first-page":"800","year":"1988","unstructured":"Hochberg, Y. (1988): A sharper Bonferroni procedure for multiple tests of significance. Biometrika, <b>75<\/b>, 800-802.","journal-title":"Biometrika","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3444","issn-type":"print"},{"key":"13","unstructured":"Hogarth, C.A., Evans, E., Onken, J., Kent, T., Mitchell, D., Petkovich, M. and Griswold, M.D. (2015): CYP26 Enzymes Are Necessary Within the Postnatal Seminiferous Epithelium for Normal Murine Spermatogenesis. Biol. Reprod., <b>93<\/b>, 19."},{"key":"14","unstructured":"ICH Draft guideline S5(R2). (2005): Detection of Toxicity to Reproduction for Medicinal products &amp; Toxicity to Male Fertility. https:\/\/www.ich.org\/fileadmin\/Public_Web_Site\/ICH_Products\/Guidelines\/Safety\/S5\/Step4\/S5_R2__Guideline.pdf"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Iwase, T., Sano, F., Murakami, T. and Inazawa, K. (1995): Male reproductive toxicity of ethinylestradiol associated with 4 weeks daily dosing prior to mating in rats. J. Toxicol. Sci., <b>20<\/b>, 265-279.","DOI":"10.2131\/jts.20.265"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Jain, A.K., Singh, D., Dubey, K., Maurya, R., Mittal, S. and Pandey, A.K. (2018): Chapter3 Models and methods for in vitro toxicity. In: In Vitro Toxicology, pp.45-65 Academic Press.","DOI":"10.1016\/B978-0-12-804667-8.00003-1"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Karlsson, E., Waltersson, M.A., Bostner, J., P\u00e9rez-Tenorio, G., Olsson, B., Hallbeck, A.L. and St\u00e5l, O. (2011): High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1. Genes Chromosomes Cancer, <b>50<\/b>, 775-787.","DOI":"10.1002\/gcc.20900"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Kaneto, M., Kanamori, S., Hishikawa, A. and Kishi, K. (1999): Epididymal sperm motion as a parameter of male reproductive toxicity: sperm motion, fertility, and histopathology in ethinylestradiol-treated rats. Reprod. Toxicol., <b>13<\/b>, 279-289.","DOI":"10.1016\/S0890-6238(99)00021-0"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Kim, D., Langmead, B. and Salzberg, S.L. (2015): HISAT: a fast spliced aligner with low memory requirements. Nat. Methods, <b>12<\/b>, 357-360.","DOI":"10.1038\/nmeth.3317"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Kretzschmar, G., Papke, A., Zierau, O., M\u00f6ller, F.J., Medjakovic, S., Jungbauer, A. and Vollmer, G. (2010): Estradiol regulates aryl hydrocarbon receptor expression in the rat uterus. Mol. Cell. Endocrinol., <b>321<\/b>, 253-257.","DOI":"10.1016\/j.mce.2010.02.018"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Lahousse, S.A., Wallace, D.G., Liu, D., Gaido, K.W. and Johnson, K.J. (2006): Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) phthalate exposure suggests a common initial genetic response at fetal and prepubertal ages. Toxicol. Sci., <b>93<\/b>, 369-381.","DOI":"10.1093\/toxsci\/kfl049"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Li, J., Hou, R., Niu, X., Liu, R., Wang, Q., Wang, C., Li, X., Hao, Z., Yin, G. and Zhang, K. (2016): Comparison of microarray and RNA-Seq analysis of mRNA expression in dermal mesenchymal stem cells. Biotechnol. Lett., <b>38<\/b>, 33-41.","DOI":"10.1007\/s10529-015-1963-5"},{"key":"23","first-page":"402","year":"2001","unstructured":"Livak, K.J. and Schmittgen, T.D. (2001): Analysis of relative gene expression data using real-time quantitative PCR and the 2<sup>-\u0394 \u0394 C<\/sup><sub><sup>T<\/sup><\/sub> Method. Methods, <b>25<\/b>, 402-408.","journal-title":"Methods A Companion to Methods in Enzymology","ISSN":"https:\/\/id.crossref.org\/issn\/1046-2023","issn-type":"print"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Martin, M. (2011): Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnet J., <b>17<\/b>, 