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The review dwells on the history of the development and improved technologies for production of monoclonal antibodies illustrated by anti-CD20-MABs which recognize different epitopes of the CD20 antigens and have a higher antitumor activity. Engineering techniques can contribute to understanding the effector mechanisms of the application of the novel anti-CD20-MABs and are intended for further improvement of the treatment results.<\/jats:p>","DOI":"10.21320\/2500-2139-2016-9-3-237-244","type":"journal-article","created":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T13:55:28Z","timestamp":1474293328000},"page":"237-244","source":"Crossref","is-referenced-by-count":2,"title":["Monoclonal Antibodies: from Development to Clinical Application","\u041c\u043e\u043d\u043e\u043a\u043b\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0435 \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430: \u043e\u0442 \u0441\u043e\u0437\u0434\u0430\u043d\u0438\u044f \u0434\u043e \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f"],"prefix":"10.21320","volume":"9","author":[{"given":"Yurii Ivanovich","family":"Budchanov","sequence":"first","affiliation":[{"name":"Tver\u2019 Medical University, 4 Sovetskaya str., Tver\u2019, Russian Federation, 170000"},{"name":"\u0413\u0411\u041e\u0423 \u0412\u041f\u041e \u00ab\u0422\u0432\u0435\u0440\u0441\u043a\u043e\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u00bb, \u0443\u043b. \u0421\u043e\u0432\u0435\u0442\u0441\u043a\u0430\u044f, \u0434. 4, \u0422\u0432\u0435\u0440\u044c, \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0430\u044f \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u044f, 170000"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8834","published-online":{"date-parts":[[2016,7,1]]},"reference":[{"key":"17291","doi-asserted-by":"publisher","DOI":"10.1038\/256495a0"},{"key":"17292","doi-asserted-by":"publisher","DOI":"10.1038\/266550a0"},{"key":"17293","unstructured":"\u0413\u043e\u0440\u0434\u0435\u0435\u0432\u0430 \u041e.\u0411., \u0421\u0435\u043c\u0438\u043a\u0438\u043d\u0430 \u0415.\u041b. \u0421\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u044f \u0433\u0440\u0443\u043f\u043f\u044b \u043a\u0440\u043e\u0432\u0438 \u0438 \u0440\u0435\u0437\u0443\u0441-\u043f\u0440\u0438\u043d\u0430\u0434\u043b\u0435\u0436\u043d\u043e\u0441\u0442\u0438 \u0432 \u043f\u0435\u0434\u0438\u0430\u0442\u0440\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043f\u0440\u0430\u043a\u0442\u0438\u043a\u0435. \u0412\u043e\u043f\u0440\u043e\u0441\u044b \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0432 \u043f\u0435\u0434\u0438\u0430\u0442\u0440\u0438\u0438. 2010;2(4):9\u201316."},{"key":"17294","unstructured":"[Gordeeva OB, Semikina EL. 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