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Gen. Comp. Endocrinol., <b>134<\/b>, 80-87.","DOI":"10.1016\/S0016-6480(03)00220-X"},{"key":"58","doi-asserted-by":"crossref","unstructured":"Rice, D. and Barone, S. Jr. (2000): Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ. Health Perspect., <b>108<\/b> (Suppl 3), 511-533.","DOI":"10.1289\/ehp.00108s3511"},{"key":"59","doi-asserted-by":"crossref","unstructured":"Savu, L., Vranckx, R., Maya, M. and Nunez, E.A. (1987): A thyroxine binding globulin (TBG)-like protein in the sera of developing and adult rats. Biochem. Biophys. Res. Commun., <b>148<\/b>, 1165-1173.","DOI":"10.1016\/S0006-291X(87)80255-3"},{"key":"60","unstructured":"USEPA. 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