10-12.","DOI":"10.14806\/ej.17.1.200"},{"key":"25","doi-asserted-by":"crossref","unstructured":"MacLean, G., Li, H., Metzger, D., Chambon, P. and Petkovich, M. (2007): Apoptotic extinction of germ cells in testes of <i>Cyp26b1<\/i> knockout mice. Endocrinology, <b>148<\/b>, 4560-4567.","DOI":"10.1210\/en.2007-0492"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Naciff, J.M., Hess, K.A., Overmann, G.J., Torontali, S.M., Carr, G.J., Tiesman, J.P., Foertsch, L.M., Richardson, B.D., Martinez, J.E. and Daston, G.P. (2005): Gene expression changes induced in the testis by transplacental exposure to high and low doses of 17alpha-ethynyl estradiol, genistein, or bisphenol A. Toxicol. Sci., <b>86<\/b>, 396-416.","DOI":"10.1093\/toxsci\/kfi198"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Nakamura, N., Merry, G.E., Inselman, A.L., Sloper, D.T., Del Valle, P.L., Sato, T., Ogawa, T. and Hansen, D.K. (2017): Evaluation of culture time and media in an <i>in vitro<\/i> testis organ culture system. Birth Defects Res., <b>109<\/b>, 465-474.","DOI":"10.1002\/bdr2.1002"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Nakamura, N., Vijay, V., Desai, V.G., Hansen, D.K., Han, T., Chang, C.-W., Chen, Y.-C., Harrouk, W., McIntyre, B., Foster, P.M., Fuscoe, J.C. and Inselman, A.L. (2018): Transcript profiling in the testes and prostates of postnatal day 30 Sprague-Dawley rats exposed prenatally and lactationally to 2-hydroxy-4-methoxybenzophenone. Reprod. Toxicol., <b>82<\/b>, 111-123.","DOI":"10.1016\/j.reprotox.2018.10.001"},{"key":"29","doi-asserted-by":"crossref","unstructured":"Nakamura, N., Sloper, D.T. and Del Valle, P.L. (2019): Evaluation of an <i>in vitro<\/i> mouse testis organ culture system for assessing male reproductive toxicity. Birth Defects Res., <b>111<\/b>, 70-77.","DOI":"10.1002\/bdr2.1431"},{"key":"30","unstructured":"National Research Council. (2011): Guide for the care and use of laboratory animals. National Academy Press, Washington, D.C."},{"key":"31","doi-asserted-by":"publisher","unstructured":"Neesen, J., Koehler, M.R., Kirschner, R., Steinlein, C., Kreutzberger, J., Engel, W. and Schmid, M. (1997): Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. Gene, <b>200<\/b>, 193-202.","DOI":"10.1016\/S0378-1119(97)00417-4"},{"key":"32","doi-asserted-by":"crossref","unstructured":"Pence, L.M., Schmitt, T.C., Beger, R.D., Del Valle, P.L. and Nakamura, N. (2019): Testicular function in cultured postnatal mouse testis fragments is similar to that of animals during the first wave of spermatogenesis. Birth Defects Res., <b>111<\/b>, 270-280.","DOI":"10.1002\/bdr2.1451"},{"key":"33","doi-asserted-by":"crossref","unstructured":"Pertea, M., Pertea, G.M., Antonescu, C.M., Chang, T.C., Mendell, J.T. and Salzberg, S.L. (2015): StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Nat. Biotechnol., <b>33<\/b>, 290-295.","DOI":"10.1038\/nbt.3122"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Purzycka-Bohdan, D., Szczerkowska-Dobosz, A., Zablotna, M., Wierzbicka, J., Piotrowska, A., Zmijewski, M.A., Nedoszytko, B. and Nowicki, R. (2016): Assessment of Interleukin 16 Serum Levels and Skin Expression in Psoriasis Patients in Correlation with Clinical Severity of the Disease. PLoS One, <b>11<\/b>, e0165577.","DOI":"10.1371\/journal.pone.0165577"},{"key":"35","doi-asserted-by":"crossref","unstructured":"Rengaraj, D., Kim, D.K., Zheng, Y.H., Lee, S.I., Kim, H. and Han, J.Y. (2008): Testis-specific novel transcripts in chicken: <i>in situ<\/i> localization and expression pattern profiling during sexual development. Biol. Reprod., <b>79<\/b>, 413-420.","DOI":"10.1095\/biolreprod.108.067959"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Sasaki, J.C., Chapin, R.E., Hall, D.G., Breslin, W., Moffit, J., Saldutti, L., Enright, B., Seger, M., Jarvi, K., Hixon, M., Mitchard, T. and Kim, J.H. (2011): Incidence and nature of testicular toxicity findings in pharmaceutical development. Birth