{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T04:39:28Z","timestamp":1698554368017},"posted":{"date-parts":[[2023]]},"group-title":"SSRN","reference-count":48,"publisher":"Elsevier BV","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.2139\/ssrn.4601854","type":"posted-content","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T03:53:18Z","timestamp":1697601198000},"source":"Crossref","is-referenced-by-count":0,"title":["Exploring Structural Determinants of Neuroprotection Bias on Novel Glypromate Bioconjugates with Bioactive Amines"],"prefix":"10.2139","author":[{"given":"Sara  C.","family":"Silva-Reis","sequence":"first","affiliation":[]},{"given":"Vera  M.","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Daniela","family":"Correia da Silva","sequence":"additional","affiliation":[]},{"given":"David  M.","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Xavier  Cruz","family":"Correia","sequence":"additional","affiliation":[]},{"given":"Hugo  F.","family":"Costa-Almeida","sequence":"additional","affiliation":[]},{"given":"Xerardo","family":"Garc\u00eda-Mera","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9  E.","family":"Rodr\u00edguez-Borges","sequence":"additional","affiliation":[]},{"given":"Ivo  E.","family":"Sampaio-Dias","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.bmc.2004.10.004","article-title":"Synthesis and pharmacological evaluation of glycine-modified analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE)","volume":"13","author":"M Y H Lai","year":"2005","journal-title":"Bioorg. Med. Chem"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1021\/jm00009a001","article-title":"Metabotropic glutamate receptors: Novel targets for drug development","volume":"38","author":"T Knoepfel","year":"1995","journal-title":"J. Med. Chem"},{"issue":"6","key":"ref3","first-page":"219","article-title":"Function of metabotropic glutamate receptors in learning and memory","volume":"19","author":"G Riedel","year":"1996","journal-title":"Trends Neurosci"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0166-2236(96)20019-0","article-title":"Metabotropic glutamate receptors: A new target for the therapy of neurodegenerative disorders?","volume":"19","author":"F Nicoletti","year":"1996","journal-title":"Trends Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0079-6123(08)60499-9","article-title":"The role of the insulin-like growth factors in the regulation of brain development","volume":"73","author":"V R Sara","year":"1988","journal-title":"Prog. Brain. Res"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0166-2236(95)93892-2","article-title":"The developing CNS: A scenario for the action of proinsulin, insulin and insulin-like growth factors","volume":"18","author":"F De Pablo","year":"1995","journal-title":"Trends Neurosci"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuron.2004.09.010","article-title":"Deciphering the molecular basis of memory failure in Alzheimer's disease","volume":"44","author":"D M Walsh","year":"2004","journal-title":"Neuron"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0006-291X(89)80032-4","article-title":"Identification of Gly-Pro-Glu (GPE), the aminoterminal tripeptide of insulin-like growth factor 1 which is truncated in brain, as a novel neuroactive peptide","volume":"165","author":"V R Sara","year":"1989","journal-title":"Biochem. Biophys. Res. Commun"},{"issue":"13","key":"ref9","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1016\/j.bmcl.2006.04.033","article-title":"The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity","volume":"16","author":"A S A De Diego","year":"2006","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1152\/jn.00290.2014","article-title":"The IGF-derived tripeptide Gly-Pro-Glu is a weak NMDA receptor agonist","volume":"112","author":"C E Vaaga","year":"2014","journal-title":"J. Neurophysiol"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S1471-4906(02)02321-9","article-title":"Growth factor treatment of demyelinating disease: At last, a leap into the light","volume":"23","author":"R M Ransohoff","year":"2002","journal-title":"Trends Immunol"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1471-4159.2009.05980.x","article-title":"The N-terminal tripeptide of insulin-like growth factor-I protects against beta-amyloid-induced somatostatin depletion by calcium and glycogen synthase kinase 3 beta modulation","volume":"109","author":"E Burgos-Ramos","year":"2009","journal-title":"J. Neurochem"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1097\/00001756-200408260-00029","article-title":"Gly-Pro-Glu protects beta-amyloid-induced somatostatin depletion in the rat cortex","volume":"15","author":"D Aguado-Llera","year":"2004","journal-title":"Neuroreport"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0306-4522(98)00338-8","article-title":"The