{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:39:56Z","timestamp":1776325196016,"version":"3.50.1"},"reference-count":55,"publisher":"Japanese Society of Toxicology","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2020]]},"DOI":"10.2131\/jts.45.549","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T22:13:12Z","timestamp":1598911992000},"page":"549-558","source":"Crossref","is-referenced-by-count":16,"title":["Mechanism in bradycardia induced by Trimethyltin chloride: Inhibition activity and expression of Na&lt;sup&gt;+&lt;\/sup&gt;\/K&lt;sup&gt;+&lt;\/sup&gt;-ATPase and apoptosis in myocardia"],"prefix":"10.2131","volume":"45","author":[{"given":"Zhenzhong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, North Sichuan Medical College, China"},{"name":"Innovative Platform of Basic Medical Sciences, School of Basic Medical Sciences, North Sichuan Medical College, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Tian","sequence":"additional","affiliation":[{"name":"School of public health, Shanxi Medical University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, North Sichuan Medical College, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of pharmacy, North Sichuan Medical College, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, North Sichuan Medical College, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miancai","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, North Sichuan Medical College, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Province Hospital for Occupational Disease Prevention and Treatment, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"898","reference":[{"key":"1","unstructured":"Bai, Z.Q., Chen, Z., Zeng, Y.M., Zhang, G.Y. and Chen, X.L. (2013): Clinical analysis of 7 cases of occupational acute trimethyltin chloride toxic encephalopathy. Int. Med. Health Guid, <b>19<\/b>, 1611-1613."},{"key":"2","doi-asserted-by":"crossref","unstructured":"Bartlett, D.E., Miller, R.B., Thiesfeldt, S., Lakhani, H.V., Shapiro, J.I. and Sodhi, K. (2018): The Role of Na\/K-ATPase Signaling in Oxidative Stress Related to Aging: Implications in Obesity and Cardiovascular Disease. Int. J. Mol. Sci., <b>19<\/b>, 2139.","DOI":"10.3390\/ijms19072139"},{"key":"3","first-page":"945","year":"1987","unstructured":"Besser, R., Kr\u00e4mer, G., Th\u00fcmler, R., Bohl, J., Gutmann, L. and Hopf, H.C. (1987): Acute trimethyltin limbic-cerebellar syndrome. Neurology, <b>37<\/b>, 945-950.","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Cameron, J.A., Kodavanti, P.R., Pentyala, S.N. and Desaiah, D. (1991): Triorganotin inhibition of rat cardiac adenosine triphosphatases and catecholamine binding. J. Appl. Toxicol., <b>11<\/b>, 403-409.","DOI":"10.1002\/jat.2550110605"},{"key":"5","doi-asserted-by":"publisher","unstructured":"Cerella, C., Dicato, M. and Diederich, M. (2013): Assembling the puzzle of anti-cancer mechanisms triggered by cardiac glycosides. Mitochondrion, <b>13<\/b>, 225-234.","DOI":"10.1016\/j.mito.2012.06.003"},{"key":"6","unstructured":"Ding, C., Xu, Q., Chen, Z., Zhang, Y. and Ping, Y. (2003): Clinical analysis of 52 cases of acute organotin poisoning. Chin. J. Integr. Med., <b>42<\/b>, 508."},{"key":"7","unstructured":"Fang, K.F., Ye, Q., Wang, X., Qiu, X.Y. and Lin, J.F. (2004): Clinical analysis of 104 cases of acute organotin poisoning. Lingnan J. Emerg. Med., <b>9<\/b>, 61-62."