{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:50:27Z","timestamp":1790416227550,"version":"4.1.0"},"reference-count":64,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CPAA"],"DOI":"10.2147\/cpaa.s374741","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T16:24:46Z","timestamp":1659457486000},"page":"61-67","source":"Crossref","is-referenced-by-count":22,"title":["Clinical Impact of Semaglutide, a Glucagon-Like Peptide-1 Receptor Agonist, on Obesity Management: A Review"],"prefix":"10.2147","volume":"Volume 14","author":[{"given":"Nasser M","family":"Alorfi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2021-8731","authenticated-orcid":true,"given":"Alanood S","family":"Algarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,8]]},"reference":[{"key":"ref1","unstructured":"World Health Orgnization. Obesity and overweight; 2021. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight. Accessed July 28, 2022."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1056\/NEJMoa055643","volume":"355","author":"Adams","year":"2006","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/01.hjr.0000114707.27531.48","volume":"11","author":"James","year":"2004","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0021-9150(00)00514-1","volume":"154","author":"Lakka","year":"2001","journal-title":"Atherosclerosis"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/nature05487","volume":"444","author":"Van Gaal","year":"2006","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.cmi.2021.02.008","volume":"27","author":"Klein","year":"2021","journal-title":"Clin Microbiol Infect"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3238\/arztebl.m2021.0108","volume":"118","author":"Koch","year":"2021","journal-title":"Dtsch Arztebl Int"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"551","DOI":"10.3390\/metabo11080551","volume":"11","author":"Mo\u010dnik","year":"2021","journal-title":"Metabolites"},{"key":"ref9","first-page":"56","volume":"1","author":"Byrne","year":"2015","journal-title":"J Diabetes Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e0246378","DOI":"10.1371\/journal.pone.0246378","volume":"16","author":"Yeh","year":"2021","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/S2213-8587(21)00246-1","volume":"9","author":"Van der Schueren","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1053\/j.gastro.2015.04.005","volume":"149","author":"Vilar-Gomez","year":"2015","journal-title":"Gastroenterology"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.orcp.2021.03.013","volume":"15","author":"Sag","year":"2021","journal-title":"Obes Res Clin Pract"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.numecd.2018.09.014","volume":"29","author":"McLaughlin","year":"2019","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.diabet.2019.05.004","volume":"46","author":"Mora-Rodriguez","year":"2020","journal-title":"Diabetes Metab"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.appet.2013.09.017","volume":"72","author":"Lasikiewicz","year":"2014","journal-title":"Appetite"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1161\/hc0702.104279","volume":"105","author":"Ziccardi","year":"2002","journal-title":"Circulation"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-013-0390-7","volume":"16","author":"Arranz","year":"2014","journal-title":"Curr Rheumatol Rep"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1111\/dom.12502","volume":"17","author":"Fujioka","year":"2015","journal-title":"Diabetes Obes Metab"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/obr.12349","volume":"16","author":"Kov\u00e1cs","year":"2015","journal-title":"Obes Rev"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.soard.2021.10.013","volume":"18","author":"Dessify","year":"2021","journal-title":"Surg Obes Relat Dis"},{"key":"ref22","first-page":"854","volume":"4","author":"Hagstr\u00f6m","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1001\/jama.2016.7602","volume":"315","author":"Khera","year":"2016","journal-title":"JAMA"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/00325481.2018.1435129","volume":"130","author":"Patel","year":"2018","journal-title":"Postgraduate Medicine"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"802","DOI":"10.4093\/dmj.2020.0258","volume":"44","author":"Son","year":"2020","journal-title":"Diabetes Metab J"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"204201882092600","DOI":"10.1177\/2042018820926000","volume":"11","author":"Pu","year":"2020","journal-title":"Ther Adv Endocrinol Metab"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s00228-018-2593-3","volume":"75","author":"Hui","year":"2018","journal-title":"Eur J Clin Pharmacol"},{"key":"ref28","first-page":"845","volume":"47","author":"Masarwa","year":"2021","journal-title":"Pediatrics"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"602","DOI":"10.3390\/vaccines9060602","volume":"9","author":"Al-Marshoudi","year":"2021","journal-title":"Vaccines"},{"key":"ref30","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/9072492","volume":"2020","author":"Mosavat","year":"2020","journal-title":"J Diabetes Res"},{"key":"ref31","first-page":"117955142110516","volume":"14","author":"Ja\u2019arah","year":"2021","journal-title":"Int J Med"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"202","DOI":"10.2337\/ds16-0026","volume":"30","author":"Hinnen","year":"2017","journal-title":"Diabetes Spectr"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.molmed.2008.01.003","volume":"14","author":"Holst","year":"2008","journal-title":"Trends