{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:49:23Z","timestamp":1781174963248,"version":"3.54.1"},"reference-count":40,"publisher":"Japan Poultry Science Association","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Poult. Sci.","Jpn. Poult. Sci."],"published-print":{"date-parts":[[2025]]},"DOI":"10.2141\/jpsa.2025021","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T22:08:10Z","timestamp":1753913290000},"page":"n\/a","source":"Crossref","is-referenced-by-count":1,"title":["Xylooligosaccharide Supplementation Mitigates Growth Performance Impairment and Intestinal Injuries in Enterohemorrhagic <i>Escherichia coli<\/i>-Challenged Broilers"],"prefix":"10.2141","volume":"62","author":[{"given":"Qingyun","family":"Cao","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Song","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarong","family":"Fang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zemin","family":"Dong","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ye","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Zuo","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"908","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"[1] Ferens WA andHovde CJ. Escherichia coli O157:H7: animal reservoir and sources of human infection. Foodborne Pathog Dis, 8: 465\u2013487. 2011. PMID:21117940, https:\/\/doi.org\/10.1089\/fpd.2010.0673","DOI":"10.1089\/fpd.2010.0673"},{"key":"2","doi-asserted-by":"crossref","unstructured":"[2] Xiang L, Ying Z, Xue M, Xiaoxian P, Xiaorong L, Chunyang L, Yu W, Mingcheng L andBinxian L. A novel Lactobacillus bulgaricus isolate can maintain the intestinal health, improve the growth performance and reduce the colonization of E. coli O157:H7 in broilers. Br Poult Sci, 63: 621\u2013632. 2022. PMID:35383527, https:\/\/doi.org\/10.1080\/00071668.2022.2062220","DOI":"10.1080\/00071668.2022.2062220"},{"key":"3","doi-asserted-by":"crossref","unstructured":"[3] Guo YN, Mou RW, Lu MH, Liang SS, He YM andTang LP. Three different routes of EHEC O157:H7 infection were used to establish EHEC broiler model. Poult Sci, 103: 103561. 2024. PMID:38417337, https:\/\/doi.org\/10.1016\/j.psj.2024.103561","DOI":"10.1016\/j.psj.2024.103561"},{"key":"4","doi-asserted-by":"crossref","unstructured":"[4] Yaqoob MU, El-Hack MEA, Hassan F, El-Saadony MT, Khafaga AF, Batiha GE, Yehia N, Elnesr SS, Alagawany M, El-Tarabily KA andWang M. The potential mechanistic insights and future implications for the effect of prebiotics on poultry performance, gut microbiome, and intestinal morphology. Poult Sci, 100: 101143. 2021. PMID:34062442, https:\/\/doi.org\/10.1016\/j.psj.2021.101143","DOI":"10.1016\/j.psj.2021.101143"},{"key":"5","doi-asserted-by":"crossref","unstructured":"[5] Pourabedin M, Guan L andZhao X. Xylo-oligosaccharides and virginiamycin differentially modulate gut microbial composition in chickens. Microbiome, 3: 15. 2015. PMID:25874109, https:\/\/doi.org\/10.1186\/s40168-015-0079-4","DOI":"10.1186\/s40168-015-0079-4"},{"key":"6","doi-asserted-by":"crossref","unstructured":"[6] Yadav S, Singh AK, Selvaraj RK, Applegate TJ, Bhattacharya P, Shinall SB, Fenn LS, Shanmugasundaram R andKim WK. Research Note: effect of dietary xylo-oligosaccharide on growth performance, intestinal histomorphology, and specific cecal bacteria in broiler chickens. Poult Sci, 103: 103189. 