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PMID:8415820,          https:\/\/doi.org\/10.1016\/0091-3057(93)90126-E","DOI":"10.1016\/0091-3057(93)90126-E"},{"key":"7","doi-asserted-by":"publisher","unstructured":"[7] Ando K andTakagi K. Solid gastric emptying          mediated by the serotonin (5-HT)3 receptor in mice is a simple marker to predict emesis. J          Toxicol Sci, 36: 23\u201329. 2011. PMID:21297338,          https:\/\/doi.org\/10.2131\/jts.36.23","DOI":"10.2131\/jts.36.23"},{"key":"8","doi-asserted-by":"publisher","unstructured":"[8] Ando K, Takagi K andTsubone H. Enhanced gastric          retention of solid resin beads as a marker for emetic potential of agents in rats. J          Toxicol Sci, 37: 549\u2013553. 2012. PMID:22687994,          https:\/\/doi.org\/10.2131\/jts.37.549","DOI":"10.2131\/jts.37.549"},{"key":"9","doi-asserted-by":"publisher","unstructured":"[9] Adeleke PA, Ajayi AM, Ben-Azu B andUmukoro S.          Involvement of oxidative stress and pro-inflammatory cytokines in copper sulfate-induced          depression-like disorders and abnormal neuronal morphology in mice. Naunyn Schmiedebergs          Arch Pharmacol, 396: 3123\u20133133. 2023. PMID:37154924,          https:\/\/doi.org\/10.1007\/s00210-023-02519-0","DOI":"10.1007\/s00210-023-02519-0"},{"key":"10","doi-asserted-by":"publisher","unstructured":"[10] Koster R. Comparative studies of emesis in          pigeons and dogs. J Pharmacol Exp Ther, 119: 406\u2013417. 1957. PMID:13417096,          https:\/\/doi.org\/10.1016\/S0022-3565(25)11889-2","DOI":"10.1016\/S0022-3565(25)11889-2"},{"key":"11","unstructured":"[11] Chaney SG andKare MR. Emesis in birds. J Am Vet          Med Assoc, 149: 938\u2013943. 1966. PMID:22413208"},{"key":"12","doi-asserted-by":"crossref","unstructured":"[12] Powell FL. Respiration. In: Sturkie\u2019s Avian          Physiology, 5th ed. (Whittow GC ed). 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