},{"key":"8","unstructured":"Fortemps, E., Amand, G., Bomboir, A., Lauwerys, R. and Laterre, E.C. (1978): Trimethyltin poisoning. Report of two cases. Int. Arch. Occup. Environ. Health, <b>41<\/b>, 1-6."},{"key":"9","unstructured":"Fu, X.Z. and He, W. (2010): Clinical analysis of 6 cases of acute organotin poisoning. China Contemp. Med., <b>16<\/b>, 79-80."},{"key":"10","doi-asserted-by":"crossref","unstructured":"Ganesan, S., Anaimalai Thirumurthi, N., Raghunath, A., Vijayakumar, S. and Perumal, E. (2016): Acute and sub-lethal exposure to copper oxide nanoparticles causes oxidative stress and teratogenicity in zebrafish embryos. J. Appl. Toxicol., <b>36<\/b>, 554-567.","DOI":"10.1002\/jat.3224"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Garcia, I.J., de Oliveira, G.C., de Moura Valadares, J.M., Banfi, F.F., Andrade, S.N., Freitas, T.R., Dos Santos Mon\u00e7\u00e3o Filho, E., Lima Santos, H., J\u00fanior, G.M., Chaves, M.H., de Jesus Rodrigues, D., Sanchez, B.A., Varotti, F.P. and Barbosa, L.A. (2019): New bufadienolides extracted from Rhinella marina inhibit Na,K-ATPase and induce apoptosis by activating caspases 3 and 9 in human breast and ovarian cancer cells. Steroids, <b>152<\/b>, 108490.","DOI":"10.1016\/j.steroids.2019.108490"},{"key":"12","doi-asserted-by":"publisher","unstructured":"Galang, N., Sasaki, H. and Maulik, N. (2000): Apoptotic cell death during ischemia\/reperfusion and its attenuation by antioxidant therapy. Toxicology, <b>148<\/b>, 111-118.","DOI":"10.1016\/S0300-483X(00)00201-8"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Gilbert, M.S., Saad, A.H., Rupnow, B.A. and Knox, S.J. (1996): Association of BCL-2 with membrane hyperpolarization and radioresistance. J. Cell. Physiol., <b>168<\/b>, 114-122.","DOI":"10.1002\/(SICI)1097-4652(199607)168:1<114::AID-JCP14>3.0.CO;2-7"},{"key":"14","unstructured":"Huang, H., Chen, Y.M., Zhu, F., Tang, S.T., Xiao, J.D., Li, L.L. and Lin, X.J. (2015): Down-regulated Na<sup>+<\/sup>\/K<sup>+<\/sup>-ATPase activity in ischemic penumbra after focal cerebral ischemia\/reperfusion in rats. Int. J. Clin. Exp. Pathol., <b>8<\/b>, 12708-12717."},{"key":"15","unstructured":"He, J., Hu, J.H., Gu, Y.C., Liang, R.G. and Li, Q.L. (2002): Investigation and analysis of an accident of trimethylstannic chloride poisoning. Chin. Occup. Med., <b>29<\/b>, 63-64."},{"key":"16","doi-asserted-by":"crossref","unstructured":"Hou, Y.M., Wang, J. and Zhang, X.Z. (2017): Lycium barbarum polysaccharide exhibits cardioprotection in an experimental model of ischemia-reperfusion damage. Mol. Med. Rep., <b>15<\/b>, 2653-2658.","DOI":"10.3892\/mmr.2017.6294"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Kawada, K., Yoneyama, M., Nagashima, R. and Ogita, K. (2008): In vivo acute treatment with trimethyltin chloride causes neuronal degeneration in the murine olfactory bulb and anterior olfactory nucleus by different cascades in each region. J. Neurosci. Res., <b>86<\/b>, 1635-1646.","DOI":"10.1002\/jnr.21612"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Ke\u00dfler, M., Berger, I.M., Just, S. and Rottbauer, W. (2015): Loss of dihydrolipoyl succinyltransferase (DLST) leads to reduced resting heart rate in the zebrafish. Basic Res. Cardiol., <b>110<\/b>, 14.","DOI":"10.1007\/s00395-015-0468-7"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Kim, B., Srivastava, S.K. and