{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T09:52:33Z","timestamp":1773654753625,"version":"3.50.1"},"reference-count":0,"publisher":"Universiti Sains Malaysia","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MJMS"],"abstract":"<jats:p>Background: This study aimed to determine the agreement between intact parathyroid hormone (iPTH) and biointact parathyroid hormone (bio-PTH) assays and to correlate them with bone markers.  Methods: This cross-sectional study included 180 patients with chronic kidney disease (CKD) stages 3b, 4 and 5D. We measured their iPTH, bio-PTH, 25-hydroxyvitaminD (25(OH)D), C-terminal telopeptide collagen (CTX), procollagen 1 intact N-terminal propeptide (P1NP), calcium, phosphate and alkaline phosphatase (ALP).  Results: Higher iPTH than bio-PTH concentrations were seen in CKD stages 3b, 4 and 5D (58[62] versus 55[67] pg\/mL, 94[85] versus 85[76] pg\/mL and 378[481] versus 252[280] pg\/mL, respectively). Both PTH assays showed good agreement among all the subjects, with an intraclass correlation coefficient of 0.832 (P-value &lt; 0.001). The Passing-Bablok showed that the equation for the bio-PTH was PTH = 0.64 iPTH + 15.80, with r = 0.99. The Bland-Altman plots showed increased bias with an increasing PTH concentration. Both PTH assays showed a high positive correlation with CTX and P1NP, a moderate correlation with phosphate, a low correlation with ALP and calcium, and a negligible correlation with phosphate and 25(OH)D.  Conclusion: The iPTH and bio-PTH assays were in agreement, but their bias increased with the PTH concentration. The unacceptable large bias indicates that the two assays cannot be used interchangeably. They had a variable correlation with the bone parameters.<\/jats:p>","DOI":"10.21315\/mjms2023.30.2.6","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T01:53:00Z","timestamp":1681869180000},"page":"69-82","source":"Crossref","is-referenced-by-count":1,"title":["Agreement of Parathyroid Hormone Status Measured by Intact and Biointact Parathyroid Hormone Assays among Chronic Kidney Disease Patients and Its Correlation with Bone Turnover Parameters"],"prefix":"10.21315","volume":"30","author":[{"name":"Chemical Pathology Unit, Hospital Raja Perempuan Zainab II, Kelantan, Malaysia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saidah Madihah","family":"Hashim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuan Salwani","family":"Tuan Ismail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor Azlin Azraini","family":"Che Soh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahaya","family":"Che Mat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Chemical Pathology Unit, Hospital Raja Perempuan Zainab II, Kelantan, Malaysia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuad Firdaus","family":"Rapiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Nephrology Unit, Department of Medical, Hospital Raja Perempuan Zainab II, Kelantan, Malaysia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noorazliyana","family":"Shafi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur Karyatee","family":"Kassim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"School of Dental Sciences, Universiti Sains Malaysia, Kelantan, Malaysia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najib Majdi","family":"Yaacob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Biostatistics and Research Methodology Unit, Universiti Sains Malaysia,  Kelantan, Malaysia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8963","published-online":{"date-parts":[[2023,4,18]]},"container-title":["Malaysian Journal of Medical Sciences"],"original-title":[],"deposited":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T01:53:09Z","timestamp":1681869189000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.mjms.usm.my\/MJMS30022023\/MJMS30022023_06.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,18]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,4,18]]}},"URL":"https:\/\/doi.org\/10.21315\/mjms2023.30.2.6","relation":{},"ISSN":["1394-195X","2180-4303"],"issn-type":[{"value":"1394-195X","type":"print"},{"value":"2180-4303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,18]]}}}