{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:52:17Z","timestamp":1783075937693,"version":"3.54.6"},"reference-count":46,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DDDT"],"DOI":"10.2147\/dddt.s247259","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T21:22:16Z","timestamp":1597094536000},"page":"3251-3262","source":"Crossref","is-referenced-by-count":12,"title":["<p>Therapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil<\/p>"],"prefix":"10.2147","volume":"Volume 14","author":[{"given":"Marion","family":"Ortner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Stange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Schr\u00f6der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Buerger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"M\u00fcller-Sarnowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7745-1382","authenticated-orcid":true,"given":"Janine","family":"Diehl-Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"F\u00f6rstl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Grimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Steimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,8]]},"reference":[{"key":"ref1","unstructured":"NICE. Dementia: A NICE-SCIE Guideline on Supporting People with Dementia and Their Carers in Health and Social Care. Leicester, London: British Psychological Society; Royal College of Psychiatrists; 2007."},{"key":"ref2","unstructured":"Deuschl G, Wea M. S3-Leitlinie Demenzen; 2016. Available from: www.dgn.org\/leitlinien. Accessed September 12, 2017."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1017\/s0317167100015183","volume":"39","author":"Gauthier","year":"2012","journal-title":"Can J Neurol Sci"},{"key":"ref4","unstructured":"Guideline Adaption Committee. Clinical Practice Guidelines and Principles of Care for People with Dementia. Sydney; 2016."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1212\/WNL.56.9.1154","volume":"56","author":"Doody","year":"2001","journal-title":"Neurology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"857","DOI":"10.3233\/JAD-2012-120109","volume":"31","author":"Chou","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.kjms.2017.04.006","volume":"33","author":"Chen","year":"2017","journal-title":"Kaohsiung J Med Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1001\/archinte.158.9.1021","volume":"158","author":"Rogers","year":"1998a","journal-title":"Arch Intern Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1097\/JCP.0b013e31828b5087","volume":"33","author":"Yang","year":"2013","journal-title":"J Clin Psychopharmacol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.jphs.2015.10.010","volume":"129","author":"Lu","year":"2015","journal-title":"J Pharmacol Sci"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"539","DOI":"10.3233\/JAD-160164","volume":"55","author":"Miranda","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1097\/FTD.0000000000000152","volume":"37","author":"Hefner","year":"2015","journal-title":"Ther Drug Monit"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1177\/00912700122012689","volume":"41","author":"Gobburu","year":"2001","journal-title":"J Clin Pharmacol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s00228-006-0168-1","volume":"62","author":"Varsaldi","year":"2006","journal-title":"Eur J Clin Pharmacol"},{"key":"ref15","unstructured":"FDA. NDA 22-083\/S016 Exelon\u00ae Patch (rivastigmine transdermal system). Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2012\/022083orig1s016.pdf. Accessed August 20, 2017."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1146\/annurev.pharmtox.37.1.269","volume":"37","author":"Meyer","year":"1997","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref17","first-page":"284","volume":"60","author":"Sachse","year":"1997","journal-title":"Am J Hum Genet"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.clpt.2004.04.009","volume":"76","author":"Raimundo","year":"2004","journal-title":"Clin Pharmacol Ther"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/clpt.2013.2","volume":"93","author":"Hicks","year":"2013","journal-title":"Clin Pharmacol Ther"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/bcp.12325","volume":"78","author":"Noetzli","year":"2014","journal-title":"Br J Clin Pharmacol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00228-010-0883-5","volume":"67","author":"Magliulo","year":"2011","journal-title":"Eur J Clin Pharmacol"},{"key":"ref22","first-page":"303","volume":"3","author":"Cacabelos","year":"2007","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1373\/clinchem.2003.030825","volume":"50","author":"Steimer","year":"2004","journal-title":"Clin Chem"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/331442a0","volume":"331","author":"Gonzalez","year":"1988","journal-title":"Nature"},{"key":"ref25","unstructured":"FDA. Aricept label information. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2015\/020690s039,021720s012,022568s008lbl.pdf. Accessed August 21, 2017."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jns.2016.05.001","volume":"366","author":"Mori","year":"2016","journal-title":"J Neurol Sci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1185\/030079906X89685","volume":"22","author":"Bullock","year":"2006","journal-title":"Curr Med Res Opin"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s00228-016-2033-1","volume":"72","author":"Coin","year":"2016","journal-title":"Eur J Clin Pharmacol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1159\/000350050","volume":"37","author":"Sonali","year":"2014","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/FPC.0b013e32833f984c","volume":"21","author":"Seripa","year":"2011","journal-title":"Pharmacogenet Genomics"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"691","DOI":"10.3389\/fphar.2020.00691","volume":"11","author":"Ortner","year":"2020","journal-title":"Front Pharmacol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.biopsych.2014.01.019","volume":"77","author":"Ortner","year":"2015","journal-title":"Biol Psychiatry"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1212\/WNL.39.9.1159","volume":"39","author":"Morris","year":"1989","journal-title":"Neurology"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1111\/j.1532-5415.1993.tb07308.x","volume":"41","author":"Watson","year":"1993","journal-title":"J Am Geriatr Soc"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1001\/archneur.1991.00530150046016","volume":"48","author":"Welsh","year":"1991","journal-title":"Arch Neurol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jns.2014.05.033","volume":"343","author":"Lu","year":"2014","journal-title":"J Neurol Sci"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1046\/j.1365-2125.1998.0460s1001.x","volume":"46","author":"Rogers","year":"1998","journal-title":"Br J Clin Pharmacol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1055\/s-0043-116492","volume":"51","author":"Hiemke","year":"2018","journal-title":"Pharmacopsychiatry"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jchromb.2011.10.027","volume":"881\u2013882","author":"Koeber","year":"2012","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/sj.clpt.6100242","volume":"83","author":"Lef\u00e8vre","year":"2008","journal-title":"Clin Pharmacol Ther"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1373\/49.4.542","volume":"49","author":"Chou","year":"2003","journal-title":"Clin Chem"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/00008571-199802000-00003","volume":"8","author":"Griese","year":"1998","journal-title":"Pharmacogenetics"},{"key":"ref45","first-page":"516","volume":"274","author":"Dahl","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1097\/00008571-200110000-00004","volume":"11","author":"Zanger","year":"2001","journal-title":"Pharmacogenetics"}],"container-title":["Drug Design, Development and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=60497","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.dovepress.com\/getfile.php?fileID=60497","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T21:22:24Z","timestamp":1597094544000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dovepress.com\/therapeutic-drug-monitoring-of-rivastigmine-and-donepezil-under-consid-peer-reviewed-article-DDDT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":46,"URL":"https:\/\/doi.org\/10.2147\/dddt.s247259","relation":{},"ISSN":["1177-8881"],"issn-type":[{"value":"1177-8881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]}}}