{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T00:44:16Z","timestamp":1699058656558},"posted":{"date-parts":[[2023]]},"group-title":"SSRN","reference-count":28,"publisher":"Elsevier BV","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.2139\/ssrn.4619886","type":"posted-content","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T15:14:45Z","timestamp":1699024485000},"source":"Crossref","is-referenced-by-count":0,"title":["Functional Impairment of COPD Patients Can Be Determined Exclusively Through Genomic Data Analysis"],"prefix":"10.2139","author":[{"given":"Rui","family":"Mar\u00e7alo","sequence":"first","affiliation":[]},{"given":"Guilherme","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Pinheiro","sequence":"additional","affiliation":[]},{"given":"Sonya","family":"Neto","sequence":"additional","affiliation":[]},{"given":"Sofia  L.","family":"Marques","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Sim\u00e3o","sequence":"additional","affiliation":[]},{"given":"Vit\u00f3ria","family":"Martins","sequence":"additional","affiliation":[]},{"given":"L\u00edlia","family":"Andrade","sequence":"additional","affiliation":[]},{"given":"Maria  Aurora","family":"Mendes","sequence":"additional","affiliation":[]},{"given":"Manuel  Ant\u00f3nio da Silva","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Vera","family":"Afreixo","sequence":"additional","affiliation":[]},{"given":"Alda","family":"Marques","sequence":"additional","affiliation":[]},{"given":"Gabriela","family":"Moura","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S2213-2600(21)00511-7","article-title":"Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis","volume":"10","author":"D Adeloye","year":"2022","journal-title":"Lancet Respir. Med"},{"key":"ref2","first-page":"108","volume":"66","author":"M D Eisner","year":"2011","journal-title":"Disease : Beyond Lung Function"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1513\/AnnalsATS.201609-733AS","article-title":"Functional tests in chronic obstructive pulmonary disease, Part 1: Clinical relevance and links to the international classification of functioning, disability, and health","volume":"14","author":"K L Bui","year":"2017","journal-title":"Ann. Am. Thorac. Soc"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1183\/16000617.00010114","article-title":"Informal caregivers of patients with copd: Home sweet home?","volume":"24","author":"N Nakken","year":"2015","journal-title":"Eur. Respir. Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1183\/09031936.00131612","article-title":"Simple functional performance tests and mortality in COPD","volume":"42","author":"M A Puhan","year":"2013","journal-title":"Eur. Respir. J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/thx.2006.062026","article-title":"Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease","volume":"62","author":"E B Swallow","year":"2007","journal-title":"Thorax"},{"key":"ref7","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.201309-1634ST","article-title":"An official American thoracic society\/European respiratory society statement: Key concepts and advances in pulmonary rehabilitation","volume":"188","author":"M A Spruit","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"ref8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076454","article-title":"Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting","volume":"24","author":"P Henrot","year":"2023","journal-title":"Int. J. Mol. Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.2147\/COPD.S134161","article-title":"Genetic polymorphism and chronic obstructive pulmonary disease","volume":"12","author":"C Yuan","year":"2017","journal-title":"Int. J. COPD"},{"key":"ref10","article-title":"GLOBAL STRATEGY FOR THE DIAGNOSIS, MANAGEMENT, AND PREVENTION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE","author":"Gold","year":"2023","journal-title":"REPORT"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0003-9993(97)90005-8","article-title":"Reference values for extremity muscle strength obtained by hand-held dynamometry from adults aged 20 to 79 years","volume":"78","author":"R W Bohannon","year":"1997","journal-title":"Arch. Phys. Med. Rehabil"},{"key":"ref12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jamda.2013.06.013","article-title":"New normative values for handgrip strength: Results from the uk biobank","volume":"14","author":"M A Spruit","year":"2013","journal-title":"J. Am. Med. Dir. Assoc"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1183\/09031936.00150314","article-title":"An official European respiratory society\/American thoracic society technical standard: Field walking tests in chronic respiratory disease","volume":"44","author":"A E Holland","year":"2014","journal-title":"Eur. Respir. J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1183\/13993003.01871-2016","article-title":"A multicentre validation of the 1-min sit-to-stand test in patients with COPD","volume":"49","author":"S Crook","year":"2017","journal-title":"Eur. Respir. J"},{"key":"ref15","doi-asserted-by":"crossref","DOI":"10.1002\/mpr.1608","article-title":"A tutorial on conducting genome-wide association studies: Quality control and statistical analysis","volume":"27","author":"A T Marees","year":"2018","journal-title":"Int. J. Methods Psychiatr. Res"},{"key":"ref16","article-title":"Evaluation of the genetic risk for COVID-19 outcomes in COPD and differences among worldwide populations","volume":"17","author":"R Mar\ufffdalo","year":"2022","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1093\/bioinformatics\/btu848","article-title":"Polygenic Risk Score software","volume":"31","author":"J Euesden","year":"2015","journal-title":"Bioinformatics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12931-018-0815-y","article-title":"Uric acid, lung function, physical capacity and exacerbation frequency in patients with COPD: A multi-dimensional approach","volume":"19","author":"K Kahnert","year":"2018","journal-title":"Respir. Res"},{"key":"ref19","article-title":"Biomarker-based clustering of patients with chronic obstructive pulmonary disease","volume":"9","author":"L E G W Vanfleteren","year":"2023","journal-title":"ERJ Open Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1164\/rccm.201209-1665OC","article-title":"Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease","volume":"187","author":"L E G W Vanfleteren","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12931-022-01954-6","article-title":"COPD profiles and treatable traits using minimal resources: identification, decision tree and stability over time","volume":"23","author":"A Marques","year":"2022","journal-title":"Respir. Res"},{"key":"ref22","first-page":"1","article-title":"Characteristics and health related quality of life in a population with advanced chronic obstructive pulmonary disease, a cross-sectional study","volume":"19","author":"D G Bove","year":"2020","journal-title":"BMC Palliat. Care"},{"key":"ref23","first-page":"385","article-title":"Pulmonary Rehabilitation for Chronic Obstructive Pulmonary Disease","volume":"32","author":"Y C Tsai","year":"2021","journal-title":"J. Intern. Med. Taiwan"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18332\/tid\/90665","article-title":"Factors associated with current smoking in COPD patients: A cross-sectional study from the Eastern Black Sea region of Turkey","volume":"16","author":"D Karadogan","year":"2018","journal-title":"Tob. Induc. Dis"},{"key":"ref25","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101513","article-title":"Physical activity and exercise: Strategies to manage frailty","volume":"35","author":"J Angulo","year":"2020","journal-title":"Redox Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/schbul\/sbl004","article-title":"Measuring changes in functional status among patients with schizophrenia: The link with cognitive impairment","volume":"32","author":"L S Matza","year":"2006","journal-title":"Schizophr. Bull"},{"key":"ref27","journal-title":"MWT"},{"key":"ref28","article-title":"Description: Values are presented as mean \ufffd standard deviation or median and interquartile range [Q1-Q3], according to the normality of data distribution. Categorical variables are presented as counts (%)","volume":"6","journal-title":"FVC: forced vital capacity; GOLD: Global Initiative for Obstructive Lung Disease; CAT: COPD assessment test; mMRC: modified British Medical Research Council questionnaire; CCI: Charlson comorbidity index; SGRQ: St. George's Respiratory Questionnaire"}],"container-title":[],"original-title":[],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T23:01:40Z","timestamp":1699052500000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ssrn.com\/abstract=4619886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":28,"URL":"https:\/\/doi.org\/10.2139\/ssrn.4619886","relation":{},"subject":[],"published":{"date-parts":[[2023]]},"subtype":"preprint"}}