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(2001): A trial on the quantitative risk assessment of man-made mineral fibers by the rat intraperitoneal administration assay using the JFM standard fibrous samples. Ind. Health, <b>39<\/b>, 168-174.","DOI":"10.2486\/indhealth.39.168"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Ahmadzadeh, K., Vanoppen, M., Rose, C.D., Matthys, P. and Wouters, C.H. (2022): Multinucleated Giant Cells: Current Insights in Phenotype, Biological Activities, and Mechanism of Formation. Front. Cell Dev. Biol., <b>10<\/b>, 873226.","DOI":"10.3389\/fcell.2022.873226"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Aiso, S., Yamazaki, K., Umeda, Y., Asakura, M., Kasai, T., Takaya, M., Toya, T., Koda, S., Nagano, K., Arito, H. and Fukushima, S. (2010): Pulmonary toxicity of intratracheally instilled multiwall carbon nanotubes in male Fischer 344 rats. Ind. 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Risk Anal., <b>35<\/b>, 1940-1956.","DOI":"10.1111\/risa.12394"},{"key":"51","doi-asserted-by":"crossref","unstructured":"Nicholson, A.G., Sauter, J.L., Nowak, A.K., Kindler, H.L., Gill, R.R., Remy-Jardin, M., Armato, S.G. 3rd, Fernandez-Cuesta, L., Bueno, R., Alcala, N., Foll, M., Pass, H., Attanoos, R., Baas, P., Beasley, M.B., Brcic, L., Butnor, K.J., Chirieac, L.R., Churg, A., Courtiol, P., Dacic, S., De Perrot, M., Frauenfelder, T., Gibbs, A., Hirsch, F.R., Hiroshima, K., Husain, A., Klebe, S., Lantuejoul, S., Moreira, A., Opitz, I., Perol, M., Roden, A., Roggli, V., Scherpereel, A., Tirode, F., Tazelaar, H., Travis, W.D., Tsao, M.S., van Schil, P., Vignaud, J.M., Weynand, B., Lang-Lazdunski, L., Cree, I., Rusch, V.W., Girard, N. and Galateau-Salle, F. (2020): EURACAN\/IASLC Proposals for Updating the Histologic Classification of Pleural Mesothelioma: Towards a More Multidisciplinary Approach. J. Thorac. Oncol., <b>15<\/b>, 29-49.","DOI":"10.1016\/j.jtho.2019.08.2506"},{"key":"52","doi-asserted-by":"crossref","unstructured":"Oberd\u00f6rster, G. and Kuhlbusch, T.A. (2018): In vivo effects: methodologies and biokinetics of inhaled nanomaterials. NanoImpact, <b>10<\/b>, 38-60.","DOI":"10.1016\/j.impact.2017.10.007"},{"key":"53","doi-asserted-by":"crossref","unstructured":"Ord\u00f3\u00f1ez, N.G. (2006): Mesothelioma with rhabdoid features: an ultrastructural and immunohistochemical study of 10 cases. Mod. Pathol., <b>19<\/b>, 373-383.","DOI":"10.1038\/modpathol.3800543"},{"key":"54","doi-asserted-by":"crossref","unstructured":"Orecchioni, M., Ghosheh, Y., Pramod, A.B. and Ley, K. (2019): Macrophage Polarization: different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages. Front. Immunol., <b>10<\/b>, 1084.","DOI":"10.3389\/fimmu.2019.01084"},{"key":"55","doi-asserted-by":"crossref","unstructured":"Orsi, M., Palmai-Pallag, M., Yakoub, Y., Ibouraadaten, S., De Beukelaer, M., Bouzin, C., Bearzatto, B., Ambroise, J., Gala, J.L., Brusa, D., Lison, D. and Huaux, F. (2021): Monocytic Ontogeny of Regenerated Macrophages Characterizes the Mesotheliomagenic Responses to Carbon Nanotubes. Front. Immunol., <b>12<\/b>, 666107.","DOI":"10.3389\/fimmu.2021.666107"},{"key":"56","doi-asserted-by":"crossref","unstructured":"Otsuka, K., Yamada, K., Taquahashi, Y., Arakaki, R., Ushio, A., Saito, M., Yamada, A., Tsunematsu, T., Kudo, Y., Kanno, J. and Ishimaru, N. (2018): Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes. 