{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:41:00Z","timestamp":1787701260946,"version":"build-2784847793"},"reference-count":24,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["COPD"],"DOI":"10.2147\/copd.s374670","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T01:01:15Z","timestamp":1670288475000},"page":"3061-3073","source":"Crossref","is-referenced-by-count":30,"title":["Benefits of Budesonide\/Glycopyrronium\/Formoterol Fumarate Dihydrate on COPD Exacerbations, Lung Function, Symptoms, and Quality of Life Across Blood Eosinophil Ranges: A Post-Hoc Analysis of Data from ETHOS"],"prefix":"10.2147","volume":"Volume 17","author":[{"given":"Mona","family":"Bafadhel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7020-1401","authenticated-orcid":true,"given":"Klaus F","family":"Rabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-3182","authenticated-orcid":true,"given":"Fernando J","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5608-2717","authenticated-orcid":true,"given":"Patrick","family":"Darken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Aurivillius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehul","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Dorinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,12]]},"reference":[{"key":"ref1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease. 2022 GOLD Report. Global strategy for the diagnosis, management and prevention of COPD. Available from: https:\/\/goldcopd.org\/2022-gold-reports-2\/. Accessed November 17, 2022."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/S2213-2600(18)30327-8","volume":"6","author":"Ferguson","year":"2018","journal-title":"Lancet Respir Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S2213-2600(18)30006-7","volume":"6","author":"Bafadhel","year":"2018","journal-title":"Lancet Respir Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1164\/rccm.201502-0235LE","volume":"192","author":"Siddiqui","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/S2213-2600(19)30190-0","volume":"7","author":"Pascoe","year":"2019","journal-title":"Lancet Respir Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1164\/rccm.202006-2618OC","volume":"203","author":"Martinez","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1902119","DOI":"10.1183\/13993003.02119-2019","volume":"55","author":"Mathioudakis","year":"2020","journal-title":"Eur Respir J"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1056\/NEJMoa1916046","volume":"383","author":"Rabe","year":"2020","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"17534666211034329","DOI":"10.1177\/17534666211034329","volume":"15","author":"Rabe","year":"2021","journal-title":"Ther Adv Respir Dis"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"106509","DOI":"10.1016\/j.rmed.2021.106509","volume":"185","author":"Martinez","year":"2021","journal-title":"Respir Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.rmed.2019.08.010","volume":"158","author":"Rabe","year":"2019","journal-title":"Respir Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.jaci.2017.04.027","volume":"140","author":"Kolsum","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1111\/all.14661","volume":"76","author":"Higham","year":"2021","journal-title":"Allergy"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/all.14016","volume":"75","author":"George","year":"2020","journal-title":"Allergy"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jaci.2020.02.040","volume":"147","author":"Dicker","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1164\/rccm.202009-3448OC","volume":"203","author":"Wang","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.3390\/biomedicines9101337","volume":"9","author":"Beech","year":"2021","journal-title":"Biomedicines"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s12931-020-01552-4","volume":"21","author":"Beech","year":"2020","journal-title":"Respir Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/S0140-6736(18)30206-X","volume":"391","author":"Papi","year":"2018","journal-title":"Lancet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"RCT208","DOI":"10.1183\/13993003.04522-2020","volume":"58","author":"Bafadhel","year":"2021","journal-title":"Eur Respir J"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1900633","DOI":"10.1183\/13993003.00633-2019","volume":"54","author":"Kolsum","year":"2019","journal-title":"Eur Respir J"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.chest.2019.04.012","volume":"156","author":"Schumann","year":"2019","journal-title":"Chest"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1901874","DOI":"10.1183\/13993003.01874-2019","volume":"55","author":"Hartl","year":"2020","journal-title":"Eur Respir J"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.7326\/M22-1460","volume":"175","author":"DeTora","year":"2022","journal-title":"Ann Intern Med"}],"container-title":["International Journal of Chronic Obstructive Pulmonary Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=85917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=85917","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T01:01:21Z","timestamp":1670288481000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/benefits-of-budesonideglycopyrroniumformoterol-fumarate-dihydrate-on-c-peer-reviewed-fulltext-article-COPD"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":24,"URL":"https:\/\/doi.org\/10.2147\/copd.s374670","relation":{},"ISSN":["1178-2005"],"issn-type":[{"value":"1178-2005","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}