{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:17:10Z","timestamp":1783649830960,"version":"3.55.0"},"reference-count":45,"publisher":"Japanese Society of Toxicology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2020]]},"DOI":"10.2131\/jts.45.423","type":"journal-article","created":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T22:05:13Z","timestamp":1596405913000},"page":"423-434","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of microRNA expression profiling during paraquat-induced injury of murine lung alveolar epithelial cells"],"prefix":"10.2131","volume":"45","author":[{"given":"Hua-Wei","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Emergency, The First Affiliated Hospital of China Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency, The First Affiliated Hospital of China Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency, The First Affiliated Hospital of China Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency, The First Affiliated Hospital of China Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Song","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Emergency, The First Affiliated Hospital of China Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Alural, B., Ozerdem, A., Allmer, J., Genc, K. and Genc, S. (2015): Lithium protects against paraquat neurotoxicity by NRF2 activation and miR-34a inhibition in SH-SY5Y cells. Front. Cell. Neurosci., <b>9<\/b>, 209.","DOI":"10.3389\/fncel.2015.00209"},{"key":"2","first-page":"281","year":"2004","unstructured":"Bartel, D.P. (2004): MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, <b>116<\/b>, 281-297.","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Chen, F., Qi, S., Zhang, X., Wu, J., Yang, X. and Wang, R. (2019a): miR-23a-3p suppresses cell proliferation in oral squamous cell carcinomas by targeting FGF2 and correlates with a better prognosis: miR-23a-3p inhibits OSCC growth by targeting FGF2. Pathol. Res. Pract., <b>215<\/b>, 660-667.","DOI":"10.1016\/j.prp.2018.12.021"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Chen, W., Zhou, Z.Q., Ren, Y.Q., Zhang, L., Sun, L.N., Man, Y.L. and Wang, Z.K. (2019b): Effects of long non-coding RNA LINC00667 on renal tubular epithelial cell proliferation, apoptosis and renal fibrosis via the miR-19b-3p\/LINC00667\/CTGF signaling pathway in chronic renal failure. Cell. Signal., <b>54<\/b>, 102-114.","DOI":"10.1016\/j.cellsig.2018.10.016"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Cui, S., Nian, Q., Chen, G., Wang, X., Zhang, J., Qiu, J. and Zhang, Z. (2019): Ghrelin ameliorates A549 cell apoptosis caused by paraquat via p38-MAPK regulated mitochondrial apoptotic pathway. Toxicology, <b>426<\/b>, 152267.","DOI":"10.1016\/j.tox.2019.152267"},{"key":"6","doi-asserted-by":"crossref","unstructured":"de Oliveira, M.R., Ferreira, G.C. and Schuck, P.F. (2016): Protective effect of carnosic acid against paraquat-induced redox impairment and mitochondrial dysfunction in SH-SY5Y cells: Role for PI3K\/Akt\/Nrf2 pathway. Toxicol. In Vitro, <b>32<\/b>, 41-54.","DOI":"10.1016\/j.tiv.2015.12.005"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Dinis-Oliveira, R.J., Duarte, J.A., S\u00e1nchez-Navarro, A., Remi\u00e3o, F., Bastos, M.L. and Carvalho, F. (2008): Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment. Crit. Rev. Toxicol., <b>38<\/b>, 13-71.","DOI":"10.1080\/10408440701669959"},{"key":"8","doi-asserted-by":"publisher","unstructured":"El-Aarag, B., Magdy, M., AlAjmi, M.F., Khalifa, S.A. and El-Seedi, H.R. (2019): Melittin Exerts Beneficial Effects on Paraquat-Induced Lung Injuries In Mice by Modifying Oxidative Stress and Apoptosis. Molecules, <b>24<\/b>, 