{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:16:40Z","timestamp":1788585400479,"version":"build-2803163510"},"reference-count":60,"publisher":"Japanese Society of Toxicology","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Toxicol. Sci."],"published-print":{"date-parts":[[2026]]},"DOI":"10.2131\/jts.51.471","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:20:49Z","timestamp":1788214849000},"page":"471-487","source":"Crossref","is-referenced-by-count":0,"title":["Polypharmacological neurotoxic effects of methylisothiazolinone revealed by integrated &lt;i&gt;in vitro&lt;\/i&gt; and network-based chemoinformatics approaches"],"prefix":"10.2131","volume":"51","author":[{"given":"G\u00fcl","family":"K\u00fc\u00e7\u00fckkahraman","sequence":"first","affiliation":[{"name":"Institute of Health Sciences, Istanbul University, Istanbul, T\u00fcrkiye"},{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Bah\u00e7e\u015fehir University, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zge Sultan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed T.","family":"Qaoud","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy, Cyprus International University, Northern Cyprus, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Arici","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istinye University, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl","family":"\u00d6zhan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"898","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"A\u00efd, S. and Bosetti, F. (2011): Targeting cyclooxygenases-1 and -2 in neuroinflammation: therapeutic implications. Biochimie, <b>93<\/b>, 46-51.","DOI":"10.1016\/j.biochi.2010.09.009"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Bao, J., Bao, Y. and Ishfaq, M. (2025): Development of next-generation tools for advancing computational pharmacology and toxicology. <i>In Computational Methods in Medicinal Chemistry<\/i>. Pharmacol. Toxicol., (pp. 253-274). Academic Press.","DOI":"10.1016\/B978-0-443-33024-7.00004-7"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Bilgehan, A., \u015eeker, Z., Qaoud, M.T. and \u00d6zhan, G. (2025): In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells. Toxicol. Res. (Camb.), <b>14<\/b>, tfaf064.","DOI":"10.1093\/toxres\/tfaf064"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Burley, S.K., Piehl, D.W., Vallat, B. and Zardecki, C. (2024): RCSB Protein Data Bank: supporting research and education worldwide through explorations of experimentally determined and computationally predicted atomic level 3D biostructures. IUCrJ, <b>11<\/b>, 279-286.","DOI":"10.1107\/S2052252524002604"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Burnett, C.L., Bergfeld, W.F., Belsito, D.V., Klaassen, C.D., Marks, J.G. Jr., Shank, R.C., Slaga, T.J., Snyder, P.W. and Alan Andersen, F. (2010): Final report of the safety assessment of methylisothiazolinone. Int. J. Toxicol., <b>29<\/b> (Suppl), 187S-213S.","DOI":"10.1177\/1091581810374651"},{"key":"6","doi-asserted-by":"crossref","unstructured":"\u00c7apan, \u0130., Hawash, M., Qaoud, M.T. and Jaradat, N. (2024): Next-generation carbazole-linked 1, 2, 4-triazole-thione derivatives: strategic design, synthesis, molecular docking, and evaluation of antidiabetic potential. ACS Omega, <b>10<\/b>, 848-861.","DOI":"10.1021\/acsomega.4c07896"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Chen, J. (2016): The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression. Cold Spring Harb. Perspect. Med., <b>6<\/b>, a026104.","DOI":"10.1101\/cshperspect.a026104"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Daina, A., Michielin, O. and Zoete, V. (2019): SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res., <b>47<\/b> (W1), W357-W364.","DOI":"10.1093\/nar\/gkz382"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Du, S., McLaughlin, B., Pal, S. and Aizenman, E. (2002): In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway. J. Neurosci., <b>22<\/b>, 7408-7416.","DOI":"10.1523\/JNEUROSCI.22-17-07408.2002"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Ettorre, A., Andreassi, M., Anselmi, C., Neri, P., Andreassi, L. and Di Stefano, A. (2003): Involvement of oxidative stress in apoptosis induced by a mixture of isothiazolinones in normal human keratinocytes. J. Invest. Dermatol., <b>121<\/b>, 328-336.","DOI":"10.1046\/j.1523-1747.2003.12360.