{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:56:36Z","timestamp":1773129396601,"version":"3.50.1"},"reference-count":34,"publisher":"Practical Medicine Publishing House","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Oncohematology"],"abstract":"<jats:p>Background &amp; Aims.\u00a0Despite significant progress achieved over last 25 years, nausea and especially vomiting remain basic side effects of chemotherapy affecting patients\u2019 quality of life. Modern antiemetic therapy permits to reduce the frequency of acute vomiting to 20\u201330\u00a0%, whereas the effectiveness of nausea prevention is higher. Available domestic publications do not describe fundamentals of the antiemetic therapy during treatment with cytostatic agents. The objective of this study is to evaluate the effectiveness of itopride in combined antiemetic therapy for prevention of acute nausea and vomiting, as well as in single drug therapy for arresting delayed vomiting.\r\nMethods.\u00a030 patients were enrolled in the study (breast cancer\u00a0\u2014 10 patients, ovarian cancer\u00a0\u2014 8 patients, gastric cancer\u00a0\u2014 2 patients, colorectal cancer\u00a0\u2014 5 patients, and lung cancer\u00a0\u2014 5 patients): 25 women and 5 men aged from 40 to 70 years. All patients received chemotherapy earlier, which had unfavorable effects on the tolerability of subsequent therapy. All patients underwent chemotherapy with different degrees of emetogenicity during the study.\r\nResults.\u00a0The study has demonstrated that overall effectiveness of a combination of itopride with 5-HT3\u00a0receptor\u00a0antagonists for prevention of acute vomiting was equal to 100\u00a0%. Overall effectiveness of itopride for prevention of delayed vomiting was equal to 80\u00a0%.\r\nConclusion.\u00a0The combination of itopride with 5-HT3\u00a0receptor\u00a0antagonists can be recommended for prevention of delayed vomiting in moderately emetogenic chemotherapeutic regimens.<\/jats:p>","DOI":"10.21320\/2500-2139-2016-9-1-75-83","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T20:09:49Z","timestamp":1463861389000},"page":"75-83","source":"Crossref","is-referenced-by-count":3,"title":["Prevention of Nausea and Vomiting in Oncology","\u041f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0430 \u0442\u043e\u0448\u043d\u043e\u0442\u044b \u0438 \u0440\u0432\u043e\u0442\u044b \u0432 \u043e\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u0438"],"prefix":"10.21320","volume":"9","author":[{"given":"Anton Vladimirovich","family":"Snegovoi","sequence":"first","affiliation":[{"name":"N.N. 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