{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:26:03Z","timestamp":1780593963539,"version":"3.54.1"},"reference-count":48,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s240862","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T22:51:51Z","timestamp":1610491911000},"page":"151-157","source":"Crossref","is-referenced-by-count":10,"title":["Spotlight on Pimavanserin Tartrate and Its Therapeutic Potential in the Treatment of Major Depressive Disorder: The Evidence to Date"],"prefix":"10.2147","volume":"Volume 15","author":[{"given":"Vicki","family":"Soogrim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0577-0111","authenticated-orcid":true,"given":"Valerie L","family":"Ruberto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Murrough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2764-2391","authenticated-orcid":true,"given":"Manish Kumar","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1001\/jamapsychiatry.2017.4602","volume":"75","author":"Hasin","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","volume":"390","author":"Vos","year":"2017","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jad.2016.07.012","volume":"206","author":"Jha","year":"2016","journal-title":"J Affect Disord"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e0167901","DOI":"10.1371\/journal.pone.0167901","volume":"11","author":"Jha","year":"2016","journal-title":"PLoS One"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1176\/appi.ajp.2016.16020176","volume":"173","author":"Jha","year":"2016","journal-title":"Am J Psychiatry"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"803","DOI":"10.2147\/NDT.S128407","volume":"13","author":"Jha","year":"2017","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","volume":"163","author":"Rush","year":"2006","journal-title":"Am J Psychiatry"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3390\/ph13060116","volume":"13","author":"Ruberto","year":"2020","journal-title":"Pharmacy (Basel)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.4088\/JCP.19r12889","volume":"81","author":"Papakostas","year":"2020","journal-title":"J Clin Psychiatry"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1176\/appi.neuropsych.17110262","volume":"30","author":"Boes","year":"2018","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1176\/appi.focus.20180013","volume":"16","author":"Jha","year":"2018","journal-title":"Focus (Am Psychiatr Publ)"},{"key":"ref12","author":"Malhi","year":"2020","journal-title":"Bipolar Disord"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1056\/NEJMcp1712493","volume":"380","author":"Park","year":"2019","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"6","DOI":"10.4088\/JCP.19m12928","volume":"80","author":"Fava","year":"2019","journal-title":"J Clin Psychiatry"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/da.23017","volume":"37","author":"Freeman","year":"2020","journal-title":"Depress Anxiety"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1097\/YIC.0000000000000328","volume":"35","author":"Papakostas","year":"2020","journal-title":"Int Clin Psychopharmacol"},{"key":"ref17","unstructured":"Prescribing Information for Pimavanserin; 2019. Available from: https:\/\/www.nuplazid.com\/sites\/nuplazid\/files\/pdf\/NUPLAZID_Prescribing_Information.pdf. Accessed November 01, 2020."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1007\/s11064-014-1293-3","volume":"39","author":"Hacksell","year":"2014","journal-title":"Neurochem Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4986","DOI":"10.1172\/JCI70678","volume":"123","author":"Meltzer","year":"2013","journal-title":"J Clin Invest"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1093\/ijnp\/pyx097","volume":"21","author":"Jha","year":"2018","journal-title":"Int J Neuropsychopharmacol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1124\/jpet.105.097006","volume":"317","author":"Vanover","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0140-6736(13)62106-6","volume":"383","author":"Cummings","year":"2014","journal-title":"Lancet"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.euroneuro.2006.08.007","volume":"17","author":"Frieling","year":"2007","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"150","DOI":"10.12688\/f1000research.2-150.v1","volume":"2","author":"Nichols","year":"2013","journal-title":"F1000Research"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.2147\/NDT.S201029","volume":"15","author":"Zhang","year":"2019","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/npp.2009.176","volume":"35","author":"Meltzer","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"f288","DOI":"10.1136\/bmj.f288","volume":"346","author":"Castro","year":"2013","journal-title":"BMJ"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/sj.npp.1300057","volume":"28","author":"Marek","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1159\/000069738","volume":"72","author":"Fava","year":"2003","journal-title":"Psychother Psychosom"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1002\/sim.6494","volume":"34","author":"Rybin","year":"2015","journal-title":"Stat Med"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1176\/appi.ajp.2011.10111704","volume":"168","author":"Posner","year":"2011","journal-title":"Am J Psychiatry"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.jad.2020.08.051","volume":"277","author":"Shelton","year":"2020","journal-title":"J Affect Disord"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1038\/npp.2009.4","volume":"34","author":"Perlis","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1517\/14740338.2014.951324","volume":"13","author":"Clayton","year":"2014","journal-title":"Expert Opin Drug Saf"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"256","DOI":"10.4088\/JCP.12m07933","volume":"74","author":"Ishak","year":"2013","journal-title":"J Clin Psychiatry"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1176\/appi.ajp.2007.06111868","volume":"165","author":"Fava","year":"2008","journal-title":"Am J Psychiatry"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1017\/S1092852913000114","volume":"18","author":"Ionescu","year":"2013","journal-title":"CNS Spectr"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e1010","DOI":"10.4088\/JCP.14076tx3c","volume":"77","author":"Cutler","year":"2016","journal-title":"J Clin Psychiatry"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"329","DOI":"10.31887\/DCNS.2008.10.3\/dnutt","volume":"10","author":"Nutt","year":"2008","journal-title":"Dialogues Clin Neurosci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4088\/JCP.v65n0411","volume":"65","author":"Fava","year":"2004","journal-title":"J Clin Psychiatry"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1016\/j.clinph.2006.03.011","volume":"117","author":"Kaida","year":"2006","journal-title":"Clin Neurophysiol"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.20m13425","volume":"82","author":"Jha","year":"2020","journal-title":"J Clin Psychiatry"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1038\/s41386-020-0769-x","volume":"45","author":"Jha","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1176\/appi.ajp.2018.18030355","volume":"176","author":"Jha","year":"2019","journal-title":"Am J Psychiatry"},{"key":"ref45","author":"Minhajuddin","year":"2020","journal-title":"Psychiatry Res Clin Pract"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.jad.2020.06.021","volume":"275","author":"Jha","year":"2020","journal-title":"J Affect Disord"},{"key":"ref47","unstructured":"News Release; 2020. Available from: https:\/\/ir.acadia-pharm.com\/news-releases\/news-release-details\/acadia-pharmaceuticals-announces-top-line-results-phase-3-0?field_nir_news_date_value%5Bmin%5D=. Accessed November 02, 2020."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1159\/000491093","volume":"87","author":"Trivedi","year":"2018","journal-title":"Psychother Psychosom"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=65644","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=65644","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T22:52:04Z","timestamp":1610491924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/spotlight-on-pimavanserin-tartrate-and-its-therapeutic-potential-in-th-peer-reviewed-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":48,"URL":"https:\/\/doi.org\/10.2147\/dddt.s240862","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}