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Friesner, R.A., Murphy, R.B., Repasky, M.P., Frye, L.L., Greenwood, J.R., Halgren, T.A., Sanschagrin, P.C. and Mainz, D.T. (2006): Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes. J. Med. Chem., <b>49<\/b>, 6177-6196.","DOI":"10.1021\/jm051256o"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Ghasemi, M., Turnbull, T., Sebastian, S. and Kempson, I. (2021): The MTT Assay: Utility, Limitations, Pitfalls, and Interpretation in Bulk and Single-Cell Analysis. Int. J. Mol. Sci., <b>22<\/b>, 12827.","DOI":"10.3390\/ijms222312827"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Guadagno, J., Swan, P., Shaikh, R. and Cregan, S.P. (2015): Microglia-derived IL-1\u03b2 triggers p53-mediated cell cycle arrest and apoptosis in neural precursor cells. Cell Death Dis., <b>6<\/b>, e1779.","DOI":"10.1038\/cddis.2015.151"},{"key":"14","unstructured":"Gupta, G., Joshi, D., Narayan, G., Sharma, S. and Hallur, R.L. (2024): GSK-3\u03b2 inhibitor can rescue neurons through the prosurvival (autophagy) mechanism in Parkinson\u2019s disease. Pravara Med. Rev., <b>16<\/b>."},{"key":"15","doi-asserted-by":"crossref","unstructured":"He, K., Huang, J., Lagenaur, C.F. and Aizenman, E. (2006): Methylisothiazolinone, a neurotoxic biocide, disrupts the association of SRC family tyrosine kinases with focal adhesion kinase in developing cortical neurons. J. Pharmacol. Exp. Ther., <b>317<\/b>, 1320-1329.","DOI":"10.1124\/jpet.106.103044"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Hegde, M., Guruprasad, K.P., Ramachandra, L., Satyamoorthy, K. and Joshi, M.B. (2020): Interleukin-6-mediated epigenetic control of the VEGFR2 gene induces disorganized angiogenesis in human breast tumors. J. Biol. Chem., <b>295<\/b>, 12086-12098.","DOI":"10.1074\/jbc.RA120.012590"},{"key":"17","doi-asserted-by":"publisher","unstructured":"Henslee, E.A., Torcal Serrano, R.M., Labeed, F.H., Jabr, R.I., Fry, C.H., Hughes, M.P. and Hoettges, K.F. (2016): Accurate quantification of apoptosis progression and toxicity using a dielectrophoretic approach. Analyst, <b>141<\/b>, 6408-6415.","DOI":"10.1039\/C6AN01596D"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Huang, K., Luo, S., Cong, Y., Zhong, S., Zhang, J.Z. and Duan, L. (2020): An accurate free energy estimator: based on MM\/PBSA combined with interaction entropy for protein-ligand binding affinity. Nanoscale, <b>12<\/b>, 10737-10750.","DOI":"10.1039\/C9NR10638C"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Huang, S., Lu, Y., Fang, W., Huang, Y., Li, Q. and Xu, Z. (2025): Neurodegenerative diseases and neuroinflammation-induced apoptosis. Open Life Sci., <b>20<\/b>, 20221051.","DOI":"10.1515\/biol-2022-1051"},{"key":"20","doi-asserted-by":"publisher","unstructured":"Ischenko, I., Guba, M., Yezhelyev, M., Papyan, A., Schmid, G., Green, T., Fennell, M., Jauch, K.W. and Bruns, C.J. (2007): Effect of Src kinase inhibition on metastasis and tumor angiogenesis in human pancreatic cancer. Angiogenesis, <b>10<\/b>, 167-182.","DOI":"10.1007\/s10456-007-9071-3"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Jia, A., Xu, L. and Wang, Y. (2021): Venn diagrams in bioinformatics. Brief. Bioinform., <b>22<\/b>, bbab108.","DOI":"10.1093\/bib\/bbab108"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Jin, Z. and El-Deiry, W.S. (2005): Overview of cell death signaling pathways. Cancer Biol. Ther., <b>4<\/b>, 