{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:11:49Z","timestamp":1773349909941,"version":"3.50.1"},"posted":{"date-parts":[[2026]]},"group-title":"SSRN","reference-count":0,"publisher":"Elsevier BV","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Adsorption therapies in hemodialysis have emerged as an innovative approach for removing protein-bound uremic toxins (PBUTs). The present work focused on the enhancement of the adsorption capacity of hemodialysis membranes through the incorporation of Metal-Organic Frameworks (MOFs).The removal capacity of PBUT p-cresyl sulfate (pCS) by cellulose acetate (CA)\/silica (SiO2)\/MOF mixed matrix membranes was investigated with two types of MOFs, UiO-66 and UiO-66-NH2. The MOFs were synthesized and characterized by infrared spectroscopy, X-ray diffraction, nitrogen adsorption-desorption equilibrium at -196 \u00b0C, and thermogravimetry analysis. The mixed matrix membranes were synthesized by coupling the phase inversion technique with the sol-gel method and with casting solutions incorporating the MOF dispersions. They were characterized in terms of hydraulic permeability, molecular weight cut-off, and rejection coefficients to pCS and bovine serum albumin (BSA).The mixed matrix membranes CA\/SiO2\/UiO-66-NH2 exhibited lower permeability and molecular weight cut-off when compared to the CA\/SiO2\/UiO-66 ones. In permeation tests simulating a hemodialysis session with a feed solution of 100 ppm pCS and 35 g\/L BSA, the membranes without MOF showed a pCS rejection coefficients of 24.8-30.4%. The incorporation of MOFs significantly improved performance, with rejection coefficients to pCS of 0.2% for the CA22\/SiO2\/UiO-66 membrane with 1.5% of MOF and 2.6% for the CA22\/SiO2\/UiO-66-NH2 membrane with 2% of MOF.Upon quantification of the pCS free and bound to BSA it is concluded that the removal capacity of pCS bound to BSA is 99.8% for the CA22\/SiO2\/UiO-66 membrane with 1.5% of MOF and 95.9% for the CA22\/SiO2\/UiO-66-NH2 membrane with 2% of MOF. Based on these results, the mixed matrix membranes CA22\/SiO2\/UiO-66 and CA22\/SiO2\/UiO-66-NH2 are promising candidates for PBUTs removal in hemodialysis.<\/jats:p>","DOI":"10.2139\/ssrn.6360860","type":"posted-content","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:40:21Z","timestamp":1773312021000},"source":"Crossref","is-referenced-by-count":0,"title":["Removal of Protein-Bound Uremic Toxins by Mixed Matrix Membranes of Cellulose Acetate\/Silica\/MOF"],"prefix":"10.2139","author":[{"given":"Jo\u00e3o  M.","family":"Santos Dion\u00edsio","sequence":"first","affiliation":[]},{"given":"Miguel  P.","family":"da Silva","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9722-1931","authenticated-orcid":true,"given":"Ricardo  F. S.","family":"Pereira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1181-7230","authenticated-orcid":true,"given":"T\u00e2nia","family":"Frade","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7488-502X","authenticated-orcid":true,"given":"Tiago  J.","family":"Ferreira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3061-9632","authenticated-orcid":true,"given":"Mois\u00e9s","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Maria Norberta","family":"de Pinho","sequence":"additional","affiliation":[]}],"member":"78","container-title":[],"original-title":[],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:40:21Z","timestamp":1773312021000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ssrn.com\/abstract=6360860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"URL":"https:\/\/doi.org\/10.2139\/ssrn.6360860","relation":{},"subject":[],"published":{"date-parts":[[2026]]},"subtype":"preprint"}}