{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T15:43:52Z","timestamp":1770565432924,"version":"3.49.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,1]]},"DOI":"10.2146\/ajhp090657","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T22:10:46Z","timestamp":1284761446000},"page":"1606-1610","source":"Crossref","is-referenced-by-count":12,"title":["Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy"],"prefix":"10.1093","volume":"67","author":[{"given":"Susan W.","family":"Publow","sequence":"first","affiliation":[{"name":"Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt, Nashville, TN; at the time of writing she was pharmacy student, College of Pharmacy, University of Tennessee, Memphis."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald L.","family":"Branam","sequence":"additional","affiliation":[{"name":"St. Mary\u2019s Medical Center of Campbell County, LaFollette, TN, and Assistant Professor of Clinical Pharmacy, College of Pharmacy, University of Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t2019041104312161800_b1-0671606","unstructured":"Lexi-Drugs Online. Tizanidine monograph. www.crlonline.com\/crlonline (accessed 2009 Jul 6)."},{"key":"key\n\t\t\t\t2019041104312161800_b2-0671606","volume-title":"Tizanidine package insert","year":"2007"},{"key":"key\n\t\t\t\t2019041104312161800_b3-0671606","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1046\/j.1365-2125.2003.02028.x","article-title":"Tizanidine is mainly metabolized by cytochrome P450 1A2 in vitro","volume":"57","author":"Granfors","year":"2003","journal-title":"Br J Clin Pharmacol"},{"key":"key\n\t\t\t\t2019041104312161800_b4-0671606","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0014-2999(02)01664-3","article-title":"Involvement of imidazoline receptors in the centrally acting muscle-relaxant effects of tizanidine","volume":"445","author":"Honda","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t2019041104312161800_b5-0671606","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1742-1241.2007.01660.x","article-title":"A clinically relevant review of tizanidine hydrochloride dose relationships to pharmacokinetics, drug safety and effectiveness in healthy subjects and patients","volume":"62","author":"Henney","year":"2008","journal-title":"Int J Clin Pract"},{"key":"key\n\t\t\t\t2019041104312161800_b6-0671606","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2165\/00003495-200059030-00006","article-title":"Drugs used to treat spasticity","volume":"59","author":"Kita","year":"2000","journal-title":"Drugs"},{"key":"key\n\t\t\t\t2019041104312161800_b7-0671606","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2165\/00003495-199753030-00007","article-title":"Tizanidine: a review of its pharmacology, clinical efficacy, and tolerability in the management of spasticity associated with cerebral and spinal disorders","volume":"53","author":"Wagstaff","year":"1997","journal-title":"Drugs"},{"key":"key\n\t\t\t\t2019041104312161800_b8-0671606","first-page":"817","article-title":"The sedative and sympatholytic effects of oral tizanidine in healthy volunteers","volume":"82","author":"Miettinen","year":"1996","journal-title":"Anesth Analg"},{"key":"key\n\t\t\t\t2019041104312161800_b9-0671606","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1213\/01.ANE.0000048087.57487.0C","article-title":"Continuous intrathecal clonidine and tizanidine in conscious dogs: analgesic and hemodynamic effects","volume":"96","author":"Kroin","year":"2003","journal-title":"Anesth Analg"},{"key":"key\n\t\t\t\t2019041104312161800_b10-0671606","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1097\/00000542-200306000-00027","article-title":"Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain","volume":"98","author":"Kawamata","year":"2003","journal-title":"Anesthesiology"},{"key":"key\n\t\t\t\t2019041104312161800_b11-0671606","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1056\/NEJM200001203420301","article-title":"Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients","volume":"342","author":"Yusuf","year":"2000","journal-title":"N Engl J Med"},{"issue":"(suppl 1)","key":"key\n\t\t\t\t2019041104312161800_b12-0671606","first-page":"S1","article-title":"Clinical practice recommendations 2005","volume":"28","author":"American Diabetes Association","year":"2005","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041104312161800_b13-0671606","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/01.HYP.0000107251.49515.c2","article-title":"Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure","volume":"42","author":"Chobanian","year":"2003","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t2019041104312161800_b14-0671606","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.jacc.2008.11.009","article-title":"2009 Focused update: ACCF\/AHA guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines developed in collaboration with the International Society for Heart and Lung Transplantation","volume":"53","author":"Jessup","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019041104312161800_b15-0671606","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1177\/088307380001501211","article-title":"Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension","volume":"15","author":"Johnson","year":"2000","journal-title":"J Child Neurol"},{"key":"key\n\t\t\t\t2019041104312161800_b16-0671606","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1345\/aph.1E161","article-title":"Hypotension