{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T05:58:29Z","timestamp":1772431109406,"version":"3.50.1"},"posted":{"date-parts":[[2026]]},"group-title":"SSRN","reference-count":0,"publisher":"Elsevier BV","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>This work describes a cost-effective, label-free electrochemical biosensor for the detection of 8-hydroxy-2\u2032-deoxyguanosine (8OHdG), the most abundant biomarker to evaluate oxidative DNA damage and early cancer risk assessment. The sensor was fabricated by modifying screen-printed carbon electrodes (SPCEs) with a novel composite of magnetic multiwalled carbon nanotubes dispersed in a molecularly imprinted polypyrrole layer (OMMWCNTs@MIPy). This material was adequately characterized, providing enhanced electrocatalytic activity and selective recognition of 8OHdG. Analytical performance was evaluated by differential pulse voltammetry (DPV) after systematic optimization of synthesis and measurement parameters. The proposed method exhibited suitable sensitivity (LOD = 0.28 \u00b5M), and excellent repeatability (average intraday RSD 2.7%, and interday RSD 5.0%). High selectivity was also confirmed, with no interference from coexisting species in real samples. The device remained stable for at least 50 measurements and after three months of storage. Validation in spiked biological matrices yielded satisfactory recovery values close to 100% through external calibration. These results demonstrate that the proposed biosensor is a robust, sustainable, low-cost, and portable alternative to conventional immunoassays, suitable for sensitive and real-time monitoring of 8OHdG in nucleic acid samples.<\/jats:p>","DOI":"10.2139\/ssrn.6303462","type":"posted-content","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T05:01:31Z","timestamp":1772427691000},"source":"Crossref","is-referenced-by-count":0,"title":["Point-of-care nanocomposite MIP-based platform for electrochemical sensing of the oxidative biomarker 8-hydroxy-2\u2019-deoxyguanosine in nucleic acid samples"],"prefix":"10.2139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7540-9415","authenticated-orcid":true,"given":"Jeniffer  C.","family":"Mart\u00ednez-Gonz\u00e1lez","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9780-910X","authenticated-orcid":true,"given":"Pablo","family":"Montoro-Leal","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6523-8592","authenticated-orcid":true,"given":"Ismael","family":"Galv\u00e1n","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1728-3097","authenticated-orcid":true,"given":"\u00c1ngel","family":"R\u00edos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6395-0172","authenticated-orcid":true,"given":"Mohammed","family":"Zougagh","sequence":"additional","affiliation":[]}],"member":"78","container-title":[],"original-title":[],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T05:01:31Z","timestamp":1772427691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ssrn.com\/abstract=6303462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"URL":"https:\/\/doi.org\/10.2139\/ssrn.6303462","relation":{},"subject":[],"published":{"date-parts":[[2026]]},"subtype":"preprint"}}