{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:30:11Z","timestamp":1782732611425,"version":"3.54.5"},"reference-count":93,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CMAR"],"DOI":"10.2147\/cmar.s510408","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T05:50:11Z","timestamp":1739944211000},"page":"357-372","source":"Crossref","is-referenced-by-count":6,"title":["Ciltacabtagene Autoleucel for the Treatment of Relapsed\/Refractory Multiple Myeloma: Efficacy, Safety, and Place in Therapy"],"prefix":"10.2147","volume":"Volume 17","author":[{"given":"Utkarsh","family":"Goel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Zanwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2473-6528","authenticated-orcid":true,"given":"Jack","family":"Khouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danai","family":"Dima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1038\/leu.2013.313","volume":"28","author":"Kumar","year":"2014","journal-title":"Leukemia"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/s41375-021-01453-5","volume":"36","author":"Binder","year":"2022","journal-title":"Leukemia"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"277","DOI":"10.2217\/fon-2021-1090","volume":"18","author":"Anderson","year":"2022","journal-title":"Future Oncol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1080\/14712598.2024.2352591","volume":"24","author":"Jagannath","year":"2024","journal-title":"Expert Opin Biol Ther"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"6330","DOI":"10.3390\/curroncol30070467","volume":"30","author":"Markouli","year":"2023","journal-title":"Curr Oncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"13366","DOI":"10.18632\/oncotarget.24351","volume":"9","author":"Rao","year":"2018","journal-title":"Oncotarget"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/S0140-6736(21)00933-8","volume":"398","author":"Berdeja","year":"2021","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1056\/NEJMoa2024850","volume":"384","author":"Munshi","year":"2021","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/s41375-020-0734-z","volume":"34","author":"Shah","year":"2020","journal-title":"Leukemia"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1182\/blood-2015-05-647636","volume":"126","author":"Rajkumar","year":"2015","journal-title":"Blood"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1056\/NEJMoa2213614","volume":"388","author":"Rodriguez-Otero","year":"2023","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1056\/NEJMoa2303379","volume":"389","author":"San-Miguel","year":"2023","journal-title":"N Engl J Med"},{"key":"ref13","unstructured":"US Food and Drug Administration. ABECMA (idecabtagene vicleucel) [Internet]. Available from: https:\/\/www.fda.gov\/vaccines-blood-biologics\/abecma-idecabtagene-vicleucel. Accessed February 12, 2025."},{"key":"ref14","unstructured":"US Food and Drug Administration. CARVYKTI."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1080\/10428194.2023.2276676","volume":"65","author":"Scheller","year":"2024","journal-title":"Leuk Lymphoma"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"991092","DOI":"10.3389\/fimmu.2022.991092","volume":"13","author":"Chekol Abebe","year":"2022","journal-title":"Front Immunol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/s41408-021-00469-5","volume":"11","author":"Teoh","year":"2021","journal-title":"Blood Cancer J"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1073\/pnas.90.2.720","volume":"90","author":"Eshhar","year":"1993","journal-title":"Proc Natl Acad Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.2217\/fon-2022-1317","volume":"19","author":"Martin","year":"2023","journal-title":"Future Oncol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13045-024-01530-z","volume":"17","author":"Xu","year":"2024","journal-title":"J Hematol Oncol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13045-022-01301-8","volume":"15","author":"Zhao","year":"2022","journal-title":"J Hematol Oncol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s13045-018-0681-6","volume":"11","author":"Zhao","year":"2018","journal-title":"J Hematol Oncol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e374","DOI":"10.1016\/S1470-2045(24)00094-9","volume":"25","author":"Lin","year":"2024","journal-title":"Lancet Oncol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41408-024-00993-0","volume":"14","author":"Afrough","year":"2024","journal-title":"Blood Cancer J"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1182\/blood-2024-202017","volume":"144","author":"Dhakal","year":"2024","journal-title":"Blood"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"16015","DOI":"10.1038\/mto.2016.15","volume":"3","author":"Wang","year":"2016","journal-title":"mol Ther Oncolytics"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41408-023-00929-0","volume":"13","author":"Sidana","year":"2023","journal-title":"Blood Cancer J"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.jtct.2022.08.002","volume":"28","author":"Maziarz","year":"2022","journal-title":"Transplant Cell