{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T20:55:04Z","timestamp":1784580904640,"version":"3.55.0"},"reference-count":28,"publisher":"Japanese Society of Toxicology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2023]]},"DOI":"10.2131\/jts.48.179","type":"journal-article","created":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T22:12:35Z","timestamp":1680473555000},"page":"179-189","source":"Crossref","is-referenced-by-count":2,"title":["The toxicity assessment of neorudin in cynomolgus monkeys"],"prefix":"10.2131","volume":"48","author":[{"given":"Yu-bin","family":"Liu","sequence":"first","affiliation":[{"name":"Beijing Institute of Radiation Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-yuan","family":"Ren","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-chen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Zheng","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-feng","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing Union Jianhao Medical Technology Development Co., LTD., China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-tse","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-de","family":"Jin","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Abubakar, B., Alhassan, A.M., Malami, I., Usman, D., Uthman, Y.A., Adeshina, K.A., Olatubosun, M.O. and Imam, M.U. (2022): Evaluation of acute and sub-acute toxicity profile of 5-methylcoumarin-4\u03b2-glucoside in mice. Toxicol. Rep., <b>9<\/b>, 366-372.","DOI":"10.1016\/j.toxrep.2022.03.013"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Agewall, S. (2017): Metabolic control, anticoagulation, and gender aspects. Eur. Heart J. Cardiovasc. Pharmacother., <b>3<\/b>, 125-126.","DOI":"10.1093\/ehjcvp\/pvx014"},{"key":"3","doi-asserted-by":"publisher","unstructured":"Antman, E.M. (1996): Hirudin in acute myocardial infarction. Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial. Circulation, <b>94<\/b>, 911-921.","DOI":"10.1161\/01.CIR.94.5.911"},{"key":"4","first-page":"1256","author":"G. Borelli","year":"1986","unstructured":"Borelli, G. and Bertoli, D. (1986): Toxic and mutagenic effects of a low molecular weight heparin in rats. Arzneimittelforschung, <b>36<\/b>, 1256-1260.","journal-title":"Arzneimittelforschung","ISSN":"https:\/\/id.crossref.org\/issn\/0004-4172","issn-type":"print"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Brien, L. (2019): Anticoagulant Medications for the Prevention and Treatment of Thromboembolism. AACN Adv. Crit. Care, <b>30<\/b>, 126-138.","DOI":"10.4037\/aacnacc2019867"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Camporese, G. and Bernardi, E. (2009): Low-molecular-weight heparin for thromboprophylaxis. Curr. Opin. Pulm. Med., <b>15<\/b>, 443-454.","DOI":"10.1097\/MCP.0b013e32832f5d9d"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Carnicelli, A.P., Hong, H., Connolly, S.J., Eikelboom, J., Giugliano, R.P., Morrow, D.A., Patel, M.R., Wallentin, L., Alexander, J.H., Cecilia Bahit, M., Benz, A.P., Bohula, E.A., Chao, T.F., Dyal, L., Ezekowitz, M., A A Fox, K., Gencer, B., Halperin, J.L., Hijazi, Z., Hohnloser, S.H., Hua, K., Hylek, E., Toda Kato, E., Kuder, J., Lopes, R.D., Mahaffey, K.W., Oldgren, J., Piccini, J.P., Ruff, C.T., Steffel, J., Wojdyla, D. and Granger, C.B.; COMBINE AF (A Collaboration Between Multiple Institutions to Better Investigate Non-Vitamin K Antagonist Oral Anticoagulant Use in Atrial Fibrillation) Investigators. (2022): Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex. Circulation, <b>145<\/b>, 242-255.","DOI":"10.1161\/CIRCULATIONAHA.121.056355"},{"key":"8","doi-asserted-by":"publisher","unstructured":"Declerck, P.J. (2011): Thrombin activatable fibrinolysis inhibitor. Hamostaseologie, <b>31<\/b>, 165-166, 168-173.","DOI":"10.5482\/ha-1155"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Dong, X., Meng, Z., Gu, R., Zhu, X., Gan, H., Jin, J., Liu, J. and Dou, G. (2020): Predicting the metabolic characteristics of neorudin, a novel anticoagulant fusion protein, in patients with deep vein thrombosis. Thromb. Res., <b>194<\/b>, 121-134.","DOI":"10.1016\/j.thromres.2020.05.048"},{"key":"10","doi-asserted-by":"publisher","unstructured":"Gando, S., Sawamura, A., Hayakawa, M., Sugano, M., Kubota, N., Uegaki, S. and Henzan, N. (2010): Coagulation and fibrinolytic responses at an early phase of trauma: the main issues in the world are reviewed and discussed. Nihon Kyukyu Igakukai Zasshi, <b>21<\/b>, 765-778.","DOI":"10.3893\/jjaam.21.765"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Greinacher, A. and Warkentin, T.E. (2008): The direct thrombin inhibitor hirudin. Thromb. Haemost., <b>99<\/b>, 819-829.","DOI":"10.1160\/TH07-11-0693"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Hull, R.D. and Pineo, G.F. (2000): Low-molecular-weight heparin in the treatment of venous