{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:17:16Z","timestamp":1787062636340,"version":"build-2736575974"},"reference-count":65,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s242521","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T17:15:10Z","timestamp":1581614110000},"page":"621-633","source":"Crossref","is-referenced-by-count":121,"title":["<p>Hydrogen Sulfide Protects Against High Glucose-Induced Human Umbilical Vein Endothelial Cell Injury Through Activating PI3K\/Akt\/eNOS Pathway<\/p>"],"prefix":"10.2147","volume":"Volume 14","author":[{"given":"Fengxia","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanyin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinzhi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1097\/JCN.0000000000000245","volume":"31","author":"Dokken","year":"2016","journal-title":"J Cardiovasc Nurs"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"404","DOI":"10.3904\/kjim.2016.208","volume":"32","author":"Lee","year":"2017","journal-title":"Korean J Intern Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"H148","DOI":"10.1152\/ajpheart.1997.272.1.H148","volume":"272","author":"Ren","year":"1997","journal-title":"Am J Physiol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1161\/ATVBAHA.113.301938","volume":"34","author":"Cheang","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1113\/EP085508","volume":"101","author":"Choi","year":"2016","journal-title":"Exp Physiol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"5695","DOI":"10.2174\/1381612811319320005","volume":"19","author":"Fiorentino","year":"2013","journal-title":"Curr Pharm Des"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.lfs.2010.03.019","volume":"86","author":"Bitar","year":"2010","journal-title":"Life Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.vph.2016.08.012","volume":"91","author":"Chu","year":"2017","journal-title":"Vascul Pharmacol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.bbrc.2011.08.083","volume":"413","author":"Jung","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/j.2040-1124.2010.00093.x","volume":"2","author":"Nakamura","year":"2011","journal-title":"J Diabetes Investig"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3121\/cmr.4.1.53","volume":"4","author":"Yang","year":"2006","journal-title":"Clin Med Res"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"S259","DOI":"10.2337\/dcS13-2018","volume":"36","author":"Mannucci","year":"2013","journal-title":"Diabetes Care"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/nyas.12044","volume":"1281","author":"Giorgino","year":"2013","journal-title":"Ann N Y Acad Sci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.ejphar.2009.11.046","volume":"628","author":"Hu","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1161\/01.ATV.0000160549.60980.a8","volume":"25","author":"Kim","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0092-8674(00)80405-5","volume":"91","author":"Datta","year":"1997","journal-title":"Cell"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.bbamcr.2008.12.002","volume":"1793","author":"Romorini","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3109\/03630260903212175","volume":"33","author":"Wei","year":"2009","journal-title":"Hemoglobin"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"696215","DOI":"10.1155\/2012\/696215","volume":"2012","author":"Naudi","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1002\/jcb.v113.3","volume":"113","author":"Huang","year":"2012","journal-title":"J Cell Biochem"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.biopha.2017.07.037","volume":"93","author":"Liu","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/1753-0407.12017","volume":"5","author":"Zhang","year":"2013","journal-title":"J Diabetes"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nrd2425","volume":"6","author":"Szabo","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.tips.2007.11.003","volume":"29","author":"Li","year":"2008","journal-title":"Trends Pharmacol Sci"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1089\/ars.2009.2956","volume":"12","author":"Jain","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1007\/s00125-010-1761-5","volume":"53","author":"Whiteman","year":"2010","journal-title":"Diabetologia"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.1161\/CIRCULATIONAHA.113.002208","volume":"127","author":"Mani","year":"2013","journal-title":"Circulation"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nchembio711","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat Chem Biol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1177\/1479164117692766","volume":"14","author":"Ng","year":"2017","journal-title":"Diabetes Vasc Dis Res"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"104","DOI":"10.3389\/fphys.2011.00104","volume":"2","author":"Predmore","year":"2011","journal-title":"Front Physiol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.3892\/ijmm.2017.2891","volume":"39","author":"Ke","year":"2017","journal-title":"Int J Mol