{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:37:32Z","timestamp":1792121852387,"version":"4.4.0"},"reference-count":43,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BTT"],"DOI":"10.2147\/btt.s500480","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T07:55:12Z","timestamp":1750751712000},"page":"379-386","source":"Crossref","is-referenced-by-count":8,"title":["Marstacimab for the Treatment of Hemophilia A or B"],"prefix":"10.2147","volume":"Volume 19","author":[{"given":"Johnny","family":"Mahlangu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/hae.14046","volume":"26","author":"Srivastava","year":"2020","journal-title":"Haemophilia"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/hae.14035","volume":"27","author":"Mahlangu","year":"2021","journal-title":"Haemophilia"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1080\/17474086.2024.2402304","volume":"17","author":"Mahlangu","year":"2024","journal-title":"Expert Rev Hematol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s40259-018-0315-0","volume":"32","author":"Mahlangu","year":"2018","journal-title":"BioDrugs"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1056\/NEJMoa1803550","volume":"379","author":"Mahlangu","year":"2018","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1056\/NEJMoa1703068","volume":"377","author":"Oldenburg","year":"2017","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e322","DOI":"10.1016\/S2352-3026(23)00037-6","volume":"10","author":"Srivastava","year":"2023","journal-title":"Lancet Haematol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1016\/S0140-6736(23)00284-2","volume":"401","author":"Young","year":"2023","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1182\/blood-2023-179969","volume":"142","author":"Baglin","year":"2023","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1056\/NEJMoa2216455","volume":"389","author":"Matsushita","year":"2023","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/bjh.18420","volume":"200","author":"Mahlangu","year":"2023","journal-title":"Br J Haematol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1111\/jth.14272","volume":"16","author":"Eichler","year":"2018","journal-title":"J Thromb Haemost"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"262","DOI":"10.2741\/3926","volume":"17","author":"Broze","year":"2012","journal-title":"Front Biosci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.3324\/haematol.2011.055699","volume":"97","author":"Marlu","year":"2012","journal-title":"Haematologica"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1111\/hae.13820","volume":"25","author":"Patel-Hett","year":"2019","journal-title":"Haemophilia"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"100018","DOI":"10.1016\/j.rpth.2022.100018","volume":"7","author":"Sidonio","year":"2023","journal-title":"Res Pract Thromb Haemost"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/bjh.18495","volume":"200","author":"Mahlangu","year":"2023","journal-title":"Br J Haematol"},{"key":"ref18","unstructured":"Hympavzi marstacimab package insert P, New York, 2025. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2024\/761369s000lbl.pdf. Accessed April 30, 2025."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"670526","DOI":"10.3389\/fmed.2021.670526","volume":"8","author":"Mahlangu","year":"2021","journal-title":"Front Med Lausanne"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1016\/j.xphs.2018.03.010","volume":"107","author":"Parng","year":"2018","journal-title":"J Pharm Sci"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1182\/blood-2024-205843","volume":"144","author":"Taylor","year":"2024","journal-title":"Blood"},{"key":"ref22","unstructured":"Acharya SS, Matin D, Mahlangu J, et al. Marstacimab, an anti-tissue factor pathway inhibitor, in participants with hemophilia A or B, with and without inhibitors: an integrated analysis of safety. presented at: 65th annual meeting of the American Society of Hematology (ASH), 9\u201312 December, San Diego, California, USA 2023."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1182\/blood-2023-181263","volume":"142","author":"Matino","year":"2023","journal-title":"Blood"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1055\/s-0043-1768660","volume":"49","author":"Pruthi","year":"2023","journal-title":"Semin Thromb Hemost"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1182\/blood-2024-199766","volume":"144","author":"Nayak","year":"2024","journal-title":"Blood"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1111\/jth.14207","volume":"16","author":"Cardinal","year":"2018","journal-title":"J Thromb Haemost"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1182\/blood-2024-205975","volume":"144","author":"Matino","year":"2024","journal-title":"Blood"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1177\/12034754231188444","volume":"27","author":"Kim","year":"2023","journal-title":"J Cutan Med Surg"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1182\/blood.2019001869","volume":"134","author":"Young","year":"2019","journal-title":"Blood"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"Artn2324836","DOI":"10.1080\/19420862.2024.2324836","volume":"16","author":"Sun","year":"2024","journal-title":"Mabs"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"ARTN105","DOI":"10.1186\/s40425-019-0586-0","volume":"7","author":"Davda","year":"2019","journal-title":"J ImmunoTherapy Cancer"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"3980","DOI":"10.1182\/blood-2023-174682","volume":"142","author":"Acharya","year":"2023","journal-title":"Blood"},{"key":"ref33","unstructured":"Benitez O, Kim HK, Taylor CT, et al. Surgical and medical procedures in participants with hemophilia A or B without inhibitors receiving marstacimab in the basis and open-label extension trials. presented at: 18th Annual Congress of the European Association for Haemophilia and Allied Disorders (EAHAD), 4\u20137 February, Milan, 2025.;"},{"key":"ref34","unstructured":"Jim\u00e9nez-Yuste V, Mazar I, Khanji C, et al. Health-related quality of life outcomes for marstacimab in participants with severe hemophilia A or moderately severe to severe hemophilia B without inhibitors: results from the phase 3 basis trial. presented at: 18th Annual Congress of the European Association for Haemophilia and Allied Disorders (EAHAD), 4\u20137 February, Milan, 2025.;"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1182\/blood-2023-180790","volume":"142","author":"Castaman","year":"2023","journal-title":"Blood"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"102364","DOI":"10.1016\/j.rpth.2024.102364","volume":"8","author":"Mahlangu","year":"2024","journal-title":"Res Pract Thromb Haemost"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1136\/annrheumdis-2013-204537","volume":"74","author":"Axelsen","year":"2015","journal-title":"Ann Rheumatic Dis"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1111\/hae.14803","volume":"29","author":"Mannucci","year":"2023","journal-title":"Haemophilia"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1111\/hae.14807","volume":"29","author":"Hermans","year":"2023","journal-title":"Haemophilia"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1080\/14712598.2019.1626370","volume":"19","author":"Mahlangu","year":"2019","journal-title":"Expert Opin Biol Ther"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"5704","DOI":"10.1021\/acsenergylett.4c02662","volume":"9","author":"Olasupo","year":"2024","journal-title":"Acs Energy Lett"},{"key":"ref42","first-page":"26","volume":"29","author":"Lopez-Jaime","year":"2023","journal-title":"Haemophilia"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2217\/frd-2023-0004","volume":"3","author":"Mahlangu","year":"2023","journal-title":"Future Rare Diseases"}],"container-title":["Biologics: Targets and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/104177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/104177","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T07:55:13Z","timestamp":1750751713000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/marstacimab-for-the-treatment-of-hemophilia-a-or-b-peer-reviewed-fulltext-article-BTT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":43,"URL":"https:\/\/doi.org\/10.2147\/btt.s500480","relation":{},"ISSN":["1177-5491"],"issn-type":[{"value":"1177-5491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}