{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:06:40Z","timestamp":1779113200307,"version":"3.51.4"},"reference-count":76,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIA"],"DOI":"10.2147\/cia.s570497","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T05:40:14Z","timestamp":1771220414000},"page":"1-19","source":"Crossref","is-referenced-by-count":2,"title":["Causal Implication of CD52-Driven Immune Dysregulation in Sarcopenic Obesity: Integrating Mendelian Randomization and Multiomics Profiling"],"prefix":"10.2147","volume":"Volume 21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4079-2364","authenticated-orcid":true,"given":"Saiyare","family":"Xuekelati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilihamu","family":"Abulitifu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoya","family":"Maimaitiwusiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuke","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1083-8048","authenticated-orcid":true,"given":"Qihong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Ke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1007\/s12603-015-0638-1","volume":"20","author":"Poggiogalle","year":"2016","journal-title":"J Nutr Health Aging"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2740","DOI":"10.1016\/j.clnu.2022.10.023","volume":"41","author":"Chuan","year":"2022","journal-title":"Clin Nutr"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13395-022-00309-5","volume":"12","author":"Murdock","year":"2022","journal-title":"Skeletal Muscle"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"100353","DOI":"10.1016\/j.jnha.2024.100353","volume":"28","author":"Yu","year":"2024","journal-title":"J Nutr Health Aging"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/ijo.2009.130","volume":"33","author":"Kim","year":"2009","journal-title":"Int J Obes"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1038\/s43587-025-01004-y","volume":"5","author":"Chen","year":"2025","journal-title":"Nat Aging"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1185221","DOI":"10.3389\/fendo.2023.1185221","volume":"14","author":"Wei","year":"2023","journal-title":"Front Endocrinol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1007\/s11357-022-00567-7","volume":"44","author":"Nunan","year":"2022","journal-title":"Geroscience"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"112390","DOI":"10.1016\/j.exger.2024.112390","volume":"188","author":"Xuekelati","year":"2024","journal-title":"Exp Gerontol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"192","DOI":"10.5534\/wjmh.180001","volume":"36","author":"Shin","year":"2018","journal-title":"World J Mens Health"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/s41574-018-0062-9","volume":"14","author":"Batsis","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1111\/jcmm.17725","volume":"27","author":"Asrih","year":"2023","journal-title":"J Cell Mol Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"115877","DOI":"10.1016\/j.bone.2021.115877","volume":"145","author":"Jung","year":"2021","journal-title":"Bone"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e13195","DOI":"10.1111\/acel.13195","volume":"19","author":"Moon","year":"2020","journal-title":"Aging Cell"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1159\/000490361","volume":"11","author":"Barazzoni","year":"2018","journal-title":"Obes Facts"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12929-020-00679-2","volume":"27","author":"Takahara","year":"2020","journal-title":"J Biomed Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3671","DOI":"10.1172\/JCI120843","volume":"128","author":"Ruegsegger","year":"2018","journal-title":"J Clin Invest"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"856","DOI":"10.3945\/jn.111.139485","volume":"141","author":"Dickinson","year":"2011","journal-title":"J Nutr"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.cmet.2008.06.006","volume":"8","author":"Dong","year":"2008","journal-title":"Cell Metab"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1126\/science.1157535","volume":"320","author":"Sancak","year":"2008","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1681\/ASN.2006010083","volume":"17","author":"Lecker","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.1038\/onc.2008.21","volume":"27","author":"Calnan","year":"2008","journal-title":"Oncogene"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1152\/physiolgenomics.00249.2004","volume":"21","author":"Giresi","year":"2005","journal-title":"Physiol Genomics"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1007\/s00125-005-1868-2","volume":"48","author":"Nair","year":"2005","journal-title":"Diabetologia"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s40001-023-01603-8","volume":"29","author":"Chen","year":"2024","journal-title":"Eur J Med Res"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/jn\/138.5.841","volume":"138","author":"Oort","year":"2008","journal-title":"J Nutr"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.2337\/db08-0349","volume":"57","author":"Lanza","year":"2008","journal-title":"Diabetes"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"14079","DOI":"10.1038\/s41598-020-70244-2","volume":"10","author":"Walker","year":"2020","journal-title":"Sci Rep"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat Commun"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"W438","DOI":"10.1093\/nar\/gkn257","volume":"36","author":"Lin","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s13059-016-1070-5","volume":"17","author":"Becht","year":"2016","journal-title":"Genome Biol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/s41531-023-00591-0","volume":"9","author":"Gu","year":"2023","journal-title":"NPJ Parkinsons Dis"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/ije\/dyr036","volume":"40","author":"Burgess","year":"2011","journal-title":"Int J Epidemiol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1159\/000521241","volume":"15","author":"Donini","year":"2022","journal-title":"Obes