Med"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1111\/bcpt.2014.114.issue-4","volume":"114","author":"Chen","year":"2014","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"7993","DOI":"10.1073\/pnas.95.14.7993","volume":"95","author":"Yu","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.3389\/fphar.2018.01266","volume":"9","author":"Han","year":"2018","journal-title":"Front Pharmacol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"8008","DOI":"10.1038\/s41598-017-06712-z","volume":"7","author":"Li","year":"2017","journal-title":"Sci Rep"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.biopha.2017.07.044","volume":"93","author":"Rezabakhsh","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.phymed.2018.11.008","volume":"56","author":"Rezabakhsh","year":"2019","journal-title":"Phytomedicine"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3390\/ijms17040483","volume":"17","author":"An","year":"2016","journal-title":"Int J Mol Sci"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1042\/CS20160235","volume":"130","author":"Yuan","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1042\/CS20040086","volume":"107","author":"Stoneman","year":"2004","journal-title":"Clin Sci (Lond)"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1126\/science.275.5303.1132","volume":"275","author":"Kluck","year":"1997","journal-title":"Science (New York, NY)"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"8661","DOI":"10.1002\/jcb.28154","volume":"120","author":"Yu","year":"2018","journal-title":"J Cell Biochem"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"481840","DOI":"10.1155\/2012\/481840","volume":"2012","author":"Basha","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.bcp.2016.12.009","volume":"127","author":"Maamoun","year":"2017","journal-title":"Biochem Pharmacol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.cmet.2010.04.005","volume":"11","author":"Yang","year":"2010","journal-title":"Cell Metab"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/nature07203","volume":"454","author":"Zhang","year":"2008","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1089\/ars.2007.1782","volume":"9","author":"Malhotra","year":"2007","journal-title":"Antioxid Redox Signal"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"e79739","DOI":"10.1371\/journal.pone.0079739","volume":"8","author":"Peng","year":"2013","journal-title":"PLoS One"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2337\/db16-0915","volume":"66","author":"Wang","year":"2017","journal-title":"Diabetes"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.carbpol.2013.12.080","volume":"103","author":"Zhu","year":"2014","journal-title":"Carbohydr Polym"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.atherosclerosis.2014.10.013","volume":"237","author":"Liu","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1161\/hh2001.097796","volume":"89","author":"Hoffmann","year":"2001","journal-title":"Circ Res"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1016\/j.jvs.2009.08.007","volume":"50","author":"Yan","year":"2009","journal-title":"J Vasc Surg"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1042\/CS20110267","volume":"121","author":"Whiteman","year":"2011","journal-title":"Clin Sci (Lond)"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13578-016-0099-1","volume":"6","author":"Liu","year":"2016","journal-title":"Cell Biosci"},{"key":"ref56","first-page":"5097","volume":"8","author":"Wang","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.3892\/ijmm.2017.3330","volume":"41","author":"Lin","year":"2018","journal-title":"Int J Mol Med"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.mad.2016.11.005","volume":"162","author":"Guo","year":"2017","journal-title":"Mech Ageing Dev"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"3182","DOI":"10.1073\/pnas.1321871111","volume":"111","author":"King","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cardiores.2007.05.026","volume":"76","author":"Cai","year":"2007","journal-title":"Cardiovasc Res"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.3892\/ijmm.2013.1513","volume":"32","author":"Zhou","year":"2013","journal-title":"Int J Mol Med"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1007\/s10753-019-00996-1","volume":"42","author":"Chen","year":"2019","journal-title":"Inflammation"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.3892\/mmr.2017.6760","volume":"16","author":"Cheng","year":"2017","journal-title":"Mol Med Rep"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.atherosclerosis.2017.03.016","volume":"260","author":"Wang","year":"2017","journal-title":"Atherosclerosis"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1161\/01.ATV.0000155462.24263.e4","volume":"25","author":"Sheu","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=56132","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=56132","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T21:40:49Z","timestamp":1583962849000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/hydrogen-sulfide-protects-against-high-glucose-induced-human-umbilical-peer-reviewed-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":65,"URL":"https:\/\/doi.org\/10.2147\/dddt.s242521","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]}}}