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Res"},{"key":"ref46","article-title":"Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat","volume":"291","author":"M H M Hessel","year":"2006","journal-title":"Am. J. Physiol. Circ. Physiol"},{"key":"ref47","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0009-2020","article-title":"BNP\/NT-proBNP in pulmonary arterial hypertension: time for point-of-care testing?","volume":"29","author":"R A Lewis","year":"2020","journal-title":"Eur. Respir. Rev"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1183\/09031936.02.00068002","article-title":"Haemodynamic evaluation of pulmonary hypertension","volume":"20","author":"D Chemla","year":"2002","journal-title":"Eur. Respir. 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Heart Assoc"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1161\/HYPERTENSIONAHA.120.15561","article-title":"Oxidation of ryanodine receptors promotes Ca 2+ leakage and contributes to right ventricular dysfunction in pulmonary hypertension","volume":"77","author":"Y Huang","year":"2021","journal-title":"Hypertension"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10741-019-09873-3","article-title":"SERCA2a: a key protein in the Ca2+ cycle of the heart failure","volume":"25","author":"L Zhihao","year":"2020","journal-title":"Heart Fail. Rev"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1161\/CIRCULATIONAHA.118.035326","volume":"139","author":"S Andersen","year":"2019","journal-title":"Circulation"},{"key":"ref55","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21207704","article-title":"Impact of Mitophagy and Mitochondrial Unfolded Protein Response as New Adaptive Mechanisms Underlying Old Pathologies: Sarcopenia and Non-Alcoholic Fatty Liver Disease","volume":"21","author":"R Urbina-Varela","year":"2020","journal-title":"Int. J. Mol. Sci"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.mito.2019.08.001","article-title":"Limited predictive value of TFAM in mitochondrial biogenesis","volume":"49","author":"N Kozhukhar","year":"2019","journal-title":"Mitochondrion"},{"key":"ref57","article-title":"Risk stratification and medical therapy of pulmonary arterial hypertension","volume":"53","author":"N Gali\ufffd","year":"2019","journal-title":"Eur. Respir. 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Respir. J"},{"key":"ref64","first-page":"L276","article-title":"Renin-angiotensin system regulates pulmonary arterial smooth muscle cell migration in chronic thromboembolic pulmonary hypertension","volume":"314","author":"Y Zhang","year":"2017","journal-title":"Am. J. Physiol. Cell. Mol. Physiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1016\/j.jacc.2019.03.482","article-title":"Threshold of pulmonary hypertension associated with increased mortality","volume":"73","author":"G Strange","year":"2019","journal-title":"J. Am. Coll. Cardiol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11626-010-9368-1","article-title":"The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro","volume":"47","author":"S J Watkins","year":"2011","journal-title":"Vitr. Cell. Dev. Biol. -Anim"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/cvr\/cvw054","article-title":"Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice","volume":"110","author":"J M Aliotta","year":"2016","journal-title":"Cardiovasc. Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s11655-020-3229-x","article-title":"Early intervention of Tongxinluo (?? ? ) on right ventricular function assessed by echocardiography in rats with pulmonary arterial hypertension induced by monocrotaline","volume":"26","author":"L Gao","year":"2020","journal-title":"Chin. J. Integr. Med"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijbiomac.2013.11.018","article-title":"Investigation of antihypertensive activity of carbopol valsartan transdermal gel containing 1,8-cineole","volume":"64","author":"A Ahad","year":"2014","journal-title":"Int. J. Biol. Macromol"},{"key":"ref70","first-page":"618","article-title":"Transdermal delivery of valsartan: I. effect of various terpenes","volume":"34","author":"M Rizwan","year":"2008","journal-title":"Drug Dev. Ind. Pharm"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2174\/157340721101150804151256","article-title":"Quantification of 1,8-cineole in human blood and plasma and the impact of liner choice in head-space chromatography","volume":"11","author":"S Friedl","year":"2015","journal-title":"Curr. Bioact. Compd"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1007\/s10886-005-8393-0","article-title":"Rapid absorption of dietary 1,8-cineole results in critical blood concentration of cineole and immediate cessation of eating in the common Brushtail Possum (Trichosurus vulpecula)","volume":"31","author":"R R Boyle","year":"2005","journal-title":"J. Chem. Ecol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1159\/000237000","article-title":"Effect of limonene and sobrerol on monocrotaline-induced lung alterations and pulmonary hypertension","volume":"107","author":"C Touvay","year":"1995","journal-title":"Int. Arch. Allergy Immunol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ejphar.2015.11.037","article-title":"Carvacrol induces the apoptosis of pulmonary artery smooth muscle cells under hypoxia","volume":"770","author":"Q Zhang","year":"2016","journal-title":"Eur. J. Pharmacol"},{"key":"ref75","first-page":"54","article-title":"The effect of carvacrol on transcription levels of Bcl-2 family proteins in hypertrophied heart of rats","volume":"22","author":"S Sadeghzadeh","year":"2018","journal-title":"Physiol. Pharmacol"},{"key":"ref76","first-page":"1380","article-title":"Carvacrol ameliorates pathological cardiac hypertrophy in both in-vivo and in-vitro models","volume":"18","author":"M Jamhiri","year":"2019","journal-title":"Iran. J. Pharm. Res"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bcp.2018.02.014","article-title":"Antihypertensive potential of linalool and linalool complexed with ?