{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:16:01Z","timestamp":1782166561060,"version":"3.54.5"},"reference-count":36,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["COPD"],"DOI":"10.2147\/copd.s246348","type":"journal-article","created":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T22:03:37Z","timestamp":1597010617000},"page":"1935-1944","source":"Crossref","is-referenced-by-count":6,"title":["<p>Absence of Adverse Effects of Tiotropium\/Olodaterol Compared with the Monocomponents on Long-Term Heart Rate and Blood Pressure in Patients with Moderate-to-Very-Severe COPD<\/p>"],"prefix":"10.2147","volume":"Volume 15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3918-6909","authenticated-orcid":true,"given":"Stefan","family":"Andreas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorcan","family":"McGarvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Bothner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Trampisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"de la Hoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matjaz","family":"Fle\u017ear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Buhl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2115-1743","authenticated-orcid":true,"given":"Peter","family":"Alter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,8]]},"reference":[{"key":"ref1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease (2019 report). Published 2019. Available from: https:\/\/goldcopd.org\/wp-content\/uploads\/2018\/11\/GOLD-2019-v1.7-FINAL-14Nov2018-WMS.pdf. Accessed November 7, 2019."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1056\/NEJMoa0805800","volume":"359","author":"Tashkin","year":"2008","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"697","DOI":"10.2147\/COPD.S62502","volume":"9","author":"Koch","year":"2014","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1183\/09031936.00136014","volume":"45","author":"Buhl","year":"2015","journal-title":"Eur Respir J"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1136\/thx.2009.128082","volume":"65","author":"Feary","year":"2010","journal-title":"Thorax"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1136\/thx.2006.061267","volume":"61","author":"Fuhrman","year":"2006","journal-title":"Thorax"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1378\/chest.128.4.2640","volume":"128","author":"Huiart","year":"2005","journal-title":"Chest"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.rmed.2016.03.008","volume":"114","author":"Karch","year":"2016","journal-title":"Respir Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.2147\/COPD.S209343","volume":"14","author":"Alter","year":"2019","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1378\/chest.128.4.2068","volume":"128","author":"Sidney","year":"2005","journal-title":"Chest"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"3128","DOI":"10.1093\/eurheartj\/ehy451","volume":"39","author":"Byrd","year":"2018","journal-title":"Eur Heart J"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.1378\/chest.128.5.3618","volume":"128","author":"Andreas","year":"2005","journal-title":"Chest"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1056\/NEJM198409273111303","volume":"311","author":"Cohn","year":"1984","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1136\/heartjnl-2012-303375","volume":"99","author":"Jensen","year":"2013","journal-title":"Heart"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s00408-013-9544-7","volume":"192","author":"Andreas","year":"2014","journal-title":"Lung"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1056\/NEJM199908193410806","volume":"341","author":"Schrier","year":"1999","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.1093\/eurheartj\/ehq328","volume":"31","author":"Bangalore","year":"2010","journal-title":"Eur Heart J"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1016\/j.jacc.2009.05.073","volume":"54","author":"Messerli","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S2213-2600(15)00518-4","volume":"4","author":"Lahousse","year":"2016","journal-title":"Lancet Respir Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1378\/chest.114.2.411","volume":"114","author":"Cazzola","year":"1998","journal-title":"Chest"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/S2213-2600(18)30054-7","volume":"6","author":"Hohlfeld","year":"2018","journal-title":"Lancet Respir Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1164\/rccm.201508-1647OC","volume":"193","author":"Stone","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1164\/rccm.201805-0995OC","volume":"199","author":"Vogel-Claussen","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pupt.2018.08.002","volume":"52","author":"Andreas","year":"2018","journal-title":"Pulm Pharmacol Ther"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/ijcp.12596","volume":"69","author":"Hohlfeld","year":"2015","journal-title":"Int J Clin Pract"},{"key":"ref26","author":"Andreas","year":"2020","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"3469","DOI":"10.2147\/COPD.S146338","volume":"12","author":"Rogliani","year":"2017","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1183\/09041950.005s1693","volume":"6","author":"Quanjer","year":"1993","journal-title":"Eur Respir J"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1001\/jamainternmed.2013.1016","volume":"173","author":"Gershon","year":"2013","journal-title":"JAMA Intern Med"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s40265-014-0326-1","volume":"75","author":"Blair","year":"2015","journal-title":"Drugs"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"164","DOI":"10.5603\/PiAP.2015.0026","volume":"83","author":"Kozielski","year":"2015","journal-title":"Pneumonol Alergol Pol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1056\/NEJMoa1608033","volume":"375","author":"Vestbo","year":"2016","journal-title":"N Engl J Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1136\/thx.2010.136077","volume":"65","author":"Calverley","year":"2010","journal-title":"Thorax"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.rmed.2016.11.011","volume":"122","author":"Buhl","year":"2017","journal-title":"Respir Med"},{"key":"ref36","author":"Andreas","year":"2020","journal-title":"Int J Chron Obstruct Pulmon Dis"}],"container-title":["International Journal of Chronic Obstructive Pulmonary Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=60472","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=60472","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T22:03:43Z","timestamp":1597010623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/absence-of-adverse-effects-of-tiotropiumolodaterol-compared-with-the-m-peer-reviewed-article-COPD"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":36,"URL":"https:\/\/doi.org\/10.2147\/copd.s246348","relation":{},"ISSN":["1178-2005"],"issn-type":[{"value":"1178-2005","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]}}}