{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:09:22Z","timestamp":1788196162092,"version":"build-2803163510"},"reference-count":37,"publisher":"Japanese Society of Toxicology","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2020]]},"DOI":"10.2131\/jts.45.539","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T22:13:11Z","timestamp":1598911991000},"page":"539-548","source":"Crossref","is-referenced-by-count":63,"title":["Involvement of metal transporters in the intestinal uptake of cadmium"],"prefix":"10.2131","volume":"45","author":[{"given":"Hisayoshi","family":"Ohta","sequence":"first","affiliation":[{"name":"Department of Environmental, Occupational Health and Toxicology, Graduate School of Medical Sciences, Kitasato University"},{"name":"Department of Health Administration, School of Allied Health Sciences, Kitasato University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Ohba","sequence":"additional","affiliation":[{"name":"Department of Health Administration, School of Allied Health Sciences, Kitasato University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Bouron, A., Kiselyov, K. and Oberwinkler, J. (2015): Permeation, regulation and control of expression of TRP channels by trace metal ions. Pflugers Arch., <b>467<\/b>, 1143-1164.","DOI":"10.1007\/s00424-014-1590-3"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Bressler, J.P., Olivi, L., Cheong, J.H., Kim, Y. and Bannona, D. (2004): Divalent metal transporter 1 in lead and cadmium transport. Ann. N. Y. Acad. Sci., <b>1012<\/b>, 142-152.","DOI":"10.1196\/annals.1306.011"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Christensen, E.I. and Birn, H. (2002): Megalin and cubilin: multifunctional endocytic receptors. Nat. Rev. Mol. Cell Biol., <b>3<\/b>, 256-266.","DOI":"10.1038\/nrm778"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Dalton, T.P., He, L., Wang, B., Miller, M.L., Jin, L., Stringer, K.F., Chang, X., Baxter, C.S. and Nebert, D.W. (2005): Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis. Proc. Natl. Acad. Sci. USA, <b>102<\/b>, 3401-3406.","DOI":"10.1073\/pnas.0406085102"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Foulkes, E.C. (1986): Absorption of Cadmium. In: Cadmium (Foulkes, E.C., ed.), pp.75-100, Springer, Berlin, Heidelberg.","DOI":"10.1007\/978-3-642-70856-5_3"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Friedman, P.A. and Gesek, F.A. (1994): Cadmium uptake by kidney distal convoluted tubule cells. Toxicol. Appl. Pharmacol., <b>128<\/b>, 257-263.","DOI":"10.1006\/taap.1994.1205"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Fujishiro, H., Hamao, S., Isawa, M. and Himeno, S. (2019): Segment-specific and direction-dependent transport of cadmium and manganese in immortalized S1, S2, and S3 cells derived from mouse kidney proximal tubules. J. Toxicol. Sci., <b>44<\/b>, 611-619.","DOI":"10.2131\/jts.44.611"},{"key":"8","first-page":"437","year":"2013","unstructured":"Fujishiro, H., Ohashi, T., Takuma, M. and Himeno, S. (2013): Suppression of ZIP8 expression is a common feature of cadmium-resistant and manganese-resistant RBL-2H3 cells. Metallomics, <b>5<\/b>, 437-444.","journal-title":"Metallomics","ISSN":"https:\/\/id.crossref.org\/issn\/1756-5901","issn-type":"print"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Fujishiro, H., Okugaki, S., Kubota, K., Fujiyama, T., Miyataka, H. and Himeno, S. (2009): The role of ZIP8 down-regulation in cadmium-resistant metallothionein-null cells. J. Appl. Toxicol., <b>29<\/b>, 367-373.","DOI":"10.1002\/jat.1419"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Girijashanker, K., He, L., Soleimani, M., Reed, J.M., Li, H., Liu, Z., Wang, B., Dalton, T.P. and Nebert, D.W. (2008): Slc39a14 gene encodes ZIP14, a metal\/bicarbonate symporter: similarities to the ZIP8 transporter. Mol. Pharmacol., <b>73<\/b>, 1413-1423.","DOI":"10.1124\/mol.107.043588"},{"key":"11","first-page":"482","year":"1997","unstructured":"Gunshin, H., Mackenzie, B., Berger, U.V., Gunshin, Y., Romero, M.F., Boron, W.F., Nussberger, S., Gollan, J.L. and