{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:59:17Z","timestamp":1780451957395,"version":"3.54.1"},"reference-count":75,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CEG"],"DOI":"10.2147\/ceg.s208020","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T23:22:40Z","timestamp":1588634560000},"page":"131-139","source":"Crossref","is-referenced-by-count":30,"title":["&lt;p&gt;Novel Therapeutic Options for People with Ulcerative Colitis: An Update on Recent Developments with Janus Kinase (JAK)\u00a0Inhibitors&lt;\/p&gt;"],"prefix":"10.2147","volume":"Volume 13","author":[{"given":"Edoardo","family":"Troncone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Marafini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6327-563X","authenticated-orcid":true,"given":"Giovanna","family":"Del Vecchio Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Di Grazia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Monteleone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","volume":"380","author":"Ordas","year":"2012","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1016\/S0140-6736(12)60026-9","volume":"380","author":"Baumgart","year":"2012","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nature06005","volume":"448","author":"Xavier","year":"2007","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/nri2340","volume":"8","author":"Cho","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1084\/jem.20011956","volume":"195","author":"Neurath","year":"2002","journal-title":"J Exp Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.4049\/jimmunol.157.3.1261","volume":"157","author":"Fuss","year":"1996","journal-title":"J Immunol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1159\/000437106","volume":"33","author":"Marafini","year":"2015","journal-title":"Dig Dis"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/S0016-5085(97)70128-8","volume":"112","author":"Monteleone","year":"1997","journal-title":"Gastroenterology"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1136\/gut.43.5.620","volume":"43","author":"Monteleone","year":"1998","journal-title":"Gut"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1126\/science.1106442","volume":"307","author":"Macdonald","year":"2005","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1172\/JCI19836","volume":"113","author":"Fuss","year":"2004","journal-title":"J Clin Invest"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.gastro.2005.05.002","volume":"129","author":"Heller","year":"2005","journal-title":"Gastroenterology"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1136\/gutjnl-2013-305947","volume":"64","author":"Nalleweg","year":"2015","journal-title":"Gut"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1146\/annurev.immunol.25.022106.141557","volume":"25","author":"Weaver","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1146\/annurev-pathol-011110-130318","volume":"8","author":"Weaver","year":"2013","journal-title":"Annu Rev Pathol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/1471-2172-11-61","volume":"11","author":"Bogaert","year":"2010","journal-title":"BMC Immunol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"526","DOI":"10.3109\/08830185.2013.823421","volume":"32","author":"Troncone","year":"2013","journal-title":"Int Rev Immunol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.it.2008.02.008","volume":"29","author":"Monteleone","year":"2008","journal-title":"Trends Immunol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1053\/j.gastro.2008.01.041","volume":"134","author":"Fina","year":"2008","journal-title":"Gastroenterology"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1053\/j.gastro.2004.12.042","volume":"128","author":"Monteleone","year":"2005","journal-title":"Gastroenterology"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1053\/j.gastro.2006.09.053","volume":"132","author":"Caruso","year":"2007","journal-title":"Gastroenterology"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1080\/14740338.2017.1340936","volume":"16","author":"Troncone","year":"2017","journal-title":"Expert Opin Drug Saf"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/ecco-jcc\/jjx009","volume":"11","author":"Harbord","year":"2017","journal-title":"J Crohns Colitis"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1177\/2050640615590302","volume":"3","author":"Cote-Daigneault","year":"2015","journal-title":"United European Gastroenterol J"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1038\/ajg.2008.88","volume":"104","author":"Gisbert","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s00535-017-1324-3","volume":"52","author":"Qiu","year":"2017","journal-title":"J Gastroenterol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1756283X17750355","DOI":"10.1177\/1756283X17750355","volume":"11","author":"Vermeire","year":"2018","journal-title":"Therap Adv Gastroenterol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"h2809","DOI":"10.1136\/bmj.h2809","volume":"350","author":"Nyboe Andersen","year":"2015","journal-title":"BMJ"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.dld.2017.01.141","volume":"49","author":"Biancone","year":"2017","journal-title":"Dig Liver Dis"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1056\/NEJMoa1215734","volume":"369","author":"Feagan","year":"2013","journal-title":"N Engl J Med"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1056\/NEJMoa1900750","volume":"381","author":"Sands","year":"2019","journal-title":"N Engl J Med"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1056\/NEJMoa1602773","volume":"375","author":"Feagan","year":"2016","journal-title":"N Engl J Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"671","DOI":"10.3389\/fphar.2019.00671","volume":"10","author":"Pagnini","year":"2019","journal-title":"Front Pharmacol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1136\/gutjnl-2016-312912","volume":"66","author":"Olivera","year":"2017","journal-title":"Gut"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1056\/NEJMoa1513248","volume":"374","author":"Sandborn","year":"2016","journal-title":"N Engl J Med"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1056\/NEJMoa1606910","volume":"376","author":"Sandborn","year":"2017","journal-title":"N