Kim, S.H. (2015): Caspase-9 as a therapeutic target for treating cancer. Expert Opin. Ther. Targets, <b>19<\/b>, 113-127.","DOI":"10.1517\/14728222.2014.961425"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Kim, M.Y., Lim, S.H. and Lee, J. (2014): Intake of hot water-extracted apple protects against myocardial injury by inhibiting apoptosis in an ischemia\/reperfusion rat model. Nutr. Res., <b>34<\/b>, 951-960.","DOI":"10.1016\/j.nutres.2014.08.007"},{"key":"21","first-page":"305","year":"2020","unstructured":"Leu, W.J., Wang, C.T., Hsu, J.L., Chen, I.S., Chang, H.S. and Guh, J.H. (2020): Ascleposide, a natural cardenolide, induces anticancer signaling in human castration-resistant prostatic cancer through Na<sup>+<\/sup> \/K<sup>+<\/sup> -ATPase internalization and tubulin acetylation. Prostate, <b>80<\/b>, 305-318.","journal-title":"The Prostate","ISSN":"https:\/\/id.crossref.org\/issn\/0270-4137","issn-type":"print"},{"key":"22","unstructured":"Li, R., Guo, Q. and Zhou, L. (2019): Clinical Study on condition observation and nursing care of patients and nursing care of patients with trimethyltin chloride poisoning. Foreign Med. Sci. Sect. Medgeogr., <b>40<\/b>, 190-193."},{"key":"23","unstructured":"Liu, T.M. (2011): Clinical analysis on 48 cases of toxic encephalopathy caused by organotin. Chin. J. Ind. Med., <b>24<\/b>, 184-185."},{"key":"24","doi-asserted-by":"crossref","unstructured":"Liu, X.L., Lu, J. and Xing, J. (2016): Stabilization of HIF-1\u03b1 modulates VEGF and Caspase-3 in the hippocampus of rats following transient global ischemia induced by asphyxial cardiac arrest. Life Sci., <b>151<\/b>, 243-249.","DOI":"10.1016\/j.lfs.2016.03.005"},{"key":"25","unstructured":"Liu, Z., Lai, G., Wang, H., Pei, Q.L., Tang, X. and Ge, Y. (2008): Study on acute toxicity and changes of serum ions in rats, mice and rabbits treated with trimethyltin chloride. Chin. Occup. Med., <b>35<\/b>, 197-199."},{"key":"26","unstructured":"Long, J.X., Zhu, C.S., Liu, Z.P., Wang, D.S., Xu, H.J. and Huang, S.S. (2000): Analysis of 225 Cases of Acute Trimethyl tin Poisoning. Chin. J. Ind. Med., <b>13<\/b>, 31-33."},{"key":"27","unstructured":"Luo, D.H., Lin, L., Luo, J.M. and Wang, Z.M. (2008): Clinical analysis of 27 cases of organotin poisoning. Zhejiang Clin. Med. J., <b>10<\/b>, 772-773."},{"key":"28","unstructured":"Luo, H.R., Zhang, X.J. and Xu, S.L. (2005): 51 cases of organotin compound acute poisoning. Chin. J. Ind. Hyg. Occup. Dis., <b>23<\/b>, 309-311."},{"key":"29","doi-asserted-by":"crossref","unstructured":"McClintock, D.S., Santore, M.T., Lee, V.Y., Brunelle, J., Budinger, G.R., Zong, W.X., Thompson, C.B., Hay, N. and Chandel, N.S. (2002): Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death. Mol. Cell. Biol., <b>22<\/b>, 94-104.","DOI":"10.1128\/MCB.22.1.94-104.2002"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Morita, Y., Yanagida, D., Shintani, N., Ogita, K., Nishiyama, N., Tsuchida, R., Hashimoto, H. and Baba, A. (2006): Lack of trimethyltin (TMT)-induced elevation of plasma corticosterone in PACAP-deficient mice. Ann. N. Y. Acad. Sci., <b>1070<\/b>, 450-456.","DOI":"10.1196\/annals.1317.060"},{"key":"31","doi-asserted-by":"crossref","unstructured":"Philipson, K.D., Bers, D.M. and Nishimoto, A.Y. (1980): The role of phospholipids in the Ca2+ binding of isolated cardiac sarcolemma. J. Mol. Cell. Cardiol., <b>12<\/b>, 1159-1173.","DOI":"10.1016\/0022-2828(80)90063-2"},{"key":"32","unstructured":"Pluta, R. and Ostrowska, B. (1987): Acute poisoning with triethyltin in the rat. Changes in cerebral blood flow, cerebral oxygen consumption, arterial and cerebral venous blood gases. Exp. Neurol., <b>98<\/b>, 67-77."