Ther"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1200\/JCO.2023.41.16_suppl.1533","volume":"41","author":"Bansal","year":"2023","journal-title":"J Clin Oncol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.1182\/bloodadvances.2024013239","volume":"8","author":"Furqan","year":"2024","journal-title":"Blood Adv"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.jtct.2024.06.012","volume":"30","author":"Wesson","year":"2024","journal-title":"Transplant Cell Ther"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"5346","DOI":"10.1182\/bloodadvances.2023012549","volume":"8","author":"Ahmed","year":"2024","journal-title":"Blood Adv"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e217","DOI":"10.1016\/j.clml.2024.01.014","volume":"24","author":"Ailawadhi","year":"2024","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1200\/JCO.22.00842","volume":"41","author":"Martin","year":"2023","journal-title":"J Clin Oncol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"8009","DOI":"10.1200\/JCO.2023.41.16_suppl.8009","volume":"41","author":"Lin","year":"2023","journal-title":"J Clin Oncol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1200\/JCO.22.00690","volume":"41","author":"Mi","year":"2023","journal-title":"J Clin Oncol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1182\/blood-2023-178882","volume":"142","author":"Hillengass","year":"2023","journal-title":"Blood"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"S36","DOI":"10.1016\/j.jtct.2023.12.054","volume":"30","author":"Hillengass","year":"2024","journal-title":"Transplant Cell Ther"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"S411","DOI":"10.1016\/S2152-2650(22)01600-7","volume":"22","author":"Hillengass","year":"2022","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1182\/blood.2022015526","volume":"141","author":"Cohen","year":"2023","journal-title":"Blood"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"7505","DOI":"10.1200\/JCO.2024.42.16_suppl.7505","volume":"42","author":"Arnulf","year":"2024","journal-title":"J Clin Oncol"},{"key":"ref42","author":"Sidana","year":"2024","journal-title":"Blood"},{"key":"ref43","unstructured":"Worcester S. CARTITUDE-4 update: cilta-cel improves OS in R\/R MM. Medscape; 2024."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"4691","DOI":"10.1182\/blood-2010-10-299487","volume":"117","author":"Rajkumar","year":"2011","journal-title":"Blood"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e433520","DOI":"10.1200\/EDBK_433520","volume":"44","author":"Rees","year":"2024","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMoa2406536","volume":"392","author":"Cohen","year":"2025","journal-title":"N Engl J Med"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1182\/blood.2024024582","volume":"144","author":"Ailawadhi","year":"2024","journal-title":"Blood"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1182\/blood-2024-194390","volume":"144","author":"Hansen","year":"2024","journal-title":"Blood"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/S0140-6736(20)30734-0","volume":"396","author":"Dimopoulos","year":"2020","journal-title":"Lancet"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e432204","DOI":"10.1200\/EDBK_432204","volume":"44","author":"Mohan","year":"2024","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1186\/s12885-020-07503-y","volume":"20","author":"Fonseca","year":"2020","journal-title":"BMC Cancer"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1002\/ajh.26161","volume":"96","author":"Goldman\u2010Mazur","year":"2021","journal-title":"Am J Hematol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"3412","DOI":"10.1200\/JCO.2005.04.242","volume":"23","author":"Greipp","year":"2005","journal-title":"J Clin Oncol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1182\/blood-2021-146210","volume":"138","author":"Dytfeld","year":"2021","journal-title":"Blood"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"4630","DOI":"10.1182\/blood-2022-157021","volume":"140","author":"Boccadoro","year":"2022","journal-title":"Blood"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1080\/10428194.2022.2068008","volume":"63","author":"Gertz","year":"2022","journal-title":"Leuk Lymphoma"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/s41408-022-00719-0","volume":"12","author":"Rajkumar","year":"2022","journal-title":"Blood Cancer J"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1182\/blood-2024-202676","volume":"144","author":"Nadeem","year":"2024","journal-title":"Blood"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"e00184","DOI":"10.1097\/BS9.0000000000000184","volume":"6","author":"Zhao","year":"2024","journal-title":"Blood Sci"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1182\/blood-2023-181573","volume":"142","author":"Yan","year":"2023","journal-title":"Blood"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1016\/S0140-6736(22)00662-6","volume":"399","author":"Kamdar","year":"2022","journal-title":"Lancet"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1056\/NEJMoa2204591","volume":"387","author":"Chari","year":"2022","journal-title":"N Engl J Med"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1056\/NEJMoa2203478","volume":"387","author":"Moreau","year":"2022","journal-title":"N