Engl J Med"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1080\/17474124.2018.1503053","volume":"12","author":"Bevivino","year":"2018","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20140712","volume":"462","author":"Babon","year":"2014","journal-title":"Biochem J"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1242\/jcs.00963","volume":"117","author":"Rawlings","year":"2004","journal-title":"J Cell Sci"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.pharmthera.2018.07.003","volume":"192","author":"Soendergaard","year":"2018","journal-title":"Pharmacol Ther"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1080\/14712598.2019.1652267","volume":"19","author":"Marafini","year":"2019","journal-title":"Expert Opin Biol Ther"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nri3661","volume":"14","author":"Neurath","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"8468","DOI":"10.1021\/jm1004286","volume":"53","author":"Flanagan","year":"2010","journal-title":"J Med Chem"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1056\/NEJMoa1112168","volume":"367","author":"Sandborn","year":"2012","journal-title":"N Engl J Med"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1056\/NEJM198712243172603","volume":"317","author":"Schroeder","year":"1987","journal-title":"N Engl J Med"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.cgh.2018.07.009","volume":"17","author":"Hanauer","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref47","unstructured":"Available from: https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/xeljanz. Accessed March 06, 2020."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1093\/ecco-jcc\/jjx133","volume":"12","author":"Panes","year":"2018","journal-title":"J Crohns Colitis"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1007\/s10620-019-05492-y","volume":"64","author":"Weisshof","year":"2019","journal-title":"Dig Dis Sci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.dld.2019.10.003","volume":"52","author":"Lair-Mehiri","year":"2020","journal-title":"Dig Liver Dis"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/apt.15555","volume":"51","author":"Sands","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"837","DOI":"10.3899\/jrheum.130683","volume":"41","author":"Wollenhaupt","year":"2014","journal-title":"J Rheumatol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13075-016-0932-2","volume":"18","author":"Yamanaka","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1111\/bjd.13551","volume":"172","author":"Bissonnette","year":"2015","journal-title":"Br J Dermatol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/S0140-6736(14)62113-9","volume":"386","author":"Bachelez","year":"2015","journal-title":"Lancet"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1093\/ibd\/izy131","volume":"24","author":"Winthrop","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1111\/apt.15514","volume":"50","author":"Sandborn","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.cgh.2019.04.059","volume":"18","author":"Sands","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.001","author":"Olivera","year":"2020","journal-title":"Gastroenterology"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"2494","DOI":"10.1093\/ibd\/izy160","volume":"24","author":"Mahadevan","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz202","author":"Ferrante","year":"2019","journal-title":"J Crohns Colitis"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"4971","DOI":"10.1016\/j.bmc.2018.08.005","volume":"26","author":"Hamaguchi","year":"2018","journal-title":"Bioorg Med Chem"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1093\/ecco-jcc\/jjy085","volume":"12","author":"Sands","year":"2018","journal-title":"J Crohns Colitis"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/apt.15297","volume":"50","author":"Ma","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"ref65","year":"2018"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/apt.14422","volume":"47","author":"Singh","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.dld.2019.02.004","volume":"51","author":"Fiorino","year":"2019","journal-title":"Dig Liver Dis"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1056\/NEJMoa1603800","volume":"375","author":"Cunningham","year":"2016","journal-title":"N Engl J Med"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1056\/NEJMoa1501184","volume":"372","author":"Lal","year":"2015","journal-title":"N Engl J Med"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1093\/ibd\/izy150","volume":"24","author":"Colombel","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"ref71","unstructured":"Available from: https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-approves-boxed-warning-about-increased-risk-blood-clots-and-death-higher-dose-arthritis-and. Accessed August 28, 2019."},{"key":"ref72","unstructured":"Available from: https:\/\/www.ema.europa.eu\/en\/news\/ema-confirms-xeljanz-be-used-caution-patients-high-risk-blood-clots. Accessed November 15, 2019."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.immuni.2012.03.014","volume":"36","author":"O\u2019Shea","year":"2012","journal-title":"Immunity"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1182\/blood-2014-03-560441","volume":"124","author":"Meyer","year":"2014","journal-title":"Blood"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1126\/science.270.5237.800","volume":"270","author":"Nosaka","year":"1995","journal-title":"Science"}],"container-title":["Clinical and Experimental Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=57866","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=57866","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T17:47:38Z","timestamp":1696096058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/novel-therapeutic-options-for-people-with-ulcerative-colitis-an-update-peer-reviewed-article-CEG"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":75,"URL":"https:\/\/doi.org\/10.2147\/ceg.s208020","relation":{},"ISSN":["1178-7023"],"issn-type":[{"value":"1178-7023","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5]]}}}