2024. PMID:37939588, https:\/\/doi.org\/10.1016\/j.psj.2023.103189","DOI":"10.1016\/j.psj.2023.103189"},{"key":"7","doi-asserted-by":"crossref","unstructured":"[7] Wu Y, Lei Z, Wang Y, Yin D, Aggrey SE, Guo Y andYuan J. Metabolome and microbiota analysis reveals the conducive effect of Pediococcus acidilactici BCC-1 and xylan oligosaccharides on broiler chickens. Front Microbiol, 12: 683905. 2021. PMID:34122394, https:\/\/doi.org\/10.3389\/fmicb.2021.683905","DOI":"10.3389\/fmicb.2021.683905"},{"key":"8","doi-asserted-by":"crossref","unstructured":"[8] Rao Z, Li Y, Yang X, Guo Y, Zhang W andWang Z. Diet xylo-oligosaccharide supplementation improves growth performance, immune function, and intestinal health of broilers. Anim Nutr, 17: 165\u2013176. 2024. PMID:38779325, https:\/\/doi.org\/10.1016\/j.aninu.2024.01.004","DOI":"10.1016\/j.aninu.2024.01.004"},{"key":"9","doi-asserted-by":"crossref","unstructured":"[9] Ferreira RBR, Gill N, Willing BP, Antunes LCM, Russell SL, Croxen MA andFinlay BB. The intestinal microbiota plays a role in Salmonella-induced colitis independent of pathogen colonization. PLoS One, 6: e20338. 2011. PMID:21633507, https:\/\/doi.org\/10.1371\/journal.pone.0020338","DOI":"10.1371\/journal.pone.0020338"},{"key":"10","doi-asserted-by":"crossref","unstructured":"[10] Wang W, Ou J, Ye H, Cao Q, Zhang C, Dong Z, Feng D andZuo J. Supplemental N-acyl homoserine lactonase alleviates intestinal disruption and improves gut microbiota in broilers challenged by Salmonella Typhimurium. J Anim Sci Biotechnol, 14: 7. 2023. PMID:36617579, https:\/\/doi.org\/10.1186\/s40104-022-00801-4","DOI":"10.1186\/s40104-022-00801-4"},{"key":"11","doi-asserted-by":"crossref","unstructured":"[11] He B, Zhu R, Yang H, Lu Q, Wang W, Song L, Sun X, Zhang G, Li S, Yang J, Tian G, Bing P andLang J. Assessing the impact of data preprocessing on analyzing next generation sequencing data. Front Bioeng Biotechnol, 8: 817. 2020. PMID:32850708, https:\/\/doi.org\/10.3389\/fbioe.2020.00817","DOI":"10.3389\/fbioe.2020.00817"},{"key":"12","doi-asserted-by":"crossref","unstructured":"[12] Callahan BJ, McMurdie PJ, Rosen MJ, Han AW, Johnson AJA andHolmes SP. DADA2: high-resolution sample inference from Illumina amplicon data. Nat Methods, 13: 581\u2013583. 2016. PMID:27214047, https:\/\/doi.org\/10.1038\/nmeth.3869","DOI":"10.1038\/nmeth.3869"},{"key":"13","doi-asserted-by":"crossref","unstructured":"[13] Deng F, Tang S, Zhao H, Zhong R, Liu L, Meng Q, Zhang H andChen L. Combined effects of sodium butyrate and xylo-oligosaccharide on growth performance, anti-inflammatory and antioxidant capacity, intestinal morphology and microbiota of broilers at early stage. Poult Sci, 102: 102585. 2023. PMID:36913758, https:\/\/doi.org\/10.1016\/j.psj.2023.102585","DOI":"10.1016\/j.psj.2023.102585"},{"key":"14","doi-asserted-by":"crossref","unstructured":"[14] Diaz Carrasco JM, Casanova NA andFern\u00e1ndez Miyakawa ME. Microbiota, gut health and chicken productivity: what is the connection? Microorganisms, 7: 374. 2019. PMID:31547108, https:\/\/doi.org\/10.3390\/microorganisms7100374","DOI":"10.3390\/microorganisms7100374"},{"key":"15","doi-asserted-by":"crossref","unstructured":"[15] Wu Q, Zhu F, Yao Y, Chen L, Ding Y, Su Y andGe C. Sini san regulates intestinal flora and short-chain fatty acids to ameliorate hepatocyte apoptosis and relieve CCl4-induced liver fibrosis in mice. Front Pharmacol, 15: 1408459. 