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Hydroxycarbamide-induced ulcers are often multiple and bilateral, and usually occur in the lower legs, although they can occur in other regions of the body. The ulcers are small-sized and shallow with sharp margins and yellow fibrine-covered base. They cause constant severe, difficult to treat pain which is a characteristic sign. The drug withdrawal usually leads to spontaneous healing of ulcers. Regular dermatologic screening must be obligatory for all the patients receiving hydroxycarbamide. 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Clinical recommendations for diagnosis and therapy of Ph-negative myeloproliferative disorders (polycythemia vera, essential thrombocythemia, primary myelofibrosis). Gematologiya i transfuziologiya. 2014;59(4):31\u201356. (In Russ)]"},{"key":"13451","unstructured":"\u041c\u0435\u043b\u0438\u043a\u044f\u043d \u0410.\u041b., \u0422\u0443\u0440\u043a\u0438\u043d\u0430 \u0410.\u0413., \u041a\u043e\u0432\u0440\u0438\u0433\u0438\u043d\u0430 \u0410.\u041c. \u0438 \u0434\u0440. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u043f\u043e \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435 \u0438 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 Ph-\u043d\u0435\u0433\u0430\u0442\u0438\u0432\u043d\u044b\u0445 \u043c\u0438\u0435\u043b\u043e\u043f\u0440\u043e\u043b\u0438\u0444\u0435\u0440\u0430\u0442\u0438\u0432\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 (\u0438\u0441\u0442\u0438\u043d\u043d\u0430\u044f \u043f\u043e\u043b\u0438\u0446\u0438\u0442\u0435\u043c\u0438\u044f, \u044d\u0441\u0441\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u0430\u044f \u0442\u0440\u043e\u043c\u0431\u043e\u0446\u0438\u0442\u0435\u043c\u0438\u044f, \u043f\u0435\u0440\u0432\u0438\u0447\u043d\u044b\u0439 \u043c\u0438\u0435\u043b\u043e\u0444\u0438\u0431\u0440\u043e\u0437). \u0413\u0435\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f \u0438 \u0442\u0440\u0430\u043d\u0441\u0444\u0443\u0437\u0438\u043e\u043b\u043e\u0433\u0438\u044f. 2017;62(1):25\u201360.[Melikyan AL, Turkina AG, Kovrigina AM, et al. Clinical recommendations for diagnosis and therapy of Ph-negative myeloproliferative disorders (polycythemia vera, essential thrombocythemia, primary myelofibrosis). Gematologiya i transfuziologiya. 2017;62(1):25\u201360. (In Russ)]"},{"key":"13452","doi-asserted-by":"publisher","DOI":"10.21320\/2500-2139-2016-9-3-314-325"},{"key":"13453","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962011000400019"},{"key":"13454","doi-asserted-by":"publisher","DOI":"10.1163\/156855900300109558"},{"key":"13455","unstructured":"Yokota K, Tasaka T, Iwata K, et al. Huge postoperative ulcer following hydroxyurea therapy in a patient with polycythemia vera. 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