effects of the Nterminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate in different regions following hypoxic-ischemic brain injury in adult rats","volume":"89","author":"J Guan","year":"1999","journal-title":"Neurosci"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neulet.2009.03.003","article-title":"Delayed peripheral administration of the N-terminal tripeptide of IGF-1 (GPE) reduces brain damage following microsphere induced embolic damage in young adult and aged rats","volume":"454","author":"S Shapira","year":"2009","journal-title":"Neurosci. Lett"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0006-8993(00)01988-0","article-title":"N-terminal tripeptide of IGF-1 (GPE) prevents the loss of TH positive neurons after 6-OHDA induced nigral lesion in rats","volume":"859","author":"J Guan","year":"2000","journal-title":"Brain. Res"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1021\/acschemneuro.2c00675","article-title":"Concise overview of Glypromate neuropeptide research: From chemistry to pharmacological applications in neurosciences","volume":"14","author":"S C Silva-Reis","year":"2023","journal-title":"ACS Chem. Neurosci"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.bmcl.2005.11.040","article-title":"New Gly-Pro-Glu (GPE) analogues: Expedite solid-phase synthesis and biological activity","volume":"16","author":"A S A De Diego","year":"2006","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jns.2008.12.003","article-title":"NNZ-2566: A Gly-Pro-Glu analogue with neuroprotective efficacy in a rat model of acute focal stroke","volume":"278","author":"M J Bickerdike","year":"2009","journal-title":"J. Neurol. Sci"},{"issue":"14","key":"ref20","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1001\/jama.2023.4003","article-title":"Trofinetide Receives FDA Approval as First Drug for Rett Syndrome","volume":"329","author":"E Harris","year":"2023","journal-title":"JAMA"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.pharmthera.2006.07.001","article-title":"Lipoic acid as a novel treatment for Alzheimer's disease and related dementias","volume":"113","author":"L Holmquist","year":"2007","journal-title":"Pharmacol. Ther"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/cmdc.201200320","article-title":"R)-?-Lipoyl-glycyl-L-prolyl-Lglutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities","volume":"7","author":"I Cacciatore","year":"2012","journal-title":"ChemMedChem"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/s00726-011-1210-x","article-title":"Molecular mechanism underlying the cerebral effect of Gly-Pro-Glu tripeptide bound to L-dopa in a Parkinson's animal model","volume":"43","author":"A Minelli","year":"2012","journal-title":"Amino Acids"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.npep.2017.09.001","article-title":"Cacciatore, I. (R)-?-Lipoyl-Gly-L-Pro-L-Glu dimethyl ester as dual acting agent for the treatment of Alzheimer's disease","volume":"66","author":"L Marinelli","year":"2017","journal-title":"Neuropeptides"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1021\/acs.bioconjchem.0c00456","article-title":"Site-specific bioconjugation approaches for enhanced delivery of protein therapeutics and protein drug carriers","volume":"31","author":"R M Lieser","year":"2020","journal-title":"Bioconj. Chem"},{"issue":"48","key":"ref26","doi-asserted-by":"crossref","first-page":"21049","DOI":"10.1039\/D0NJ04851H","article-title":"Bioinspired design for the assembly of Glypromate \ufffd neuropeptide conjugates with active pharmaceutical ingredients","volume":"44","author":"S C Silva-Reis","year":"2020","journal-title":"New J. Chem"},{"issue":"36","key":"ref27","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.1039\/C7OB01544E","article-title":"Highly efficient one-pot assembly of peptides by double chemoselective coupling","volume":"15","author":"I E Sampaio-Dias","year":"2017","journal-title":"Org. Biomol. Chem"},{"issue":"2","key":"ref28","article-title":"Amantadine for dyskinesia in Parkinson's disease","volume":"2003","author":"N J Crosby","year":"2003","journal-title":"CDSR"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2004.05.005","article-title":"Dementia of Alzheimer's disease and other neurodegenerative disorders -memantine, a new hope","volume":"51","author":"S K Sonkusare","year":"2005","journal-title":"Pharmacol. Res"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/j.1471-4159.2009.06542.x","article-title":"The neuroprotective mechanism of 1-(R)-aminoindan, the major metabolite of the anti-parkinsonian drug rasagiline","volume":"112","author":"O Bar-Am","year":"2010","journal-title":"J. Neurochem"},{"issue":"10","key":"ref31","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/s41593-018-0235-9","article-title":"Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases","volume":"21","author":"C Soto","year":"2018","journal-title":"Nat. Neurosci"},{"issue":"11","key":"ref32","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1021\/cn3000982","article-title":"Amyloid ?