{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:25:17Z","timestamp":1790673917515,"version":"4.1.0"},"reference-count":25,"publisher":"Japanese Society for the Study of Xenobiotics","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Metabolism and Pharmacokinetics"],"published-print":{"date-parts":[[2014]]},"DOI":"10.2133\/dmpk.dmpk-13-nt-070","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T19:21:58Z","timestamp":1378754518000},"page":"208-210","source":"Crossref","is-referenced-by-count":50,"title":["A Common Variant of Organic Anion Transporter 4 (OAT4\/SLC22A11) Gene Is Associated with Renal Underexcretion Type Gout"],"prefix":"10.2133","volume":"29","author":[{"given":"Masayuki","family":"Sakiyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiko","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinori","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Naito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tappei","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Hamajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiyoshi","family":"Ichida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nariyoshi","family":"Shinomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"900","reference":[{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0005","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1056\/NEJMra0800885","article-title":"Uric acid and cardiovascular risk","volume":"359","author":"Feig","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0010","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1056\/NEJM196609012750902","article-title":"Hyperuricemia in primary and renal hypertension","volume":"275","author":"Cannon","year":"1966","journal-title":"N. Engl. J. Med."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0015","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1001\/archinternmed.2008.521","article-title":"Uric acid and insulin sensitivity and risk of incident hypertension","volume":"169","author":"Forman","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0020","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/S0002-9149(01)01566-1","article-title":"Sex differences in uric acid and risk factors for coronary artery disease","volume":"87","author":"Tuttle","year":"2001","journal-title":"Am. J. Cardiol."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0025","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1159\/000235626","article-title":"Gouty arthritis in acute cerebrovascular disease","volume":"28","author":"Lin","year":"2009","journal-title":"Cerebrovasc. Dis."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0030","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1159\/000105142","article-title":"The effect of mild hyperuricemia on urinary transforming growth factor beta and the progression of chronic kidney disease","volume":"27","author":"Talaat","year":"2007","journal-title":"Am. J. Nephrol"},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0035","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/ncomms1756","article-title":"Decreased extra-renal urate excretion is a common cause of hyperuricemia","volume":"3","author":"Ichida","year":"2012","journal-title":"Nat. Commun."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000504","article-title":"Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations","volume":"5","author":"Kolz","year":"2009","journal-title":"PLoS Genet."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0045","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/CIRCGENETICS.109.934455","article-title":"Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors","volume":"3","author":"Yang","year":"2010","journal-title":"Circ Cardiovasc Genet."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0050","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/art.1780200320","article-title":"Preliminary criteria for the classification of the acute arthritis of primary gout","volume":"20","author":"Wallace","year":"1977","journal-title":"Arthritis Rheum."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0055","first-page":"317","article-title":"J-MICC Study Group: The Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study) to detect gene-environment interactions for cancer","volume":"8","author":"Hamajima","year":"2007","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0060","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1136\/ard.2008.106856","article-title":"Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout","volume":"69","author":"Urano","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0065","series-title":"Guideline for the management of hyperuricemia and gout","first-page":"60","article-title":"The guideline revising committee of Japanese Society of Gout and Nucleic Acid Metabolism: Diagnosis of hyperuricemia and gout","year":"2010"},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0070","series-title":"The Metabolic & Molecular Bases of Inherited Disease","first-page":"2513","article-title":"Hyperuricemia and gout","author":"Becker","year":"2001"},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0075","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00002281-200205000-00015","article-title":"Gout and hyperuricemia","volume":"14","author":"Wortmann","year":"2002","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0080","series-title":"Harrison's Principles of Internal Medicine","first-page":"2444","article-title":"Disorders of purine and pyrimidine metabolism","author":"Wortmann","year":"2008"},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0085","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1172\/JCI119421","article-title":"Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria","volume":"99","author":"Ichida","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0090","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2353\/jmoldx.2008.070111","article-title":"Rapid diagnosis of MEN2B using unlabeled probe melting analysis and the LightCycler 480 instrument","volume":"10","author":"Margraf","year":"2008","journal-title":"J. Mol. Diagn."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0095","doi-asserted-by":"crossref","first-page":"5ra11","DOI":"10.1126\/scitranslmed.3000237","article-title":"Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population","volume":"1","author":"Matsuo","year":"2009","journal-title":"Sci. Transl. Med"},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007729","article-title":"Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease","volume":"4","author":"Stark","year":"2009","journal-title":"PLoS ONE"},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0105","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1074\/jbc.275.6.4507","article-title":"Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta","volume":"275","author":"Cha","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0110","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1254\/jphs.94.297","article-title":"Human organic anion transporter 4 is a renal apical organic anion\/dicarboxylate exchanger in the proximal tubules","volume":"94","author":"Ekaratanawong","year":"2004","journal-title":"J. Pharmacol. Sci."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0115","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/gm118","article-title":"What lies behind serum urate concentration? Insights from genetic and genomic studies","volume":"1","author":"Ichida","year":"2009","journal-title":"Genome Med."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0120","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1681\/ASN.2006040415","article-title":"Human renal organic anion transporter 4 operates as an asymmetric urate transporter","volume":"18","author":"Hagos","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.2133\/dmpk.DMPK-13-NT-070_bb0125","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/hmg\/ddp489","article-title":"Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms","volume":"19","author":"van der Harst","year":"2010","journal-title":"Hum. Mol. Genet."}],"container-title":["Drug Metabolism and Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1347436715303190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1347436715303190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T17:38:40Z","timestamp":1498066720000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1347436715303190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014]]}},"alternative-id":["S1347436715303190"],"URL":"https:\/\/doi.org\/10.2133\/dmpk.dmpk-13-nt-070","relation":{},"ISSN":["1347-4367"],"issn-type":[{"value":"1347-4367","type":"print"}],"subject":[],"published":{"date-parts":[[2014]]}}}