{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:50:05Z","timestamp":1782190205888,"version":"3.54.5"},"reference-count":69,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AABC"],"DOI":"10.2147\/aabc.s495947","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T04:05:11Z","timestamp":1738728311000},"page":"179-201","source":"Crossref","is-referenced-by-count":4,"title":["Virtual Screening, Toxicity Evaluation and Pharmacokinetics of Erythrina Alkaloids as Acetylcholinesterase Inhibitor Candidates from Natural Products"],"prefix":"10.2147","volume":"Volume 17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6691-1173","authenticated-orcid":true,"given":"Afri","family":"Permana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1830-1389","authenticated-orcid":true,"given":"Abd Wahid Rizaldi","family":"Akili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6065-5437","authenticated-orcid":true,"given":"Ari","family":"Hardianto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalifah","family":"Latip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8977-2485","authenticated-orcid":true,"given":"Allyn","family":"Sulaeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0007-8695","authenticated-orcid":true,"given":"Tati","family":"Herlina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"5541","DOI":"10.2147\/IJN.S200490","volume":"14","author":"Tiwari","year":"2019","journal-title":"Int J Nanomed"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1094351","DOI":"10.3389\/fphar.2022.1094351","volume":"13","author":"Subramanian","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e13587","DOI":"10.1590\/1414-431X2024e13587","volume":"57","author":"Reshma","year":"2024","journal-title":"Braz J Med Biol Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e202401430","DOI":"10.1002\/cbdv.202401430","volume":"21","author":"Subramanian","year":"2024","journal-title":"Chem Biodivers"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e202401430","DOI":"10.1002\/cbdv.202401430","volume":"21","author":"Giacobini","year":"2003","journal-title":"Neurochem Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.20959\/wjpps20217-19427","volume":"10","author":"Anawal","year":"2021","journal-title":"World J Pharm Pharm Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"101715","DOI":"10.1016\/j.toxrep.2024.101715","volume":"13","author":"Subramanian","year":"2024","journal-title":"Toxicol Rep"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s43042-020-00127-8","volume":"22","author":"Sarkar","year":"2021","journal-title":"Egypt J Med Hum Genet"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2","DOI":"10.14283\/jpad.2018.43","volume":"6","author":"Hampel","year":"2019","journal-title":"J Prev Alzheimers Dis"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1093\/brain\/awy132","volume":"141","author":"Hampel","year":"2018","journal-title":"Brain"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"926607","DOI":"10.3389\/fphar.2022.926607","volume":"13","author":"Asgharian","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.aquaculture.2015.03.014","volume":"446","author":"Van","year":"2015","journal-title":"Aquaculture"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1111\/jphp.12090","volume":"65","author":"Konrath","year":"2013","journal-title":"J Pharm Pharmacol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2018.01192","volume":"9","author":"Dos Santos","year":"2018","journal-title":"Front Pharmacol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/emboj\/cdg005","volume":"22","author":"Bourne","year":"2003","journal-title":"EMBO J."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.2174\/156802607782507466","volume":"7","author":"Kikuchi","year":"2007","journal-title":"Curr Top Med Chem"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1038\/s41598-018-19999-3","volume":"8","author":"Zhou","year":"2018","journal-title":"Sci Rep"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1584\/jpestics.G08-25","volume":"33","author":"Zhao","year":"2008","journal-title":"J Pestic Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"4250","DOI":"10.1021\/jm070100g","volume":"50","author":"Piazzi","year":"2007","journal-title":"J Med Chem"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"89","DOI":"10.14529\/jsfi180410","volume":"5","author":"Lushchekina","year":"2008","journal-title":"Supercomput Front Innov"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1080\/14786419.2018.1564300","volume":"34","author":"Fahmy","year":"2020","journal-title":"Nat Prod Res"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"919","DOI":"10.3109\/13880209.2011.649429","volume":"50","author":"Santos","year":"2012","journal-title":"Pharm Biol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s40203-021-00110-0","volume":"9","author":"Patil","year":"2021","journal-title":"In Silico Pharmacol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"171","DOI":"10.21608\/aps.2023.207482.1119","volume":"7","author":"Salem","year":"2023","journal-title":"Archiv Pharmaceutical Sci Ain Shams Univ"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e82726","DOI":"10.1371\/journal.pone.0082726","volume":"8","author":"Setti-Perdig\u00e3o","year":"2013","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/jphp.13039","volume":"71","author":"Dias","year":"2019","journal-title":"J Pharm Pharmacol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"6","DOI":"10.36647\/TTRRAMB\/02.01.A002","volume":"2","author":"Patel","year":"2023","journal-title":"Technoarete Transact Recent Res Appl Microbiol Biotechnol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/nprot.2016.051","volume":"11","author":"Forli","year":"2016","journal-title":"J Nat Protoc"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"10282","DOI":"10.1021\/jm300871x","volume":"55","author":"Cheung","year":"2012","journal-title":"J Med Chem"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"4066","DOI":"10.1021\/acs.jmedchem.5b00104","volume":"58","author":"Pires","year":"2015","journal-title":"J Med Che"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"3099","DOI":"10.1021\/ci300367a","volume":"52","author":"Cheng","year":"2012","journal-title":"J Chem Inf Model"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.addr.2012.09.019","volume":"64","author":"Lipinski","year":"2012","journal-title":"J Adv Drug Deliv