1498.","DOI":"10.3390\/molecules24081498"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Fan, Q.W., Cheng, C., Hackett, C., Feldman, M., Houseman, B.T., Nicolaides, T., Haas-Kogan, D., James, C.D., Oakes, S.A., Debnath, J., Shokat, K.M. and Weiss, W.A. (2010): Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci. Signal., <b>3<\/b>, ra81.","DOI":"10.1126\/scisignal.2001017"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Fukushima, T., Tanaka, K., Lim, H. and Moriyama, M. (2002): Mechanism of cytotoxicity of paraquat. Environ. Health Prev. Med., <b>7<\/b>, 89-94.","DOI":"10.1265\/ehpm.2002.89"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Gunnell, D. and Eddleston, M. (2003): Suicide by intentional ingestion of pesticides: a continuing tragedy in developing countries. Int. J. Epidemiol., <b>32<\/b>, 902-909.","DOI":"10.1093\/ije\/dyg307"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Hale, V., Hale, G.A., Brown, P.A. and Amankwah, E.K. (2017): A Review of DNA Methylation and microRNA Expression in Recurrent Pediatric Acute Leukemia. Oncology, <b>92<\/b>, 61-67.","DOI":"10.1159\/000452091"},{"key":"13","unstructured":"Jiang, Y., Wang, W., Liu, Z.Y., Xie, Y., Qian, Y. and Cai, X.N. (2018): Overexpression of miR-130a-3p\/301a-3p attenuates high glucose-induced MPC5 podocyte dysfunction through suppression of TNF-\u03b1 signaling. Exp. Ther. Med., <b>15<\/b>, 1021-1028."},{"key":"14","doi-asserted-by":"crossref","unstructured":"Jin, Y., Liu, W., Liu, X., Ma, T., Yang, C., Cai, Q. and Liu, Z. (2018): Transplantation of endothelial progenitor cells attenuated paraquat-induced acute lung injury via miR-141-3p-Notch-Nrf2 axis. Cell Biosci., <b>8<\/b>, 21.","DOI":"10.1186\/s13578-018-0219-1"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Karbasforooshan, H. and Karimi, G. (2018): The role of SIRT1 in diabetic retinopathy. Biomed. Pharmacother., <b>97<\/b>, 190-194.","DOI":"10.1016\/j.biopha.2017.10.075"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Li, S., Zhao, G., Chen, L., Ding, Y., Lian, J., Hong, G. and Lu, Z. (2016): Resveratrol protects mice from paraquat-induced lung injury: the important role of SIRT1 and NRF2 antioxidant pathways. Mol. Med. Rep., <b>13<\/b>, 1833-1838.","DOI":"10.3892\/mmr.2015.4710"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Lima, R.T., Busacca, S., Almeida, G.M., Gaudino, G., Fennell, D.A. and Vasconcelos, M.H. (2011): MicroRNA regulation of core apoptosis pathways in cancer. Eur. J. Cancer, <b>47<\/b>, 163-174.","DOI":"10.1016\/j.ejca.2010.11.005"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Liu, M.W., Su, M.X., Tang, D.Y., Hao, L., Xun, X.H. and Huang, Y.Q. (2019): Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K\/Akt\/mTOR and hedgehog signalling via increasing miR-193a expression. BMC Pulm. Med., <b>19<\/b>, 35.","DOI":"10.1186\/s12890-019-0799-5"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Ma, X.M. and Blenis, J. (2009): Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell Biol., <b>10<\/b>, 307-318.","DOI":"10.1038\/nrm2672"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Ma, Y., Tian, S., He, S., Chen, Q., Wang, Z., Xiao, X., Fu, L. and Lei, X. (2016): The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y. Gene, <b>588<\/b>, 62-68.","DOI":"10.1016\/j.gene.2016.04.037"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Mohr, A.M. and Mott, J.L. (2015): Overview of microRNA biology. Semin. Liver Dis., <b>35<\/b>, 3-11.","DOI":"10.1055\/s-0034-1397344"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Ouyang, M., Li, Y., Ye, S., Ma, J., Lu, L., Lv, W., Chang, G., Li, X., Li, Q., Wang, S. and Wang, W. (2014): MicroRNA profiling implies new markers of chemoresistance of triple-negative