{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T21:41:14Z","timestamp":1785361274097,"version":"3.55.0"},"reference-count":65,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CMAR"],"DOI":"10.2147\/cmar.s533380","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:45:12Z","timestamp":1754916312000},"page":"1613-1623","source":"Crossref","is-referenced-by-count":2,"title":["The Chemotherapy Medication of Evodia lepta (Spreng). Merr. on the Viability of Tongue Cancer Cells Through the PD-L1\/MMP14\/HSPA5 Pathway"],"prefix":"10.2147","volume":"Volume 17","author":[{"given":"Jingkun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9747-8697","authenticated-orcid":true,"given":"Ching-Feng","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nrc1782","volume":"6","author":"de Visser","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3831","DOI":"10.2174\/138161212802083707","volume":"18","author":"Vendramini-Costa","year":"2012","journal-title":"Curr Pharm"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"721087","DOI":"10.1155\/2014\/721087","volume":"2014","author":"Almatroodi","year":"2014","journal-title":"Lung Cancer Int"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"14007","DOI":"10.1073\/pnas.1211509109","volume":"109","author":"Shaked","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref5","first-page":"854","volume":"63","author":"Maeda","year":"1998","journal-title":"Biochemistry"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/nature11465","volume":"491","author":"Grivennikov","year":"2012","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.immuni.2014.11.009","volume":"41","author":"Wang","year":"2014","journal-title":"Immunity"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"6297","DOI":"10.19540\/j.cnki.cjcmm.20220725.501","volume":"47","author":"Du","year":"2022","journal-title":"China J Chin Materia Medica"},{"key":"ref9","first-page":"42","volume":"14","author":"Zou","year":"2024","journal-title":"CHINA MED Pharm"},{"key":"ref10","first-page":"140","volume":"10","author":"Zhou","year":"2023","journal-title":"Electro J Metabol Nutrit Cancer"},{"key":"ref11","volume-title":"Basic Theory of Traditional Chinese Medicine M","year":"2021"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.phytochem.2016.06.011","volume":"130","author":"Nguyen","year":"2016","journal-title":"Phytochemistry"},{"key":"ref13","first-page":"78","volume":"29","author":"Cui","year":"2018","journal-title":"Trad Chin Drug Res Clin Pharmacol"},{"key":"ref14","first-page":"1076","volume":"48","author":"Li","year":"2017","journal-title":"Chin Traditional Herbal Drugs"},{"key":"ref15","first-page":"430","volume":"36","author":"Peng","year":"2019","journal-title":"Chin J Mod Appl Pharm"},{"key":"ref16","first-page":"52","volume":"48","author":"Zhu","year":"2021","journal-title":"Guangdong Chem Indus"},{"key":"ref17","first-page":"1","volume":"24","author":"Luo","year":"2022","journal-title":"Food and Drug"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"811","DOI":"10.3390\/plants9070811","volume":"9","author":"Kantasrila","year":"2020","journal-title":"Plants"},{"key":"ref19","first-page":"151","volume":"47","author":"Zang","year":"2020","journal-title":"Liaoning JTrad Chin Med"},{"key":"ref20","volume-title":"Researches on the Quality Analysis and Processing Methods of Guangxi Melicope Pteleifolia\u2019s Stem[D]","year":"2017"},{"key":"ref21","first-page":"580","volume":"36","author":"Yang","year":"2014","journal-title":"Chinese Traditional Patent Med"},{"key":"ref22","first-page":"69","volume":"42","author":"Chu","year":"2021","journal-title":"J Zhaoqing Univ"},{"key":"ref23","first-page":"3","volume":"44","author":"Zeng","year":"2023","journal-title":"South-Central Agricul Sci Technol"},{"key":"ref24","first-page":"90","volume":"39","author":"Liao","year":"2012","journal-title":"Guangdong Agricul Sci"},{"key":"ref25","first-page":"46","volume":"14","author":"Wei","year":"2015","journal-title":"Industrial & Science Tribune"},{"key":"ref26","volume-title":"Experimental Study of Evodia lepta (Spr.) Merr on the Anti-Inflammatory and Analgesic Effects and Its Chemical Constituent of Liposolubility","year":"2010"},{"key":"ref27","volume-title":"Melicope Pteleifolia Quality Control and in Vitro Anti-Inflammatory, Antioxidation Action Study","year":"2018"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.3892\/ijmm.2018.3849","volume":"42","author":"Kim","year":"2018","journal-title":"Int J Mol Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.3390\/antiox10111842","volume":"10","author":"Xiong","year":"2021","journal-title":"Antioxidants"},{"key":"ref30","first-page":"74","volume":"17","author":"Chu","year":"2021","journal-title":"Asia-Pacific Tradit Med"},{"key":"ref31","unstructured":"Li S, Ye W, Jiang R. Chemical composition and anti-prostate cancer activity of Evodia lepta. Proceedings of the Eighth Symposium on Natural Organic Chemistry of the Chinese Chemical Society. 2010. 231."