{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:23:10Z","timestamp":1787505790275,"version":"build-2736575974"},"reference-count":119,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"DOI":"10.2146\/ajhp160144","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T13:05:07Z","timestamp":1487336707000},"page":"295-311","source":"Crossref","is-referenced-by-count":24,"title":["Major publications in the critical care pharmacotherapy literature in 2015"],"prefix":"10.1093","volume":"74","author":[{"given":"Adrian","family":"Wong","sequence":"first","affiliation":[{"name":"Brigham and Women\u2019s Hospital\/MCPHS University, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Erdman","sequence":"additional","affiliation":[{"name":"University of Florida Health\u2013Jacksonville, Jacksonville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drayton A.","family":"Hammond","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Little Rock, AR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Holt","sequence":"additional","affiliation":[{"name":"IU Health Methodist, Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna M.","family":"Holzhausen","sequence":"additional","affiliation":[{"name":"Beaumont Hospital\u2013Royal Oak, Royal Oak, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Horng","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori Lynn","family":"Huang","sequence":"additional","affiliation":[{"name":"VA Medical Center, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Jarvis","sequence":"additional","affiliation":[{"name":"St. Mary\u2019s of Michigan, Saginaw, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridgette","family":"Kram","sequence":"additional","affiliation":[{"name":"Duke University Hospital, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Kram","sequence":"additional","affiliation":[{"name":"Medical and Cardiothoracic ICU, Duke University Medical Center, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Lesch","sequence":"additional","affiliation":[{"name":"NeuroICU, NewYork-Presbyterian Hospital, Columbia University Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Mercer","sequence":"additional","affiliation":[{"name":"Roper St. Francis Health Care, Charleston, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan A.","family":"Rech","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center, Maywood, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Rivosecchi","sequence":"additional","affiliation":[{"name":"UPMC Presbyterian, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Stump","sequence":"additional","affiliation":[{"name":"Frederick Memorial Hospital, Frederick, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Teevan","sequence":"additional","affiliation":[{"name":"Hospital of Central Connecticut, New Britain, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Day","sequence":"additional","affiliation":[{"name":"Doctors Hospital OhioHealth, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t2019041103204474700_b1-0740295","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1136\/bmj.328.7454.1490","article-title":"Grading quality of evidence and strength of recommendations","volume":"328","author":"Atkins","year":"2004","journal-title":"BMJ"},{"key":"key\n\t\t\t\t2019041103204474700_b2-0740295","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"key\n\t\t\t\t2019041103204474700_b3-0740295","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/STR.0000000000000069","article-title":"Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"46","author":"Hemphill","year":"2015","journal-title":"Stroke"},{"key":"key\n\t\t\t\t2019041103204474700_b4-0740295","doi-asserted-by":"crossref","first-page":"S444","DOI":"10.1161\/CIR.0000000000000261","article-title":"Part 7: adult advanced cardiovascular life support: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care","volume":"132","author":"Link","year":"2015","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041103204474700_b5-0740295","doi-asserted-by":"crossref","first-page":"S465","DOI":"10.1161\/CIR.0000000000000262","article-title":"Part 8: post-cardiac arrest care: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care","volume":"132","author":"Callaway","year":"2015","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041103204474700_b6-0740295","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1016\/j.jacc.2015.08.856","article-title":"2015 ACC\/AHA\/HRS guidelines for the management of adult patients with supraventricular tachycardia: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society","volume":"67","author":"Page","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019041103204474700_b7-0740295","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1056\/NEJMoa1502826","article-title":"Permissive underfeeding or standard enteral feeding in critically ill adults","volume":"372","author":"Arabi","year":"2015","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b8-0740295","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/0148607114528541","article-title":"Intensive nutrition in acute lung injury: a clinical trial (INTACT)","volume":"39","author":"Braunschweig","year":"2015","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"key\n\t\t\t\t2019041103204474700_b9-0740295","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1164\/rccm.201505-0857OC","article-title":"A multicenter randomized trial of continuous versus intermittent \u03b2-lactam infusion in severe sepsis","volume":"192","author":"Dulhunty","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t2019041103204474700_b10-0740295","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1097\/CCM.0000000000001004","article-title":"A randomized controlled trial of regional citrate versus regional heparin anticoagulation for continuous renal replacement therapy in critically ill adults","volume":"43","author":"Gattas","year":"2015","journal-title":"Crit Care Med"},{"key":"key\n\t\t\t\t2019041103204474700_b11-0740295","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1097\/CCM.0000000000000938","article-title":"Volatile-based short-term sedation in cardiac surgical patients: a prospective randomized controlled trial","volume":"43","author":"Jerath","year":"2015","journal-title":"Crit Care Med"},{"key":"key\n\t\t\t\t2019041103204474700_b12-0740295","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1213\/ANE.0000000000000873","article-title":"Intraoperative magnesium administration does not reduce postoperative atrial fibrillation after cardiac surgery","volume":"121","author":"Klinger","year":"2015","journal-title":"Anesth Analg"},{"key":"key\n\t\t\t\t2019041103204474700_b13-0740295","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJMoa1500896","article-title":"Trial of early, goal-directed resuscitation for septic shock","volume":"372","author":"Mouncey","year":"2015","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b14-0740295","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/jama.2014.18400","article-title":"Chlorhexidine bathing and healthcare-associated infections: a randomized clinical trial","volume":"313","author":"Noto","year":"2015","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041103204474700_b15-0740295","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1056\/NEJMoa1408827","article-title":"Prehospital use of magnesium sulfate as neuroprotection in acute stroke","volume":"372","author":"Saver","year":"2015","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b16-0740295","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1056\/NEJMoa1411162","article-title":"Trial of short-course antimicrobial therapy for intraabdominal infection","volume":"372","author":"Sawyer","year":"2015","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b17-0740295","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1056\/NEJMoa1411090","article-title":"A clinical trial of progesterone for severe traumatic brain injury","volume":"371","author":"Skolnick","year":"2014","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b18-0740295","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1056\/NEJMoa1404304","article-title":"Very early administration of progesterone for acute traumatic brain injury","volume":"371","author":"Wright","year":"2014","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b19-0740295","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1161\/STR.0b013e3181ec611b","article-title":"Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"41","author":"Morgenstern","year":"2010","journal-title":"Stroke"},{"key":"key\n\t\t\t\t2019041103204474700_b20-0740295","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1161\/CIRCULATIONAHA.113.002283","article-title":"Efficacy and safety of 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study","volume":"128","author":"Sarode","year":"2013","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041103204474700_b21-0740295","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/ajh.21046","article-title":"Role of prothrombin complex concentrates in reversing warfarin anticoagulation: a review of the literature","volume":"83","author":"Leissinger","year":"2008","journal-title":"Am J Hematol"},{"key":"key\n\t\t\t\t2019041103204474700_b22-0740295","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.annemergmed.2015.04.036","article-title":"Thromboembolic events after vitamin K antagonist reversal with 4-factor prothrombin complex concentrate: exploratory analyses of two randomized, plasma-controlled studies","volume":"67","author":"Milling","year":"2016","journal-title":"Ann Emerg Med"},{"key":"key\n\t\t\t\t2019041103204474700_b23-0740295","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1056\/NEJMoa0707534","article-title":"Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage","volume":"358","author":"Mayer","year":"2008","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b24-0740295","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1161\/STROKEAHA.112.651422","article-title":"Earlier blood pressure-lowering and greater attenuation of hematoma growth in acute intracerebral hemorrhage: INTERACT pilot