Defects Res. B Dev. Reprod. Toxicol., <b>92<\/b>, 511-525.","DOI":"10.1002\/bdrb.20338"},{"key":"37","first-page":"504","year":"2011","unstructured":"Sato, T., Katagiri, K., Gohbara, A., Inoue, K., Ogonuki, N., Ogura, A., Kubota, Y. and Ogawa, T. (2011): In vitro production of functional sperm in cultured neonatal mouse testes. Nature, <b>471<\/b>, 504-507.","journal-title":"?Nature","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"key":"38","doi-asserted-by":"crossref","unstructured":"Schrimpf, R., Dierks, C., Martinsson, G., Sieme, H. and Distl, O. (2014): Genome-wide association study identifies phospholipase C zeta 1 (PLCz1) as a stallion fertility locus in Hanoverian warmblood horses. PLoS One, <b>9<\/b>, e109675.","DOI":"10.1371\/journal.pone.0109675"},{"key":"39","doi-asserted-by":"crossref","unstructured":"Shaffer, J.P. (1995): Multiple hypothesis testing. Annu. Rev. sychol., <b>46<\/b>, 561-584.","DOI":"10.1146\/annurev.ps.46.020195.003021"},{"key":"40","doi-asserted-by":"publisher","unstructured":"Semet, M., Paci, M., Sa\u00efas-Magnan, J., Metzler-Guillemain, C., Boissier, R., Lejeune, H. and Perrin, J. (2017): The impact of drugs on male fertility: a review. Andrology, <b>5<\/b>, 640-663.","DOI":"10.1111\/andr.12366"},{"key":"41","doi-asserted-by":"crossref","unstructured":"Shimomura, K., Shimada, M., Hagiwara, M., Harada, S., Kato, M. and Furuhama, K. (2005): Insights into testicular damage induced by ethinylestradiol in rats. Reprod. Toxicol., <b>20<\/b>, 157-163.","DOI":"10.1016\/j.reprotox.2004.12.013"},{"key":"42","doi-asserted-by":"crossref","unstructured":"Sironen, A., Hansen, J., Thomsen, B., Andersson, M., Vilkki, J., Toppari, J. and Kotaja, N. (2010): Expression of SPEF2 during mouse spermatogenesis and identification of IFT20 as an interacting protein. Biol. Reprod., <b>82<\/b>, 580-590.","DOI":"10.1095\/biolreprod.108.074971"},{"key":"43","doi-asserted-by":"crossref","unstructured":"Sironen, A., Kotaja, N., Mulhern, H., Wyatt, T.A., Sisson, J.H., Pavlik, J.A., Miiluniemi, M., Fleming, M.D. and Lee, L. (2011): Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia. Biol. Reprod., <b>85<\/b>, 690-701.","DOI":"10.1095\/biolreprod.111.091132"},{"key":"44","doi-asserted-by":"crossref","unstructured":"Sousa, M., Ferreira, C., Rabaca, A. and Sa, R. (2017): Assessing male reproductive toxicity during drug development. Andrology (Los Angel.), <b>6<\/b>, 185.","DOI":"10.4172\/2167-0250.1000185"},{"key":"45","doi-asserted-by":"publisher","unstructured":"Steinberger, A. and Steinberger, E. (1970): Tissue culture of male mammalian gonads. In Vitro, <b>5<\/b>, 17-27.","DOI":"10.1007\/BF02618371"},{"key":"46","doi-asserted-by":"crossref","unstructured":"Sun, J., Nawaz, Z. and Slingerland, J.M. (2007): Long-range activation of GREB1 by estrogen receptor via three distal consensus estrogen-responsive elements in breast cancer cells. Mol. Endocrinol., <b>21<\/b>, 2651-2662.","DOI":"10.1210\/me.2007-0082"},{"key":"47","doi-asserted-by":"crossref","unstructured":"Tan, X.J., Xing, X.W., Li, L.Y., Wu, Z.D., Zhong, C.G., Nie, D.S., Fu, J.J., Xiang, Y., Deng, Y. and Lu, G.X. (2005): Molecular cloning of a novel mouse testis-specific spermatogenic cell apoptosis inhibitor gene mTSARG7 as a candidate oncogene. Acta Biochim. Biophys. Sin. (Shanghai), <b>37<\/b>, 396-405.","DOI":"10.1111\/j.1745-7270.2005.00057.x"},{"key":"48","doi-asserted-by":"crossref","unstructured":"Vaughan, K.T., Mikami, A., Paschal, B.M., Holzbaur, E.L., Hughes, S.M., Echeverri, C.J., Moore, K.J., Gilbert, D.J., Copeland, N.G., Jenkins, N.A. and Vallee, R.B. (1996): Multiple mouse chromosomal loci for dynein-based motility. Genomics, <b>36<\/b>, 29-38.","DOI":"10.1006\/geno.1996.0422"},{"key":"49","doi-asserted-by":"crossref","unstructured":"Vijay, V., Moland, C.L., Han, T., Fuscoe, J.C., Lee, T., Herman, E.H., Jenkins, G.R., Lewis, S.M., Cummings, C.A., Gao, Y., Cao, Z., Yu, L.R. and