{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:02:19Z","timestamp":1779782539755,"version":"3.53.1"},"reference-count":43,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CIA"],"DOI":"10.2147\/cia.s613629","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:05:14Z","timestamp":1779779114000},"page":"1-20","source":"Crossref","is-referenced-by-count":0,"title":["Multi-Omics Reveals Dysregulation of the Endosome-Lysosome-Autophagy Axis and Immune-Inflammatory Imbalance in Elderly Sepsis"],"prefix":"10.2147","volume":"Volume 21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5653-2266","authenticated-orcid":true,"given":"Yi","family":"Gou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazila","family":"Haireti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailikuti","family":"Aikepaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1602016","DOI":"10.3389\/fnut.2025.1602016","volume":"12","author":"Cai","year":"2025","journal-title":"Front Nutr"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12979-024-00446-z","volume":"21","author":"He","year":"2024","journal-title":"Immun Ageing"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S552626","volume":"2025","author":"Huang","year":"2049\u20132064","journal-title":"Clin Interventions Aging"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1186\/s12879-025-12031-w","volume":"25","author":"Zhu","year":"2025","journal-title":"BMC Infect Dis"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1549138","DOI":"10.3389\/fphys.2025.1549138","volume":"16","author":"Zhu","year":"2025","journal-title":"Front Physiol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1605319","DOI":"10.3389\/fmed.2025.1605319","volume":"12","author":"Zhang","year":"2025","journal-title":"Front Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-025-01966-2","author":"Lin","year":"2025","journal-title":"Geroscience"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.jss.2026.03.002","volume":"321","author":"Wu","year":"2026","journal-title":"J Surg Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"854","DOI":"10.14336\/AD.2018.1027","volume":"10","author":"Xu","year":"2019","journal-title":"Aging and Disease"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"12068","DOI":"10.1038\/s41598-025-92631-3","volume":"15","author":"Gou","year":"2025","journal-title":"Sci Rep"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s12967-022-03320-y","volume":"20","author":"Chen","year":"2022","journal-title":"J Transl Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"112934","DOI":"10.1016\/j.injury.2025.112934","volume":"57","author":"Gou","year":"2026","journal-title":"Injury"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/s41586-022-05354-0","volume":"610","author":"Liu","year":"2022","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"114385","DOI":"10.1016\/j.intimp.2025.114385","volume":"152","author":"Liu","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1242\/jcs.192104","volume":"130","author":"Silva","year":"2017","journal-title":"J Cell Sci"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"eadq7307","DOI":"10.1126\/sciadv.adq7307","volume":"11","author":"Zotta","year":"2025","journal-title":"Sci Adv"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"8133","DOI":"10.1038\/s41467-023-43573-9","volume":"14","author":"Hackert","year":"2023","journal-title":"Nat Commun"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"477","DOI":"10.4161\/auto.7.5.14811","volume":"7","author":"Jegga","year":"2011","journal-title":"Autophagy"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"145","DOI":"10.21315\/mjms2022.29.3.14","volume":"29","author":"Wan Muhd Shukeri","year":"2022","journal-title":"Malays J Med Sci"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1111\/jgs.16435","volume":"68","author":"Mankowski","year":"2020","journal-title":"J American Geriatrics Society"},{"key":"ref22","first-page":"124","volume":"30","author":"Xu","year":"2024","journal-title":"Altern Ther Health Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e02707","DOI":"10.1002\/advs.202502707","volume":"12","author":"Yu","year":"2025","journal-title":"Adv Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"e02931","DOI":"10.1002\/advs.202502931","volume":"12","author":"Zhan","year":"2025","journal-title":"Adv Sci"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Chen J. Mycobacterium tuberculosis modulates phosphorylation of host ATP6V1E1 to promote intracellular survival. Nature Communications. 2026.","DOI":"10.1038\/s41467-026-69331-1"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1438231","DOI":"10.3389\/fcell.2024.1438231","volume":"12","author":"Falvo","year":"2024","journal-title":"Front Cell Dev Biol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1002\/cbdv.200900345","volume":"7","author":"Kinouchi","year":"2010","journal-title":"Chem Biodivers"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"5821","DOI":"10.1007\/s11033-022-07335-y","volume":"49","author":"Du","year":"2022","journal-title":"Mol Biol Rep"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41531-025-00902-7","volume":"11","author":"Mu","year":"2025","journal-title":"npj Parkinsons Dis"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s00232-007-9002-7","volume":"215","author":"Hu","year":"2007","journal-title":"J Membrane Biol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.3390\/biom13121732","volume":"13","author":"Albright","year":"2023","journal-title":"Biomolecules"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"989","DOI":"10.14348\/molcells.2020.0030","volume":"43","author":"Lee","year":"2020","journal-title":"Mol Cells"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1186\/s13054-025-05668-1","volume":"29","author":"Guo","year":"2025","journal-title":"Crit Care"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"159606","DOI":"10.1016\/j.bbalip.2025.159606","volume":"1870","author":"Rosanaly","year":"2025","journal-title":"Biochimica et Biophysica Acta BBA"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1098322","DOI":"10.3389\/fvets.2023.1098322","volume":"10","author":"Bulgarelli","year":"2023","journal-title":"Front Vet Sci"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.3390\/cells11111745","volume":"11","author":"Sehgal","year":"2022","journal-title":"Cells"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1038\/s42003-025-09274-3","volume":"8","author":"Wang","year":"2025","journal-title":"Commun Biol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"3498","DOI":"10.1021\/acs.jproteome.5c00148","volume":"24","author":"Liu","year":"2025","journal-title":"J Proteome Res"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"843","DOI":"10.3390\/ijms22020843","volume":"22","author":"Korbecki","year":"2021","journal-title":"IJMS"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1165\/rcmb.2022-0249OC","volume":"67","author":"Lai","year":"2022","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"e2116027119","DOI":"10.1073\/pnas.2116027119","volume":"119","author":"Tsujihana","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"11","DOI":"10.5152\/ThoracResPract.2023.23024","volume":"25","author":"G\u00fcng\u00f6r","year":"2023","journal-title":"Thorac Res Pract"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1177\/08850666231222838","volume":"39","author":"Baykara","year":"2024","journal-title":"J Intensive Care Med"}],"container-title":["Clinical Interventions in Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/115644","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/115644","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:05:16Z","timestamp":1779779116000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/multi-omics-reveals-dysregulation-of-the-endosome-lysosome-autophagy-a-peer-reviewed-fulltext-article-CIA"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":43,"URL":"https:\/\/doi.org\/10.2147\/cia.s613629","relation":{},"ISSN":["1178-1998"],"issn-type":[{"value":"1178-1998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}