Mol Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nrneph.2017.123","volume":"13","author":"Muskiet","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"101090","DOI":"10.1016\/j.molmet.2020.101090","volume":"46","author":"Baggio","year":"2021","journal-title":"Mol Metab"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1210\/en.2010-0115","volume":"151","author":"Brubaker","year":"2010","journal-title":"Endocrinology"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.molmet.2019.09.010","volume":"30","author":"M\u00fcller","year":"2019","journal-title":"Mol Metab"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"251","DOI":"10.21037\/atm.2017.04.20","volume":"5","author":"Holst","year":"2017","journal-title":"Ann Transl Med"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/S0140-6736(21)00845-X","volume":"397","author":"Enebo","year":"2021","journal-title":"Lancet"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1007\/s13300-020-00894-y","volume":"11","author":"Kalra","year":"2020","journal-title":"Diabetes Ther"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/jcph.443","volume":"55","author":"Kapitza","year":"2015","journal-title":"J Clin Pharmacol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"7370","DOI":"10.1021\/acs.jmedchem.5b00726","volume":"58","author":"Lau","year":"2015","journal-title":"J Med Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"584","DOI":"10.3389\/fendo.2018.00584","volume":"1","author":"Paternoster","year":"2018","journal-title":"Front Endocrinol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1111\/dom.12932","volume":"19","author":"Blundell","year":"2017","journal-title":"Diabetes Obes Metab"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1161\/CIRCULATIONAHA.117.028136","volume":"136","author":"Nauck","year":"2017","journal-title":"Circulation"},{"key":"ref46","unstructured":"FDA. FDA Approves New Drug Treatment for Chronic Weight Management, First Since 2014 | FDA; 2021. Available from: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-new-drug-treatment-chronic-weight-management-first-2014. Accessed July 28, 2022."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s11154-014-9289-5","volume":"15","author":"Shah","year":"2014","journal-title":"Rev Endocr Metab Disord"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1111\/dom.14280","volume":"23","author":"Friedrichsen","year":"2021","journal-title":"Diabetes Obes Metab"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"100387","DOI":"10.1016\/j.xcrm.2021.100387","volume":"2","author":"Overgaard","year":"2021","journal-title":"Cell Reports Med"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.diabet.2018.12.001","volume":"45","author":"Aroda","year":"2019","journal-title":"Diabetes Metab"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/dom.14290","volume":"23","author":"Sarma","year":"2021","journal-title":"Diabetes Obes Metab"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1111\/obr.12839","volume":"20","author":"Christou","year":"2019","journal-title":"Obes Rev"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1056\/NEJMoa2032183","volume":"384","author":"Wilding","year":"2021","journal-title":"The New England Journal of Medicine"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1001\/jama.2021.3224","volume":"325","author":"Rubino","year":"2021","journal-title":"JAMA"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1002\/jcph.1131","volume":"58","author":"B\u00e6kdal","year":"2018","journal-title":"J Clin Pharmacol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/jcpt.13224","volume":"45","author":"Patel","year":"2020","journal-title":"J Clin Pharm Ther"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ahj.2020.07.008","volume":"229","author":"Ryan","year":"2020","journal-title":"Am Heart J"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1007\/s13300-018-0458-5","volume":"9","author":"Carlsson Petri","year":"2018","journal-title":"Diabetes Ther"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1007\/s40262-018-0668-z","volume":"57","author":"Hall","year":"2018","journal-title":"Clin Pharmacokinet"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00155","volume":"10","author":"Knudsen","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"4725","DOI":"10.1039\/D0RA00104J","volume":"10","author":"Niu","year":"2020","journal-title":"RSC Adv"},{"key":"ref62","first-page":"87","volume":"5","author":"Gabery","year":"2021","journal-title":"JCI Insight"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"487","DOI":"10.2337\/dci19-0066","volume":"43","author":"Buse","year":"2020","journal-title":"Diabetes Care"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ejps.2017.03.020","volume":"104","author":"Jensen","year":"2017","journal-title":"Eur J Pharm Sci"}],"container-title":["Clinical Pharmacology: Advances and Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=82635","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=82635","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T16:24:56Z","timestamp":1659457496000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/clinical-impact-of-semaglutide-a-glucagon-like-peptide-1-receptor-agon-peer-reviewed-fulltext-article-CPAA"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":64,"URL":"https:\/\/doi.org\/10.2147\/cpaa.s374741","relation":{},"ISSN":["1179-1438"],"issn-type":[{"value":"1179-1438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8]]}}}