{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T11:42:37Z","timestamp":1792323757756,"version":"4.4.0"},"reference-count":28,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["COPD"],"DOI":"10.2147\/copd.s478349","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T07:15:12Z","timestamp":1733987712000},"page":"2729-2737","source":"Crossref","is-referenced-by-count":4,"title":["Triple Therapy with Budesonide\/Glycopyrronium\/Formoterol Fumarate Dihydrate versus Dual Therapies for Patients with COPD and Phenotypic Features of Asthma: A Pooled Post Hoc Analysis of KRONOS and ETHOS"],"prefix":"10.2147","volume":"Volume 19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7452-9191","authenticated-orcid":true,"given":"Shigeo","family":"Muro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7899-9120","authenticated-orcid":true,"given":"Munehiro","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7246-6040","authenticated-orcid":true,"given":"John","family":"Hurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Petullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5608-2717","authenticated-orcid":true,"given":"Patrick","family":"Darken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Megally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehul","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1900561","DOI":"10.1183\/13993003.00561-2019","volume":"54","author":"Janson","year":"2019","journal-title":"Eur Respir J"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/1471-2466-14-112","volume":"14","author":"Eltboli","year":"2014","journal-title":"BMC Pulm Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1183\/09031936.06.00072105","volume":"27","author":"Leigh","year":"2006","journal-title":"Eur Respir J"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1164\/ajrccm.158.5.9804028","volume":"158","author":"Pizzichini","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1183\/09031936.00162414","volume":"44","author":"Singh","year":"2014","journal-title":"Eur Respir J"},{"key":"ref6","unstructured":"Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention 2024. Available from: https:\/\/ginasthma.org\/wp-content\/uploads\/2024\/05\/GINA-2024-Strategy-Report-24_05_22_WMS.pdf. Accessed June 26, 2024."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1111\/all.14661","volume":"76","author":"Higham","year":"2021","journal-title":"Allergy"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/all.14016","volume":"75","author":"George","year":"2020","journal-title":"Allergy"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1164\/rccm.202201-0209PP","volume":"206","author":"Singh","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1111\/resp.13780","volume":"25","author":"Barrecheguren","year":"2020","journal-title":"Respirology"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1164\/rccm.201602-0353OC","volume":"194","author":"Suzuki","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"ref12","unstructured":"Global Initiative for Chronic Obstructive Lung Disease. GOLD Report: Global Strategy for Prevention, Diagnosis and Management of COPD; 2024. Available from: https:\/\/goldcopd.org\/2024-gold-report\/. Accessed September 17, 2024."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.resinv.2023.08.007","volume":"61","author":"Shibata","year":"2023","journal-title":"Respir Investig"},{"key":"ref14","unstructured":"National Institute for Health and Care Excellence. Chronic obstructive pulmonary disease in over 16s: diagnosis and management. NICE guideline [NG115]. 2018. Available from: https:\/\/www.nice.org.uk\/guidance\/ng115. Accessed April 5, 2024."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1602265","DOI":"10.1183\/13993003.02265-2016","volume":"50","author":"Wedzicha","year":"2017","journal-title":"Eur Respir J"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/S2213-2600(18)30327-8","volume":"6","author":"Ferguson","year":"2018","journal-title":"Lancet Respir Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1056\/NEJMoa1916046","volume":"383","author":"Rabe","year":"2020","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"17534666211034329","DOI":"10.1177\/17534666211034329","volume":"15","author":"Rabe","year":"2021","journal-title":"Ther Adv Respir Dis"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3390\/arm91040023","volume":"91","author":"Kotoulas","year":"2023","journal-title":"Adv Respir Med"},{"key":"ref20","unstructured":"Global Initiative for Asthma. GINA Report, Global Strategy for Asthma Management and Prevention; 2023. Available from: https:\/\/ginasthma.org\/2023-gina-main-report\/. Accessed February 6, 2024."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.rmed.2019.08.010","volume":"158","author":"Rabe","year":"2019","journal-title":"Respir Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.alit.2018.01.002","volume":"67","author":"Yanagisawa","year":"2018","journal-title":"Allergol Int"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15412555.2019.1575802","volume":"16","author":"Nunez","year":"2019","journal-title":"COPD"},{"key":"ref24","unstructured":"European Medicines Agency. Trixeo Aerosphere. Summary of Product Characteristics; 2023. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/trixeo-aerosphere-epar-product-information_en.pdf. Accessed October 4, 2024."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/s12931-021-01773-1","volume":"22","author":"Muro","year":"2021","journal-title":"Respir Res"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1193730","DOI":"10.3389\/fonc.2023.1193730","volume":"13","author":"Thomsen","year":"2023","journal-title":"Front Oncol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2147\/COPD.S385186","volume":"18","author":"Hashimoto","year":"2023","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.7326\/M22-1460","volume":"175","author":"DeTora","year":"2022","journal-title":"Ann Intern Med"}],"container-title":["International Journal of Chronic Obstructive Pulmonary Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/article\/download\/98296","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/article\/download\/98296","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T07:15:19Z","timestamp":1733987719000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/triple-therapy-with-budesonideglycopyrroniumformoterol-fumarate-dihydr-peer-reviewed-fulltext-article-COPD"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":28,"URL":"https:\/\/doi.org\/10.2147\/copd.s478349","relation":{},"ISSN":["1178-2005"],"issn-type":[{"value":"1178-2005","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]}}}