{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:16:06Z","timestamp":1791526566768,"version":"4.3.4"},"reference-count":21,"publisher":"Japanese Society of Toxicology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2021]]},"DOI":"10.2131\/jts.46.371","type":"journal-article","created":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T18:07:45Z","timestamp":1627841265000},"page":"371-378","source":"Crossref","is-referenced-by-count":14,"title":["Metabolic activation and deactivation of dietary-derived coumarin mediated by cytochrome P450 enzymes in rat and human liver preparations"],"prefix":"10.2131","volume":"46","author":[{"given":"Norie","family":"Murayama","sequence":"first","affiliation":[{"name":"Showa Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Showa Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Abraham, K., W\u00f6hrlin, F., Lindtner, O., Heinemeyer, G. and Lampen, A. (2010): Toxicology and risk assessment of coumarin: focus on human data. Mol. Nutr. Food Res., <b>54<\/b>, 228-239.","DOI":"10.1002\/mnfr.200900281"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Baltazar, M.T., Cable, S., Carmichael, P.L., Cubberley, R., Cull, T., Delagrange, M., Dent, M.P., Hatherell, S., Houghton, J., Kukic, P., Li, H., Lee, M.Y., Malcomber, S., Middleton, A.M., Moxon, T.E., Nathanail, A.V., Nicol, B., Pendlington, R., Reynolds, G., Reynolds, J., White, A. and Westmoreland, C. (2020): A next-generation risk assessment case study for coumarin in cosmetic products. Toxicol. Sci., <b>176<\/b>, 236-252.","DOI":"10.1093\/toxsci\/kfaa048"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Born, S.L., Caudill, D., Fliter, K.L. and Purdon, M.P. (2002): Identification of the cytochromes P450 that catalyze coumarin 3,4-epoxidation and 3-hydroxylation. Drug Metab. Dispos., <b>30<\/b>, 483-487.","DOI":"10.1124\/dmd.30.5.483"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Born, S.L., Caudill, D., Smith, B.J. and Lehman-McKeeman, L.D. (2000): In vitro kinetics of coumarin 3,4-epoxidation: application to species differences in toxicity and carcinogenicity. Toxicol. Sci., <b>58<\/b>, 23-31.","DOI":"10.1093\/toxsci\/58.1.23"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Hadidi, H., Irshaid, Y., V\u00e5gb\u00f8, C.B., Brunsvik, A., Cholerton, S., Zahlsen, K. and Idle, J.R. (1998): Variability of coumarin 7- and 3-hydroxylation in a Jordanian population is suggestive of a functional polymorphism in cytochrome P450 CYP2A6. Eur. J. Clin. Pharmacol., <b>54<\/b>, 437-441.","DOI":"10.1007\/s002280050489"},{"key":"6","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/00008571-200311000-00005","author":"K. Kiyotani","year":"2003","unstructured":"Kiyotani, K., Yamazaki, H., Fujieda, M., Iwano, S., Matsumura, K., Satarug, S., Ujjin, P., Shimada, T., Guengerich, F.P., Parkinson, A., Honda, G., Nakagawa, K., Ishizaki, T. and Kamataki, T. (2003): Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (<i>CYP2A6*9<\/i>). Pharmacogenetics, <b>13<\/b>, 689-695.","journal-title":"Pharmacogenetics","ISSN":"https:\/\/id.crossref.org\/issn\/0960-314X","issn-type":"print"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Lake, B.G. (1999): Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment. Food Chem. Toxicol., <b>37<\/b>, 423-453.","DOI":"10.1016\/S0278-6915(99)00010-1"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Miura, T., Kamiya, Y., Hina, S., Kobayashi, Y., Murayama, N., Shimizu, M. and Yamazaki, H. (2020): Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model. J. Toxicol. Sci., <b>45<\/b>, 695-700.","DOI":"10.2131\/jts.45.695"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Miura, T., Uehara, S., Nakazato, M., Kusama, T., Toda, A., Kamiya, Y., Murayama, N., Shimizu, M., Suemizu, H. and Yamazaki, H. (2019): Human plasma and liver concentrations of styrene estimated by combining a simple physiologically based pharmacokinetic model with rodent data. J. Toxicol. Sci., <b>44<\/b>, 543-548.","DOI":"10.2131\/jts.44.543"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Okubo, M., Murayama, N., Shimizu, M., Shimada, T., Guengerich, F.P. and Yamazaki, H. (2013): CYP3A4 intron 6 C&gt;T polymorphism (<i>CYP3A4*22<\/i>) is associated with reduced CYP3A4 protein level and function in human liver microsomes. J. Toxicol. Sci., <b>38<\/b>, 