{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T16:02:49Z","timestamp":1782057769420,"version":"3.54.5"},"reference-count":15,"publisher":"Japanese Society of Toxicology","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2025]]},"DOI":"10.2131\/jts.50.325","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T22:15:19Z","timestamp":1751321719000},"page":"325-332","source":"Crossref","is-referenced-by-count":3,"title":["Identification of postmortem product of amlodipine decomposition by hemoglobin with LC-Q-Orbitrap-MS"],"prefix":"10.2131","volume":"50","author":[{"given":"Yoshikazu","family":"Yamagishi","sequence":"first","affiliation":[{"name":"Department of Legal Medicine, Graduate School of Medicine, Chiba University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine, Graduate School of Medicine, Chiba University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Nagasawa","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine, Graduate School of Medicine, Chiba University"},{"name":"Laboratory of Forensic Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaro","family":"Iwase","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine, Graduate School of Medicine, Chiba University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumitsu","family":"Ogra","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine, Graduate School of Medicine, Chiba University"},{"name":"Laboratory of Forensic Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University"},{"name":"Laboratory of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Alvarez, J.C., Mayer-Duverneuil, C., Cappy, J., Lorin de la Grandamison, G. and Knapp-Gisclon, A. (2020): Postmortem fatal and non-fatal concentrations of amlodipine. Forensic Sci. Int., <b>316<\/b>, 110555.","DOI":"10.1016\/j.forsciint.2020.110555"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Hirawa, N., Umemura, S. and Ito, S. (2019): Viewpoint on Guidelines for Treatment of Hypertension in Japan. Circ. Res., <b>124<\/b>, 981-983.","DOI":"10.1161\/CIRCRESAHA.119.314991"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Hansen, J., Palmfeldt, J., Pedersen, K.W., Funder, A.D., Frost, L., Hasselstr\u00f8m, J.B. and Jornil, J.R. (2019): Postmortem protein stability investigations of the human hepatic drug-metabolizing cytochrome P450 enzymes CYP1A2 and CYP3A4 using mass spectrometry. J. Proteomics, <b>194<\/b>, 125-131.","DOI":"10.1016\/j.jprot.2018.11.024"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Hirabayashi, A. (1953): Experimente \u00fcber die h\u00e4molyse des blutes aus leichen in verschiedener zeit nach dem Tode. Arch. Histol. Jpn., <b>5<\/b>, 565-571.","DOI":"10.1679\/aohc1950.5.565"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Lifschultz, B.D. and Donoghue, E.R. (1998): Forensic pathology of heat-and cold-related injuries. Clin. Lab. Med., <b>18<\/b>, 77-90.","DOI":"10.1016\/S0272-2712(18)30180-X"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Meredith, P.A. and Elliott, H.L. (1992): Clinical pharmacokinetics of amlodipine. Clin. Pharmacokinet., <b>22<\/b>, 22-31.","DOI":"10.2165\/00003088-199222010-00003"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Peters, F.T. and Steuer, A.E. (2019): Antemortem and postmortem influences on drug concentrations and metabolite patterns in postmortem specimens. WIREs Forensic Sci., <b>1<\/b>, e1297.","DOI":"10.1002\/wfs2.1297"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Schulz, M., Schmoldt, A., Andresen-Streichert, H. and Iwersen-Bergmann, S. (2020): Revisited: therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics. Crit. Care (Fullerton), <b>24<\/b>, 195.","DOI":"10.1186\/s13054-020-02915-5"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Shikama, K. (1998): The molecular mechanism of autoxidation for myoglobin and hemoglobin.\u2005a venerable puzzle. Chem. Rev., <b>98<\/b>, 1357-1374.","DOI":"10.1021\/cr970042e"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Stopher, D.A., Beresford, A.P., Macrae, P.V. and Humphrey, M.J. (1988): The metabolism and pharmacokinetics of amlodipine in humans and animals. J. Cardiovasc. Pharmacol., <b>12<\/b> (Suppl 7), S55-S59.","DOI":"10.1097\/00005344-198812007-00012"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Yamagishi, Y., Iwase, H. and Ogra, Y. (2021a): Post-mortem changes of methomyl in blood with hemoglobin. Chem. Res. Toxicol., <b>34<\/b>, 161-168.","DOI":"10.1021\/acs.chemrestox.0c00472"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Yamagishi, Y., Iwase, H. and Ogra, Y. (2021b): Effects of hemoglobin on post-mortem oxidation of bromazepam. Fundam. Toxicol. Sci., <b>8<\/b>, 61-67.","DOI":"10.2131\/fts.8.61"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Yamagishi, Y., Nagasawa, S., Iwase, H. and Ogra, Y. (2022): Evaluation of post-Mortem interaction between hemoglobin and oxime-type carbamate pesticides. Chem. Res. Toxicol., <b>35<\/b>, 1110-1116.","DOI":"10.1021\/acs.chemrestox.2c00092"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Yamagishi, Y., Inokuchi, G., Hoshioka, Y., Nagasawa, S., Iwase, H. and Ogra, Y. (2023): Identification of postmortem paliperidone metabolite in human blood by LC-Q-Orbitrap-MS. J. Anal. Toxicol., <b>47<\/b>, 517-522.","DOI":"10.1093\/jat\/bkad033"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Yamagishi, Y., Nagasawa, S., Iwase, H. and Ogra, Y. (2024): Identification of post-mortem product of zolpidem degradation by hemoglobin via the Fenton reaction. J. Toxicol. Sci., <b>49<\/b>, 261-268.","DOI":"10.2131\/jts.49.261"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/50\/7\/50_325\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T03:40:07Z","timestamp":1751686807000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/50\/7\/50_325\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.50.325","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}