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Identifier\u00a0NCT04545580; (2020, September\u00a0\u2013 2022, February).\u00a0Available from:\u00a0https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04545580.\u00a0Accessed\u00a0November\u00a07, 2021."},{"key":"ref114","doi-asserted-by":"crossref","unstructured":"Li\u00a0M,\u00a0Wang\u00a0Y,\u00a0Banerjee\u00a0R, et\u00a0al.\u00a0Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound\u00a0ATP.\u00a0Elife.\u00a02019;8:e47060. doi:10.7554\/eLife.47060","DOI":"10.7554\/eLife.47060"},{"key":"ref115","doi-asserted-by":"crossref","unstructured":"Ford\u00a0AP,\u00a0Undem\u00a0BJ.\u00a0The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological\u00a0disorders.\u00a0Front Cell Neurosci.\u00a02013;7:267. doi:10.3389\/fncel.2013.00267","DOI":"10.3389\/fncel.2013.00267"},{"key":"ref116","doi-asserted-by":"crossref","unstructured":"Peyronnet\u00a0B,\u00a0Mironska\u00a0E,\u00a0Chapple\u00a0C, et\u00a0al.\u00a0A\u00a0comprehensive review of overactive bladder pathophysiology: on the way to tailored\u00a0treatment.\u00a0Eur Urol.\u00a02019;75(6):988\u20131000. doi:10.1016\/j.eururo.2019.02.038","DOI":"10.1016\/j.eururo.2019.02.038"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"S104","DOI":"10.1002\/nau.24207","volume":"39","author":"Malde","year":"2020","journal-title":"Neurourol Urodyn"}],"container-title":["Clinical Pharmacology: Advances and Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=76168","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=76168","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T16:11:00Z","timestamp":1637770260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/pharmacological-management-of-urinary-incontinence-current-and-emergin-peer-reviewed-fulltext-article-CPAA"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":117,"URL":"https:\/\/doi.org\/10.2147\/cpaa.s289323","relation":{},"ISSN":["1179-1438"],"issn-type":[{"value":"1179-1438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11]]}}}