phase","volume":"43","author":"Arima","year":"2012","journal-title":"Stroke"},{"key":"key\n\t\t\t\t2019041103204474700_b25-0740295","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1056\/NEJMoa1214609","article-title":"Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage","volume":"368","author":"Anderson","year":"2013","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b26-0740295","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/ajh\/hpt076","article-title":"Blood pressure after recent stroke: baseline findings from the Secondary Prevention of Small Subcortical Strokes trial","volume":"26","author":"White","year":"2013","journal-title":"Am J Hypertens"},{"key":"key\n\t\t\t\t2019041103204474700_b27-0740295","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1056\/NEJM198705143162001","article-title":"Effects of dexamethasone in primary supratentorial intracerebral hemorrhage","volume":"316","author":"Poungvarin","year":"1987","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b28-0740295","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1161\/STROKEAHA.110.593087","article-title":"Optimal timing of resumption of warfarin after intracranial hemorrhage","volume":"41","author":"Majeed","year":"2010","journal-title":"Stroke"},{"key":"key\n\t\t\t\t2019041103204474700_b29-0740295","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1212\/01.wnl.0000194267.09060.77","article-title":"Antiplatelet use after intracerebral hemorrhage","volume":"66","author":"Viswanathan","year":"2006","journal-title":"Neurology"},{"key":"key\n\t\t\t\t2019041103204474700_b30-0740295","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s12028-015-0222-x","article-title":"Guideline for reversal of antithrombotics in intracranial hemorrhage: a statement for healthcare professionals from the Neurocritical Care Society and Society of Critical Care Medicine","volume":"24","author":"Frontera","year":"2016","journal-title":"Neurocrit Care"},{"key":"key\n\t\t\t\t2019041103204474700_b31-0740295","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1056\/NEJMoa1502000","article-title":"Idarucizumab for dabigatran reversal","volume":"373","author":"Pollack","year":"2015","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b32-0740295","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1056\/NEJMoa1510991","article-title":"Andexanet alfa for the reversal of factor Xa inhibitor activity","volume":"373","author":"Siegal","year":"2015","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b33-0740295","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s12028-011-9538-3","article-title":"Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH) II: design, methods, and rationale","volume":"15","author":"Qureshi","year":"2011","journal-title":"Neurocrit Care"},{"key":"key\n\t\t\t\t2019041103204474700_b34-0740295","doi-asserted-by":"crossref","first-page":"S640","DOI":"10.1161\/CIRCULATIONAHA.110.970889","article-title":"Part 1: executive summary: 2010 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care","volume":"122","author":"Field","year":"2010","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041103204474700_b35-0740295","doi-asserted-by":"crossref","first-page":"S368","DOI":"10.1161\/CIR.0000000000000253","article-title":"Part 2: evidence evaluation and management of conflicts of interest: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care","volume":"132","author":"Morrison","year":"2015","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041103204474700_b36-0740295","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.resuscitation.2009.04.005","article-title":"Reduced effectiveness of vasopressin in repeated doses for patients undergoing prolonged cardiopulmonary resuscitation","volume":"80","author":"Mukoyama","year":"2009","journal-title":"Resuscitation"},{"key":"key\n\t\t\t\t2019041103204474700_b37-0740295","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1056\/NEJMoa0706873","article-title":"Vasopressin and epinephrine vs. epinephrine alone in cardiopulmonary resuscitation","volume":"359","author":"Gueugniaud","year":"2008","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b38-0740295","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.resuscitation.2012.02.005","article-title":"A randomised, double-blind, multi-centre trial comparing vasopressin and adrenaline in patients with cardiac arrest presenting to or in the emergency department","volume":"83","author":"Ong","year":"2012","journal-title":"Resuscitation"},{"key":"key\n\t\t\t\t2019041103204474700_b39-0740295","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1056\/NEJMoa025431","article-title":"A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation","volume":"350","author":"Wenzel","year":"2004","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b40-0740295","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jemermed.2010.02.030","article-title":"Effect of the addition of vasopressin or vasopressin plus nitroglycerin to epinephrine on arterial blood pressure during cardiopulmonary resuscitation in humans","volume":"41","author":"Ducros","year":"2011","journal-title":"J Emerg Med"},{"key":"key\n\t\t\t\t2019041103204474700_b41-0740295","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0140-6736(97)80087-6","article-title":"Randomised comparison of epinephrine and vasopressin in patients with out-of-hospital