Engl J Med"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1056\/NEJMoa2301665","volume":"389","author":"Westin","year":"2023","journal-title":"N Engl J Med"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41577-021-00547-6","volume":"22","author":"Morris","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.bbmt.2018.12.758","volume":"25","author":"Lee","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1093\/jnci\/djz017","volume":"111","author":"Hunter","year":"2019","journal-title":"JNCI J Natl Cancer Inst"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41408-022-00629-1","volume":"12","author":"Cohen","year":"2022","journal-title":"Blood Cancer J"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1056\/NEJMoa1817226","volume":"380","author":"Raje","year":"2019","journal-title":"N Engl J Med"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1182\/blood.2023021860","volume":"142","author":"Gust","year":"2023","journal-title":"Blood"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1182\/blood.2023021429","volume":"142","author":"Graham","year":"2023","journal-title":"Blood"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1182\/blood-2018-12-893396","volume":"133","author":"Karschnia","year":"2019","journal-title":"Blood"},{"key":"ref73","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. U.S. Department of Health and Human Services; 2017."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1182\/bloodadvances.2023012336","volume":"8","author":"Banerjee","year":"2024","journal-title":"Blood Adv"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41408-023-00920-9","volume":"13","author":"Zanwar","year":"2023","journal-title":"Blood Cancer J"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"4690","DOI":"10.1158\/1078-0432.CCR-24-1798","volume":"30","author":"Tix","year":"2024","journal-title":"Clin Cancer Res"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"6939","DOI":"10.1182\/blood-2023-178806","volume":"142","author":"Harrison","year":"2023","journal-title":"Blood"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1056\/NEJMoa2401361","volume":"390","author":"Hamilton","year":"2024","journal-title":"N Engl J Med"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1182\/blood.2024024166","volume":"143","author":"Elsallab","year":"2024","journal-title":"Blood"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1056\/NEJMoa2402730","volume":"391","author":"Kobbe","year":"2024","journal-title":"N Engl J Med"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1093\/annonc\/mdw606","volume":"28","author":"Musto","year":"2017","journal-title":"Ann Oncol"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1038\/s41591-023-02528-9","volume":"29","author":"Lesokhin","year":"2023","journal-title":"Nat Med"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1056\/NEJMoa2405090","volume":"391","author":"Hungria","year":"2024","journal-title":"N Engl J Med"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"3765","DOI":"10.1182\/blood-2024-199609","volume":"144","author":"Banerjee","year":"2024","journal-title":"Blood"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/s41408-023-00886-8","volume":"13","author":"Ferreri","year":"2023","journal-title":"Blood Cancer J"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/s41375-024-02154-5","volume":"38","author":"Riedhammer","year":"2024","journal-title":"Leukemia"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1182\/blood-2024-203409","volume":"144","author":"Dima","year":"2024","journal-title":"Blood"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"308.e1","DOI":"10.1016\/j.jtct.2023.12.016","volume":"30","author":"Dima","year":"2024","journal-title":"Transplant Cell Ther"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"3478","DOI":"10.1182\/bloodadvances.2024012773","volume":"8","author":"Puertas","year":"2024","journal-title":"Blood Adv"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1111\/bjh.19303","volume":"204","author":"Ravi","year":"2024","journal-title":"Br J Haematol"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"S554","DOI":"10.1016\/S2152-2650(24)01676-8","volume":"24","author":"Martin","year":"2024","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1182\/blood-2024-198499","volume":"144","author":"Freeman","year":"2024","journal-title":"Blood"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1182\/blood.2024025628","volume":"144","author":"Bal","year":"2024","journal-title":"Blood"}],"container-title":["Cancer Management and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/100348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/100348","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T05:50:17Z","timestamp":1739944217000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/ciltacabtagene-autoleucel-for-the-treatment-of-relapsedrefractory-mult-peer-reviewed-fulltext-article-CMAR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":93,"URL":"https:\/\/doi.org\/10.2147\/cmar.s510408","relation":{},"ISSN":["1179-1322"],"issn-type":[{"value":"1179-1322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]}}}