Hediger, M.A. (1997): Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature, <b>388<\/b>, 482-488.","journal-title":"?Nature","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"key":"12","doi-asserted-by":"crossref","unstructured":"He, L., Girijashanker, K., Dalton, T.P., Reed, J., Li, H., Soleimani, M. and Nebert, D.W. (2006): ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties. Mol. Pharmacol., <b>70<\/b>, 171-180.","DOI":"10.1124\/mol.106.024521"},{"key":"13","doi-asserted-by":"publisher","unstructured":"Himeno, S., Yanagiya, T. and Fujishiro, H. (2009): The role of zinc transporters in cadmium and manganese transport in mammalian cells. Biochimie, <b>91<\/b>, 1218-1222.","DOI":"10.1016\/j.biochi.2009.04.002"},{"key":"14","unstructured":"J\u00e4rup, L., Berglund, M., Elinder, C.G., Nordberg, G. and Vahter, M. (1998): Health effects of cadmium exposure--a review of the literature and a risk estimate. Scand. J. Work Environ. Health, <b>24<\/b> (Suppl 1), 1-51."},{"key":"15","doi-asserted-by":"crossref","unstructured":"Kambe, T. (2013): [Overview of and update on the physiological functions of mammalian zinc transporters]. Jpn. J. Hyg., <b>68<\/b>, 92-102.","DOI":"10.1265\/jjh.68.92"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Kim, D.W., Kim, K.Y., Choi, B.S., Youn, P., Ryu, D.Y., Klaassen, C.D. and Park, J.D. (2007): Regulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptake. Arch. Toxicol., <b>81<\/b>, 327-334.","DOI":"10.1007\/s00204-006-0160-7"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Kimura, T. and Kambe, T. (2016): The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective. Int. J. Mol. Sci., <b>17<\/b>, 336.","DOI":"10.3390\/ijms17030336"},{"key":"18","first-page":"276","year":"2013","unstructured":"Kovacs, G., Montalbetti, N., Franz, M.-C., Graeter, S., Simonin, A. and Hediger, M.A. (2013): Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity. Cell Calcium, <b>54<\/b>, 276-286.","journal-title":"Cell Calcium","ISSN":"https:\/\/id.crossref.org\/issn\/0143-4160","issn-type":"print"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Leazer, T.M., Liu, Y. and Klaassen, C.D. (2002): Cadmium absorption and its relationship to divalent metal transporter-1 in the pregnant rat. Toxicol. Appl. Pharmacol., <b>185<\/b>, 18-24.","DOI":"10.1006\/taap.2002.9505"},{"key":"20","doi-asserted-by":"crossref","unstructured":"He, L., Wang, B., Hay, E.B. and Nebert, D.W. (2009): Discovery of ZIP transporters that participate in cadmium damage to testis and kidney. Toxicol. Appl. Pharmacol., <b>238<\/b>, 250-257.","DOI":"10.1016\/j.taap.2009.02.017"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Min, K.S., Ueda, H. and Tanaka, K. (2008): Involvement of intestinal calcium transporter 1 and metallothionein in cadmium accumulation in the liver and kidney of mice fed a low-calcium diet. Toxicol. Lett., <b>176<\/b>, 85-92.","DOI":"10.1016\/j.toxlet.2007.10.011"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Min, K.S., Iwata, N., Tetsutikawahara, N., Onosaka, S. and Tanaka, K. (2008b): Effect of hemolytic and iron-deficiency anemia on intestinal absorption and tissue accumulation of cadmium. Toxicol. Lett., <b>179<\/b>, 48-52.","DOI":"10.1016\/j.toxlet.2008.04.001"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Moreau, R., Simoneau, L. and Lafond, J. (2003): Calcium fluxes in human trophoblast (BeWo) cells: calcium channels, calcium-ATPase, and sodium-calcium exchanger expression. Mol. Reprod. Dev., <b>64<\/b>, 189-198.","DOI":"10.1002\/mrd.10247"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Nakamura, Y., Ohba, K., Suzuki, K. and Ohta, H. (2012): Health effects of low-level cadmium intake and the role of metallothionein on cadmium transport from mother rats to fetus. J. Toxicol. Sci., <b>37<\/b>, 149-156.","DOI":"10.2131\/jts.37.149"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Nishijo, M., Satarug, S., Honda, R., Tsuritani, I. and Aoshima, K. (2004): The gender differences in health effects of environmental cadmium