{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:19:37Z","timestamp":1792433977754,"version":"4.5.0"},"reference-count":80,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CCID"],"DOI":"10.2147\/ccid.s380218","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T14:20:37Z","timestamp":1666707637000},"page":"2253-2274","source":"Crossref","is-referenced-by-count":12,"title":["The Anti-Psoriatic Efficacy and Safety Profile of Topical and Intralesional Methotrexate: A Literature Review"],"prefix":"10.2147","volume":"Volume 15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3161-5206","authenticated-orcid":true,"given":"Chayada","family":"Chaiyabutr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Primana","family":"Punnakitikashem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narumol","family":"Silpa-archa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9014-3229","authenticated-orcid":true,"given":"Chanisada","family":"Wongpraprarut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Chularojanamontri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1111\/jdv.16915","volume":"34","author":"Nast","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"199","DOI":"10.7326\/0003-4819-86-2-199","volume":"86","author":"Weinstein","year":"1977","journal-title":"Ann Intern Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1016\/j.ijbiomac.2018.08.136","volume":"120","author":"Tripathi","year":"2018","journal-title":"Int J Biol Macromol"},{"key":"ref4","first-page":"1","volume":"3","author":"Aickara","year":"2020","journal-title":"J Dermatolog Treat"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1177\/247553030814a00105","volume":"14a","author":"Law","year":"2008","journal-title":"Psoriasis Forum"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"S98","DOI":"10.1016\/S0140-6736(15)60413-5","volume":"385","author":"Thomas","year":"2015","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.colsurfb.2010.09.015","volume":"82","author":"Javadzadeh","year":"2011","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3109\/1061186X.2015.1058804","volume":"24","author":"Amarji","year":"2016","journal-title":"J Drug Target"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2340\/0001555566515519","volume":"66","author":"Bjerring","year":"1986","journal-title":"Acta Derm Venereol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1111\/j.1365-4632.2006.02911.x","volume":"45","author":"Eskicirak","year":"2006","journal-title":"Int J Dermatol"},{"key":"ref11","first-page":"3087","volume":"29","author":"Faghihi","year":"2012","journal-title":"J Isfahan Med Sch"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1001\/archderm.1967.01610050005001","volume":"96","author":"Fry","year":"1967","journal-title":"Arch Dermatol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1111\/j.1346-8138.2004.tb00602.x","volume":"31","author":"Kumar","year":"2004","journal-title":"J Dermatol"},{"key":"ref14","first-page":"270","volume":"65","author":"Ravi Kumar","year":"1999","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1001\/archderm.1972.01620120045009","volume":"106","author":"Stewart","year":"1972","journal-title":"Arch Dermatol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1046\/j.1365-4362.2001.01244.x","volume":"40","author":"Sutton","year":"2001","journal-title":"Int J Dermatol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1177\/120347540100500403","volume":"5","author":"Syed","year":"2001","journal-title":"J Cutan Med Surg"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1001\/archderm.1989.01670140079014","volume":"125","author":"Weinstein","year":"1989","journal-title":"Arch Dermatol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"4763","DOI":"10.2147\/IJN.S247007","volume":"15","author":"Agrawal","year":"2020","journal-title":"Int J Nanomedicine"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"554","DOI":"10.3109\/10837450.2015.1026605","volume":"21","author":"Avasatthi","year":"2016","journal-title":"Pharm Dev Technol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.ijpharm.2019.05.036","author":"Bahramizadeh","year":"2019","journal-title":"Int J Pharm"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/exd.12448","volume":"23","author":"Byamba","year":"2014","journal-title":"Exp Dermatol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"362","DOI":"10.2174\/2211738507666190906123643","volume":"7","author":"Chandra","year":"2019","journal-title":"Pharm Nanotechnol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.nano.2019.01.006","volume":"17","author":"Fratoddi","year":"2019","journal-title":"Nanomedicine"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"157","DOI":"10.4103\/0378-6323.32709","volume":"73","author":"Lakshmi","year":"2007","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.colsurfb.2019.06.018","volume":"181","author":"Lim\u00f3n","year":"2019","journal-title":"Colloids Surf B Biointerfaces"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.jid.2019.09.018","volume":"140","author":"\u00d6zcan","year":"2020","journal-title":"J Invest Dermatol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.ijbiomac.2017.10.112","volume":"110","author":"Panonnummal","year":"2018","journal-title":"Int J Biol Macromol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.jddst.2018.12.020","volume":"49","author":"Rajitha","year":"2019","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1080\/10601330701885116","volume":"25","author":"Vanaja","year":"2008","journal-title":"Clin Res Regul Aff"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1093\/jpp\/rgac006","volume":"74","author":"Alves","year":"2022","journal-title":"J Pharm Pharmacol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/nano11123433","volume":"11","author":"Asad","year":"2021","journal-title":"Nanomaterials"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"105956","DOI":"10.1016\/j.ejps.2021.105956","volume":"165","author":"Bernardes","year":"2021","journal-title":"Eur J Pharm Sci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/biology10111121","volume":"10","author":"Rashid","year":"2021","journal-title":"Biology"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1186\/s12951-022-01368-y","volume":"20","author":"Xu","year":"2022","journal-title":"J Nanobiotechnology"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"120826","DOI":"10.1016\/j.ijpharm.2021.120826","volume":"605","author":"Yang","year":"2021","journal-title":"Int J Pharm"},{"key":"ref37","first-page":"I66","volume":"14","author":"Ali","year":"2008","journal-title":"Med Sci Monit"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/ajd.13228","volume":"61","author":"Andanooru Chandrappa","year":"2020","journal-title":"Australas J