ventricular fibrillation","volume":"349","author":"Lindner","year":"1997","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041103204474700_b42-0740295","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.amjcard.2006.06.022","article-title":"Usefulness of vasopressin administered with epinephrine during out-of-hospital cardiac arrest","volume":"98","author":"Callaway","year":"2006","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t2019041103204474700_b43-0740295","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.resuscitation.2011.06.029","article-title":"Effect of adrenaline on survival in out-of-hospital cardiac arrest: a randomized double-blind placebo-controlled trial","volume":"82","author":"Jacobs","year":"2011","journal-title":"Resuscitation"},{"key":"key\n\t\t\t\t2019041103204474700_b44-0740295","doi-asserted-by":"crossref","first-page":"g3028","DOI":"10.1136\/bmj.g3028","article-title":"Time to administration of epinephrine and outcome after in-hospital cardiac arrest with non-shockable rhythms: retrospective analysis of large in-hospital data registry","volume":"348","author":"Donnino","year":"2014","journal-title":"BMJ"},{"key":"key\n\t\t\t\t2019041103204474700_b45-0740295","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.resuscitation.2013.03.023","article-title":"Rapid epinephrine administration improves early outcomes in out-of-hospital cardiac arrest","volume":"84","author":"Koscik","year":"2013","journal-title":"Resuscitation"},{"key":"key\n\t\t\t\t2019041103204474700_b46-0740295","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1553-2712.2012.01387.x","article-title":"Association between timing of epinephrine administration and intact neurologic survival following out-of-hospital cardiac arrest in Japan: a population-based prospective observational study","volume":"19","author":"Nakahara","year":"2012","journal-title":"Acad Emerg Med"},{"key":"key\n\t\t\t\t2019041103204474700_b47-0740295","doi-asserted-by":"crossref","first-page":"R188","DOI":"10.1186\/cc12872","article-title":"Effects of prehospital epinephrine during out of-hospital cardiac arrest with initial non-shockable rhythm: an observational cohort study","volume":"17","author":"Goto","year":"2013","journal-title":"Crit Care"},{"key":"key\n\t\t\t\t2019041103204474700_b48-0740295","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1001\/archinternmed.2008.509","article-title":"Vasopressin, epinephrine, and corticosteroids for in-hospital cardiac arrest","volume":"169","author":"Mentzelopoulos","year":"2009","journal-title":"Arch Intern Med"},{"key":"key\n\t\t\t\t2019041103204474700_b49-0740295","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1001\/jama.2013.7832","article-title":"Vasopressin, steroids, and epinephrine and neurologically favorable survival after in-hospital cardiac arrest: a randomized clinical trial","volume":"310","author":"Mentzelopoulos","year":"2013","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041103204474700_b50-0740295","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0196-0644(84)80059-1","article-title":"Prehospital use of dexamethasone in pulseless idioventricular rhythm","volume":"13","author":"Paris","year":"1984","journal-title":"Ann Emerg Med"},{"key":"key\n\t\t\t\t2019041103204474700_b51-0740295","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ajem.2006.12.007","article-title":"The effect of hydrocortisone on the outcome of out-of-hospital cardiac arrest patients: a pilot study","volume":"25","author":"Tsai","year":"2007","journal-title":"Am J Emerg Med"},{"key":"key\n\t\t\t\t2019041103204474700_b52-0740295","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJMoa003289","article-title":"Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia","volume":"346","author":"Bernard","year":"2002","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b53-0740295","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJMoa012689","article-title":"Mild hypothermia to improve the neurologic outcome after cardiac arrest","volume":"346","author":"The Hypothermia after Cardiac Arrest Study Group","year":"2002","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b54-0740295","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1056\/NEJMoa1310519","article-title":"Targeted temperature management at 33 \u00b0C versus 36 \u00b0C after cardiac arrest","volume":"369","author":"Nielsen","year":"2013","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b55-0740295","first-page":"1493","article-title":"ACC\/AHA\/ESC guidelines for the management of patients with supraventricular arrhythmias\u2014executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Supraventricular Arrhythmias) developed in collaboration with NASPE-Heart Rhythm Society","volume":"42","author":"Bl\u00f6mstrom-Lundqvist","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019041103204474700_b56-0740295","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1161\/CIR.0000000000000040","article-title":"2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society","volume":"130","author":"January","year":"2014","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041103204474700_b57-0740295","first-page":"e222","article-title":"Risk