},{"key":"33","unstructured":"Pott, A., Bock, S., Berger, I.M., Frese, K., Dahme, T., Ke\u00dfler, M., Rinn\u00e9, S., Decher, N., Just, S. and Rottbauer, W. (2018): Mutation of the Na<sup>+<\/sup>\/K<sup>+<\/sup>-ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish. J. Mol. Cell. Cardiol., <b>120<\/b>, 42-52."},{"key":"34","doi-asserted-by":"crossref","unstructured":"Qiao, X., Chen, X., Wu, D., Ding, R., Wang, J., Hong, Q., Shi, S., Li, J., Xie, Y., Lu, Y. and Wang, Z. (2005): Mitochondrial pathway is responsible for aging-related increase of tubular cell apoptosis in renal ischemia\/reperfusion injury. J. Gerontol. A Biol. Sci. Med. Sci., <b>60<\/b>, 830-839.","DOI":"10.1093\/gerona\/60.7.830"},{"key":"35","doi-asserted-by":"crossref","unstructured":"Ren, X., Wu, X., Sui, G., Gong, Z., Yawson, E., Wu, B., Lai, G., Ruan, X., Gao, H., Zhou, F., Su, B., Olson, J.R. and Tang, X. (2015): Chronic trimethyltin chloride exposure and the development of kidney stones in rats. J. Appl. Toxicol., <b>35<\/b>, 500-507.","DOI":"10.1002\/jat.3054"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Saary, M.J. and House, R.A. (2002): Preventable exposure to trimethyl tin chloride: a case report. Occup. Med. (Lond.), <b>52<\/b>, 227-230.","DOI":"10.1093\/occmed\/52.4.227"},{"key":"37","doi-asserted-by":"crossref","unstructured":"Sanguinetti, M.C., Curran, M.E., Spector, P.S. and Keating, M.T. (1996): Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. Proc. Natl. Acad. Sci. USA, <b>93<\/b>, 2208-2212.","DOI":"10.1073\/pnas.93.5.2208"},{"key":"38","doi-asserted-by":"crossref","unstructured":"Shattock, M.J., Ottolia, M., Bers, D.M., Blaustein, M.P., Boguslavskyi, A., Bossuyt, J., Bridge, J.H., Chen-Izu, Y., Clancy, C.E., Edwards, A., Goldhaber, J., Kaplan, J., Lingrel, J.B., Pavlovic, D., Philipson, K., Sipido, K.R. and Xie, Z.J. (2015): Na+\/Ca2+ exchange and Na+\/K+-ATPase in the heart. J. Physiol., <b>593<\/b>, 1361-1382.","DOI":"10.1113\/jphysiol.2014.282319"},{"key":"39","unstructured":"Sun, D., Zhang, X., Chen, J., Tang, X., Ping, Y. and Peng, B. (2007): Clinical analysis on 52 cases of acute trimethyl tin poisoning. Chin. J. Ind. Med., <b>20<\/b>, 289-292."},{"key":"40","doi-asserted-by":"crossref","unstructured":"Tang, X., Wu, X., Dubois, A.M., Sui, G., Wu, B., Lai, G., Gong, Z., Gao, H., Liu, S., Zhong, Z., Lin, Z., Olson, J. and Ren, X. (2013a): Toxicity of trimethyltin and dimethyltin in rats and mice. Bull. Environ. Contam. Toxicol., <b>90<\/b>, 626-633.","DOI":"10.1007\/s00128-013-0975-x"},{"key":"41","first-page":"45","year":"2010","unstructured":"Tang, X., Yang, X., Lai, G., Guo, J., Xia, L., Wu, B., Xie, Y., Huang, M., Chen, J., Ruan, X., Sui, G., Ge, Y., Zuo, W., Zhao, N., Zhu, G., Zhang, J., Li, L. and Zhou, W. (2010): Mechanism underlying hypokalemia induced by trimethyltin chloride: inhibition of H+\/K+-ATPase in renal intercalated cells. Toxicology, <b>271<\/b>, 45-50.","journal-title":"Toxicology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-483X","issn-type":"print"},{"key":"42","doi-asserted-by":"crossref","unstructured":"Tang, X., Li, N., Kang, L., Dubois, A.M., Gong, Z., Wu, B., Lai, G., Yang, A., Ruan, X., Gao, H., Zhu, G., Ge, Y., Zhang, J., Lin, Z., Olson, J.R. and