{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T05:10:10Z","timestamp":1778476210466,"version":"3.51.4"},"reference-count":30,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CLEP"],"DOI":"10.2147\/clep.s580997","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T04:35:13Z","timestamp":1778474113000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Logistical Challenges in Platform Randomized Trials - Operational Realities That Curb the Promise of Efficiency"],"prefix":"10.2147","volume":"Volume 18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5848-3111","authenticated-orcid":true,"given":"Kristian","family":"Thorlund","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt","family":"Wise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett","family":"Doleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanne","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theis","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Mathiesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Skrifvars","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Grand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janus","family":"Jakobsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1056\/NEJMra1510062","volume":"377","author":"Woodcock","year":"2017","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jclinepi.2020.04.025","volume":"125","author":"Park","year":"2020","journal-title":"J Clin Epidemiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1177\/1740774515626362","volume":"13","author":"Saville","year":"2016","journal-title":"Clin Trials"},{"key":"ref4","first-page":"87","volume":"18","author":"Berry","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e2221140","DOI":"10.1001\/jamanetworkopen.2022.21140","volume":"5","author":"Park","year":"2022","journal-title":"JAMA\u202fNetw\u202fOpen"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e2518503","DOI":"10.1001\/jamanetworkopen.2025.18503","volume":"8","author":"van Hout","year":"2025","journal-title":"JAMA Network Open"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/clpt.2009.68","volume":"86","author":"Barker","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"ref8","first-page":"882","volume":"106","author":"James","year":"2012","journal-title":"Br J Cancer"},{"key":"ref9","first-page":"e1497","volume":"95","author":"Paganoni","year":"2020","journal-title":"Neurology"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13063-024-08684-8","volume":"26","author":"Mahar","year":"2025","journal-title":"Trials"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1186\/s13063-019-3322-7","volume":"20","author":"Hague","year":"2019","journal-title":"Trials"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3978\/j.issn.2304-3865.2015.02.03","volume":"4","author":"Kaplan","year":"2015","journal-title":"Chin Clin Oncol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13063-020-04971-2","volume":"22","author":"Howard","year":"2021","journal-title":"Trials"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e153","DOI":"10.1016\/S1473-3099(21)00705-2","volume":"22","author":"Goossens","year":"2022","journal-title":"Lancet Infect Dis"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"106892","DOI":"10.1016\/j.cct.2022.106892","volume":"119","author":"Vanderbeek","year":"2022","journal-title":"Contemp Clin Trials"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s13063-019-3216-8","volume":"20","author":"Schiavone","year":"2019","journal-title":"Trials"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"102384","DOI":"10.1016\/j.eclinm.2023.102384","volume":"67","author":"Koenig","year":"2024","journal-title":"eClinicalMedicine"},{"key":"ref18","unstructured":"National Institute for Health and Care Research (NIHR). Australia\u2013UK platform studies in areas of unmet clinical need (Reference ID: 97018). NIHR; 2024. Available from: https:\/\/www.nihr.ac.uk\/funding\/australia-uk-platform-studies-areas-unmet-clinical-need\/97018. Accessed April 22, 2026."},{"key":"ref19","unstructured":"Government of Canada. Canadian Institutes of Health Research (CIHR): funding opportunities related to platform trials. Canada Gazette. 2025. Available from: https:\/\/gazette.gc.ca\/rp-pr\/p1\/2025\/2025-12-20\/html\/reg2-eng.html. Accessed April 22, 2026."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"291","DOI":"10.2147\/CLEP.S129268","volume":"9","author":"Balijepalli","year":"2017","journal-title":"Clin Epidemiol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e001906","DOI":"10.1136\/bmjdrc-2020-001906","volume":"9","author":"Rodr\u00edguez-Guti\u00e9rrez","year":"2021","journal-title":"BMJ Open Diabetes Res Care"},{"key":"ref22","unstructured":"Davis P. The evolution of the definition of myocardial infarction. RGA Knowledge Center. 2018. Available from: https:\/\/www.rgare.com\/knowledge-center\/article\/the-evolution-of-the-definition-of-myocardial-infarction. Accessed April 22, 2026."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s43856-023-00281-1","volume":"3","author":"Thorlund","year":"2023","journal-title":"Commun Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1056\/NEJMoa2021436","volume":"384","author":"Horby","year":"2021","journal-title":"N Engl J Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1056\/NEJMoa2100433","volume":"384","author":"Gordon","year":"2021","journal-title":"N Engl J Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"5143","DOI":"10.1002\/alz.13859","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimers Dement"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/d41573-021-00037-5","volume":"20","author":"Bugin","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1056\/NEJMoa2100591","volume":"384","author":"Dankiewicz","year":"2021","journal-title":"N Engl J Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e70033","DOI":"10.1111\/aas.70033","volume":"69","author":"Kamp","year":"2025","journal-title":"Acta Anaesthesiol Scand"}],"container-title":["Clinical Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/115007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/115007","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T04:35:22Z","timestamp":1778474122000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/logistical-challenges-in-platform-randomized-trials---operational-real-peer-reviewed-fulltext-article-CLEP"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":30,"URL":"https:\/\/doi.org\/10.2147\/clep.s580997","relation":{},"ISSN":["1179-1349"],"issn-type":[{"value":"1179-1349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}