{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:37:46Z","timestamp":1783953466759,"version":"3.55.0"},"reference-count":28,"publisher":"Japanese Society for the Study of Xenobiotics","issue":"5","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Metabolism and Pharmacokinetics"],"published-print":{"date-parts":[[2012]]},"DOI":"10.2133\/dmpk.dmpk-11-nt-144","type":"journal-article","created":{"date-parts":[[2012,10,26]],"date-time":"2012-10-26T06:00:00Z","timestamp":1351231200000},"page":"536-542","source":"Crossref","is-referenced-by-count":79,"title":["Effects of UGT1A6, UGT2B7, and CYP2C9 Genotypes on Plasma Concentrations of Valproic Acid in Chinese Children with Epilepsy"],"prefix":"10.2133","volume":"27","author":[{"given":"Yingjie","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"900","reference":[{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0005","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2165\/00003088-198510020-00003","article-title":"Concentration-effect relationships of valproic acid","volume":"10","author":"Chadwick","year":"1985","journal-title":"Clin. Pharmacokinet."},{"issue":"Suppl 2","key":"10.2133\/dmpk.DMPK-11-NT-144_bb0010","first-page":"25","article-title":"Pharmacokinetics, drug interactions, and tolerability of valproate","volume":"37","author":"DeVane","year":"2003","journal-title":"Psychopharmacol. Bull."},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0015","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0090-9556(25)07335-0","article-title":"Substrate specificities of two stably expressed human liver UDP-glucuronosyltransferases of the UGT1 gene family","volume":"21","author":"Ebner","year":"1993","journal-title":"Drug Metab. Dispos."},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0020","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/toxsci\/kfl096","article-title":"Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1\/*1 genotype","volume":"94","author":"Kiang","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0025","doi-asserted-by":"crossref","first-page":"741","DOI":"10.2217\/pgs.09.21","article-title":"Systematic screening for polymorphisms within the UGT1A6 gene in three Chinese populations and function prediction through structural modeling","volume":"10","author":"Xing","year":"2009","journal-title":"Pharmacogenomics"},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0030","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1124\/jpet.104.081968","article-title":"UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S)","volume":"313","author":"Krishnaswamy","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0035","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/01.fpc.0000114771.78957.cb","article-title":"Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells","volume":"14","author":"Nagar","year":"2004","journal-title":"Pharmacogenetics"},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0040","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/toxsci\/kfi068","article-title":"An association of UDP-glucuronosyltransferase 2B7 C802T (His268Tyr) polymorphism with bladder cancer in benzidine-exposed workers in China","volume":"85","author":"Lin","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0045","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/00008571-200011000-00002","article-title":"Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance","volume":"10","author":"Bhasker","year":"2000","journal-title":"Pharmacogenetics"},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0050","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3109\/03602530903209288","article-title":"Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system","volume":"42","author":"Court","year":"2010","journal-title":"Drug Metab. Rev."},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0055","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1158\/0008-5472.CAN-05-2857","article-title":"Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone","volume":"66","author":"Thibaudeau","year":"2006","journal-title":"Cancer Res."},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0060","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1046\/j.1472-8206.2003.00148.x","article-title":"Frequency of cytochrome P450 2C9 allelic variants in the Chinese and French populations","volume":"17","author":"Yang","year":"2003","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0065","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00008571-200204000-00010","article-title":"Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data","volume":"12","author":"Lee","year":"2002","journal-title":"Pharmacogenetics"},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0070","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3109\/15376516.2010.497977","article-title":"Influence of CYP2C9 polymorphism on metabolism of valproate and its hepatotoxin metabolite in Iranian patients","volume":"20","author":"Amini-Shirazi","year":"2010","journal-title":"Toxicol. Mech. Methods"},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0075","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/sj.clpt.6100324","article-title":"Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects","volume":"83","author":"Chung","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0080","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/sj.tpj.6500210","article-title":"Influence of CYP2C9 genotypes on the formation of a hepatotoxic metabolite of valproic acid in human liver microsomes","volume":"3","author":"Ho","year":"2003","journal-title":"Pharmacogenomics J."},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0085","first-page":"2033","article-title":"Effect of UGT1A6 genetic polymorphisms on the metabolism of sodium valproate","volume":"87","author":"Sun","year":"2007","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0090","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.clineuro.2010.01.002","article-title":"The influence of cytochrome oxidase CYP2A6, CYP2B6, and CYP2C9 polymorphisms on the plasma concentrations of valproic acid in epileptic patients","volume":"112","author":"Tan","year":"2010","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0095","first-page":"429","article-title":"Effect of UGTIA6 A541G genetic polymorphism on the metabolism of valproic acid in Han epileptic children from Henan","volume":"12","author":"Wang","year":"2010","journal-title":"Zhongguo Dangdai Erke Zazhi"},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0100","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.2217\/pgs.11.64","article-title":"Association of genetic variants in six candidate genes with valproic acid therapy optimization","volume":"12","author":"Hung","year":"2011","journal-title":"Pharmacogenomics"},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0105","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.rvsc.2007.09.009","article-title":"Assessment of the quality and quantity of genomic DNA recovered from canine blood samples by three different extraction methods","volume":"85","author":"Clements","year":"2008","journal-title":"Res. Vet. Sci."},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0110","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000097908","article-title":"Effects of combined UDP-glucuronosyltransferase (UGT) 1A1*28 and 1A6*2 on paracetamol pharmacokinetics in beta-thalassemia\/HbE","volume":"79","author":"Tankanitlert","year":"2007","journal-title":"Pharmacology"},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0115","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00008571-199502000-00004","article-title":"Detection of CYP2C9 polymorphism based on the polymerase chain reaction in Chinese","volume":"5","author":"Wang","year":"1995","journal-title":"Pharmacogenetics"},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0120","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1124\/dmd.108.022426","article-title":"Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10","volume":"37","author":"Argikar","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0125","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/gut.50.2.259","article-title":"Developmental aspects of human hepatic drug glucuronidation in young children and adults","volume":"50","author":"Strassburg","year":"2002","journal-title":"Gut"},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0130","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1124\/dmd.110.037192","article-title":"The development of UDP-glucuronosyltransferases 1A1 and 1A6 in the pediatric liver","volume":"39","author":"Miyagi","year":"2011","journal-title":"Drug Metab. Dispos."},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0135","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1124\/dmd.108.022426","article-title":"Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10","volume":"37","author":"Argikar","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"10.2133\/dmpk.DMPK-11-NT-144_bb0140","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s00228-009-0712-x","article-title":"Effects of CYP2C19 and CYP2C9 genotypes on pharmacokinetic variability of valproic acid in Chinese epileptic patients: nonlinear mixed-effect modeling","volume":"65","author":"Jiang","year":"2009","journal-title":"Eur. J. Clin. Pharmacol."}],"container-title":["Drug Metabolism and Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1347436715305231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1347436715305231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T18:14:03Z","timestamp":1745086443000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347436715305231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012]]}},"alternative-id":["S1347436715305231"],"URL":"https:\/\/doi.org\/10.2133\/dmpk.dmpk-11-nt-144","relation":{},"ISSN":["1347-4367"],"issn-type":[{"value":"1347-4367","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]}}}