stratification for arrhythmic events in patients with asymptomatic pre-excitation: a systematic review for the 2015 ACC\/AHA\/HRS guideline for the management of adult patients with supraventricular tachycardia: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society","volume":"13","author":"Al-Khatib","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019041103204474700_b58-0740295","volume-title":"Corlanor (ivabradine) package insert","year":"2015"},{"key":"key\n\t\t\t\t2019041103204474700_b59-0740295","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0140-6736(08)61170-8","article-title":"Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial","volume":"372","author":"Fox","year":"2008","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041103204474700_b60-0740295","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0140-6736(10)61198-1","article-title":"Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study","volume":"376","author":"Swedberg","year":"2010","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041103204474700_b61-0740295","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.jacc.2012.06.031","article-title":"Clinical efficacy of ivabradine in patients with inappropriate sinus tachycardia: a prospective, randomized, placebo-controlled, double-blind, crossover evaluation","volume":"60","author":"Cappato","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2019041103204474700_b62-0740295","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/pace.12118","article-title":"Long-term outcomes of ivabradine in inappropriate sinus tachycardia patients: appropriate efficacy or inappropriate patients","volume":"36","author":"Benezet-Mazuecos","year":"2013","journal-title":"Pacing Clin Electrophysiol"},{"key":"key\n\t\t\t\t2019041103204474700_b63-0740295","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/europace\/eus204","article-title":"Metoprolol succinate vs. ivabradine in the treatment of inappropriate sinus tachycardia in patients unresponsive to previous pharmacological therapy","volume":"15","author":"Ptaszynski","year":"2013","journal-title":"Europace"},{"key":"key\n\t\t\t\t2019041103204474700_b64-0740295","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1067\/mhj.2001.115439","article-title":"Efficacy and safety of dofetilide in the prevention of symptomatic episodes of paroxysmal supraventricular tachycardia: a 6-month double-blind comparison with propaf-enone and placebo","volume":"142","author":"Tendera","year":"2001","journal-title":"Am Heart J"},{"key":"key\n\t\t\t\t2019041103204474700_b65-0740295","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1161\/01.CIR.102.19.2385","article-title":"Efficacy and safety of oral dofetilide in converting to and maintaining sinus rhythm in patients with chronic atrial fibrillation or atrial flutter: the Symptomatic Atrial Fibrillation Investigative Research on Dofetilide (SAFIRE-D) study","volume":"102","author":"Singh","year":"2000","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041103204474700_b66-0740295","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1097\/CCM.0b013e3181a40116","article-title":"Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition","volume":"37","author":"Martindale","year":"2009","journal-title":"Crit Care Med"},{"key":"key\n\t\t\t\t2019041103204474700_b67-0740295","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/CCM.0000000000001525","article-title":"Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)","volume":"44","author":"Taylor","year":"2016","journal-title":"Crit Care Med"},{"key":"key\n\t\t\t\t2019041103204474700_b68-0740295","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.3945\/ajcn.114.088609","article-title":"Hypocaloric compared with eucaloric nutritional support and its effect on infection rates in a surgical intensive care unit: a randomized controlled trial","volume":"100","author":"Charles","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"key\n\t\t\t\t2019041103204474700_b69-0740295","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13613-015-0079-3","article-title":"A J-shaped relationship between caloric intake and survival in critically ill patients","volume":"5","author":"Crosara","year":"2015","journal-title":"Ann Intensive Care"},{"key":"key\n\t\t\t\t2019041103204474700_b70-0740295","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1001\/jama.2012.137","article-title":"Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial","volume":"307","author":"Rice","year":"2012","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041103204474700_b71-0740295","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00134-015-4131-4","article-title":"Normocaloric versus hypocaloric feeding on the outcomes of ICU patients: a systematic review and meta-analysis","volume":"42","author":"Marik","year":"2016","journal-title":"Intensive Care Med"},{"key":"key\n\t\t\t\t2019041103204474700_b72-0740295","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/CCM.0b013e31827e83af","article-title":"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2012","volume":"41","author":"Dellinger","year":"2013","journal-title":"Crit