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Dermatol., <b>131<\/b>, 1322-1330.","DOI":"10.1038\/jid.2011.9"},{"key":"59","doi-asserted-by":"crossref","unstructured":"Poland, C.A., Duffin, R., Kinloch, I., Maynard, A., Wallace, W.A., Seaton, A., Stone, V., Brown, S., Macnee, W. and Donaldson, K. (2008): Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat. Nanotechnol., <b>3<\/b>, 423-428.","DOI":"10.1038\/nnano.2008.111"},{"key":"60","doi-asserted-by":"crossref","unstructured":"Rabolli, V., Lo Re, S., Uwambayinema, F., Yakoub, Y., Lison, D. and Huaux, F. (2011): Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice. Toxicol. Lett., <b>203<\/b>, 127-134.","DOI":"10.1016\/j.toxlet.2011.03.009"},{"key":"61","doi-asserted-by":"crossref","unstructured":"Ramachandran, P., Pellicoro, A., Vernon, M.A., et al. (2012): Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proceedings of the National Academy of Sciences, <b>109<\/b>.","DOI":"10.1073\/pnas.1119964109"},{"key":"62","doi-asserted-by":"crossref","unstructured":"Rittinghausen, S., Hackbarth, A., Creutzenberg, O., Ernst, H., Heinrich, U., Leonhardt, A. and Schaudien, D. (2014): The carcinogenic effect of various multi-walled carbon nanotubes (MWCNTs) after intraperitoneal injection in rats. Part. Fibre Toxicol., <b>11<\/b>, 59.","DOI":"10.1186\/s12989-014-0059-z"},{"key":"63","doi-asserted-by":"crossref","unstructured":"R\u0151szer, T. (2015): Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. 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Sci., <b>43<\/b>, 587-600.","DOI":"10.2131\/jts.43.587"},{"key":"68","doi-asserted-by":"crossref","unstructured":"Sakamoto, Y., Nakae, D., Fukumori, N., Tayama, K., Maekawa, A., Imai, K., Hirose, A., Nishimura, T., Ohashi, N. and Ogata, A. (2009): Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats. J. Toxicol. Sci., <b>34<\/b>, 65-76.","DOI":"10.2131\/jts.34.65"},{"key":"69","doi-asserted-by":"crossref","unstructured":"Saleh, D.M., Luo, S., Ahmed, O.H., Alexander, D.B., Alexander, W.T., Gunasekaran, S., El-Gazzar, A.M., Abdelgied, M., Numano, T., Takase, H., Ohnishi, M., Tomono, S., Hady, R.H., Fukamachi, K., Kanno, J., Hirose, A., Xu, J., Suzuki, S., Naiki-Ito, A., Takahashi, S. and Tsuda, H. (2022): Assessment of the toxicity and carcinogenicity of double-walled carbon nanotubes in the rat lung after intratracheal instillation: a two-year study. Part. Fibre Toxicol., <b>19<\/b>, 30.","DOI":"10.1186\/s12989-022-00469-8"},{"key":"70","doi-asserted-by":"publisher","unstructured":"Satoh, T., Kidoya, H., Naito, H., Yamamoto, M., Takemura, N., Nakagawa, K., Yoshioka, Y., Morii, E., Takakura, N., Takeuchi, O. and Akira, S. (2013): Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages. Nature, <b>495<\/b>, 524-528.","DOI":"10.1038\/nature11930"},{"key":"71","doi-asserted-by":"crossref","unstructured":"Shichino, S., Abe, J., Ueha, S., Otsuji, M., Tsukui, T., Kosugi-Kanaya, M., Shand, F.H., Hashimoto, S., Suzuki, H.I., Morikawa, T., Inagaki, Y. and Matsushima, K. (2015): Reduced supply of monocyte-derived macrophages leads to a transition from nodular to diffuse lesions and tissue cell activation in silica-induced pulmonary fibrosis in mice. Am. J. Pathol., <b>185<\/b>, 2923-2938.","DOI":"10.1016\/j.ajpath.2015.07.013"},{"key":"72","doi-asserted-by":"publisher","unstructured":"Shvedova, A.A., Tkach, A.V., Kisin, E.R., Khaliullin, T., Stanley, S., Gutkin, D.W., Star, A., Chen, Y., Shurin, G.V., Kagan, V.E. and Shurin, M.R. (2013): Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells. Small, <b>9<\/b>, 1691-1695.","DOI":"10.1002\/smll.201201470"},{"key":"73","doi-asserted-by":"crossref","unstructured":"Sica, A. and Mantovani, A. (2012): Macrophage plasticity and polarization: <i>in vivo<\/i> veritas. J. Clin. Invest., <b>122<\/b>, 787-795.","DOI":"10.1172\/JCI59643"},{"key":"74","doi-asserted-by":"crossref","unstructured":"Silva, M.T. (2011): Macrophage phagocytosis of neutrophils at inflammatory\/infectious foci: a cooperative mechanism in the control of infection and infectious inflammation. J. Leukoc. Biol., <b>89<\/b>, 675-683.","DOI":"10.1189\/jlb.0910536"},{"key":"75","doi-asserted-by":"crossref","unstructured":"Stanton, M.F., Laynard, M., Tegeris, A., Miller, E., May, M. and Kent, E. (1977): Carcinogenicity of fibrous glass: pleural response in the rat in relation to fiber dimension. J. Natl. Cancer Inst., <b>58<\/b>, 587-603.","DOI":"10.1093\/jnci\/58.3.587"},{"key":"76","doi-asserted-by":"crossref","unstructured":"Suresh, M.V., Yu, B., Machado-Aranda, D., Bender, M.D., Ochoa-Frongia, L., Helinski, J.D., Davidson, B.A., Knight, P.R., Hogaboam, C.M., Moore, B.B. and