},{"key":"ref32","first-page":"2079","volume":"27","author":"Lin","year":"2016","journal-title":"Hainan Med J"},{"key":"ref33","first-page":"961","volume":"06","author":"Pang","year":"2006","journal-title":"J Guangxi Med Univ"},{"key":"ref34","first-page":"2514","volume":"23","author":"Hu","year":"2012","journal-title":"Lishizhen Med Materia Medica Res"},{"key":"ref35","first-page":"50","volume":"19","author":"Gu","year":"2021","journal-title":"ChinForeign Med Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13046-024-03007-w","volume":"43","author":"Li","year":"2024","journal-title":"J Exp Clin Cancer Res"},{"key":"ref37","volume":"2","author":"Yu","year":"2024","journal-title":"Guangdong Med J"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"216642","DOI":"10.1016\/j.canlet.2024.216642","volume":"586","author":"Liu","year":"2024","journal-title":"Cancer Lett"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e007670","DOI":"10.1136\/jitc-2023-007670","volume":"11","author":"Wu","year":"2023","journal-title":"J Immunother Cancer"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1159\/000369916","volume":"134","author":"Zheng","year":"2015","journal-title":"Acta Haematol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1093\/cei\/uxad060","volume":"213","author":"Chen","year":"2023","journal-title":"Clin Exp Immunol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"12","DOI":"10.14715\/cmb\/2020.66.7.3","volume":"66","author":"Ma","year":"2020","journal-title":"Cell Mol Biol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13046-016-0487-8","volume":"36","author":"Xu","year":"2017","journal-title":"J Exp Clin Cancer Res"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","volume":"6","author":"Johnson","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1177\/00220345211014795","volume":"100","author":"Warnakulasuriya","year":"2021","journal-title":"J Dent Res"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s11306-020-01727-6","volume":"16","author":"Vitorio","year":"2020","journal-title":"Metabolomics"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"7877","DOI":"10.1038\/s41598-020-64748-0","volume":"10","author":"Kim","year":"2020","journal-title":"Sci Rep"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1086\/722708","volume":"96","author":"Treat","year":"2023","journal-title":"Physiol Biochem Zool"},{"key":"ref49","first-page":"514","volume":"42","author":"Sun","year":"2022","journal-title":"J Xuzhou Med Univ"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/kjm2.12298","volume":"37","author":"Liang","year":"2021","journal-title":"Kaohsiung J Med Sci"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"14803","DOI":"10.1038\/s41598-023-41992-8","volume":"13","author":"Yu","year":"2023","journal-title":"Sci Rep"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s00795-020-00261-7","volume":"54","author":"Akisada","year":"2021","journal-title":"Med Mol Morphol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"5512894","DOI":"10.1155\/2023\/5512894","volume":"2023","author":"Shojaei","year":"2023","journal-title":"Biochem Res Int"},{"key":"ref54","first-page":"912","volume":"52","author":"Xu","year":"2023","journal-title":"Shanxi Med J"},{"key":"ref55","first-page":"1996","volume":"31","author":"Hu","year":"2023","journal-title":"J Modern Oncol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3390\/genes14010045","volume":"14","author":"Shimura","year":"2022","journal-title":"Genes"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1038\/s41418-022-01008-w","volume":"29","author":"Wang","year":"2022","journal-title":"Cell Death Differ"},{"key":"ref58","volume-title":"Expression and clinical Significance of Vascular and Vasculogenic Mimicry Generation Factors VEGFA and MMP14 in Lung Adenocarcinoma","year":"2023"},{"key":"ref59","first-page":"157","volume":"33","author":"Zheng","year":"2023","journal-title":"Biotechnology"},{"key":"ref60","volume-title":"Effect and Mechanism of MMP14 in Regulating Macrophages Phenotypic Transformation in Pancreatic Cancer[D]","year":"2023"},{"key":"ref61","first-page":"312","volume":"42","author":"Xu","year":"2022","journal-title":"J Shanghai Jiaotong Univ"},{"key":"ref62","first-page":"15","volume":"33","author":"Zheng","year":"2023","journal-title":"Chin J Health Lab Technol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"6095","DOI":"10.21873\/anticanres.15429","volume":"41","author":"Yue","year":"2021","journal-title":"Anticancer Res"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.jobcr.2024.02.011","volume":"14","author":"Arini","year":"2024","journal-title":"J Oral Biol Craniofac Res"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"533","DOI":"10.21037\/tcr.2018.05.09","volume":"7","author":"Bates","year":"2018","journal-title":"Transl Cancer Res"}],"container-title":["Cancer Management and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/105691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/105691","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:45:18Z","timestamp":1754916318000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/the-chemotherapy-medication-of-evodia-lepta-spreng-merr-on-the-viabili-peer-reviewed-fulltext-article-CMAR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":65,"URL":"https:\/\/doi.org\/10.2147\/cmar.s533380","relation":{},"ISSN":["1179-1322"],"issn-type":[{"value":"1179-1322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]}}}