2024. PMID:39281277, https:\/\/doi.org\/10.3389\/fphar.2024.1408459","DOI":"10.3389\/fphar.2024.1408459"},{"key":"16","doi-asserted-by":"crossref","unstructured":"[16] Lensu S, Pariyani R, M\u00e4kinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Lind\u00e9n J, Tiirola M, Lahti L andPekkala S. Prebiotic xylo-oligosaccharides ameliorate high-fat-diet-induced hepatic steatosis in rats. Nutrients, 12: 3225. 2020. PMID:33105554, https:\/\/doi.org\/10.3390\/nu12113225","DOI":"10.3390\/nu12113225"},{"key":"17","doi-asserted-by":"crossref","unstructured":"[17] Tang X, Xiong K, Fang R andLi M. Weaning stress and intestinal health of piglets: A review. Front Immunol, 13: 1042778. 2022. PMID:36505434, https:\/\/doi.org\/10.3389\/fimmu.2022.1042778","DOI":"10.3389\/fimmu.2022.1042778"},{"key":"18","doi-asserted-by":"crossref","unstructured":"[18] Small JT andWeiss AA. Intestinal enteroid monolayers model the human intestinal environment for Escherichia coli infection. J Bacteriol, 204: e00620-21. 2022. PMID:35389257, https:\/\/doi.org\/10.1128\/jb.00620-21","DOI":"10.1128\/jb.00620-21"},{"key":"19","doi-asserted-by":"crossref","unstructured":"[19] Li H, Xie X, Li Y, Chen M, Xue L, Wang J, Zhang J, Wu S, Ye Q, Zhang S, Yang R, Zhao H, Wu L, Liang T, Ding Y andWu Q. Pediococcus pentosaceus IM96 exerts protective effects against enterohemorrhagic Escherichia coli O157:H7 infection in vivo. Foods, 10: 2945. 2021. PMID:34945495, https:\/\/doi.org\/10.3390\/foods10122945","DOI":"10.3390\/foods10122945"},{"key":"20","doi-asserted-by":"crossref","unstructured":"[20]Wang WW, Chen YL, Ye H, Dong ZM, Zhang CM, Feng DY, Cao QY, Liang SJ andZuo JJ. N-acyl homoserine lactonase attenuates the virulence of Salmonella typhimurium and its induction of intestinal damages in broilers. Anim Nutr, 14: 334\u2013342. 2023. https:\/\/doi.org\/10.1016\/j.aninu.2023.04.010","DOI":"10.1016\/j.aninu.2023.04.010"},{"key":"21","doi-asserted-by":"crossref","unstructured":"[21] Fang X, Nong K, Wang Z, Jin Y, Gao F, Zeng Q, Wang X andZhang H. Human cathelicidin LL-37 exerts amelioration effects against EHEC O157:H7 infection regarding inflammation, enteric dysbacteriosis, and impairment of gut barrier function. Peptides, 159: 170903. 2023. PMID:36370932, https:\/\/doi.org\/10.1016\/j.peptides.2022.170903","DOI":"10.1016\/j.peptides.2022.170903"},{"key":"22","doi-asserted-by":"crossref","unstructured":"[22] Wang X, Xiao K, Yu C, Wang L, Liang T, Zhu H, Xu X andLiu Y. Xylooligosaccharide attenuates lipopolysaccharide-induced intestinal injury in piglets via suppressing inflammation and modulating cecal microbial communities. Anim Nutr, 7: 609\u2013620. 2021. PMID:34377847, https:\/\/doi.org\/10.1016\/j.aninu.2020.11.008","DOI":"10.1016\/j.aninu.2020.11.008"},{"key":"23","doi-asserted-by":"crossref","unstructured":"[23] Paneru D, Tellez-Isaias G, Bottje WG, Asiamah E, Abdel-Wareth AAA, Salahuddin M andLohakare J. Modulation of immune response and cecal microbiota by dietary fenugreek seeds in broilers. Vet Sci, 11: 57. 2024. PMID:38393075, https:\/\/doi.org\/10.3390\/vetsci11020057","DOI":"10.3390\/vetsci11020057"},{"key":"24","doi-asserted-by":"crossref","unstructured":"[24] Guo X, Huang C, Xu J, Xu H, Liu L, Zhao H, Wang J, Huang W, Peng W, Chen Y, Nie Y, Zhou Y andZhou Y. Gut microbiota is a potential biomarker in inflammatory bowel disease. Front Nutr, 8: 818902. 