Care Med"},{"key":"key\n\t\t\t\t2019041103204474700_b73-0740295","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/jac\/dkl478","article-title":"Is continuous infusion ceftriaxone better than once-a-day dosing in intensive care? A randomized controlled pilot study","volume":"59","author":"Roberts","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019041103204474700_b74-0740295","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/cid\/cis856","article-title":"Continuous infusion of beta-lactam antibiotics in severe sepsis: a multicenter double-blind, randomized controlled trial","volume":"56","author":"Dulhunty","year":"2013","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t2019041103204474700_b75-0740295","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s00134-015-4188-0","article-title":"Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis","volume":"42","author":"Abdul-Aziz","year":"2016","journal-title":"Intensive Care Med"},{"key":"key\n\t\t\t\t2019041103204474700_b76-0740295","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/MCC.0b013e3282e2a98f","article-title":"Continuous infusion of beta-lactams","volume":"13","author":"Mouton","year":"2007","journal-title":"Curr Opin Crit Care"},{"key":"key\n\t\t\t\t2019041103204474700_b77-0740295","doi-asserted-by":"crossref","first-page":"E219","DOI":"10.33321\/cdi.2013.37.33","article-title":"Australian Group on Antimicrobial Resistance community-onset gram-negative surveillance program annual report, 2010","volume":"37","author":"Turnidge","year":"2013","journal-title":"Commun Dis Intell Q Rep"},{"key":"key\n\t\t\t\t2019041103204474700_b78-0740295","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13054-015-0822-z","article-title":"Efficacy and safety of citrate-based anticoagulation compared to heparin in patients with acute kidney injury requiring continuous renal replacement therapy: a randomized controlled trial","volume":"19","author":"Stucker","year":"2015","journal-title":"Crit Care"},{"key":"key\n\t\t\t\t2019041103204474700_b79-0740295","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1007\/s00134-015-4099-0","article-title":"Citrate versus heparin anticoagulation for continuous renal replacement therapy: an updated meta-analysis of RCTs","volume":"41","author":"Bai","year":"2015","journal-title":"Intensive Care Med"},{"key":"key\n\t\t\t\t2019041103204474700_b80-0740295","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40560-015-0102-7","article-title":"Implementation of continuous renal replacement therapy with regional citrate anticoagulation on a surgical and trauma intensive care unit: impact on clinical and economic aspects\u2014an observational study","volume":"3","author":"Hafner","year":"2015","journal-title":"J Intensive Care"},{"key":"key\n\t\t\t\t2019041103204474700_b81-0740295","doi-asserted-by":"crossref","first-page":"R162","DOI":"10.1186\/cc11485","article-title":"Continuous venovenous hemodialysis with regional citrate anticoagulation in patients with liver failure: a prospective observational study","volume":"16","author":"Schultheiss","year":"2012","journal-title":"Crit Care"},{"key":"key\n\t\t\t\t2019041103204474700_b82-0740295","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s13054-015-1066-7","article-title":"Safety and efficacy of regional citrate anticoagulation in continuous venovenous hemodialysis in the presence of liver failure: the Liver Citrate Anticoagulation Threshold (L-CAT) observational study","volume":"19","author":"Slowinski","year":"2015","journal-title":"Crit Care"},{"key":"key\n\t\t\t\t2019041103204474700_b83-0740295","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jcrc.2009.01.003","article-title":"State of the art: sedation concepts with volatile anesthetics in critically ill patients","volume":"24","author":"Soukup","year":"2009","journal-title":"J Crit Care"},{"key":"key\n\t\t\t\t2019041103204474700_b84-0740295","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1161\/STROKEAHA.113.002703","article-title":"Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery","volume":"44","author":"Mathew","year":"2013","journal-title":"Stroke"},{"key":"key\n\t\t\t\t2019041103204474700_b85-0740295","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1001\/jama.291.14.1720","article-title":"A multicenter risk index for atrial fibrillation after cardiac surgery","volume":"291","author":"Mathew","year":"2004","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041103204474700_b86-0740295","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/1053-0770(91)90274-W","article-title":"Hypomagnesemia is common following cardiac surgery","volume":"5","author":"Aglio","year":"1991","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"key\n\t\t\t\t2019041103204474700_b87-0740295","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1136\/hrt.2004.033811","article-title":"Effects of magnesium on atrial fibrillation after cardiac surgery: a meta-analysis","volume":"91","author":"Miller","year":"2005","journal-title":"Heart"},{"key":"key\n\t\t\t\t2019041103204474700_b88-0740295","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1161\/01.CIR.94.3.390","article-title":"Predictors