{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:15:53Z","timestamp":1784121353109,"version":"3.55.0"},"reference-count":38,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CMAR"],"DOI":"10.2147\/cmar.s515434","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T16:30:13Z","timestamp":1763137813000},"page":"2807-2819","source":"Crossref","is-referenced-by-count":1,"title":["Advancing Prognostic Accuracy Beyond Classical N Staging in Colorectal Cancer: An Observational Cohort Study to Define a Lymph Node Ratio Based Risk Score"],"prefix":"10.2147","volume":"Volume 17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5089-5178","authenticated-orcid":true,"given":"Lucia","family":"Mangone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fortunato","family":"Morabito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Tripepi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella","family":"D'Arrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9225-781X","authenticated-orcid":true,"given":"Isabella","family":"Bisceglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-456X","authenticated-orcid":true,"given":"Francesco","family":"Marinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Giorgi Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Neri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"998","DOI":"10.2174\/18735592MTEx9NTk2y","volume":"22","author":"Baidoun","year":"2021","journal-title":"Curr Drug Targets"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.2147\/CMAR.S481656","volume":"16","author":"Yang","year":"2024","journal-title":"Cancer Manag Res"},{"key":"ref4","unstructured":"National Cancer Institute. Cancer Stat Facts: colorectal Cancer. Available online: https:\/\/seer.cancer.gov\/statfacts\/html\/colorect.html. (Accessed 19, October 2024.)."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3322\/caac.21388","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/S1470-2045(07)70205-X","volume":"8","author":"Quirke","year":"2007","journal-title":"Lancet Oncol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"291","DOI":"10.2147\/CMAR.S38827","volume":"6","author":"Schneider","year":"2014","journal-title":"Cancer Manag Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/COC.0b013e3181cae8dd","volume":"34","author":"Kornprat","year":"2011","journal-title":"Am J Clin Oncol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.surg.2020.11.011","volume":"169","author":"Feng","year":"2021","journal-title":"Surgery"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1111\/j.1440-1746.2006.04792.x","volume":"22","author":"Crozier","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"ref11","volume-title":"TNM Classification of Malignant Tumours","year":"2017"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/jnci\/djk092","volume":"99","author":"Chang","year":"2007","journal-title":"J Natl Cancer Inst"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2912","DOI":"10.1200\/JCO.2003.05.062","volume":"21","author":"Le Voyer","year":"2003","journal-title":"J Clin Oncol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"5356","DOI":"10.3390\/curroncol28060447","volume":"28","author":"Chen","year":"2021","journal-title":"Curr Oncol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"673","DOI":"10.3390\/medicina55100673","volume":"55","author":"Pyo","year":"2019","journal-title":"Medicina"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1002\/jso.27789","volume":"130","author":"Mainali","year":"2024","journal-title":"J Surg Oncol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"4003","DOI":"10.1007\/s00261-024-04373-x","volume":"49","author":"Guimar\u00e3es","year":"2024","journal-title":"Abdom Radiol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.14670\/HH-11-633","volume":"30","author":"Barresi","year":"2015","journal-title":"Histol Histopathol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.path.2020.05.008","volume":"13","author":"Johncilla","year":"2020","journal-title":"Surg Pathol Clin"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1001\/jamaoncol.2016.4227","volume":"3","author":"Petrelli","year":"2017","journal-title":"JAMA Oncol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.3390\/jcm10081751","volume":"10","author":"Kellokumpu","year":"2021","journal-title":"J Clin Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.3390\/cancers16152746","volume":"16","author":"Maida","year":"2024","journal-title":"Cancers"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1007\/s11912-024-01574-x","volume":"26","author":"Rouhafzay","year":"2024","journal-title":"Curr Oncol Rep"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1186\/s12885-015-1683-1","volume":"15","author":"Munro","year":"2015","journal-title":"BMC Cancer"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1111\/j.1463-1318.2008.01648.x","volume":"11","author":"Segelman","year":"2009","journal-title":"Color Dis"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1186\/s12913-021-07022-x","volume":"21","author":"Rollet","year":"2021","journal-title":"BMC Health Serv Res"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.3390\/cancers16132390","volume":"16","author":"Mangone","year":"2024","journal-title":"Cancers"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/cancers13010012","volume":"13","author":"Koncina","year":"2020","journal-title":"Cancers"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1093\/annonc\/mdw645","volume":"28","author":"Seligmann","year":"2017","journal-title":"Ann Oncol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1177\/03008916241298810","volume":"111","author":"Mangone","year":"2025","journal-title":"Registri Tumori"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"982461","DOI":"10.3389\/fonc.2022.982461","volume":"12","author":"Mangone","year":"2022","journal-title":"Front Oncol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jclinepi.2016.03.031","volume":"79","author":"Mehta","year":"2016","journal-title":"J Clin Epidemiol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1093\/ndt\/gft095","volume":"28","author":"Tripepi","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s40520-020-01542-y","volume":"33","author":"D\u2019Arrigo","year":"2021","journal-title":"Aging Clin Exp Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1007\/DCR.0b013e3181a65f0b","volume":"52","author":"Vaccaro","year":"2009","journal-title":"Dis Colon Rectum"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1097\/SLA.0b013e318190eddc","volume":"248","author":"Rosenberg","year":"2008","journal-title":"Ann Surg"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1477-7819-11-79","volume":"11","author":"Schiffmann","year":"2013","journal-title":"World J Surg Oncol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s10151-024-02984-6","volume":"28","author":"Naidu","year":"2024","journal-title":"Tech Coloproctol"}],"container-title":["Cancer Management and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/108965","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/108965","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T16:30:14Z","timestamp":1763137814000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/advancing-prognostic-accuracy-beyond-classical-n-staging-in-colorectal-peer-reviewed-fulltext-article-CMAR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":38,"URL":"https:\/\/doi.org\/10.2147\/cmar.s515434","relation":{},"ISSN":["1179-1322"],"issn-type":[{"value":"1179-1322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]}}}