349-354.","DOI":"10.2131\/jts.38.349"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Okubo, M., Narita, M., Murayama, N., Akimoto, Y., Goto, A. and Yamazaki, H. (2016): Individual differences in <i>in vitro<\/i> and <i>in vivo<\/i> metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavin-containing monooxygenase 3. Hum. Psychopharmacol., <b>31<\/b>, 83-92.","DOI":"10.1002\/hup.2515"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Peamkrasatam, S., Sriwatanakul, K., Kiyotani, K., Fujieda, M., Yamazaki, H., Kamataki, T. and Yoovathaworn, K. (2006): In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais. Drug Metab. Pharmacokinet., <b>21<\/b>, 475-484.","DOI":"10.2133\/dmpk.21.475"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Rietjens, I.M., Punt, A., Schilter, B., Scholz, G., Delatour, T. and van Bladeren, P.J. (2010): In silico methods for physiologically based biokinetic models describing bioactivation and detoxification of coumarin and estragole: implications for risk assessment. Mol. Nutr. Food Res., <b>54<\/b>, 195-207.","DOI":"10.1002\/mnfr.200900211"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Tanaka, Y., Fujii, W., Hori, H., Kitagawa, Y. and Ozaki, K. (2017): Changes in coumarin kinetics and subcellular localization of CYP2E1 contribute to bile duct damage and reduce hepatocellular damage after repeated administration of coumarin in rats. Toxicol. Lett., <b>280<\/b>, 99-105.","DOI":"10.1016\/j.toxlet.2017.08.007"},{"key":"15","doi-asserted-by":"publisher","unstructured":"Ujjin, P., Satarug, S., Vanavanitkun, Y., Daigo, S., Ariyoshi, N., Yamazaki, H., Reilly, P.E., Moore, M.R. and Kamataki, T. (2002): Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females. Pharmacogenetics, <b>12<\/b>, 241-249.","DOI":"10.1097\/00008571-200204000-00009"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Vassallo, J.D., Hicks, S.M., Daston, G.P. and Lehman-McKeeman, L.D. (2004): Metabolic detoxification determines species differences in coumarin-induced hepatotoxicity. Toxicol. Sci., <b>80<\/b>, 249-257.","DOI":"10.1093\/toxsci\/kfh162"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Vassallo, J.D., Morrall, S.W., Fliter, K.L., Curry, S.M., Daston, G.P. and Lehman-McKeeman, L.D. (2003): Liquid chromatographic determination of the glutathione conjugate and ring-opened metabolites formed from coumarin epoxidation. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., <b>794<\/b>, 257-271.","DOI":"10.1016\/S1570-0232(03)00473-2"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Yamazaki, H., Inui, Y., Yun, C.H., Guengerich, F.P. and Shimada, T. (1992): Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes. Carcinogenesis, <b>13<\/b>, 1789-1794.","DOI":"10.1093\/carcin\/13.10.1789"},{"key":"19","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3769\/radioisotopes.64.509","author":"H. Yamazaki","year":"2015","unstructured":"Yamazaki, H., Kunikane, E., Nishiyama, S., Murayama, N., Shimizu, M., Sugiyama, Y., Chiba, K. and Ikeda, T. (2015): Human plasma concentrations of tolbutamide and acetaminophen extrapolated from <i>in vivo<\/i> animal pharmacokinetics using <i>in vitro<\/i> human hepatic clearances and simple physiologically based pharmacokinetic modeling for radio-labeled microdose clinical studies. Radioisotopes, <b>64<\/b>, 509-519.","journal-title":"RADIOISOTOPES","ISSN":"https:\/\/id.crossref.org\/issn\/0033-8303","issn-type":"print"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Yamazaki, H., Mimura, M., Sugahara, C. and Shimada, T. (1994): Catalytic roles of rat and human cytochrome P450 2A enzymes in testosterone 7 alpha- and coumarin 7-hydroxylations. Biochem. Pharmacol., <b>48<\/b>, 1524-1527.","DOI":"10.1016\/0006-2952(94)90579-7"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Yamazaki, H., Tanaka, M. and Shimada, T. (1999): Highly sensitive high-performance liquid chromatographic assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human liver cytochrome P450 enzymes. J. Chromatogr. B Biomed. Sci. Appl., <b>721<\/b>, 13-19.","DOI":"10.1016\/S0378-4347(98)00472-1"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/46\/8\/46_371\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:14:21Z","timestamp":1628295261000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/46\/8\/46_371\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.46.371","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}