{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:32:00Z","timestamp":1770813120078,"version":"3.50.1"},"posted":{"date-parts":[[2026]]},"group-title":"SSRN","reference-count":63,"publisher":"Elsevier BV","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>High internal phase water\u2010in\u2010oil emulsions (W\/O HIPEs), are emerging as promising vehicles for low-calorie formulations and incorporation of bioactive compounds. This study evaluated W\/O HIPEs to co-deliver bioactive compounds, \u03b2-carotene and catechins from green tea extract, into each phase, focusing on stability, digestion (lipolysis and bioaccessibility), and cytotoxicity. W\/O HIPEs remained physically stable for 60 days despite some droplet coalescence and slight darkening, more pronounced in catechin-loaded HIPEs at 23 \u00baC. W\/O HIPEs exhibited gel-like behavior, that provided resistance to gastric conditions and inverted phases only in intestinal conditions where 80\u201395% free fatty acids were released during lipolysis. \u03b2-Carotene bioaccessibility improved from 37% (in its free form) to 65\u201373% after incorporation and reached 99% when co-delivered with catechins. Catechins bioaccessibility increased from 9% to 14\u201331% after incorporation. In vitro digested W\/O HIPEs showed no cytotoxicity in differentiated co-cultures, supporting their potential for functional foods with enhanced nutrient delivery.<\/jats:p>","DOI":"10.2139\/ssrn.6205249","type":"posted-content","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T18:47:02Z","timestamp":1770662822000},"source":"Crossref","is-referenced-by-count":0,"title":["Co-delivery of bioactive compounds in W\/O High Internal Phase Emulsions: Stability, In vitro digestion, and cytotoxicity"],"prefix":"10.2139","author":[{"given":"Larissa","family":"Fonseca","sequence":"first","affiliation":[]},{"given":"Marisol  Gouveia","family":"Dias","sequence":"additional","affiliation":[]},{"given":"Ana  Isabel","family":"Bourbon","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0221-5633","authenticated-orcid":true,"given":"Fernanda 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