Facts"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.3760\/cma.j.issn.0254-9026.2024.12.006","volume":"43","author":"YU","year":"2024","journal-title":"Chin J Geriatr"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.jamda.2014.04.021","volume":"15","author":"Woo","year":"2014","journal-title":"J Am Med Dir Assoc"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363(9403):157\u2013163. doi:10.1016\/S0140-6736(03)15268-3","DOI":"10.1016\/S0140-6736(03)15268-3"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","volume":"21","author":"Chen","year":"2020","journal-title":"J Am Med Dir Assoc"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1046\/j.1532-5415.2002.50216.x","volume":"50","author":"Janssen","year":"2002","journal-title":"J Am Geriatr Soc"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1093\/ndt\/gfm517","volume":"23","author":"Eknoyan","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"M146","DOI":"10.1093\/gerona\/56.3.m146","volume":"56","author":"Fried","year":"2001","journal-title":"J Gerontol a Biol Sci Med Sci"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"112567","DOI":"10.1016\/j.exger.2024.112567","volume":"196","author":"Xuekelati","year":"2024","journal-title":"Exp Gerontol"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34408","author":"Hemani","year":"2018","journal-title":"Elife"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/gepi.21758","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet Epidemiol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1093\/ije\/dyy258","volume":"48","author":"Bowden","year":"2019","journal-title":"Int J Epidemiol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12920-023-01531-w","volume":"16","author":"Zheng","year":"2023","journal-title":"BMC Med Genomics"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.2147\/JIR.S504480","volume":"18","author":"Wu","year":"2025","journal-title":"J Inflamm Res"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1189570","DOI":"10.3389\/fendo.2023.1189570","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Endocrinol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.4049\/jimmunol.157.7.2939","volume":"157","author":"Sz\u00f6ll\u00f3si","year":"1996","journal-title":"J Immunol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s00430-020-00677-z","volume":"209","author":"Dunlock","year":"2020","journal-title":"Med Microbiol Immunol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"919436","DOI":"10.3389\/fonc.2022.919436","volume":"12","author":"Meng","year":"2022","journal-title":"Front Oncol"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"6793346","DOI":"10.1038\/s41574-018-0062-9","volume":"2022","author":"Wen","year":"2022","journal-title":"Genetics Res"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1080\/15548627.2021.1936356","volume":"18","author":"Han","year":"2022","journal-title":"Autophagy"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"4471","DOI":"10.1074\/jbc.M311327200","volume":"279","author":"Zhang","year":"2004","journal-title":"J Biol Chem"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"5776","DOI":"10.1245\/s10434-023-13569-2","volume":"30","author":"Masuda","year":"2023","journal-title":"Ann Surg Oncol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1186\/s12877-023-04152-1","volume":"23","author":"Zhang","year":"2023","journal-title":"BMC Geriatr"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.3390\/medicina59101700","volume":"59","author":"Heo","year":"2023","journal-title":"Medicina"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"3592","DOI":"10.3390\/cancers15143592","volume":"15","author":"Tenuta","year":"2023","journal-title":"Cancers"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1007\/s00125-009-1364-1","volume":"52","author":"Matthews","year":"2009","journal-title":"Diabetologia"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"6856","DOI":"10.1007\/s12035-019-1550-1","volume":"56","author":"Just-Borr\u00e0s","year":"2019","journal-title":"Mol Neurobiol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/s41598-021-03740-8","volume":"12","author":"Cefis","year":"2022","journal-title":"Sci Rep"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.tem.2018.09.003","volume":"29","author":"Graupera","year":"2018","journal-title":"Trends Endocrinol Metab"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/s0145-2126(97)00158-6","volume":"22","author":"Ginaldi","year":"1998","journal-title":"Leuk Res"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.324172","volume":"135","author":"Jiang","year":"2024","journal-title":"Circulation Res"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202714","volume":"13","author":"Mao","year":"2021","journal-title":"Aging"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"3609","DOI":"10.3390\/ijms22073609","volume":"22","author":"De Biase","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s12603-020-1329-0","volume":"24","author":"Huang","year":"2020","journal-title":"J Nutr Health Aging"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.ebiom.2019.10.034","volume":"49","author":"Nelke","year":"2019","journal-title":"EBioMedicine"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.arr.2016.03.006","volume":"27","author":"Saini","year":"2016","journal-title":"Ageing Res Rev"}],"container-title":["Clinical Interventions in Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/112053","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/112053","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T05:40:17Z","timestamp":1771220417000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/causal-implication-of-cd52-driven-immune-dysregulation-in-sarcopenic-o-peer-reviewed-fulltext-article-CIA"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":76,"URL":"https:\/\/doi.org\/10.2147\/cia.s570497","relation":{},"ISSN":["1178-1998"],"issn-type":[{"value":"1178-1998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]}}}