-peptide 25-35 self-assembly and its inhibition: A model undecapeptide system to gain atomistic and secondary structure details of the Alzheimer's disease process and treatment","volume":"3","author":"M Naldi","year":"2012","journal-title":"ACS Chem. Neurosci"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jsb.2005.06.006","article-title":"Mechanism of thioflavin T binding to amyloid fibrils","volume":"151","author":"R Khurana","year":"2005","journal-title":"J. Struct. Biol"},{"key":"ref34","first-page":"159","volume":"216","author":"P S Ferreira","year":"2013","journal-title":"Neurotoxicity of \"ecstasy\" and its metabolites in human dopaminergic differentiated SH-SY5Y cells"},{"issue":"9","key":"ref35","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1021\/acs.jmedchem.1c00252","article-title":"Discovery of new potent positive allosteric modulators of dopamine D 2 receptors: Insights into the bioisosteric replacement of proline to 3-furoic acid in the Melanostatin neuropeptide","volume":"64","author":"I E Sampaio-Dias","year":"2021","journal-title":"J. Med. Chem"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-017-0149-0","article-title":"The SH-SY5Y cell line in Parkinson's disease research: A systematic review","volume":"12","author":"H Xicoy","year":"2017","journal-title":"Mol. Neurodegener"},{"issue":"108","key":"ref37","doi-asserted-by":"crossref","DOI":"10.3791\/53193","article-title":"Differentiation of the SH-SY5Y human neuroblastoma cell line","author":"M M Shipley","year":"2016","journal-title":"J. Vis. Exp"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1111\/j.1471-4159.2007.05115.x","article-title":"6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA","volume":"104","author":"M Gomez-Lazaro","year":"2008","journal-title":"J. Neurochem"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-07706-2","article-title":"Low dose DMSO treatment induces oligomerization and accelerates aggregation of ?-synuclein","volume":"12","author":"L Reimer","year":"2022","journal-title":"Sci. Rep"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1021\/jm00316a018","article-title":"The adamantyl group in medicinal agents. iv. sedative action of 3,5,7-trimethyladamantane-1-carboxamide and related agents","volume":"10","author":"K Gerzon","year":"1967","journal-title":"J. Med. Chem"},{"key":"ref41","author":"P A Swift"},{"issue":"5","key":"ref42","first-page":"465","article-title":"]decane derivatives: a novel class of anti-hypoxia agents","volume":"23","author":"2?-Hydroxy-2?-Alkyl","year":"1988","journal-title":"Eur. J. Med. Chem"},{"issue":"5","key":"ref43","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1021\/cr100264t","article-title":"The lipophilic bullet hits the targets: Medicinal chemistry of adamantane derivatives","volume":"113","author":"L Wanka","year":"2013","journal-title":"Chem. Rev"},{"issue":"20","key":"ref44","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1021\/jm00072a005","article-title":"Cholecystokinin peptidomimetics as selective CCK-B antagonists: Design, synthesis, and in vitro and in vivo biochemical properties","volume":"36","author":"A G S Blommaert","year":"1993","journal-title":"J. Med. Chem"},{"issue":"24","key":"ref45","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1021\/jm970439a","article-title":"Synthesis and Biological Properties of New Constrained CCK-B Antagonists: Discrimination of two affinity states of the CCK-B receptor on transfected CHO cells","volume":"40","author":"B Bellier","year":"1997","journal-title":"J. Med. Chem"},{"issue":"21","key":"ref46","doi-asserted-by":"crossref","first-page":"7512","DOI":"10.1021\/jo971176v","article-title":"NMR chemical shifts of common laboratory solvents as trace impurities","volume":"62","author":"H E Gottlieb","year":"1997","journal-title":"J. Org. Chem"},{"key":"ref47","article-title":"A pipeline for natural small molecule inhibitors of endoplasmic reticulum stress","volume":"13","author":"C D Da Silva","year":"2022","journal-title":"Front. Pharmacol"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.toxlet.2005.07.001","article-title":"In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride","volume":"160","author":"G Fotakis","year":"2006","journal-title":"Toxicol. Lett"}],"container-title":[],"original-title":[],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T04:16:21Z","timestamp":1698466581000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ssrn.com\/abstract=4601854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":48,"URL":"https:\/\/doi.org\/10.2139\/ssrn.4601854","relation":{},"subject":[],"published":{"date-parts":[[2023]]},"subtype":"preprint"}}