-cyclodextrin: Effects of subchronic treatment on blood pressure and vascular reactivity","volume":"151","author":"S B Camargo","year":"2018","journal-title":"Biochem. Pharmacol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jff.2015.01.013","article-title":"Thymol attenuates altered lipid metabolism in ?-adrenergic agonist induced myocardial infarcted rats by inhibiting tachycardia, altered electrocardiogram, apoptosis and cardiac hypertrophy","volume":"14","author":"M F Nagoor Meeran","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s12325-020-01279-0","article-title":"New perspectives for mucolytic, antiinflammatory and adjunctive therapy with 1,8-cineole in COPD and asthma: Review on the new therapeutic approach","volume":"37","author":"L J Juergens","year":"2020","journal-title":"Adv. Ther"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1164\/rccm.201209-1687OC","article-title":"PGC1?-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension","volume":"187","author":"J J Ryan","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00109-017-1522-8","article-title":"Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension","volume":"95","author":"L Tian","year":"2017","journal-title":"J. Mol. Med"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1161\/01.RES.80.6.765","article-title":"Changes in cell-to-cell electrical coupling associated with left ventricular hypertrophy","volume":"80","author":"M Cooklin","year":"1997","journal-title":"Circ. Res"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijcard.2014.02.022","article-title":"N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity","volume":"173","author":"A K N Alencar","year":"2014","journal-title":"Int. J. Cardiol"},{"key":"ref84","first-page":"59","volume":"30","author":"A M Reilly","year":"2001","journal-title":"Restoration of calcium handling properties of adult cardiac myocytes from hypertrophied hearts, Cell Calcium"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1016\/j.bbadis.2017.07.018","article-title":"Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells","author":"V Parra","year":"2017","journal-title":"Biochim. Biophys. Acta -Mol. Basis Dis"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1161\/CIRCRESAHA.111.263848","article-title":"Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension","volume":"110","author":"G Marsboom","year":"2012","journal-title":"Circ. Res"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00109-014-1244-0","article-title":"Skeletal muscle proteomic signature and metabolic impairment in pulmonary hypertension","volume":"93","author":"S Malenfant","year":"2015","journal-title":"J. Mol. Med"},{"key":"ref88","article-title":"Skeletal muscle dysfunction in idiopathic pulmonary arterial hypertension","author":"J Batt","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1161\/CIRCHEARTFAILURE.111.966127","article-title":"Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension","volume":"6","author":"J Gomez-Arroyo","year":"2013","journal-title":"Circ. Hear. Fail"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1161\/ATVBAHA.114.304865","article-title":"Endothelial uncoupling protein 2 regulates mitophagy and pulmonary hypertension during intermittent hypoxia","volume":"35","author":"M Haslip","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/cvr\/cvw014","article-title":"Modulators of right ventricular apoptosis and contractility in a rat model of pulmonary hypertension","volume":"110","author":"M Zungu-Edmondson","year":"2016","journal-title":"Cardiovasc. Res"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s00109-013-1064-7","article-title":"Cardiac glutaminolysis: A maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension","volume":"91","author":"L Piao","year":"2013","journal-title":"J. Mol. Med"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.2967\/jnumed.112.115915","article-title":"11 C-Acetate Clearance as an Index of Oxygen Consumption of the Right Myocardium in Idiopathic Pulmonary Arterial Hypertension: A Validation Study Using 15 O-Labeled Tracers and PET","volume":"54","author":"Y Y Wong","year":"2013","journal-title":"J. Nucl. Med"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1007\/s00259-014-2736-4","article-title":"Attenuated right ventricular energetics evaluated using 11C-acetate PET in patients with pulmonary hypertension","volume":"41","author":"K Yoshinaga","year":"2014","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref95","doi-asserted-by":"crossref","DOI":"10.1177\/2045894020925762","article-title":"Endurance exercise training in pulmonary hypertension increases skeletal muscle electron transport chain supercomplex assembly","volume":"10","author":"D J Mccullough","year":"2020","journal-title":"Pulm. Circ"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.redox.2015.07.016","article-title":"Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells","volume":"6","author":"R Rafikov","year":"2015","journal-title":"Redox Biol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/s41440-021-00660-y","article-title":"Pulmonary arterial hypertension induces the release of circulating extracellular vesicles with oxidative content and alters redox and mitochondrial homeostasis in the brains of rats","volume":"44","author":"G B Corssac","year":"2021","journal-title":"Hypertens. Res"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cbi.2009.02.012","article-title":"Linalool decreases HepG2 viability by inhibiting mitochondrial complexes I and II, increasing reactive oxygen species and decreasing ATP and GSH levels","volume":"180","author":"J Usta","year":"2009","journal-title":"Chem. Biol. Interact"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"H688","DOI":"10.1152\/ajpheart.00777.2011","article-title":"Autophagy mechanism of right ventricular remodeling in murine model of pulmonary artery constriction","volume":"302","author":"N Qipshidze","year":"2012","journal-title":"Am. J. Physiol. Circ. 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