Rev"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"15033","DOI":"10.3390\/ijms241915033","volume":"24","author":"Hardianto","year":"2023","journal-title":"Int J mol Sci"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.22146\/ijc.65951","volume":"21","author":"Hardianto","year":"2021","journal-title":"Indonesian J Chem"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"829","DOI":"10.2147\/OTT.S482469","volume":"17","author":"Herlina","year":"2024","journal-title":"Onco Targets Ther"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/b978-0-323-98367-9.00016-0","author":"Gupta","year":"2022","journal-title":"Pharmacokinetics and Toxicokinetic Considerations"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1177\/026119290903700506","volume":"37","author":"Vedani","year":"2009","journal-title":"Altern Lab Anim"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1080\/07391102.2020.1841028","volume":"40","author":"Azam","year":"2022","journal-title":"J Biomol Struct Dyn"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"73","DOI":"10.26686\/nzsr.v68.8841","volume":"68","author":"Lillis","year":"2023","journal-title":"New Zealand Science Review"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"100847","DOI":"10.1016\/j.bbrep.2020.100847","volume":"25","author":"Raj","year":"2021","journal-title":"Biochem Biophys Rep"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ph14090937","volume":"14","author":"Iqbal","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40985-018-0099-2","volume":"39","author":"Okocha","year":"2018","journal-title":"Public Health Rev"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2019.01482","volume":"10","author":"Meunier","year":"2019","journal-title":"Front Pharmacol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"6526","DOI":"10.1021\/jp412776d","volume":"118","author":"Pitera","year":"2014","journal-title":"J Phys Chem B"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"78","DOI":"10.7324\/japs.2023.130209","volume":"13","author":"Nishinarizki","year":"2023","journal-title":"J Appl Pharm Sci"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.bpj.2009.11.011","volume":"98","author":"Kuzmanic","year":"2010","journal-title":"Biophysj"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.molliq.2022.118901","author":"Ghahremanian","year":"2022","journal-title":"J Mol Liq"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"3387","DOI":"10.3390\/molecules24183387","volume":"24","author":"Cob-Calan","year":"2019","journal-title":"Molecules"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"3655","DOI":"10.1080\/07391102.2020.1848630","volume":"40","author":"Tripathi","year":"2022","journal-title":"J Biomol Struct Dyn"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.cbi.2008.05.035","volume":"175","author":"Silman","year":"2008","journal-title":"Chem Biol Interact"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"7046","DOI":"10.1021\/bi300955k","volume":"51","author":"Macdonald","year":"2012","journal-title":"Biochemistry"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ijbiomac.2021.03.198","volume":"182","author":"Liu","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"10572","DOI":"10.1021\/ja020243m","volume":"124","author":"Zhang","year":"2002","journal-title":"J Am Chem Soc"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"23070","DOI":"10.1021\/jp053736x","volume":"109","author":"Gao","year":"2005","journal-title":"J Phys Chem B"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"30905","DOI":"10.1074\/jbc.M303730200","volume":"278","author":"Shi","year":"2003","journal-title":"J Biol Chem"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1016\/s0006-3495(03)74651-7","volume":"85","author":"Bui","year":"2003","journal-title":"Biophys. J."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.bbrc.2005.05.068","volume":"332","author":"Choudhary","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/molecules26061776","volume":"26","author":"Zhu","year":"2021","journal-title":"Molecules"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"20","DOI":"10.2174\/1386207323666200609141517","volume":"24","author":"Son","year":"2021","journal-title":"Comb Chem High Throughput Screen"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/S0006-291X(03)01006-4","volume":"306","author":"Plaper","year":"2023","journal-title":"Biochem Biophys Res Commun"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13321-020-0408-x","volume":"12","author":"Schaduangrat","year":"2020","journal-title":"J Cheminform"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"e0190319","DOI":"10.1371\/journal.pone.0190319","volume":"12","author":"Bittermann","year":"2017","journal-title":"PLoS One"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s13311-021-01146-y","volume":"19","author":"Trejo-Lopez","year":"2022","journal-title":"Neurotherapeutics"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.3389\/fmicb.2020.01669","volume":"11","author":"\u00c1","year":"2020","journal-title":"Front Microbiol"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1517\/17460441.2.5.697","volume":"2","author":"Lahlou","year":"2007","journal-title":"Expert Opin Drug Discov"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"8010","DOI":"10.3390\/molecules28248010","volume":"28","author":"Akili","year":"2023","journal-title":"Molecules"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fneur.2020.594672","volume":"11","author":"Bernardo-castro","year":"2020","journal-title":"Front Neurol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/jpm8010001","volume":"8","author":"Daly","year":"2018","journal-title":"J Pers Med"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"221","DOI":"10.2967\/jnmt.117.199638","author":"Currie","year":"2021","journal-title":"J Nucl Med Technol"}],"container-title":["Advances and Applications in Bioinformatics and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/99912","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/99912","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T04:05:15Z","timestamp":1738728315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/virtual-screening-toxicity-evaluation-and-pharmacokinetics-of-erythrin-peer-reviewed-fulltext-article-AABC"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":69,"URL":"https:\/\/doi.org\/10.2147\/aabc.s495947","relation":{},"ISSN":["1178-6949"],"issn-type":[{"value":"1178-6949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]}}}