Desai, V.G. (2016): Early transcriptional changes in cardiac mitochondria during chronic doxorubicin exposure and mitigation by dexrazoxane in mice. Toxicol. Appl. Pharmacol., <b>295<\/b>, 68-84.","DOI":"10.1016\/j.taap.2016.02.003"},{"key":"50","doi-asserted-by":"crossref","unstructured":"Wang, T. and Hong, W. (2006): RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment. Biochem. Biophys. Res. Commun., <b>350<\/b>, 413-423.","DOI":"10.1016\/j.bbrc.2006.09.064"},{"key":"51","doi-asserted-by":"crossref","unstructured":"Wang, X., Wei, Y., Fu, G., Li, H., Saiyin, H., Lin, G., Wang, Z., Chen, S. and Yu, L. (2015a): Tssk4 is essential for maintaining the structural integrity of sperm flagellum. Mol. Hum. Reprod., <b>21<\/b>, 136-145.","DOI":"10.1093\/molehr\/gau097"},{"key":"52","doi-asserted-by":"crossref","unstructured":"Wang, X.L., Wei, Y.H., Fu, G.L. and Yu, L. (2015b): Testis specific serine\/threonine protein kinase 4 (TSSK4) leads to cell apoptosis relying on its kinase activity. J. Huazhong Univ. Sci. Technolog. Med. Sci., <b>35<\/b>, 235-240.","DOI":"10.1007\/s11596-015-1417-2"},{"key":"53","doi-asserted-by":"crossref","unstructured":"Wang, Z., Gerstein, M. and Snyder, M. (2009): RNA-Seq: a revolutionary tool for transcriptomics. Nat. Rev. Genet., <b>10<\/b>, 57-63.","DOI":"10.1038\/nrg2484"},{"key":"54","doi-asserted-by":"crossref","unstructured":"Wu, F.J., Lin, T.Y., Sung, L.Y., Chang, W.F., Wu, P.C. and Luo, C.W. (2017): BMP8A sustains spermatogenesis by activating both SMAD1\/5\/8 and SMAD2\/3 in spermatogonia. Sci. Signal., <b>10<\/b>, eaal1910.","DOI":"10.1126\/scisignal.aal1910"},{"key":"55","doi-asserted-by":"crossref","unstructured":"Yang, B., Yang, E., Liao, H., Wang, Z., Den, Z. and Ren, H. (2015): ARNT2 is downregulated and serves as a potential tumor suppressor gene in non-small cell lung cancer. Tumour Biol., <b>36<\/b>, 2111-2119.","DOI":"10.1007\/s13277-014-2820-1"},{"key":"56","doi-asserted-by":"crossref","unstructured":"Yu, X., Sidhu, J.S., Hong, S. and Faustman, E.M. (2005): Essential role of extracellular matrix (ECM) overlay in establishing the functional integrity of primary neonatal rat Sertoli cell\/gonocyte co-cultures: an improved <i>in vitro<\/i> model for assessment of male reproductive toxicity. Toxicol. Sci., <b>84<\/b>, 378-393.","DOI":"10.1093\/toxsci\/kfi085"},{"key":"57","doi-asserted-by":"crossref","unstructured":"Yu, X., Hong, S., Moreira, E.G. and Faustman, E.M. (2009): Improving <i>in vitro<\/i> Sertoli cell\/gonocyte co-culture model for assessing male reproductive toxicity: lessons learned from comparisons of cytotoxicity versus genomic responses to phthalates. Toxicol. Appl. Pharmacol., <b>239<\/b>, 325-336.","DOI":"10.1016\/j.taap.2009.06.014"},{"key":"58","doi-asserted-by":"crossref","unstructured":"Zeleniak, A.E., Huang, W., Brinkman, M.K., Fishel, M.L. and Hill, R. (2017): Loss of MTSS1 results in increased metastatic potential in pancreatic cancer. Oncotarget, <b>8<\/b>, 16473-16487.","DOI":"10.18632\/oncotarget.14869"},{"key":"59","doi-asserted-by":"crossref","unstructured":"Zhou, Q., Nie, R., Li, Y., Friel, P., Mitchell, D., Hess, R.A., Small, C. and Griswold, M.D. (2008): Expression of stimulated by retinoic acid gene 8 (<i>Stra8<\/i>) in spermatogenic cells induced by retinoic acid: an <i>in vivo<\/i> study in vitamin A-sufficient postnatal murine testes. Biol. Reprod., <b>79<\/b>, 35-42.","DOI":"10.1095\/biolreprod.107.066795"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/44\/10\/44_667\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T06:53:25Z","timestamp":1695279205000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/44\/10\/44_667\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":59,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.44.667","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}