breast cancer. PLoS One, <b>9<\/b>, e96228.","DOI":"10.1371\/journal.pone.0096228"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Park, J.S., Park, K.H., Kim, H. and Choi, S.Y. (2014): Effects of sivelestat treatment on acute lung injury in paraquat-intoxicated rats. Drug Chem. Toxicol., <b>37<\/b>, 114-120.","DOI":"10.3109\/01480545.2013.834351"},{"key":"24","first-page":"330","year":"1979","unstructured":"Proudfoot, A.T., Stewart, M.S., Levitt, T. and Widdop, B. (1979): Paraquat poisoning: significance of plasma-paraquat concentrations. Lancet, <b>2<\/b>, 330-332.","journal-title":"The Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Quan, J., Pan, X., Li, Y., Hu, Y., Tao, L., Li, Z., Zhao, L., Wang, J., Li, H., Lai, Y., Zhou, L., Lin, C., Gui, Y., Ye, J., Zhang, F. and Lai, Y. (2019): MiR-23a-3p acts as an oncogene and potential prognostic biomarker by targeting PNRC2 in RCC. Biomed. Pharmacother., <b>110<\/b>, 656-666.","DOI":"10.1016\/j.biopha.2018.11.065"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Rezatabar, S., Karimian, A., Rameshknia, V., Parsian, H., Majidinia, M., Kopi, T.A., Bishayee, A., Sadeghinia, A., Yousefi, M., Monirialamdari, M. and Yousefi, B. (2019): RAS\/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression. J. Cell. Physiol., <b>234<\/b>, 14951-14965.","DOI":"10.1002\/jcp.28334"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Rizwan, H., Pal, S., Sabnam, S. and Pal, A. (2020): High glucose augments ROS generation regulates mitochondrial dysfunction and apoptosis via stress signalling cascades in keratinocytes. Life Sci., <b>241<\/b>, 117148.","DOI":"10.1016\/j.lfs.2019.117148"},{"key":"28","unstructured":"Serra, A., Domingos, F. and Prata, M.M. (2003): [Paraquat intoxication]. Acta Med. Port., <b>16<\/b>, 25-32."},{"key":"29","unstructured":"Smith, L.L., Lewis, C.P., Wyatt, I. and Cohen, G.M. (1990): The importance of epithelial uptake systems in lung toxicity. Environ. Health Perspect., <b>85<\/b>, 25-30."},{"key":"30","doi-asserted-by":"crossref","unstructured":"Sun, D.Z., Song, C.Q., Xu, Y.M., Wang, R., Liu, W., Liu, Z. and Dong, X.S. (2018): Involvement of PINK1\/Parkin-mediated mitophagy in paraquat- induced apoptosis in human lung epithelial-like A549 cells. Toxicol. In Vitro, <b>53<\/b>, 148-159.","DOI":"10.1016\/j.tiv.2018.08.009"},{"key":"31","first-page":"65","year":"2002","unstructured":"Suntres, Z.E. (2002): Role of antioxidants in paraquat toxicity. Toxicology, <b>180<\/b>, 65-77.","journal-title":"Toxicology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-483X","issn-type":"print"},{"key":"32","doi-asserted-by":"crossref","unstructured":"Takahashi, Y., Karbowski, M., Yamaguchi, H., Kazi, A., Wu, J., Sebti, S.M., Youle, R.J. and Wang, H.G. (2005): Loss of Bif-1 suppresses Bax\/Bak conformational change and mitochondrial apoptosis. Mol. Cell. Biol., <b>25<\/b>, 9369-9382.","DOI":"10.1128\/MCB.25.21.9369-9382.2005"},{"key":"33","doi-asserted-by":"crossref","unstructured":"Tiwari, A., Mukherjee, B. and Dixit, M. (2018): MicroRNA Key to Angiogenesis Regulation: MiRNA Biology and Therapy. Curr. Cancer Drug Targets, <b>18<\/b>, 266-277.","DOI":"10.2174\/1568009617666170630142725"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Vicentini, C., Galuppini, F., Corbo, V. and Fassan, M. (2019): Current role of non-coding RNAs in the clinical setting. Noncoding RNA Res., <b>4<\/b>, 82-85.","DOI":"10.1016\/j.ncrna.2019.09.001"},{"key":"35","doi-asserted-by":"crossref","unstructured":"Wang, Q., Zhan, Y., Ren, N., Wang, Z., Zhang, Q., Wu, S. and Li, H. (2018a): Paraquat and MPTP alter microRNA expression profiles, and downregulated expression of miR-17-5p contributes to PQ-induced dopaminergic