{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:51:37Z","timestamp":1788871897782,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009823","name":"Wisconsin Department of Natural Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CBET\u20100547484"],"award-info":[{"award-number":["CBET\u20100547484"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CBET\u20100826204"],"award-info":[{"award-number":["CBET\u20100826204"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000139","name":"U.S. Environmental Protection Agency","doi-asserted-by":"publisher","award":["4C\u2010R070\u2010NAEX"],"award-info":[{"award-number":["4C\u2010R070\u2010NAEX"]}],"id":[{"id":"10.13039\/100000139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH 5 T32 GM08349"],"award-info":[{"award-number":["NIH 5 T32 GM08349"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsess.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Env Quality"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p>\n                    Transmissible spongiform encephalopathies (TSEs) are progressive neurodegenerative diseases and include bovine spongiform encephalopathy of cattle, chronic wasting disease (CWD) of deer and elk, scrapie in sheep and goats, and Creutzfeldt\u2010Jakob disease in humans. An abnormally folded form of the prion protein (designated PrP\n                    <jats:sup>TSE<\/jats:sup>\n                    ) is typically associated with TSE infectivity and may constitute the major, if not sole, component of the infectious agent. Transmission of CWD and scrapie is mediated in part by an environmental reservoir of infectivity. Soil appears to be a plausible candidate for this reservoir. The transport of TSE agent through soil is expected to influence the accessibility of the pathogen to animals after deposition and must be understood to assess the risks associated with burial of infected carcasses. We report the results of saturated column experiments designed to evaluate PrP\n                    <jats:sup>TSE<\/jats:sup>\n                    transport through five soils with relatively high sand or silt contents and low organic carbon content. Protease\u2010treated TSE\u2010infected brain homogenate was used as a model for PrP\n                    <jats:sup>TSE<\/jats:sup>\n                    present in decomposing infected tissue. Synthetic rainwater was used as the eluent. All five soils retained PrP\n                    <jats:sup>TSE<\/jats:sup>\n                    ; no detectable PrP\n                    <jats:sup>TSE<\/jats:sup>\n                    was eluted over more than 40 pore volumes of flow. Lower bound apparent attachment coefficients were estimated for each soil. Our results suggest that TSE agent released from decomposing tissues to soils with low organic carbon content would remain near the site of initial deposition. In the case of infected carcasses deposited on the land surface, this may result in local sources of infectivity to other animals.\n                  <\/jats:p>","DOI":"10.2134\/jeq2009.0137","type":"journal-article","created":{"date-parts":[[2010,7,20]],"date-time":"2010-07-20T10:23:42Z","timestamp":1279621422000},"page":"1145-1152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Transport of the Pathogenic Prion Protein through Soils"],"prefix":"10.1002","volume":"39","author":[{"given":"Kurt H.","family":"Jacobson","sequence":"first","affiliation":[{"name":"Civil &amp; Environmental Engineering Univ. of Wisconsin Madison WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghak","family":"Lee","sequence":"additional","affiliation":[{"name":"Research and Development Planning Dep. Technology &amp; Innovation Development Office, Hyundai Engineering Company Ltd. Hyundai 41 Tower 917\u20109, Mok\u2010dong, Yangcheon\u2010gu Seoul 158\u2010723 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Somerville","sequence":"additional","affiliation":[{"name":"Neuropathogenesis Division The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh Edinburgh EH9 3JF &gt;Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Centre for Prions and Protein Folding Diseases, Dep. of Biological Sciences Univ. of Alberta Edmonton AB T6G 2M8 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig H.","family":"Benson","sequence":"additional","affiliation":[{"name":"Geological Engineering Univ. of Wisconsin Madison WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel A.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Dep. of Soil Science and Civil &amp; Environmental Engineering, Environmental Chemistry and Technology Program Univ. of Wisconsin Madison WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/es001069"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1656\/1092-6194(2003)010[0409:SPOMLP]2.0.CO;2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.12.7859-7868.1994"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2307\/3809405"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(87)90380-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4485-2"},{"key":"e_1_2_7_8_1","first-page":"42","article-title":"Significance of straining in colloid deposition: Evidence and implications","author":"Bradford S.A.","year":"2006","journal-title":"Water Resour. 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