139-163.","DOI":"10.4161\/cbt.4.2.1508"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Kerkis, I., da Silva, \u00c1.P. and Araldi, R.P. (2024): The impact of interleukin-6 (IL-6) and mesenchymal stem cell-derived IL-6 on neurological conditions. Front. Immunol., <b>15<\/b>, 1400533.","DOI":"10.3389\/fimmu.2024.1400533"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Kim, S., &amp; Bolton, E. E. (2024). PubChem: a large\u2010scale public chemical database for drug discovery. <i>Open Access Databases and Datasets for Drug Discovery<\/i>, 39-66.","DOI":"10.1002\/9783527830497.ch2"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Kovalevich, J., Santerre, M. and Langford, D. (2021). Considerations for the Use of SH-SY5YNeuroblastoma Cells in Neurobiology. <i>In Neuronal Cell Culture: Methods and Protocols<\/i> (pp. 9-23). New York, NY: Springer US.","DOI":"10.1007\/978-1-0716-1437-2_2"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Lan, Y., Peng, Q., Fu, B. and Liu, H. (2025): Effective analysis of thyroid toxicity and mechanisms of acetyltributyl citrate using network toxicology, molecular docking, and machine learning strategies. Toxicology, <b>511<\/b>, 154029.","DOI":"10.1016\/j.tox.2024.154029"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Lee, H., Kim, Y., Cho, Y., Jeon, E.J., Jeong, S.H., Lee, J.H. and Kim, S. (2025): Nociceptive effects and gene alterations of CMIT\/MIT mixture in zebrafish embryos and larvae. J. Hazard. Mater., <b>493<\/b>, 138392.","DOI":"10.1016\/j.jhazmat.2025.138392"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Li, R., Qu, J., Hu, X., Song, T., Hu, J., Fan, X., Zhang, Y., Xia, W. and Yu, T. (2024): Anxiety caused by chronic exposure to methylisothiazolinone in zebrafish: behavioral analysis, brain histology and gene responses. Chemosphere, <b>368<\/b>, 143767.","DOI":"10.1016\/j.chemosphere.2024.143767"},{"key":"29","doi-asserted-by":"crossref","unstructured":"Liu, X., Fan, L., Lu, C., Yin, S. and Hu, H. (2020): Functional Role of p53 in the Regulation of Chemical-Induced Oxidative Stress. Oxid. Med. Cell. Longev., <b>2020<\/b>, 6039769.","DOI":"10.1155\/2020\/6039769"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Lundov, M.D., Krongaard, T., Menn\u00e9, T.L. and Johansen, J.D. (2011): Methylisothiazolinone contact allergy: a review. Br. J. Dermatol., <b>165<\/b>, 1178-1182.","DOI":"10.1111\/j.1365-2133.2011.10523.x"},{"key":"31","doi-asserted-by":"crossref","unstructured":"Manukjan, N., Fulton, D., Ahmed, Z., Blankesteijn, W.M. and Foulquier, S. (2025): Vascular endothelial growth factor: a double-edged sword in the development of white matter lesions. Neural Regen. Res., <b>20<\/b>, 191-192.","DOI":"10.4103\/NRR.NRR-D-23-01843"},{"key":"32","doi-asserted-by":"crossref","unstructured":"Molinari, F., Tranchida, N., Inferrera, F., Fusco, R., Faggio, C., Impellitteri, F., Cuzzocrea, S., Cordaro, M. and Di Paola, R. (2025): Biocide mixture (CMIT\/MIT) induces neurotoxicity through the upregulation of the MAPKs signaling pathways. J. Neurophysiol., <b>134<\/b>, 183-192.","DOI":"10.1152\/jn.00104.2025"},{"key":"33","doi-asserted-by":"crossref","unstructured":"Naderi, S., Zare, H., Taghavinia, N., Irajizad, A., Aghaei, M. and Panjehpour, M. (2018): Cadmium telluride quantum dots induce apoptosis in human breast cancer cell lines. Toxicol. Ind. Health, <b>34<\/b>, 339-352.","DOI":"10.1177\/0748233718763517"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Neeb, L., Hellen, P., Boehnke, C., Hoffmann, J., Schuh-Hofer, S., Dirnagl, U. and Reuter, U. (2011): IL-1\u03b2 stimulates COX-2 dependent PGE<sub>2<\/sub> synthesis and CGRP release in rat trigeminal ganglia cells. PLoS One, <b>6<\/b>, e17360.","DOI":"10.1371\/journal.pone.0017360"},{"key":"35","doi-asserted-by":"crossref","unstructured":"Nitsch, L., Schneider, L., Zimmermann, J. and M\u00fcller, M. (2021): Microglia-Derived Interleukin 23: A Crucial