due to interaction between lisinopril and tizanidine","volume":"38","author":"Kao","year":"2004","journal-title":"Ann Pharmacother"},{"key":"key\n\t\t\t\t2019041104312161800_b17-0671606","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin Pharmacol Ther"},{"key":"key\n\t\t\t\t2019041104312161800_b18-0671606","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1345\/aph.1H423","article-title":"Proposal for a new tool to evaluate drug interaction cases","volume":"41","author":"Horn","year":"2007","journal-title":"Ann Pharmacother"},{"key":"key\n\t\t\t\t2019041104312161800_b19-0671606","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00004872-200301000-00027","article-title":"Importance of imidazoline-preferring receptors in the cardiovascular actions of chronically administered moxonidine, rilmenidine and clonidine in conscious rabbits","volume":"21","author":"Parkin","year":"2003","journal-title":"J Hypertens"},{"key":"key\n\t\t\t\t2019041104312161800_b20-0671606","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1254\/jjp.59.457","article-title":"Tizanidine may discriminate between imidazoline-receptors and \u03b12-adrenoceptors","volume":"59","author":"Muramatsu","year":"1992","journal-title":"Jpn J Pharmacol"},{"key":"key\n\t\t\t\t2019041104312161800_b21-0671606","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1254\/jphs.FP0050520","article-title":"Involvement of supraspinal imidazoline receptors and descending monoaminergic pathways in tizanidine-induced inhibition of rat spinal reflexes","volume":"99","author":"Kino","year":"2005","journal-title":"J Pharmacol Sci"},{"key":"key\n\t\t\t\t2019041104312161800_b22-0671606","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1213\/00000539-199910000-00012","article-title":"Refractory hypotension after induction of anesthesia in a patient chronically treated with angiotensin receptor antagonists","volume":"89","author":"Brabant","year":"1999","journal-title":"Anesth Analg"},{"key":"key\n\t\t\t\t2019041104312161800_b23-0671606","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1053\/j.jvca.2007.12.020","article-title":"Chronic angiotensin-converting enzyme inhibitor or angiotensin receptor blocker therapy combined with diuretic therapy is associated with increased episodes of hypotension in noncardiac surgery","volume":"22","author":"Kheterpal","year":"2008","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"key\n\t\t\t\t2019041104312161800_b24-0671606","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/jhm.323","article-title":"Clinical consequences of withholding versus administering renin-angiotensin-aldosterone system antagonists in the preoperative period","volume":"3","author":"Rosenman","year":"2008","journal-title":"J Hosp Med"},{"key":"key\n\t\t\t\t2019041104312161800_b25-0671606","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.clpt.2004.08.018","article-title":"Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism","volume":"76","author":"Granfors","year":"2004","journal-title":"Clin Pharmacol Ther"},{"key":"key\n\t\t\t\t2019041104312161800_b26-0671606","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.clpt.2003.12.005","article-title":"Fluvoxamine drastically increases concentrations and effects of tizanidine: a potentially hazardous interaction","volume":"75","author":"Granfors","year":"2004","journal-title":"Clin Pharmacol Ther"},{"key":"key\n\t\t\t\t2019041104312161800_b27-0671606","unstructured":"Lexi-Drugs Online. Omeprazole monograph. www.crlonline.com\/crlonline (accessed 2009 Jul 6)."},{"key":"key\n\t\t\t\t2019041104312161800_b28-0671606","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S0149-2918(08)80047-1","article-title":"Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: an update","volume":"30","author":"Spina","year":"2008","journal-title":"Clin Ther"},{"key":"key\n\t\t\t\t2019041104312161800_b29-0671606","unstructured":"Lexi-Drugs Online. Theophylline monograph. www.crlonline.com\/crlonline (accessed 2009 Jul 6)."},{"key":"key\n\t\t\t\t2019041104312161800_b30-0671606","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S0022-5347(17)67149-0","article-title":"Effect of trimethoprim-sulfamethoxazole on the renal excretion of creatinine in man","volume":"114","author":"Berglund","year":"1975","journal-title":"J Urol"},{"key":"key\n\t\t\t\t2019041104312161800_b31-0671606","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2165\/00002018-200022030-00006","article-title":"Trimethoprim-induced hyperkalaemia: clinical data, mechanism, prevention and management","volume":"22","author":"Perazella","year":"2000","journal-title":"Drug Saf"}],"container-title":["American Journal of Health-System Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ajhp\/article-pdf\/67\/19\/1606\/28345159\/ajhp1606.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T04:43:57Z","timestamp":1636519437000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajhp\/article\/67\/19\/1606\/5130718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,1]]},"references-count":31,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2010,10,1]]}},"URL":"https:\/\/doi.org\/10.2146\/ajhp090657","relation":{},"ISSN":["1079-2082","1535-2900"],"issn-type":[{"value":"1079-2082","type":"print"},{"value":"1535-2900","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,10,1]]},"published":{"date-parts":[[2010,10,1]]}}}