of atrial fibrillation after coronary artery surgery. Current trends and impact on hospital resources","volume":"94","author":"Aranki","year":"1996","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041103204474700_b89-0740295","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.athoracsur.2003.08.027","article-title":"The efficacy of supplemental magnesium in reducing atrial fibrillation after coronary artery bypass grafting","volume":"77","author":"Hazelrigg","year":"2004","journal-title":"Ann Thorac Surg"},{"key":"key\n\t\t\t\t2019041103204474700_b90-0740295","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1745-6215-13-41","article-title":"Intravenous magnesium prevents atrial fibrillation after coronary artery bypass grafting: a meta-analysis of 7 double-blind, placebo-controlled, randomized clinical trials","volume":"13","author":"Gu","year":"2012","journal-title":"Trials"},{"key":"key\n\t\t\t\t2019041103204474700_b91-0740295","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1056\/NEJMoa1404380","article-title":"Goal-directed resuscitation for patients with early septic shock","volume":"371","author":"Peake","year":"2014","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b92-0740295","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1056\/NEJMoa1401602","article-title":"A randomized trial of protocol-based care for early septic shock","volume":"370","author":"Yealy","year":"2014","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b93-0740295","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa010307","article-title":"Early goal-directed therapy in the treatment of severe sepsis and septic shock","volume":"345","author":"Rivers","year":"2001","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b94-0740295","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.2014.2637","article-title":"Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000\u20132012","volume":"311","author":"Kaukonen","year":"2014","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041103204474700_b95-0740295","unstructured":"Surviving Sepsis Campaign. Updated bundles in response to new evidence (April2015). www.survivingsepsis.org\/SiteCollectionDocuments\/SSC_Bundle.pdf (accessed 2015 Dec 28)."},{"key":"key\n\t\t\t\t2019041103204474700_b96-0740295","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1001\/jama.2010.158","article-title":"Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial","volume":"303","author":"Jones","year":"2010","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041103204474700_b97-0740295","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1164\/rccm.200912-1918OC","article-title":"Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial","volume":"182","author":"Jansen","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t2019041103204474700_b98-0740295","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1007\/s00134-015-3822-1","article-title":"A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators","volume":"41","author":"Angus","year":"2015","journal-title":"Intensive Care Med"},{"key":"key\n\t\t\t\t2019041103204474700_b99-0740295","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1056\/NEJMoa1113849","article-title":"Effect of daily chlorhexidine bathing on hospital-acquired infection","volume":"368","author":"Climo","year":"2013","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b100-0740295","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1161\/STR.0b013e318284056a","article-title":"Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"44","author":"Jauch","year":"2013","journal-title":"Stroke"},{"key":"key\n\t\t\t\t2019041103204474700_b101-0740295","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1161\/STROKEAHA.110.612358","article-title":"Recombinant tissue-type plasminogen activator use for ischemic stroke in the United States: a doubling of treatment rates over the course of 5 years","volume":"42","author":"Adeoye","year":"2011","journal-title":"Stroke"},{"key":"key\n\t\t\t\t2019041103204474700_b102-0740295","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3171\/jns.1992.77.2.0169","article-title":"Pathophysiology and treatment of focal cerebral ischemia. Part I: pathophysiology","volume":"77","author":"Siesio","year":"1992","journal-title":"J Neurosurg"},{"key":"key\n\t\t\t\t2019041103204474700_b103-0740295","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0304-3940(00)01048-X","article-title":"Survival and histological evaluation of therapeutic window of post-ischemia treatment with magnesium sulfate in embolic stroke model of rat","volume":"285","author":"Yang","year":"2000","journal-title":"Neurosci Lett"},{"key":"key\n\t\t\t\t2019041103204474700_b104-0740295","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jstrokecerebrovasdis.2004.04.001","article-title":"Hyperacute treatment initiation in neuroprotective agent stroke trials","volume":"13","author":"Ferguson","year":"2004","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"key\n\t\t\t\t2019041103204474700_b105-0740295","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1086\/649554","article-title":"Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America","volume":"50","author":"Solomkin","year":"2010","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t2019041103204474700_b106-0740295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1749-7922-8-1","article-title":"Complicated