Raghavendran, K. (2012): Role of macrophage chemoattractant protein-1 in acute inflammation after lung contusion. Am. J. Respir. Cell Mol. Biol., <b>46<\/b>, 797-806.","DOI":"10.1165\/rcmb.2011-0358OC"},{"key":"77","doi-asserted-by":"crossref","unstructured":"Suzuki, Y. and Kohyama, N. (1984): Malignant mesothelioma induced by asbestos and zeolite in the mouse peritoneal cavity. Environ. Res., <b>35<\/b>, 277-292.","DOI":"10.1016\/0013-9351(84)90136-1"},{"key":"78","doi-asserted-by":"crossref","unstructured":"Takagi, A., Hirose, A., Futakuchi, M., Tsuda, H. and Kanno, J. (2012): Dose-dependent mesothelioma induction by intraperitoneal administration of multi-wall carbon nanotubes in p53 heterozygous mice. Cancer Sci., <b>103<\/b>, 1440-1444.","DOI":"10.1111\/j.1349-7006.2012.02318.x"},{"key":"79","doi-asserted-by":"crossref","unstructured":"Takagi, A., Hirose, A., Nishimura, T., Fukumori, N., Ogata, A., Ohashi, N., Kitajima, S. and Kanno, J. (2008): Induction of mesothelioma in p53+\/- mouse by intraperitoneal application of multi-wall carbon nanotube. J. Toxicol. Sci., <b>33<\/b>, 105-116.","DOI":"10.2131\/jts.33.105"},{"key":"80","doi-asserted-by":"crossref","unstructured":"Takahashi, M., Galligan, C., Tessarollo, L. and Yoshimura, T. (2009): Monocyte chemoattractant protein-1 (MCP-1), not MCP-3, is the primary chemokine required for monocyte recruitment in mouse peritonitis induced with thioglycollate or zymosan A. J. Immunol., <b>183<\/b>, 3463-3471.","DOI":"10.4049\/jimmunol.0802812"},{"key":"81","doi-asserted-by":"crossref","unstructured":"Tamoutounour, S., Henri, S., Lelouard, H., de Bovis, B., de Haar, C., van der Woude, C.J., Woltman, A.M., Reyal, Y., Bonnet, D., Sichien, D., Bain, C.C., Mowat, A.M., Reis e Sousa, C., Poulin, L.F., Malissen, B. and Guilliams, M. (2012): CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis. Eur. J. Immunol., <b>42<\/b>, 3150-3166.","DOI":"10.1002\/eji.201242847"},{"key":"82","doi-asserted-by":"crossref","unstructured":"Taquahashi, Y., Ogawa, Y., Takagi, A., Tsuji, M., Morita, K. and Kanno, J. (2013): Improved dispersion method of multi-wall carbon nanotube for inhalation toxicity studies of experimental animals. J. Toxicol. Sci., <b>38<\/b>, 619-628.","DOI":"10.2131\/jts.38.619"},{"key":"83","doi-asserted-by":"crossref","unstructured":"Terri, M., Trionfetti, F., Montaldo, C., Cordani, M., Tripodi, M., Lopez-Cabrera, M. and Strippoli, R. (2021): Mechanisms of Peritoneal Fibrosis: Focus on Immune Cells-Peritoneal Stroma Interactions. Front. Immunol., <b>12<\/b>, 607204.","DOI":"10.3389\/fimmu.2021.607204"},{"key":"84","doi-asserted-by":"crossref","unstructured":"Vogel, D.Y., Vereyken, E.J., Glim, J.E., Heijnen, P.D., Moeton, M., van der Valk, P., Amor, S., Teunissen, C.E., van Horssen, J. and Dijkstra, C.D. (2013): Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status. J. Neuroinflammation, <b>10<\/b>, 35.","DOI":"10.1186\/1742-2094-10-35"},{"key":"85","doi-asserted-by":"crossref","unstructured":"Wareing, M.D., Lyon, A., Inglis, C., Giannoni, F., Charo, I. and Sarawar, S.R. (2007): Chemokine regulation of the inflammatory response to a low-dose influenza infection in CCR2-\/- mice. J. Leukoc. Biol., <b>81<\/b>, 793-801.","DOI":"10.1189\/jlb.0506299"},{"key":"86","doi-asserted-by":"crossref","unstructured":"Witherel, C.E., Abebayehu, D., Barker, T.H. and Spiller, K.L. (2019): Macrophage and Fibroblast Interactions in Biomaterial-Mediated Fibrosis. Adv. Healthc. Mater., <b>8<\/b>, e1801451.","DOI":"10.1002\/adhm.201801451"},{"key":"87","doi-asserted-by":"crossref","unstructured":"Yamaguchi, A., Fujitani, T., Ohyama, K., Nakae, D., Hirose, A., Nishimura, T. and Ogata, A. (2012): Effects of sustained stimulation with multi-wall carbon nanotubes on immune and inflammatory responses in mice. J. Toxicol. 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