2022. PMID:35127797, https:\/\/doi.org\/10.3389\/fnut.2021.818902","DOI":"10.3389\/fnut.2021.818902"},{"key":"25","doi-asserted-by":"crossref","unstructured":"[25] Litvak Y, Byndloss MX, Tsolis RM andB\u00e4umler AJ. Dysbiotic Proteobacteria expansion: a microbial signature of epithelial dysfunction. Curr Opin Microbiol, 39: 1\u20136. 2017. PMID:28783509, https:\/\/doi.org\/10.1016\/j.mib.2017.07.003","DOI":"10.1016\/j.mib.2017.07.003"},{"key":"26","doi-asserted-by":"crossref","unstructured":"[26] Jumpertz R, Le DS, Turnbaugh PJ, Trinidad C, Bogardus C, Gordon JI andKrakoff J. Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. Am J Clin Nutr, 94: 58\u201365. 2011. PMID:21543530, https:\/\/doi.org\/10.3945\/ajcn.110.010132","DOI":"10.3945\/ajcn.110.010132"},{"key":"27","doi-asserted-by":"crossref","unstructured":"[27] Torok VA, Hughes RJ, Mikkelsen LL, Perez-Maldonado R, Balding K, MacAlpine R, Percy NJ andOphel-Keller K. Identification and characterization of potential performance-related gut microbiotas in broiler chickens across various feeding trials. Appl Environ Microbiol, 77: 5868\u20135878. 2011. PMID:21742925, https:\/\/doi.org\/10.1128\/AEM.00165-11","DOI":"10.1128\/AEM.00165-11"},{"key":"28","doi-asserted-by":"crossref","unstructured":"[28] Zhou J, Zhang H, Wu S, Qiu K, Fu Y, Qi G andWang J. Supplemental xylooligosaccharide modulates intestinal mucosal barrier and cecal microbiota in laying hens fed oxidized fish oil. Front Microbiol, 12: 635333. 2021. PMID:33692770, https:\/\/doi.org\/10.3389\/fmicb.2021.635333","DOI":"10.3389\/fmicb.2021.635333"},{"key":"29","doi-asserted-by":"crossref","unstructured":"[29] Zeng Z, Yue W, Kined C, Raciheon B, Liu J andChen X. Effect of Lysinibacillus isolated from environment on probiotic properties and gut microbiota in mice. Ecotoxicol Environ Saf, 258: 114952. 2023. PMID:37141683, https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114952","DOI":"10.1016\/j.ecoenv.2023.114952"},{"key":"30","doi-asserted-by":"crossref","unstructured":"[30] Mani SR, Vijayan K, Jacob JP, Vijayakumar S andKandhasamy S. Evaluation of probiotic properties of Lysinibacillus macroides under in vitro conditions and culture of Cyprinus carpio on growth parameters. Arch Microbiol, 203: 4705\u20134714. 2021. PMID:34185117, https:\/\/doi.org\/10.1007\/s00203-021-02452-x","DOI":"10.1007\/s00203-021-02452-x"},{"key":"31","doi-asserted-by":"crossref","unstructured":"[31] Devi WM, Irungbam S, Kumar M, Choudhury TG andKamilya D. Probiotic potential of Bacillus pumilus COFAHE_Pro08 and Lysinibacillus macroides COFAHE_Pro06 isolated from the intestine of labeo catla. Turk J Fish Aquat Sci, 24: TRJFAS24144. 2023. https:\/\/doi.org\/10.4194\/TRJFAS24144","DOI":"10.4194\/TRJFAS24144"},{"key":"32","doi-asserted-by":"crossref","unstructured":"[32] Liu Y, Feng Y, Yang X, Lv Z, Li P, Zhang M, Wei F, Jin X, Hu Y, Guo Y andLiu D. Mining chicken ileal microbiota for immunomodulatory microorganisms. ISME J, 17: 758\u2013774. 2023. PMID:36849630, https:\/\/doi.org\/10.1038\/s41396-023-01387-z","DOI":"10.1038\/s41396-023-01387-z"},{"key":"33","doi-asserted-by":"crossref","unstructured":"[33] Brown EM, Ke X, Hitchcock D, Jeanfavre S, Avila-Pacheco J, Nakata T, Arthur TD, Fornelos N, Heim C, Franzosa EA, Watson N, Huttenhower C, Haiser HJ, Dillow G, Graham DB, Finlay BB, Kostic AD, Porter JA, Vlamakis H, Clish CB andXavier RJ. Bacteroides-derived sphingolipids are critical for maintaining intestinal homeostasis and symbiosis. Cell Host Microbe, 25: 668\u2013680.e7. 