neurodegeneration. J. Appl. Toxicol., <b>38<\/b>, 665-677.","DOI":"10.1002\/jat.3571"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Wang, R., Sun, D.Z., Song, C.Q., Xu, Y.M., Liu, W., Liu, Z. and Dong, X.S. (2018b): Eukaryotic translation initiation factor 2 subunit \u03b1 (eIF2\u03b1) inhibitor salubrinal attenuates paraquat-induced human lung epithelial-like A549 cell apoptosis by regulating the PERK-eIF2\u03b1 signaling pathway. Toxicol. In Vitro, <b>46<\/b>, 58-65.","DOI":"10.1016\/j.tiv.2017.10.006"},{"key":"37","unstructured":"Wang, X., Li, A.J., Li, W.Z., Lu, W.J. and Cui, W.Z. (2018c): [The effects of Xuebijing injection on apoptosis and expression of regulatory factors TNF-\u03b1, NF-\u03baB and Caspase-3 expression in the lung tissues of acute paraquat-induced rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, <b>36<\/b>, 551-555."},{"key":"38","doi-asserted-by":"crossref","unstructured":"Wei, Y.P., Wang, X.H., Liu, G., Zhang, J.F., Yang, Y.X., Zhang, J., Song, X.L., Li, Z.D. and Zhao, L.D. (2018): Matrine exerts inhibitory effects in melanoma through the regulation of miR-19b-3p\/PTEN. Int. J. Oncol., <b>53<\/b>, 791-800.","DOI":"10.3892\/ijo.2018.4414"},{"key":"39","doi-asserted-by":"crossref","unstructured":"Xiong, G., Zhao, L., Yan, M., Wang, X., Zhou, Z. and Chang, X. (2019): N-acetylcysteine alleviated paraquat-induced mitochondrial fragmentation and autophagy in primary murine neural progenitor cells. J. Appl. Toxicol., <b>39<\/b>, 1557-1567.","DOI":"10.1002\/jat.3839"},{"key":"40","doi-asserted-by":"crossref","unstructured":"Xu, L., Xu, J. and Wang, Z. (2014): Molecular mechanisms of paraquat-induced acute lung injury: a current review. Drug Chem. Toxicol., <b>37<\/b>, 130-134.","DOI":"10.3109\/01480545.2013.834361"},{"key":"41","doi-asserted-by":"crossref","unstructured":"Xue, Y., Wei, Z., Ding, H., Wang, Q., Zhou, Z., Zheng, S., Zhang, Y., Hou, D., Liu, Y., Zen, K., Zhang, C.Y., Li, J., Wang, D. and Jiang, X. (2015): MicroRNA-19b\/221\/222 induces endothelial cell dysfunction via suppression of PGC-1\u03b1 in the progression of atherosclerosis. Atherosclerosis, <b>241<\/b>, 671-681.","DOI":"10.1016\/j.atherosclerosis.2015.06.031"},{"key":"42","doi-asserted-by":"crossref","unstructured":"Yasaka, T., Ohya, I., Matsumoto, J., Shiramizu, T. and Sasaguri, Y. (1981): Acceleration of lipid peroxidation in human paraquat poisoning. Arch. Intern. Med., <b>141<\/b>, 1169-1171.","DOI":"10.1001\/archinte.1981.00340090065015"},{"key":"43","unstructured":"Yin, Y., Guo, X., Zhang, S.L. and Sun, C.Y. (2013): Analysis of paraquat intoxication epidemic (2002-2011) within China. Biomed. Environ. Sci., <b>26<\/b>, 509-512."},{"key":"44","doi-asserted-by":"crossref","unstructured":"Zhang, J., Li, S.F., Chen, H. and Song, J.X. (2016): MiR-106b-5p Inhibits Tumor Necrosis Factor-\u03b1-induced Apoptosis by Targeting Phosphatase and Tensin Homolog Deleted on Chromosome 10 in Vascular Endothelial Cells. Chin. Med. J. (Engl.), <b>129<\/b>, 1406-1412.","DOI":"10.4103\/0366-6999.183414"},{"key":"45","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Wang, J., Meng, X., Xie, H., Tan, J., Guo, X., Han, P. and Wang, R. (2017): A positive feedback loop promotes HIF-1\u03b1 stability through miR-210-mediated suppression of RUNX3 in paraquat-induced EMT. J. Cell. Mol. Med., <b>21<\/b>, 3529-3539.","DOI":"10.1111\/jcmm.13264"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/45\/8\/45_423\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T03:19:09Z","timestamp":1596856749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/45\/8\/45_423\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.45.423","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}