Ren, X. (2013b): Chronic low level trimethyltin exposure and the risk of developing nephrolithiasis. Occup. Environ. Med., <b>70<\/b>, 561-567.","DOI":"10.1136\/oemed-2012-101261"},{"key":"43","unstructured":"Tang, X., Xia, L., Chen, J., Wang, M., Lai, G., Li, S., Wu, B., Wang, J. and Zhu, G. (2008): Clinical Study on 76 Cases of 13 Trimethyltin Chloride Poisoning Accidents. China Occup. Med., <b>35<\/b>, 91-94."},{"key":"44","unstructured":"Wang, L., Chen, F., Wu, X. and Zhao, L. (2017): Research progress on trimethyltin chloride poisoning. Chin. Occup. Med., <b>44<\/b>, 89-94."},{"key":"45","doi-asserted-by":"crossref","unstructured":"Wang, S., Chi, Q., Hu, X., Cong, Y. and Li, S. (2019): Hydrogen sulfide-induced oxidative stress leads to excessive mitochondrial fission to activate apoptosis in broiler myocardia. Ecotoxicol. Environ. Saf., <b>183<\/b>, 109578.","DOI":"10.1016\/j.ecoenv.2019.109578"},{"key":"46","unstructured":"Xia, L.H., Zhu, G.H., Liang, W.H., Zeng, Z.F., He, J. and Tang, X.J. (2007): Analysis of 2 cases of misdiagonosis on occupational acute poisoning of trimethytin choride. China Occup. Med., <b>34<\/b>, 215."},{"key":"47","unstructured":"Xia, L.H., Huang, J.W., Li, B., Liu, H.F. and Kuang, S.R. (2002): Clinical analysis of 22 cases of subacute trimethyltin chloride poisoning. Chin. Occup. Med., <b>29<\/b>, 32-33."},{"key":"48","unstructured":"Xiao, H.Y. and Wen, G.M. (2000): Investigation report of an occupational organotin poisoning accident. Chin. Occup. Med., <b>27<\/b>, 63."},{"key":"49","unstructured":"Yang, Y.X., Fang, K.F. and Ye, Q. (2006): Clinical analysis on 82 cases of arrhythmias caused by acute organic tin compound poisoning. Chin. J. Ind. Med., <b>19<\/b>, 22-23."},{"key":"50","unstructured":"Yang, C., Yuan, J., Lai, P. and Liu, X. (2018): A case of cardiac arrest caused by acute inhalation trimethyltin chloride poisoning. J. Gannan Med. Coll., <b>38<\/b>, 169-170."},{"key":"51","unstructured":"Zhang, M.T. (2001): An investigation report on an organotin poisoning accident. J. Occup. Health Damage, <b>16<\/b>, 184."},{"key":"52","unstructured":"Zhang, G., Xu, Q. and Huang, H. (2006): 45 cases of acute trimethyl tin chloride poisoning. Chin. J. Ind. Hyp. Occup. Dis., <b>24<\/b>, 308-309."},{"key":"53","unstructured":"Zhu, J.Q., He, J. and Zhai, M.F. (2008): Analysis of an occupational organotin poisoning accident. Chin. J. Ind. Med., <b>21<\/b>, 132-133."},{"key":"54","unstructured":"Zhu, S. (2006): 58 cases of acute organotin poisoning. Chin. J. Ind. Hyg. Occup. Dis., <b>24<\/b>, 623-624."},{"key":"55","doi-asserted-by":"crossref","unstructured":"Zhuang, J., Nie, G., Yang, F., Dai, X., Cao, H., Xing, C., Hu, G. and Zhang, C. (2019): Cadmium induces cytotoxicity through oxidative stress-mediated apoptosis pathway in duck renal tubular epithelial cells. Toxicol. In Vitro, <b>61<\/b>, 104625.","DOI":"10.1016\/j.tiv.2019.104625"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/45\/9\/45_549\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T03:33:12Z","timestamp":1599276792000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/45\/9\/45_549\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.45.549","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}