Cytokine in Alzheimer\u2019s Disease? Front. Neurol., <b>12<\/b>, 639353.","DOI":"10.3389\/fneur.2021.639353"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Park, E.J. and Seong, E. (2020): Methylisothiazolinone induces apoptotic cell death via matrix metalloproteinase activation in human bronchial epithelial cells. Toxicol. In Vitro, <b>62<\/b>, 104661.","DOI":"10.1016\/j.tiv.2019.104661"},{"key":"37","doi-asserted-by":"crossref","unstructured":"Park, E.J., Kim, S. and Chang, J. (2018): Methylisothiazolinone may induce cell death and inflammatory response through DNA damage in human liver epithelium cells. Environ. Toxicol., <b>33<\/b>, 156-166.","DOI":"10.1002\/tox.22503"},{"key":"38","doi-asserted-by":"crossref","unstructured":"Sastry, G.M., Adzhigirey, M., Day, T., Annabhimoju, R. and Sherman, W. (2013): Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments. J. Comput. Aided Mol. Des., <b>27<\/b>, 221-234.","DOI":"10.1007\/s10822-013-9644-8"},{"key":"39","doi-asserted-by":"crossref","unstructured":"Sayas, C.L. and \u00c1vila, J. (2021): GSK-3 and Tau: A Key Duet in Alzheimer\u2019s Disease, <b>10<\/b>, 721.","DOI":"10.3390\/cells10040721"},{"key":"40","doi-asserted-by":"crossref","unstructured":"Scherrer, M.A., Rocha, V.B. and Andrade, A.R. (2015): Contact dermatitis to methylisothiazolinone. An. Bras. Dermatol., <b>90<\/b>, 912-914.","DOI":"10.1590\/abd1806-4841.20153992"},{"key":"41","doi-asserted-by":"publisher","unstructured":"Schlessinger, J. (2000): New roles for Src kinases in control of cell survival and angiogenesis. Cell, <b>100<\/b>, 293-296.","DOI":"10.1016\/S0092-8674(00)80664-9"},{"key":"42","unstructured":"Shank, P.D., Slaga, T.J. and Snyder, P.W. (2020). Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics."},{"key":"43","doi-asserted-by":"crossref","unstructured":"Shivakumar, D., Harder, E., Damm, W., Friesner, R.A. and Sherman, W. (2012): Improving the prediction of absolute solvation free energies using the next generation OPLS force field. J. Chem. Theory Comput., <b>8<\/b>, 2553-2558.","DOI":"10.1021\/ct300203w"},{"key":"44","doi-asserted-by":"publisher","unstructured":"Silva, V., Silva, C., Soares, P., Garrido, E.M., Borges, F. and Garrido, J. (2020): Isothiazolinone Biocides: Chemistry, Biological, and Toxicity Profiles. Molecules, <b>25<\/b>, 991.","DOI":"10.3390\/molecules25040991"},{"key":"45","doi-asserted-by":"crossref","unstructured":"Smith, W.L., DeWitt, D.L. and Garavito, R.M. (2000): Cyclooxygenases: structural, cellular, and molecular biology. Annu. Rev. Biochem., <b>69<\/b>, 145-182.","DOI":"10.1146\/annurev.biochem.69.1.145"},{"key":"46","doi-asserted-by":"crossref","unstructured":"Snel, B., Lehmann, G., Bork, P. and Huynen, M.A. (2000): STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene. Nucleic Acids Res., <b>28<\/b>, 3442-3444.","DOI":"10.1093\/nar\/28.18.3442"},{"key":"47","doi-asserted-by":"publisher","unstructured":"Spawn, A. and Aizenman, C.D. (2012): Abnormal visual processing and increased seizure susceptibility result from developmental exposure to the biocide methylisothiazolinone. Neuroscience, <b>205<\/b>, 194-204.","DOI":"10.1016\/j.neuroscience.2011.12.052"},{"key":"48","doi-asserted-by":"crossref","unstructured":"Szklarczyk, D., Nastou, K., Koutrouli, M., Kirsch, R., Mehryary, F., Hachilif, R., Hu, D., Peluso, M.E., Huang, Q., Fang, T., Doncheva, N.T., Pyysalo, S., Bork, P., Jensen, L.J. and von Mering, C. (2025): The STRING database in 2025: protein networks with directionality of regulation. Nucleic Acids Res., <b>53<\/b> (D1), D730-D737.","DOI":"10.1093\/nar\/gkae1113"},{"key":"49","doi-asserted-by":"crossref","unstructured":"\u00dcremi\u015f, N. and \u00dcremi\u015f, M.M. (2025): Oxidative\/nitrosative stress, apoptosis, and redox signaling: key players in neurodegenerative diseases. J. Biochem. Mol. Toxicol., <b>39<\/b>, e70133.","DOI":"10.1002\/jbt.70133"},{"key":"50","doi-asserted-by":"crossref","unstructured":"Van