exposure and potential mechanisms. Mol. Cell. Biochem., <b>255<\/b>, 87-92.","DOI":"10.1023\/B:MCBI.0000007264.37170.39"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Ohta, H., DeAngelis, M.V. and Cherian, M.G. (1989): Uptake of cadmium and metallothionein by rat everted intestinal sacs. Toxicol. Appl. Pharmacol., <b>101<\/b>, 62-69.","DOI":"10.1016\/0041-008X(89)90212-3"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Ohta, H. and Cherian, M.G. (1991): Gastrointestinal absorption of cadmium and metallothionein. Toxicol. Appl. Pharmacol., <b>107<\/b>, 63-72.","DOI":"10.1016\/0041-008X(91)90331-8"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Onodera, A., Tani, M., Michigami, T., Yamagata, M., Min, K.S., Tanaka, K., Nakanishi, T., Kimura, T. and Itoh, N. (2012): Role of megalin and the soluble form of its ligand RAP in Cd-metallothionein endocytosis and Cd-metallothionein-induced nephrotoxicity <i>in vivo.<\/i> Toxicol. Lett., <b>212<\/b>, 91-96.","DOI":"10.1016\/j.toxlet.2012.05.012"},{"key":"29","doi-asserted-by":"crossref","unstructured":"Reeves, P.G. and Chaney, R.L. (2004): Marginal nutritional status of zinc, iron, and calcium increases cadmium retention in the duodenum and other organs of rats fed rice-based diets. Environ. Res., <b>96<\/b>, 311-322.","DOI":"10.1016\/j.envres.2004.02.013"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Reeves, P.G. and Chaney, R.L. (2008): Bioavailability as an issue in risk assessment and management of food cadmium: a review. Sci. Total Environ., <b>398<\/b>, 13-19.","DOI":"10.1016\/j.scitotenv.2008.03.009"},{"key":"31","doi-asserted-by":"crossref","unstructured":"Reeves, P.G., Chaney, R.L., Simmons, R.W. and Cherian, M.G. (2005): Metallothionein induction is not involved in cadmium accumulation in the duodenum of mice and rats fed diets containing high-cadmium rice or sunflower kernels and a marginal supply of zinc, iron, and calcium. J. Nutr., <b>135<\/b>, 99-108.","DOI":"10.1093\/jn\/135.1.99"},{"key":"32","doi-asserted-by":"crossref","unstructured":"Ryu, D.Y., Lee, S.J., Park, D.W., Choi, B.S., Klaassen, C.D. and Park, J.D. (2004): Dietary iron regulates intestinal cadmium absorption through iron transporters in rats. Toxicol. Lett., <b>152<\/b>, 19-25.","DOI":"10.1016\/j.toxlet.2004.03.015"},{"key":"33","doi-asserted-by":"crossref","unstructured":"Souza, V., Bucio, L., Jay, D., Ch\u00e1vez, E. and Guti\u00e9rrez-Ruiz, M.C. (1996): Effect of cadmium on calcium transport in a human fetal hepatic cell line (WRL-68 cells). Toxicology, <b>112<\/b>, 97-104.","DOI":"10.1016\/0300-483X(96)03335-5"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Suzuki, T., Momoi, K., Hosoyamada, M., Kimura, M. and Shibasaki, T. (2008): Normal cadmium uptake in microcytic anemia mk\/mk mice suggests that DMT1 is not the only cadmium transporter <i>in vivo.<\/i> Toxicol. Appl. Pharmacol., <b>227<\/b>, 462-467.","DOI":"10.1016\/j.taap.2007.10.026"},{"key":"35","doi-asserted-by":"crossref","unstructured":"Vahter, M., Akesson, A., Lid\u00e9n, C., Ceccatelli, S. and Berglund, M. (2007): Gender differences in the disposition and toxicity of metals. Environ. Res., <b>104<\/b>, 85-95.","DOI":"10.1016\/j.envres.2006.08.003"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Vesey, D.A. (2010): Transport pathways for cadmium in the intestine and kidney proximal tubule: focus on the interaction with essential metals. Toxicol. Lett., <b>198<\/b>, 13-19.","DOI":"10.1016\/j.toxlet.2010.05.004"},{"key":"37","doi-asserted-by":"crossref","unstructured":"Zalups, R.K. and Ahmad, S. (2003): Molecular handling of cadmium in transporting epithelia. Toxicol. Appl. Pharmacol., <b>186<\/b>, 163-188.","DOI":"10.1016\/S0041-008X(02)00021-2"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/45\/9\/45_539\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T03:33:00Z","timestamp":1599276780000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/45\/9\/45_539\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.45.539","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}