intra-abdominal infections in a worldwide context: an observational prospective study (CIAOW study)","volume":"8","author":"Sartelli","year":"2013","journal-title":"World J Emerg Surg"},{"key":"key\n\t\t\t\t2019041103204474700_b107-0740295","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/bjs.1800810720","article-title":"Minimal antibiotic therapy after emergency abdominal surgery: a prospective study","volume":"81","author":"Schein","year":"1994","journal-title":"Br J Surg"},{"key":"key\n\t\t\t\t2019041103204474700_b108-0740295","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s11605-007-0277-x","article-title":"A prospective, double-blind, multicenter, randomized trial comparing ertapenem 3 vs \u22655 days in community-acquired intraabdominal infection","volume":"12","author":"Basoli","year":"2008","journal-title":"J Gastrointest Surg"},{"key":"key\n\t\t\t\t2019041103204474700_b109-0740295","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1749-7922-7-36","article-title":"Complicated intra-abdominal infections in Europe: a comprehensive review of the CIAO study","volume":"7","author":"Sartelli","year":"2012","journal-title":"World J Emerg Surg"},{"key":"key\n\t\t\t\t2019041103204474700_b110-0740295","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/MCC.0b013e32825a6720","article-title":"Intra-abdominal infections","volume":"13","author":"Pieracci","year":"2007","journal-title":"Curr Opin Crit Care"},{"key":"key\n\t\t\t\t2019041103204474700_b111-0740295","first-page":"CD008409","article-title":"Progesterone for acute traumatic brain injury","volume":"10","author":"Ma","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t2019041103204474700_b112-0740295","doi-asserted-by":"crossref","first-page":"7070","DOI":"10.1007\/s12035-015-9614-3","article-title":"Efficacy of progesterone for acute traumatic brain injury: a meta-analysis of randomized controlled trials","volume":"53","author":"Wang","year":"2016","journal-title":"Mol Neurobiol"},{"key":"key\n\t\t\t\t2019041103204474700_b113-0740295","doi-asserted-by":"crossref","first-page":"e0140624","DOI":"10.1371\/journal.pone.0140624","article-title":"Progesterone for acute traumatic brain injury: a systematic review of randomized controlled trials","volume":"10","author":"Zeng","year":"2015","journal-title":"PloS One"},{"key":"key\n\t\t\t\t2019041103204474700_b114-0740295","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jsbmb.2015.11.010","article-title":"Progesterone neuroprotection: the background of clinical trial failure","volume":"160","author":"Schumacher","year":"2016","journal-title":"J Steroid Biochem Mol Biol"},{"key":"key\n\t\t\t\t2019041103204474700_b115-0740295","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1056\/NEJMe1412951","article-title":"Progesterone for traumatic brain injury\u2014resisting the siren\u2019s song","volume":"371","author":"Schwamm","year":"2014","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041103204474700_b116-0740295","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.annemergmed.2006.07.932","article-title":"ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury","volume":"49","author":"Wright","year":"2007","journal-title":"Ann Emerg Med"},{"key":"key\n\t\t\t\t2019041103204474700_b117-0740295","doi-asserted-by":"crossref","first-page":"R61","DOI":"10.1186\/cc6887","article-title":"Improved outcomes from the administration of progesterone for patients with severe traumatic brain injury: a randomized controlled trial","volume":"12","author":"Xiao","year":"2008","journal-title":"Crit Care"},{"key":"key\n\t\t\t\t2019041103204474700_b118-0740295","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1227\/NEU.0000000000000575","article-title":"Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study","volume":"76","author":"Maas","year":"2015","journal-title":"Neurosurgery"},{"key":"key\n\t\t\t\t2019041103204474700_b119-0740295","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.3109\/02699052.2015.1065344","article-title":"Embracing failure: what the phase III progesterone studies can teach about TBI clinical trials","volume":"29","author":"Stein","year":"2015","journal-title":"Brain Inj"}],"container-title":["American Journal of Health-System Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ajhp\/article-pdf\/74\/5\/295\/28336998\/ajhp0295.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T09:26:46Z","timestamp":1749979606000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajhp\/article\/74\/5\/295\/5102726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,1]]},"references-count":119,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,3,1]]}},"URL":"https:\/\/doi.org\/10.2146\/ajhp160144","relation":{},"ISSN":["1079-2082","1535-2900"],"issn-type":[{"value":"1079-2082","type":"print"},{"value":"1535-2900","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,3,1]]},"published":{"date-parts":[[2017,3,1]]}}}