Huizen, A.V., Tseng, A.S. and Beane, W.S. (2017): Methylisothiazolinone toxicity and inhibition of wound healing and regeneration in planaria. Aquat. Toxicol., <b>191<\/b>, 226-235.","DOI":"10.1016\/j.aquatox.2017.08.013"},{"key":"51","doi-asserted-by":"crossref","unstructured":"Wang, C., Wang, X., Deng, Y., Hu, Y. and Hu, L. (2025b): Network toxicology combined with molecular docking technology to explore the molecular mechanism of amatoxin causing liver injury. Sci. Rep., <b>15<\/b>, 26068.","DOI":"10.1038\/s41598-025-11720-5"},{"key":"52","doi-asserted-by":"crossref","unstructured":"Wang, F., Yuan, Q., Chen, F., Pang, J., Pan, C., Xu, F. and Chen, Y. (2021): Fundamental mechanisms of the cell death caused by nitrosative stress. Front. Cell Dev. Biol., <b>9<\/b>, 742483.","DOI":"10.3389\/fcell.2021.742483"},{"key":"53","doi-asserted-by":"crossref","unstructured":"Wang, Y., Luo, W. and Wang, Y. (2019): PARP-1 and its associated nucleases in DNA damage response. DNA Repair (Amst.), <b>81<\/b>, 102651.","DOI":"10.1016\/j.dnarep.2019.102651"},{"key":"54","doi-asserted-by":"crossref","unstructured":"Wang, Z., Zhou, Z., Zhao, Z., Zhang, J., Zhang, S., Li, L., Fan, Y. and Li, Q. (2025a): A network toxicology and machine learning approach to investigate the mechanism of kidney injury from melamine and cyanuric acid co-exposure. Ecotoxicol. Environ. Saf., <b>293<\/b>, 118029.","DOI":"10.1016\/j.ecoenv.2025.118029"},{"key":"55","doi-asserted-by":"crossref","unstructured":"Wen, N., Guo, B., Zheng, H., Xu, L., Liang, H., Wang, Q., Wang, D., Chen, X., Zhang, S., Li, Y. and Zhang, L. (2019): Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF\/PI3K\/AKT signaling pathway. Int. J. Oncol., <b>55<\/b>, 879-895.","DOI":"10.3892\/ijo.2019.4863"},{"key":"56","doi-asserted-by":"crossref","unstructured":"Xia, Y., Pan, X. and Shen, H.B. (2024): A comprehensive survey on protein-ligand binding site prediction. Curr. Opin. Struct. Biol., <b>86<\/b>, 102793.","DOI":"10.1016\/j.sbi.2024.102793"},{"key":"57","doi-asserted-by":"crossref","unstructured":"Yang, K., Chen, Z., Gao, J., Shi, W., Li, L., Jiang, S., Hu, H., Liu, Z., Xu, D. and Wu, L. (2017): The key roles of GSK-3\u03b2 in regulating mitochondrial activity. Cell. Physiol. Biochem., <b>44<\/b>, 1445-1459.","DOI":"10.1159\/000485580"},{"key":"58","first-page":"95","author":"Z. Yang","year":"2020","unstructured":"Yang, Z., Liu, Y., Yan, H., ZhaoGe, Z., Chen, H., LinWang, L. and Lv, T. (2020): Screening key target genes for coronavirus disease 2019 based on bioinformatics and gene network. Precision Medicine Research, <b>2<\/b>, 95-103.","journal-title":"Precision Medicine Research","ISSN":"https:\/\/id.crossref.org\/issn\/2624-3474","issn-type":"print"},{"key":"59","unstructured":"Yanli, L.I., Zehua, T.A., Zhao, X.I., Chenxu, H.U., Bobo, Y.A., Ya, W.A. and Rongzhu, L.U. (2025): Network toxicology and its application in studying exogenous chemical toxicity. Huanjing Yu Zhiye Yixue, <b>42<\/b>, 238-244."},{"key":"60","doi-asserted-by":"crossref","unstructured":"Zhang, J., Zhao, L., Wang, W., Xing, D.F., Wang, Z.X., et al. (2025): New trend on chemical structure representation learning in toxicology: in reviews of machine learning model methodology. Crit. Rev. Environ. Sci. Technol., <b>55<\/b>, 951-976.","DOI":"10.1080\/10643389.2025.2469868"}],"container-title":["The Journal of Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/51\/9\/51_471\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:44:44Z","timestamp":1788583484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jts\/51\/9\/51_471\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":60,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2131\/jts.51.471","relation":{},"ISSN":["0388-1350","1880-3989"],"issn-type":[{"value":"0388-1350","type":"print"},{"value":"1880-3989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}