thromboembolism. Semin. Thromb. Hemost., <b>26<\/b> (Suppl 1), 61-67.","DOI":"10.1055\/s-2000-9495"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Jin, Y., Teh, S.S., Lau, H.L. and Mah, S.H. (2021): In vivo Toxicity Assessment of Refined Red Palm-pressed Mesocarp Olein in Sprague-Dawley Rats. J. Oleo Sci., <b>70<\/b>, 1749-1759.","DOI":"10.5650\/jos.ess21215"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Junren, C., Xiaofang, X., Huiqiong, Z., Gangmin, L., Yanpeng, Y., Xiaoyu, C., Yuqing, G., Yanan, L., Yue, Z., Fu, P. and Cheng, P. (2021): Pharmacological Activities and Mechanisms of Hirudin and Its Derivatives - A Review. Front. Pharmacol., <b>12<\/b>, 660757.","DOI":"10.3389\/fphar.2021.660757"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Kim, C.-Y., Kim, J., Han, K., Kim, S., Park, K. and Byun, Y. (2007): Toxicity screening after repeated dose of a newly developed oral heparin derivative in male cynomolgus monkeys. J. Toxicol. Sci., <b>32<\/b>, 411-420.","DOI":"10.2131\/jts.32.411"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Kurata, M. and Horii, I. (2004): Blood coagulation tests in toxicological studies--review of methods and their significance for drug safety assessment. J. Toxicol. Sci., <b>29<\/b>, 13-32.","DOI":"10.2131\/jts.29.13"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Liu, Y.B., Zhang, L., Zhou, X.C., Zhou, Y., Liu, Y., Zheng, C., Xu, X., Geng, P.P., Hao, C.H., Zhao, Z.Y., Wu, C.T. and Jin, J.D. (2022a): The Antithrombotic Effect of Recombinant Neorudin on Thrombi. Drug Des. Devel. Ther., <b>16<\/b>, 1667-1678.","DOI":"10.2147\/DDDT.S353088"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Liu, Y.B., Zhou, X.C., Liu, Y., Zhang, L., Zhou, Y., Xu, X., Zheng, C., Zhao, Z.Y., Wu, C.T. and Jin, J.D. (2022b): Inhibitory role of recombinant neorudin on canine coronary artery thrombosis. Pharmacol. Res. Perspect., <b>10<\/b>, e00956.","DOI":"10.1002\/prp2.956"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Lubenow, N. and Greinacher, A. (2002): Hirudin in heparin-induced thrombocytopenia. Semin. Thromb. Hemost., <b>28<\/b>, 431-438.","DOI":"10.1055\/s-2002-35283"},{"key":"20","unstructured":"Manolov, I., Topashka-Ancheva, M. and Klouchek, E. (1993): The synthesis, toxicological and comparative cytogenetic characteristics of the anticoagulant warfarin. Eksp. Med. Morfol., <b>31<\/b>, 49-60."},{"key":"21","doi-asserted-by":"crossref","unstructured":"Mohs, R.C. and Greig, N.H. (2017): Drug discovery and development: role of basic biological research. Alzheimers Dement. (N. Y.), <b>3<\/b>, 651-657.","DOI":"10.1016\/j.trci.2017.10.005"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Ohishi, T., Kitazawa, T., Suzuki, S., Nakamura, D., Nishihara, Y. and Mochizuki, M. (2010): Effects of pregnancy and lactation on warfarin-induced changes in blood coagulation-related parameters in rats. J. Toxicol. Sci., <b>35<\/b>, 189-196.","DOI":"10.2131\/jts.35.189"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Reiner, A.P. and Bell, W.R. (1984): The fibrinolytic system in man. Crit. Rev. Oncol. Hematol., <b>2<\/b>, 33-81.","DOI":"10.1016\/S1040-8428(84)80004-9"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Sedlak, T., Shufelt, C., Iribarren, C. and Merz, C.N. (2012): Sex hormones and the QT interval: a review. J. Womens Health (Larchmt.), <b>21<\/b>, 933-941.","DOI":"10.1089\/jwh.2011.3444"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Seki, Y., Muneyuki, K., Kandori, A., Tsukada, K., Terao, K. and Ageyama, N. (2008): Standardization of magnetocardiography in nonhuman primates. Phys. Med. Biol., <b>53<\/b>, 1609-1618.","DOI":"10.1088\/0031-9155\/53\/6\/007"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Takeshita, J.-i., Kishimoto, A. and Gamo, M. (2014): Investigation of organ-specific assessment factors related to sub-acute and sub-chronic toxicity studies. Fundam. Toxicol. Sci., <b>1<\/b>, 1-6.","DOI":"10.2131\/fts.1.1"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Vink, A.S., Clur, S.B., Wilde, A.A. and Blom, N.A. (2018): Effect of age and gender on the QTc-interval in healthy individuals and patients with long-QT syndrome. Trends Cardiovasc. Med., <b>28<\/b>, 64-75.","DOI":"10.1016\/j.tcm.2017.07.012"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Zhang, C., Yu, A., Yuan, B., Dong, C., Yu, H., Wang, L. and Wu, C. (2008): Construction and functional evaluation of hirudin derivatives with low bleeding risk. Thromb. Haemost., <b>99<\/b>, 324-330.","DOI":"10.1160\/TH07-07-0453"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/48\/4\/48_179\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T04:36:28Z","timestamp":1680928588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/48\/4\/48_179\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.48.179","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}