2019. PMID:31071294, https:\/\/doi.org\/10.1016\/j.chom.2019.04.002","DOI":"10.1016\/j.chom.2019.04.002"},{"key":"34","doi-asserted-by":"crossref","unstructured":"[34] Tan H, Zhao J, Zhang H, Zhai Q andChen W. Novel strains of Bacteroides fragilis and Bacteroides ovatus alleviate the LPS-induced inflammation in mice. Appl Microbiol Biotechnol, 103: 2353\u20132365. 2019. PMID:30666361, https:\/\/doi.org\/10.1007\/s00253-019-09617-1","DOI":"10.1007\/s00253-019-09617-1"},{"key":"35","doi-asserted-by":"crossref","unstructured":"[35] Eeckhaut V, Wang J, Van Parys A, Haesebrouck F, Joossens M, Falony G, Raes J, Ducatelle R andVan Immerseel F. The probiotic Butyricicoccus pullicaecorum reduces feed conversion and protects from potentially harmful intestinal microorganisms and necrotic enteritis in broilers. Front Microbiol, 7: 1416. 2016. PMID:27708624, https:\/\/doi.org\/10.3389\/fmicb.2016.01416","DOI":"10.3389\/fmicb.2016.01416"},{"key":"36","doi-asserted-by":"crossref","unstructured":"[36] Trachsel J, Humphrey S andAllen HK. Butyricicoccus porcorum sp. nov., a butyrate-producing bacterium from swine intestinal tract. Int J Syst Evol Microbiol, 68: 1737\u20131742. 2018. PMID:29620502, https:\/\/doi.org\/10.1099\/ijsem.0.002738","DOI":"10.1099\/ijsem.0.002738"},{"key":"37","doi-asserted-by":"crossref","unstructured":"[37] Bedford A andGong J. Implications of butyrate and its derivatives for gut health and animal production. Anim Nutr, 4: 151\u2013159. 2018. PMID:30140754, https:\/\/doi.org\/10.1016\/j.aninu.2017.08.010","DOI":"10.1016\/j.aninu.2017.08.010"},{"key":"38","doi-asserted-by":"crossref","unstructured":"[38] Pathak A, Jaswal R andChauhan A. Genomic characterization of a mercury resistant Arthrobacter sp. H-02-3 reveals the presence heavy metal and antibiotic resistance determinants. Front Microbiol, 10: 3039. 2020. PMID:32010097, https:\/\/doi.org\/10.3389\/fmicb.2019.03039","DOI":"10.3389\/fmicb.2019.03039"},{"key":"39","doi-asserted-by":"crossref","unstructured":"[39] Weng Y, Qiao Y, Xiao C andFeng L. Seasonal variation of microbial community, potential opportunistic pathogens and antibiotic resistance genes in a novel underground reservoir of an island. Int J Environ Res, 16: 59. 2022. https:\/\/doi.org\/10.1007\/s41742-022-00435-4","DOI":"10.1007\/s41742-022-00435-4"},{"key":"40","doi-asserted-by":"crossref","unstructured":"[40] Zhao Y, Gao J, Wang Z, Dai H andWang Y. Responses of bacterial communities and resistance genes on microplastics to antibiotics and heavy metals in sewage environment. J Hazard Mater, 402: 123550. 2021. PMID:33254740, https:\/\/doi.org\/10.1016\/j.jhazmat.2020.123550","DOI":"10.1016\/j.jhazmat.2020.123550"}],"container-title":["The Journal of Poultry Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jpsa\/62\/0\/62_2025021\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T05:00:36Z","timestamp":1754110836000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jpsa\/62\/0\/62_2025021\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":40,"journal-issue":{"issue":"0","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.2141\/jpsa.2025021","relation":{},"ISSN":["1346-7395","1349-0486"],"issn-type":[{"value":"1346-7395","type":"print"},{"value":"1349-0486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"2025021"}}