Dermatol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"43588","DOI":"10.1021\/acsami.9b15668","volume":"11","author":"Du","year":"2019","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"569","DOI":"10.4103\/ijdvl.IJDVL_185_16","volume":"83","author":"Haseena","year":"2017","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1080\/21691401.2018.1440236","volume":"46","author":"Ramez","year":"2018","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1046\/j.1365-4362.2003.01718.x","volume":"42","author":"Tiwari","year":"2003","journal-title":"Intl J Dermatol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"118819","DOI":"10.1016\/j.carbpol.2021.118819","volume":"277","author":"Wang","year":"2022","journal-title":"Carbohydr Polym"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.jaad.2020.04.159","volume":"84","author":"Choudhary","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1590\/abd1806-4841.20198170","volume":"94","author":"Duarte","year":"2019","journal-title":"An Bras Dermatol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1111\/ced.13087","volume":"42","author":"Grover","year":"2017","journal-title":"Clin Exp Dermatol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"e13787","DOI":"10.1111\/dth.13787","volume":"33","author":"Jindal","year":"2020","journal-title":"Dermatol Ther"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"419","DOI":"10.4103\/ijdvl.IJDVL_73_16","volume":"84","author":"Mittal","year":"2018","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1007\/s13555-018-0261-2","volume":"8","author":"Mokni","year":"2018","journal-title":"Dermatol Ther (Heidelb)"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1159\/000323004","volume":"222","author":"Saricaoglu","year":"2011","journal-title":"Dermatology"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"e15660","DOI":"10.1111\/dth.15660","volume":"35","author":"Abdelmeniem","year":"2022","journal-title":"Dermatol Ther"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1097\/DSS.0000000000003418","volume":"48","author":"Alakad","year":"2022","journal-title":"Dermatol Surg"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1111\/ced.15110","volume":"47","author":"Starace","year":"2022","journal-title":"Clin Exp Dermatol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"169","DOI":"10.15171\/apb.2018.021","volume":"8","author":"Haque","year":"2018","journal-title":"Adv Pharm Bull"},{"key":"ref55","first-page":"299","volume":"31","author":"Songkro","year":"2009","journal-title":"Songklanakarin J Sci Technol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e12690","DOI":"10.1111\/dth.12690","volume":"31","author":"Celleno","year":"2018","journal-title":"Dermatol Ther"},{"key":"ref57","volume-title":"Essential Chemistry for Formulators of Semisolid and Liquid Dosages","year":"2016"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3109\/09687688.2010.522203","volume":"27","author":"Desai","year":"2010","journal-title":"Mol Membr Biol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.biopha.2018.07.156","volume":"107","author":"Pradhan","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"606","DOI":"10.2174\/0929867324666171009120154","volume":"25","author":"Carita","year":"2018","journal-title":"Curr Med Chem"},{"key":"ref61","volume-title":"Pharmaceutical Nanotechnology: Basic Protocols","year":"2019"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"807","DOI":"10.4155\/tde-2020-0081","volume":"11","author":"Nayak","year":"2020","journal-title":"Ther Deliv"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"374","DOI":"10.4103\/0110-5558.76435","volume":"1","author":"Kazi","year":"2010","journal-title":"J Adv Pharm Technol Res"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"855","DOI":"10.3390\/pharmaceutics12090855","volume":"12","author":"Opatha","year":"2020","journal-title":"Pharmaceutics"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.jddst.2019.02.017","volume":"51","author":"Salvi","year":"2019","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"5451","DOI":"10.4081\/dr.2014.5451","volume":"6","author":"Vincent","year":"2014","journal-title":"Dermatol Rep"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.addr.2019.07.010","volume":"144","author":"Majumder","year":"2019","journal-title":"Adv Drug Deliv Rev"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.jksus.2017.10.004","volume":"31","author":"Venditti","year":"2019","journal-title":"J King Saud Univ Sci"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1080\/10717544.2016.1276232","volume":"24","author":"Neamtu","year":"2017","journal-title":"Drug Deliv"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nano10010135","volume":"10","author":"Pavoni","year":"2020","journal-title":"Nanomaterials"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3390\/pharmaceutics9040037","volume":"9","author":"CMRR","year":"2017","journal-title":"Pharmaceutics"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.2147\/IJN.S96243","volume":"11","author":"Erdal","year":"2016","journal-title":"Int J Nanomedicine"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.3109\/21691401.2015.1012261","volume":"44","author":"Sharma","year":"2016","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"39","DOI":"10.5530\/srp.2017.1.8","volume":"8","author":"Kale","year":"2016","journal-title":"Sys Rev Pharm"},{"key":"ref75","first-page":"e244","volume":"177","author":"\u00d6zcan","year":"2017","journal-title":"Br J Dermatol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4172\/pharmaceutical-sciences.1000474","volume":"81","author":"Rajak","year":"2019","journal-title":"Indian J Pharm Sci"},{"key":"ref77","volume-title":"Drug Delivery Trends","year":"2020"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.addr.2019.10.003","volume":"153","author":"Wenande","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"key":"ref79","first-page":"1","volume":"6","author":"Lang","year":"2001","journal-title":"Skin Therapy Lett"},{"key":"ref80","volume-title":"Challenges in Delivery of Therapeutic Genomics and Proteomics","year":"2011"}],"container-title":["Clinical, Cosmetic and Investigational Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=84945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=84945","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T14:41:37Z","timestamp":1701268897000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/the-anti-psoriatic-efficacy-and-safety-profile-of-topical-and-intrales-peer-reviewed-fulltext-article-CCID"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":80,"URL":"https:\/\/doi.org\/10.2147\/ccid.s380218","relation":{},"ISSN":["1178-7015"],"issn-type":[{"value":"1178-7015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10]]}}}